• Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
  • Nearly 20% of human cancers harbour mutations in GPCRs. (nature.com)
  • The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
  • Aberrant expression, overexpression or signal reprogramming of GPCRs and G proteins in tumour cells can contribute to cancer development and progression. (nature.com)
  • G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
  • Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
  • Many human cancer-associated viruses also express constitutively active viral GPCRs. (nature.com)
  • These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
  • Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety of tumours. (wikipedia.org)
  • Formal G protein-coupled signalling has been demonstrated for a number for adhesion GPCRs, however, the orphan receptor status of many of the receptors still hampers full characterisation of potential signal transduction pathways. (wikipedia.org)
  • There are 33 human adhesion GPCRs that can be broken down in the 8 groups and 2 independent receptors. (wikipedia.org)
  • Analysis of fungi showed that there were no secretin receptor family GPCRs, which suggests that they evolved from adhesion GPCRs in a later organism. (wikipedia.org)
  • While ligands for many receptors are still not known, researchers are utilizing drug libraries to investigate compounds that can activate GPCRs and using these data for future ligand research. (wikipedia.org)
  • As of today, many of the adhesion GPCRs are still orphan receptors and their signalling pathways have not been identified. (wikipedia.org)
  • G-protein-coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. (nih.gov)
  • G-protein-coupled receptors (GPCRs) form the largest receptor family, relay environmental stimuli to changes in cell behavior and represent prime drug targets. (ista.ac.at)
  • Many GPCRs are classified as orphan receptors because of the limited knowledge on their ligands and coupling to cellular signaling machineries. (ista.ac.at)
  • Here, we engineer a library of 63 chimeric receptors that contain the signaling domains of human orphan and understudied GPCRs functionally linked to the light-sensing domain of rhodopsin. (ista.ac.at)
  • These results demonstrate that substituting unknown chemical activators with a light switch can reveal information about protein function and provide an optically controlled protein library for exploring the physiology and therapeutic potential of understudied GPCRs. (ista.ac.at)
  • While expression patterns of many proteins in human medulloblastoma subgroups have been discerned, the expression pattern of GPCRs in medulloblastoma has not been investigated. (biomedcentral.com)
  • However, the physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). (ku.dk)
  • Integrating comparative genomics across 313 species and bioinformatics on all protein sequences and structures of human class A GPCRs, we identify universal characteristics that uncover additional potential peptidergic signaling systems. (ku.dk)
  • We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
  • Moreover, we dissected the signaling pathway from the cell surface receptors to RhoA using a broad-spectrum G protein coupled receptor (GPCR) antagonist, [D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP), and a recently reported Galphaq/11-selective inhibitor, YM-254890. (nih.gov)
  • Our results suggest that RhoA is activated in various lung cancer cells independent of its expression levels, and the high activation state of RhoA in SCLC cells mainly depends on a neuroendocrine peptide autocrine system which signals through Galpha12 coupled GPCR to RhoA. (nih.gov)
  • These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
  • The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes. (wikipedia.org)
  • This integrated computational and multifaceted experimental approach expands the peptide-GPCR network and opens the way for studies to elucidate the roles of these signaling systems in human physiology and disease. (ku.dk)
  • CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). (biolegend.com)
  • RNA sequencing revealed that genes involved in G protein-coupled receptor (GPCR) signaling were significantly up-regulated in the high-erythroid output donors. (lu.se)
  • The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. (nih.gov)
  • GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand. (nih.gov)
  • Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activation of downstream signalling effectors such as G proteins and β-arrestins. (nih.gov)
