Protein cysteine residues. Medical search. Frequent questions

Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)

His research contributed to the understanding of protein diagenesis (degradation) in the late 1960s, and highlighted that ancient amino acid profiles alone might not be sufficient for protein identification. (wikipedia.org)
Additionally, they found a rapid degradation of spike protein following its synthesis when ZDHHC enzymes were silenced. (news-medical.net)
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. (antibodies-online.com)
Critical cysteine residues of Keap1 in suppression of Nrf2 basal activity and arsenic-sensing by regulating the ubiquitination-proteasomal degradation of Nrf2 protein. (cdc.gov)

She was the first to improve the sequence coverage of ancient proteins by combining different techniques such as peptide mass fingerprinting and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Understanding how ancient proteins are formed and incorporated into archaeological materials are essential in sampling, evaluating contamination and planning analyses. (wikipedia.org)
A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)
Top down versus bottom up protein characterization by tandem high-resolution mass spectrometry," J Amer Chem Soc , 121:806-12, 1999. (the-scientist.com)

Proteins were known to be composed of 20 distinct amino acids whereas DNA is composed of only 4 nucleotides. (proprofs.com)
In the early twentieth century, it was believed that proteins might carry genetic information because proteins were known to be composed of 20 distinct amino acids, whereas DNA is composed of only 4 nucleotides. (proprofs.com)
IGF-1 is a 8.28 kDa protein consisting of 69 amino acids. (proteopedia.org)
SARS-CoV-2 Spike consists of ten conserved cysteine residues within its first 20 cytosolic amino acids. (news-medical.net)
Dietary supplementation with methionine and threonine spares body protein in rats fed a low protein diet, but the effect is not observed for other essential amino acids. (bvsalud.org)
Although the requirement for sulfur amino acids is relatively high in rodents, the precise mechanisms underlying protein retention are not fully understood. (bvsalud.org)
A simple, sensitive and green micellar liquid chromatographic method (RP-HPLC) was developed for enantioseparation of four racemic amino acids, namely, (RS)-selenomethionine, (RS)-methionine, (RS)-cysteine and (RS)-penicillamine. (bvsalud.org)

The human cuticle is around 6 to 8 layers thick and consists of keratin protein, structural lipids, and high sulfur keratin-associated proteins (KAP). (thieme-connect.com)

Here, we combine in-vitro structural measurements, which used EPR spectroscopy and UV-Vis measurements, with cell experiments to explore the role of the various methionine residues in CusB. (biorxiv.org)
We targeted two methionine residues (M227 and M241) that are essential for the proper function of CusB. (biorxiv.org)
Because methionine is a thioether and relatively chemically inert compared with cysteine's thiol, modifying methionine is less likely to change the function of a protein. (acs.org)
E.A. Orabi and A.M. English ( 2016 ) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Binding toTyrosinate and Histidinium Ions to Assess Their Influence on Protein Electron Transfer , Isr. (concordia.ca)
The aim of this study was to explore whether the activation of mammalian target of rapamycin complex 1 (mTORC1) downstream factors in skeletal muscle by supplementation with threonine and/or methionine contributes to protein retention under sufficient cystine requirement. (bvsalud.org)
These experimental rats were then fed a restricted diet (14.5 g/day) containing 12% soy protein supplemented with both cystine and, methionine and threonine (MT), methionine (M), threonine (T), or neither (NA) (n = 8) for an additional 12 days. (bvsalud.org)
These results suggest that methionine regulates mTORC1 downstream factors in skeletal muscle, leading to spare body protein in rats fed a low protein diet meeting cystine requirements. (bvsalud.org)
The sulfur amino acid (cysteine + methionine) content of the experimental lines ranged from 1.1 % to 1.26 % while the parents Lee 5 and CS had 0.79 % and 1.1 %, respectively. (bvsalud.org)

They altered the Sulfolobus genes to produce a protein with a slightly different structure, then inserted the altered genes into common E. coli bacteria, which manufactured large amounts of the modified protein. (trnmag.com)

