• Sherman, SA , Andrianov, AM & Akhrem, AA 1987, ' Method of determining protein conformations by the two-dimensional nuclear overhauser enhancement spectroscopy data ', Journal of Biomolecular Structure and Dynamics , vol. 4, no. 5, pp. 869-884. (elsevier.com)
  • A method is suggested to determine the most probable values of the angles, y of the protein backbone by the data on the availability and absence of d connectivities in the two-dimensional nuclear Overhauser enhancement spectra. (elsevier.com)
  • When a potential is applied to the scaffolds, reversible changes take place in their electrical doping state, which in turn enables precise control over the conformation of adsorbed proteins ( e.g. , fibronectin). (rsc.org)
  • We conclude that HDX of protein ions in a TWIG is highly sensitive to protein conformation, enables the detection of conformers present on sub-milliseconds timescales and can readily be combined with ion mobility spectrometry. (pubmedcentralcanada.ca)
  • Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress. (wiley.com)
  • The information and insights gained following data analysis using the HDExaminer software can be used to probe protein conformational changes in the presence of a perturbation. (bruker.com)
  • We elucidate a strong electrostatic interaction between BSA and the SPIONs, although the secondary structure of the protein is not affected. (icmab.es)
  • From these frequencies a set of probability parameters were derived for the appearance of each amino acid in each secondary structure type, and these parameters are used to predict the probability that a given sequence of amino acids would form a helix, a beta strand, or a turn in a protein. (wikipedia.org)
  • How good are predictions of protein secondary structure? (wikipedia.org)
  • In particular, larger systems require running many concurrent instances of these algorithms, but these algorithms can quickly become memory intensive because they typically keep previously sampled conformations in memory to maintain coverage estimates. (rice.edu)
  • In addition, robotics-inspired algorithms depend on defining useful perturbation strategies for exploring the conformational space, which is a difficult task for large proteins because such systems are typically more constrained and exhibit complex motions. (rice.edu)
  • Proteins are commonly the first biomolecules that NPs encounter when they interact with biological systems either in vitro or in vivo . (icmab.es)
  • Nuclear magnetic resonance studies of protein conformation: I. Ribonuclease S. II. (caltech.edu)
  • Other studies have shown that HDX can sometimes expose the presence of additional gas-phase protein conformers not resolved by IMS and vice versa 18 - 20 . (pubmedcentralcanada.ca)
  • Studies of protein conformation (DPhil thesis). (wikipedia.org)
  • We believe that a complete understanding of the behavior and morphology of BSA-SPIONs and how the protein interacts with SPIONs is crucial for improving NP surface design and expanding the potential applications of SPIONs in nanomedicine. (icmab.es)
  • We characterized recombinant Env proteins and virus particles produced in mammalian cells that lack N-acetylglucosaminyltransferase I (GnTI), an enzyme necessary for the conversion of oligomannose N-glycans to complex N-glycans. (iavi.org)
  • Tanaka, M. A protein transformation protocol for introducing yeast prion particles into yeast. (riken.jp)
  • Similar arguments, such as protein confinement by the crystal lattice and using cryogenic temperatures for collecting diffraction pattern could be (and are) applied to X-ray crystallography. (grantome.com)
  • Very large aggregates can be formed from protein subunits . (bioscience.ws)
  • However, large proteins present special challenges. (rice.edu)
  • These 3D matrix-mimicking platforms offer precise control of protein conformation and major cell functions, over large volumes and long cell culture times. (rsc.org)
  • The award is given annually by the international society "to recognize eminent leaders in protein science who have made sustained high-impact research contributions to the field. (ucsf.edu)
  • Computations of d are made using x-ray data for 17 proteins. (elsevier.com)
  • Therefore it is important to test what the distance distributions from PDS conducted on proteins in solution in the absence of confinement by crystal contacts may represent. (grantome.com)
  • The fractional water occupancy of each was found by comparison of the total number of conformations in the database regardless of the presence or absence of bound water. (pnas.org)