  • Assessing the binding of 17 ligands of varying efficacy to the β2AR in the absence and presence of Nb60 or Nb80 reveals large ligand-specific effects that can only be explained using an allosteric model which assumes equilibrium amongst at least three receptor states. (nih.gov)
  • We previously used bioluminescence resonance energy transfer (BRET) to demonstrate that the prototypic family B secretin receptor forms ligand-independent oligomeric complexes. (aspetjournals.org)
  • Unlike secretin receptor oligomers that were unaffected by ligand binding, the VPAC receptor homo-oligomers were modulated by vasoactive intestinal polypeptide. (aspetjournals.org)
  • The VPAC1-VPAC2 hetero-oligomers were modulated by vasoactive intestinal polypeptide binding, whereas the secretin-VPAC1 and secretin-VPAC2 receptor hetero-oligomers were unaffected by ligand treatment. (aspetjournals.org)
  • The peptidergic system is the most abundant network of ligand-receptor-mediated signaling in humans. (ku.dk)
  • with interest in protein structure determination as well as protein-ligand interaction characterization. (gu.se)
  • Motixafortide is an inhibitor of C-X-C motif chemokine receptor 4 (CXCR4) and blocks binding of its cognate ligand, stromal-derived factor-1α (SDF-1α)/C-X-C motif chemokine ligand 12 (CXCL12). (medscape.com)
  • These data demonstrate that ligands can initiate a wide range of cellular responses by differentially stabilizing multiple receptor states. (nih.gov)
  • The current studies provide novel insights into the pharmacology of GPR40 and indicate that G protein-coupled receptors which respond to fatty acids, and potentially to other lipid ligands, can be occupied by endogenous agonists before assay and that this may mask the pharmacology of the receptor and may be mistaken for high levels of constitutive activity. (aspetjournals.org)
  • Allosteric ligands modulate receptor function by binding to a site distinct from the recognition site for the endogenous agonist. (aspetjournals.org)
  • We also identify additional peptides for nine receptors with recognized ligands and pathophysiological roles. (ku.dk)
  • EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. (thermofisher.com)
  • The action of BDNF on CB 1 R (GABA) function was tyrosine kinase dependent and was complete even after receptor sensitization with cocaine or environmental manipulations activating the dopamine (DA)-dependent reward system. (jneurosci.org)
  • Quizartinib and its active metabolite (AC886) inhibit FLT3 kinase activity, preventing autophosphorylation of the receptor, thereby inhibiting downstream FLT3 receptor signaling and blocking FLT3-ITD-dependent cell proliferation. (medscape.com)
  • Increased adhesion of the cancer cells depended on activation of cyclooxygenase-2, an enzyme that is involved in progression of colon cancers, whereas adhesion of the intestinal epithelial cells was augmented by LTD4-induced translocation of protein kinase C to areas where integrins bind to matrix proteins (focal adhesions). (lu.se)
  • False positive non-synonymous polymorphisms of G-protein coupled receptor genes. (nih.gov)
  • Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (wikipedia.org)
  • 2002). „Identification of G protein-coupled receptor genes from the human genome sequence. (wikipedia.org)
  • Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes. (cdc.gov)
  • SUMMARY A direct correlation between HIV infection and mutation in the chemokine receptor ( CCR5 ) gene has been established. (who.int)
  • HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)
  • Description: A sandwich ELISA kit for detection of G Protein Coupled Receptor 172A from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. (myelisakit.com)
  • However, how agonists with varying efficacy modulate these receptor states to initiate cellular responses is not well understood. (nih.gov)
  • Agonists generally exert efficacy by stabilizing the active Nb80-stabilized receptor state (R80). (nih.gov)
  • In contrast, for a number of partial agonists, both stabilization of R80 and destabilization of the inactive, Nb60-bound state (R60) contribute to their ability to modulate receptor activation. (nih.gov)
  • Upon stimulation with visible light, we identify activation of canonical cell signaling pathways, including cAMP-, Ca2+-, MAPK/ERK-, and Rho-dependent pathways, downstream of the engineered receptors. (ista.ac.at)
  • We showed that receptor pathways mediated by Gs-coupling were regulated through a strictly phosphorylation-dependent process, while Gq-mediated signalling could be modulated in a phosphorylation-independent way. (open.ac.uk)