He also pioneered the use of antibodies for the study of ancient proteins in the 1970s and 1980s, utilising different immunological techniques such as Ouchterlony double immunodiffusion (interactions of antibodies and antigens in a gel). (wikipedia.org)
Dental calculi are defined as calcified biofilms, created and mediated by interactions between calcium phosphate ions and a wide range of oral microbial, human, and food proteins during episodic biomineralisation. (wikipedia.org)
Over the past several years, we have engineered a range of proteins with new functions, including protein-protein interactions that are specific enough to control complex biological processes in mammalian cells (Kapp*, Liu* et al. (ucsf.edu)
Adenovirus protein- protein interactions: hexon and protein VI. (microbiologyresearch.org)
We also found out that AD fluoxetine prevents nitration of TRKB receptors in vivo and antidepressant drugs fluoxetine, phenelzine and imipramine disrupt the interactions of TRKB, NOS1 and NOS1 adaptor protein (CAPON) in co-immunoprecipitation assay. (helsinki.fi)
Here we analyzed arsenic-Keap1 cysteine thiol interactions for Nrf2 activation. (cdc.gov)
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. (embl-heidelberg.de)
MRD is among the few methods that can provide molecular-level informa- tion about protein solvation in native as well as denatured states, and it is used here to simultaneously monitor the interactions of urea and water with the unfolding protein. (lu.se)
1 nsec) interactions of urea and water with the native and denatured protein. (lu.se)
Solvent denaturation is a result of altered protein-solvent vorably with water-peptide interactions. (lu.se)
If this is the case, interactions, but it is not clear whether denaturants like urea then solvent denaturation can be driven simply by the ex- act directly by binding to the protein surface or indirectly by posure of more binding sites in the denatured protein perturbing solvent-mediated hydrophobic interactions or by (Schellman 1987). (lu.se)

Reduced glutathione (GSH) is currently used, but it binds to our peptides via two disulfide bonds to two cysteines in our target peptide. (bio.net)
DTT removes the GSH, but it produces the target peptide with reduced cysteine residues. (bio.net)
1995), the molecular mechanism and the peptide group, suggesting that urea-peptide inter- whereby urea unfolds proteins has not been established. (lu.se)
Thus, the principle of protein or peptide haptenation could be used in in vitro assays to predict the sensitization potential of a new chemical entity. (cdc.gov)
We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)

These regions are highly conserved amongst mastadenovirus pVI proteins. (microbiologyresearch.org)
Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). (novusbio.com)

Mutations in the conserved cysteine residues in the cysteine-rich region led to a decrease in bound iron. (nih.gov)
Several point mutations have now been identified in the fibrillin gene, most of which affect cysteine residues within the microfibril. (medscape.com)

It chemically links, via a covalent bond, a protein to the sulfur atom of cytosolic cysteines. (news-medical.net)
If scientists could find a different amino acid to modify, they'd be less likely to disrupt protein function when making antibody-drug conjugates or preparing covalent protein probes. (acs.org)
Lumakras is a highly specific KRAS G12C inhibitor that deactivates the mutant protein by forming an irreversible covalent bond with aberrant cysteine residue. (biospace.com)

The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Predicting and designing the structures of proteins with biologically useful accuracy has been a key challenge in computational structural biology and molecular engineering. (ucsf.edu)
CoVs are enveloped by a protein membrane that consists of a minimum of three structural proteins, namely, Spike (S), Membrane (M), and Envelope (E). They also contain accessory factors such as Orf3a. (news-medical.net)
The role of adenovirus structural proteins in the regulation of adenovirus infection. (microbiologyresearch.org)
E.A. Orabi and A.M. English ( 2018 ) Modeling protein S-aromatic motifs reveals their structural and redox flexibility, J. Phys Chem. (concordia.ca)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Our findings support the notion that arsenic binds to different sets of Keap1 cysteine residues to regulate divergent functions in Nrf2 signaling. (cdc.gov)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
NO regulates the function of many proteins by e.g. interacting with tyrosine and cysteine residues, thus inducing post-translational modifications. (helsinki.fi)
The method can be used for automated detection of chemical/post- translational modifications, quality control of experiments and labelling approaches, and to control the modification settings of protein identification tools. (lu.se)

Reactive oxygen species interacting with cysteine residues can alter protein function. (nature.com)
When 7 histidine and 12 cysteine residues of rat (r)MATE1 conserved among species were mutated, substitution of His-385, Cys-62, and Cys-126 led to a significant loss of tetraethylammonium (TEA) transport activity. (aspetjournals.org)
Find PPT1 Proteins for a variety of species such as anti-Human PPT1, anti-Mouse PPT1, anti-C. elegans PPT1. (antibodies-online.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)

Like modern proteomics, the study of ancient proteins has also been enabled by technological advances. (wikipedia.org)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

Posttranslational heterocyclization of cysteine and serine residues in the antibiotic Microcin B17: Distributivity and directionality," Biochemistry , 38:15623-30, 1999. (the-scientist.com)

Another method for enhancing the crystallizability of proteins involves chemical modification of specific sidechains. (uni-konstanz.de)
Major targets of ROS-induced modification of proteins are reactive cysteine residues. (nature.com)
A protein modification that effectively removes or replaces an L-tyrosine. (reactome.org)
A protein modification that effectively converts a source amino acid residue to an L-cysteine. (reactome.org)
One of the key molecular events in skin sensitization is protein haptenation, i.e. the chemical modification of self-skin protein(s) thus forming macromolecular immunogens. (cdc.gov)

This method, also called 'surface entropy-reduction mutagenesis', involves mutation of sidechains on the surface of proteins, in order to reduce the entropic cost of forming ordered intermolecular crystal contacts and thus enhance the crystallizability of proteins. (uni-konstanz.de)
Mutation of the corresponding residues in human (h)MATE1 and hMATE2-K also diminished the transport activity. (aspetjournals.org)
Mutation of C273 or C288A in linker region resulted in higher level expression of Nrf2 protein in the absence of inducers. (cdc.gov)

A reactive cysteine contains a thiolate group (S-) which reacts with H 2 O 2 with rates ranging from 10 to 10 5 M −1 s −1 , depending on their local environment, while the thiol groups (SH) do not react physiologically with H 2 O 2 unless the reaction is catalyzed 10 . (nature.com)
Thanks to the chemistry of its thiol group, cysteine has long been the go-to amino acid when researchers want to modify a protein. (acs.org)

Those cysteine residues are often involved in catalysis or play a role in stabilizing the protein via formation of disulfide bonds. (acs.org)

Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. (bvsalud.org)

Additionally, mild oxidation can induce reversible cysteine disulfide bond formation and thus prevent further irreversible cysteine modifications 11 . (nature.com)
The inhibition is mainly mediated through the reactive cysteine C195 at the exit of transmembrane region 3 (TM3) of Orai1, a residue that is not conserved in the paralogue Orai3, which currents are not inhibited by oxidation 22 . (nature.com)
this response is mediated by oxidation of the cysteine residue on its DNA binding domain, which enhances DNA binding. (lu.se)

The abnormality of the connective tissue protein fibrillin causes a variety of problems in the affected individual. (medscape.com)

This effectively neutralizes the cysteine residues (some of which are chemically reactive), increases the overall solubility of the protein and can help prevent aggregation and denaturation problems. (uni-konstanz.de)
C-reactive protein,mannose-binding lectin, and serum amyloid P component activate complement and act as opsonins. (msdmanuals.com)
Elevated C-reactive protein levels are a nonspecific indicator of infection or inflammation. (msdmanuals.com)

The protease of adenovirus serotype 2 requires cysteine residues for both activation and catalysis. (microbiologyresearch.org)

HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. (fishersci.com)
Eotaxin-2 contains the four conserved cysteine residues present in CC chemokines. (peprotech.com)

The transport of TEA via rMATE1 was inhibited by the sulfhydryl reagent p -chloromercuribenzenesulfonate (PCMBS) and the histidine residue modifier diethyl pyrocarbonate (DEPC) in a concentration-dependent manner. (aspetjournals.org)
IRDye 680LT Maleimide is used to label molecules with free sulfhydryl groups, such as cysteine residues in proteins, at physiological pH. (licor.com)

The 18-methyl eicosanoic (18-MEA) acid is located at the cuticle-cuticle cell (CMC), attached to ultrahigh sulfur protein. (thieme-connect.com)
In this study, we have developed experimental soybean lines that not only contain significantly higher amounts of protein but also improved sulfur amino acid content. (bvsalud.org)
This objective was achieved by crossing a O-acetylserine sulfhydrylase (OASS) overexpressing transgenic soybean line with elevated levels of sulfur amino acid content (CS) with a high protein Korean soybean cultivar (Lee 5). (bvsalud.org)

Our results demonstrate a novel mechanistic model for ROS-mediated inhibition of Orai1 and identify a candidate residue for pharmaceutical intervention. (nature.com)
The PCMBS-caused inhibition of the transport via rMATE1 was protected by an excess of various organic cations such as TEA, suggesting that cysteine residues act as substrate-binding sites. (aspetjournals.org)

It has also characterized Spike acylation and has also identified other acylated viral proteins and host enzymes involved in the process of infection. (news-medical.net)
Temperature sensitivity of processing of viral proteins. (microbiologyresearch.org)

The human IL-11 cDNA encodes a 199 amino acid residue precursor polypeptide with a 21 amino acid residue hydrophobic signal that is processed proteolytically to generate the 178 amino acid residue mature protein. (rndsystems.com)
PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)