  • In contrast, constitutively active receptors lead to darker color. (thermofisher.com)
  • Mutational analysis and chimeric constructs have revealed that allosteric modulators of the calcium-sensing, metabotropic glutamate and GABA B receptors bind to the seven transmembrane domain, through which they modify signal transduction after receptor activation. (aspetjournals.org)
  • The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (harvard.edu)
  • In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • Furthermore, increasing biophysical evidence, primarily using the β2-adrenergic receptor (β2AR) as a model system, supports the existence of multiple active and inactive conformational states. (nih.gov)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human G Protein Coupled Estrogen Receptor 1 (GPER) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
  • Multi-walled carbon nanotube s inhibit estrogen receptor expression in vivo and in vitro through transforming growth factor beta1. (cdc.gov)
  • Mice exposed to MWCNTs had reduced mRNA expression of estrogen receptor alpha and beta (Esr1 and Esr2, respectively) in lung tissue at multiple time-points post exposure, whereas expression of G-protein coupled estrogen receptor 1 (Gper1) was more variable. (cdc.gov)
  • The reduction in estrogen receptor expression was concomitant to an increase in TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of MWCNT-exposed animals. (cdc.gov)
  • Overall these results highlight a novel mechanism of MWCNT-induced signaling where MWCNT-induced regulation of TGF-β1 represses estrogen receptor expression. (cdc.gov)
  • In mice lacking one copy of the BDNF gene ( BDNF +/− ), CB 1 R (GABA) responses were potentiated and were preserved from the action of haloperidol, a DA D 2 receptor (D 2 R) antagonist able to fully abolish CB 1 R (GABA) function in rewarded animals. (jneurosci.org)
  • Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. (nih.gov)
  • Schematic diagram of the human X chromosome indicating the location of the P2RY8 gene. (atlasgeneticsoncology.org)
  • 2003). „The DNA sequence and analysis of human chromosome 6. (wikipedia.org)
  • Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. (medlineplus.gov)
  • In general, cell adhesion favours cell survival signalling, and integrins are the main receptors responsible for mediating the attachment of different types of cells to matrix proteins. (lu.se)
  • In cells lacking expression of Ca 2+ -mobilizing G proteins, coexpression of human GPR40 and Gα q allowed medium- and long-chain fatty acids to elevate intracellular [Ca 2+ ]. (aspetjournals.org)
  • We showed that in a heterologous expression system recombinant hPAFR stimulated inositol phosphates production and intracellular cAMP accumulation, through the coupling with Gq/ 11 and Gs proteins, respectively. (open.ac.uk)
  • We also showed that PAF could stimulate intracellular cAMP accumulation in lymphocytes, suggesting that PAFR-coupling with adenylyl cyclase may be important also for endogenously expressed receptors. (open.ac.uk)
  • However, coexpression of secretin receptors with either type of VPAC receptor resulted in intracellular trapping of the hetero-oligomeric complexes within the biosynthetic pathway. (aspetjournals.org)
  • Chimeric receptors between human and zebrafish OGR1s showed that the amino acid residues that determine the species specificity of ogerin-induced enhancement reside in the transmembrane and/or intracellular regions of OGR1. (bioone.org)
  • The effect of BDNF was restricted to CB 1 Rs controlling GABA-mediated IPSCs (CB 1 R (GABA) ), whereas CB 1 Rs modulating glutamate transmission and GABA B receptors were not affected. (jneurosci.org)
  • Allosteric receptor modulation is an attractive concept in drug targeting because it offers important potential advantages over conventional orthosteric agonism or antagonism. (aspetjournals.org)
  • This article reviews the current status of allosteric modulation at family C G-protein coupled receptors in the light of their specific structural features on the one hand and current concepts in receptor theory on the other hand. (aspetjournals.org)
  • The positive allosteric calcium sensing receptor modulator cinacalcet is the first drug of this type to enter the market and therefore provides proof of principle in humans. (aspetjournals.org)
  • Ogerin is a positive allosteric modulator of human and mouse ovarian cancer G protein-coupled receptors (OGR1s). (bioone.org)
  • G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. (nih.gov)
  • No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. (uni-regensburg.de)
  • also known as the thymic stromal lymphopoietin receptor), which together with IL7 receptor alpha forms a heterodimeric complex that acts at the functional receptor for thymic stromal lymphopoietin (reviewed in Roll and Reuther, 2010). (atlasgeneticsoncology.org)
  • Non-functional, truncated forms of the receptor lead to lighter coat color in animals. (thermofisher.com)
  • Here, we addressed the functional interplay between BDNF and cannabinoid CB 1 receptors (CB 1 Rs) in the striatum, a brain area in which both BDNF and CB 1 s play a role in the emotional consequences of stress and of rewarding experiences. (jneurosci.org)
  • GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. (nih.gov)
  • Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. (uc.edu)
  • MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). (thermofisher.com)
  • Most of the identified mutations change a single protein building block (amino acid) in the ADGRG1 protein. (medlineplus.gov)
  • The transcribed RNA has 4198 base-pairs and encodes a 359 amino acid protein. (atlasgeneticsoncology.org)
  • A particular challenge is the synthesis of oligosaccharyltransferases (OSTs), which catalyze the attachment of glycans to specific amino acid residues in target proteins. (biorxiv.org)
  • The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER. (mousephenotype.org)
  • Characterization of differentiated and undifferentiated HIE in a study of human norovirus replication in HIEs. (cdc.gov)
  • 2005). „Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. (wikipedia.org)
  • 2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Receptor 172A (GPR172A) in Tissue homogenates, saliva and other biological fluids. (myelisakit.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Receptor, Family C, Group 5, Member A (GPRC5A) in Tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
  • The following product was used in this experiment: MC1 Receptor Polyclonal Antibody from Thermo Fisher Scientific, catalog # AMR-020-200UL. (thermofisher.com)
  • It is a bispecific humanized monoclonal antibody against CD3, a T-cell surface antigen, and GPRC5D (human G-protein coupled receptor family C group 5 member D), a tumor-associated antigen with potential antineoplastic activity. (medscape.com)
  • They often have no effect on their own and therefore act only in conjunction with physiological receptor activation. (aspetjournals.org)
  • The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. (harvard.edu)
  • Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex. (uc.edu)
  • Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers. (uc.edu)
  • We confirmed a role for TGF-β1 in mediating MWCNT-induced repression of ESR1 mRNA expression using a TGF-β type-I receptor inhibitor in bronchial epithelial cells in vitro. (cdc.gov)
  • Cell-cell and cell-matrix complexes of epithelial cells are interconnected through cytoskeletal filaments and proteins, and they influence the activities and outcome of various cellular processes. (lu.se)
  • We found that LTD4 caused dramatic changes in the actin cytoskeleton in intestinal epithelial cells, and an important factor in this context was the impact of this leukotriene on the actin-binding protein vinculin, which included inducing translocation of vinculin from a cell-cell to a cell-matrix complex. (lu.se)
  • We have unequivocally established that direct signalling occurs between the LTD4 receptor and the collagen integrins in two different cell lines respectively derived from human colon carcinoma and intestinal epithelial cells. (lu.se)
  • The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)
  • Family C G-protein-coupled receptors are characterized by a large extracellular domain containing the orthosteric agonist binding site known as the "venus flytrap module" because of its bilobal structure and the dynamics of its activation mechanism. (aspetjournals.org)
  • Here, we show that subtypes of human vasoactive intestinal polypeptide receptors (VPAC1 and VPAC2) that represent the closest structurally related receptors to the secretin receptor also form constitutive oligomers with themselves and with the secretin receptor. (aspetjournals.org)
  • We prepared tagged constructs expressing Renilla reniformis luciferase, yellow fluorescent protein, or cyan fluorescent protein at the carboxyl terminus of VPAC1, VPAC2, and secretin receptors, and performed BRET and morphologic fluorescence resonance energy transfer (FRET) studies with all combinations. (aspetjournals.org)
  • BRET studies showed that, like the secretin receptor, both VPAC receptors exhibited constitutive homo-oligomerization in COS cells. (aspetjournals.org)