GSNOR indirectly regulates the level of protein S-nitrosothiol in the cells. (muni.cz)
Therefore, the various concentration of the insulin proteins regulates the cell activity in different context, for instance in excess of glucose or lack of Growth Hormone. (proteopedia.org)

This study was focused on the dynamic regulation of the activity of plant GSNORs through reversible S-nitrosation and/or oxidative modifications of target cysteine residues. (muni.cz)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)

Cell surface biotinylation and immunofluorescence analyses with confocal microscopy indicated that rMATE1 mutant proteins were localized at plasma membranes. (aspetjournals.org)
Transport of proteins across membranes is a fundamental process, achieved in every cell by the 'Sec' translocon. (elifesciences.org)
The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)

Previous studies using rat renal brush-border membrane vesicles indicated that cysteine and histidine residues played critical roles in H + /organic cation antiport activity. (aspetjournals.org)
The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)
While studying the importance of these cysteine residues, researchers found that these are targets of S-acylation and lipidation of those closest to the membrane required to bring the distal cysteines closer to the membrane, making it more accessible to the ZDHHC active site. (news-medical.net)

In this review we will highlight mechanisms that control targeting of PSD-95 at the synapse, and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic structure and strength. (frontiersin.org)

Amino acid sequence alignment of the fusion (F) protein of various human metapneumovirus (HMPV) strains and other paramyxoviruses. (cdc.gov)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)
Different proteins were known to have unique sequences, whereas it was thought that all DNA molecules have the same sequence. (proprofs.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
The proposed method is novel because it works independently of protein sequence databases and without any prior knowledge about modifica- tions. (lu.se)
The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)

They heated the E. coli to 85 degrees Celsius to destroy the E. coli and its own proteins, leaving behind the engineered Sulfolobus protein. (trnmag.com)

Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of the C-5 DNA methyltransferase family (DNMTs). (mdpi.com)
p70 S6 kinase 1 abundance was higher, and eukaryotic translation initiation factor 4E-binding protein 1 abundance and mRNA levels were lower, in the skeletal muscles of the M and MT groups. (bvsalud.org)

To understand the nature of TRKB and NOS1 interaction, we thus examined the protein domains in NOS1 and TRKB using Uniprot database, and we were unable to identify sites that could interact directly. (helsinki.fi)
Literature search for NOS1 adapting proteins followed by Uniprot data mining indicated CAPON as a potential candidate to mediate NOS1: TRKB interaction. (helsinki.fi)

This may be the water molecule buried near the small hydrophobic folding core at the D-E turn in the native protein. (lu.se)
hydrophobic stabilization of the folded protein. (lu.se)

Researchers have also studied how S-acylation modifies the turnover rate of proteins. (news-medical.net)

The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 amino acid residues for the murine homolog, without C-terminal truncation). (peprotech.com)

They also mutated the genetic code of both variants to produce cysteine residues on the chaperonins' openings. (trnmag.com)
Without the activity of enzymes and proteins, the genetic information in the genome would not be able to be expressed and translated into functional proteins. (proprofs.com)
In the early tvventieth century it was thought that proteins might carry genetic information. (proprofs.com)
This difference in complexity led scientists to speculate that proteins, with their larger variety of building blocks, might be better suited to carry genetic information. (proprofs.com)

Chaperonins are essential proteins that exist in nearly all organisms, said McMillan. (trnmag.com)
The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. (genome.jp)
These organisms digest proteins and several fetid substances arise, leading to bad breath. (medscape.com)

Can someone guide me on the references of spectrophotometer methods used to measure enzymes or proteins newly discovered in the blood serum? (researchgate.net)
What are the main references (book or research) for one or more, that specify methods for measuring newly discovered enzymes or proteins, in which simple manual methods are used. (researchgate.net)
Previously, the genome of the cereal pathogen Fg was sequenced and shown to encode a larger number of proteins in pathogenicity related protein families compared to non-pathogenic fungi, including predicted transcription factors, hydrolytic enzymes, and transmembrane transporters 5 . (nature.com)
The given statement that the genome is able to express its own information without the activity of enzymes and proteins is FALSE. (proprofs.com)
Enzymes and proteins play a crucial role in gene expression by facilitating the transcription and translation processes. (proprofs.com)

I am trying to measure GUS expression, and was wondering if anyone knew what concentration hydrogen peroxide inhibits the GUS protein? (researchgate.net)
D. Martins and A.M. English ( 2015 ) Peroxynitrite and hydrogen peroxide elicit a similar cellular stress response mediated by the Ccp1 sensor protein, Free Rad. (concordia.ca)