  • GPR75 is a member of the G protein-coupled receptor family. (nih.gov)
  • They are believed to have evolved from the cAMP receptor family, arising approximately 1275 million years ago before the split of Unikonts from a common ancestor. (wikipedia.org)
  • Formation of oligomeric complexes of family A G protein-coupled receptors has been shown to influence their function and regulation. (aspetjournals.org)
  • However, little is known about the existence of such complexes for family B receptors in this superfamily. (aspetjournals.org)
  • These studies provide new insight into the ability of family B G protein-coupled receptors to associate with each other in cells. (aspetjournals.org)
  • Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (wikipedia.org)
  • G-protein-coupled receptor signaling and neural tube closure defects. (nih.gov)
  • Iguchi T, Sakata K, Yoshizaki K, Tago K, Mizuno N, Itoh H. Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. (medlineplus.gov)
  • Polymorphisms in the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 and the risk of human adenomyosis. (cdc.gov)
  • Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
  • Autocatalytic processing gives rise to an extracellular (α) and a membrane-spanning (β) subunit, which are associated non-covalently, resulting in expression of a heterodimeric receptor at the cell surface. (wikipedia.org)
  • This protein interacts with other proteins on the cell surface to trigger a series of chemical signals within the cell. (medlineplus.gov)
  • The abnormal protein becomes trapped within the cell, where it is unable to reach the cell surface to carry out its normal signaling functions. (medlineplus.gov)
  • Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. (medlineplus.gov)
  • Morphologic FRET studies demonstrated that each of the homo-oligomers and the VPAC1-VPAC2 receptor hetero-oligomers reached the cell surface, where receptor interactions were clear. (aspetjournals.org)
  • This is in contrast to taste-enhancing molecules, which bind to different parts of sweet and umami receptors. (aspetjournals.org)
  • To stimulate the olfactory receptors, airborne molecules must pass through the nasal cavity with relatively turbulent air currents and contact the receptors. (medscape.com)
  • Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. (harvard.edu)
  • Here we report the pairing of cognate peptides and receptors. (ku.dk)
  • Protein glycosylation, or the attachment of sugar moieties (glycans) to proteins, is important for protein stability, activity, and immunogenicity. (biorxiv.org)
  • [2] [3] The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose . (wikipedia.org)
  • Atypical patterns of human cytomegalovirus infection and spread in U373 glioblastoma cells. (uc.edu)
  • Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium. (uc.edu)
  • Transforming mutations in GNAS have been well documented in human thyroid and pituitary tumours, and recent sequencing efforts have shown these mutations to be present in a wide variety of additional tumour types, including colon cancer, hepatocellular carcinoma, and parathyroid, ovarian, endometrial, biliary tract and pancreatic tumours. (nature.com)
  • These mutations interfere with the normal processing of the protein. (medlineplus.gov)
  • The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. (nih.gov)
  • No human diseases associated to this gene by orthology or annotation . (mousephenotype.org)
  • The table below shows human diseases predicted to be associated to Adgrg4 by phenotypic similarity . (mousephenotype.org)
  • Toll-like diseases and causes severe and long-lasting health problems in the case of chronifi- receptor. (cdc.gov)
  • There are eight mammalian P2Y receptors known to date ( P2Y1 , P2Y2 , P2Y4 , P2Y6 , P2Y11 , P2Y12 , P2Y13 and P2Y14 ) and they are found in most human tissues. (atlasgeneticsoncology.org)
  • Calcium mobilization in response to A. suum-derived products was completely abrogated by pretreatment with pertussis toxin, implicating a classical G protein-coupled receptor mechanism in the response to ABF. (ed.ac.uk)
  • The sense of smell is mediated through stimulation of the olfactory receptor cells by volatile chemicals. (medscape.com)
  • Using an innovative protein array platform, we surveyed antibodies against hundreds of full-length microbial antigens from 80 different viruses and bacteria in COVID-19 patients from different geographic regions with mild or severe disease. (bvsalud.org)
  • In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)