This position requires a person with strong background in recombinant DNA techniques including some skill in protein purification and cell culturing (preferably with insect cells). (bio.net)

This method, pioneered by the Rayment laboratory, involves the methylation -- under reducing conditions -- of lysine residues. (uni-konstanz.de)
This method involves the carboxymethylation -- under reducing conditions -- of single cysteine residues. (uni-konstanz.de)
The second project involves mutagenesis of complement protein C9 to introduce cysteine residues for site- specific labeling. (bio.net)

Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl-heidelberg.de)
Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. (lu.se)

Once IGF1 is bound to Insulin-like Growth Binding Protein (IGFBP), IGF-1 cannot be linked to IGF1R any longer. (proteopedia.org)
We report here that SRE1, a gene encoding a GATA-type protein, bound to promoter sequences of genes involved in siderophore biosynthesis. (nih.gov)
Metal analysis indicated that a substoichiometric amount of iron, predominately Fe (3+), was bound to the purified protein. (nih.gov)
The observed behavior indicates conformational exchange between bound and free states upon protein-micelle interaction. (embl-heidelberg.de)
I was wondering if anyone has used a glutathione analog in which the sulfhydral group is blocked to elude bound GST-fusion proteins from a GSH-Sepharose Chromatography Column (Pharmacia). (bio.net)

Like Amgen's Lumakras, adagrasib is also a KRAS G12C inhibitor that works by selectively and irreversibly binding to the mutant protein, keeping it inactive. (biospace.com)

Certain portions of the protein bind to certain metals. (trnmag.com)
Cysteine, an amino acid, acts like glue to bind a bit of gold or zinc to each opening like sticking a ball to the end of a tube. (trnmag.com)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl-heidelberg.de)

In the present study, essential histidine and cysteine residues of MATE1 family were elucidated. (aspetjournals.org)
This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. (embl.de)
Insulin-like Growth Factor ( IGF-1 ) is a member of the insulin protein family. (proteopedia.org)
Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. (embl-heidelberg.de)
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. (bvsalud.org)

Similarly, the minerals of a ceramic matrix might interact with food proteins during food processing and cooking. (wikipedia.org)
IGF-1 then acts as a ligand and can interact with Insulin Receptor protein and Insulin-like Growth Factor Binding Protein . (proteopedia.org)

Insulin-like Growth Factor 1 Receptor ( IGF-1R ) is a transmembrane protein receptor. (proteopedia.org)

Our predictions generate hypotheses on protein conformations controlling biological processes - such as protein recognition, signal transduction, and enzyme active site gating - and are laying the foundation for our work reengineering and "reshaping" protein interfaces and active sites for new functions. (ucsf.edu)
The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. (antibodies-online.com)

the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain. (embl-heidelberg.de)

Their predominant function is thought to be facilitating protein folding inside cells, he said. (trnmag.com)
These results suggest that histidine and cysteine residues are required for MATE1 to function and that cysteine residues may serve as substrate-recognition sites. (aspetjournals.org)
The primary function of the S protein is infectivity. (news-medical.net)
Taxonomy and function of C1 protein kinase C homology domains. (embl-heidelberg.de)
Fibrillin's structure and function are altered by abnormal protein folding due to the alteration of bonding between cysteine residues, which in turn causes defective microfibril production. (medscape.com)
Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response. (lu.se)

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
Percentage points are related to the number of proteins with C8 domain which could be assigned to a KEGG orthologous group, and not all proteins containing C8 domain. (embl.de)

Anatomy10

Organisms8

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes68

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science5

Health Care3

Nucleic acids2

Degradation4

Mass Spectrometry3

Amino acids7

Lipids1

Methionine8

Altered genes1

Interactions11

Peptide6

Highly conserved2

Mutations2

Covalent3

Structural7

Keap13

Post-translational3

Species5

Proteomics2

Serine1

Modification5

Mutation3

Thiol2

Disulfide bonds1

Peptides2

Oxidation3

Connective tissue protein fibrillin1

Reactive3

Catalysis1

Redox1

Chemokines2

Sulfhydryl2

Sulfur3

Inhibition2

Viral proteins2

Precursor2

Regulates2

Oxidative3

Membranes3

Membrane3

Regulate1

Sequence6

Coli1

Eukaryotic2

UniProt2

Hydrophobic2

Modifies1

Mature protein1

Genetic4

Organisms3

Enzymes5

Hydrogen peroxide2

Purification1

Involves3

Atypical2

Bound5

Selectively1

Bind4

Family5

Interact2

Transmembrane1

Enzyme2

Ligands1

Function6

KEGG2