• MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Though endocytic protein abundance in S. pombe and S. cerevisiae are more similar than previously thought, membrane invagination speed and depth are two-fold greater in fission yeast than in budding yeast. (biorxiv.org)
  • In contrast to budding yeast, WASP-mediated actin nucleation activity plays an essential role in fission yeast endocytosis. (biorxiv.org)
  • In contrast, one protein forms various structures and implements other biological phenomena depending on the situation. (springeropen.com)
  • The basic principle that forms these hierarchical structures is protein self-assembly. (springeropen.com)
  • A single building block is sufficient to create homogeneous structures with complex shapes, such as rings, filaments, or containers. (springeropen.com)
  • Supramolecular assembly is a very common phenomena in nature and these natural supramolecular proteins have various structures, from simple structures to complex structures [ 1 , 2 ]. (springeropen.com)
  • however, more protein structures have been identified by advanced technology (Fig. 1 ). (springeropen.com)
  • A better understanding of the proteins contributes to designing new supramolecular structures from rational design to de novo design. (springeropen.com)
  • Recently, the de novo design of proteins that start from scratch can create a new topology beyond experimentally determined structures. (springeropen.com)
  • Here, we report structures of Drosophila Slo in the Ca2+-bound and Ca2+-free form and in complex with the fungal neurotoxin verruculogen and the anthelmintic drug emodepside. (bvsalud.org)
  • Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. (ibecbarcelona.eu)
  • Profuse dendritic-synaptic interconnections among neurons in the neocortex embed intricate logic structures enabling sophisticated decision-making that vastly outperforms any artificial electronic analogues. (regenerativemedicine.net)
  • How various organisms utilize a similar set of proteins to satisfy their particular force generation requirements for endocytosis is an unanswered, fundamental question. (biorxiv.org)
  • Although nanoscopy is broadly applicable, classical model organisms, such as fruit flies, worms and mice, remained the leading subjects because combining the strength of sophisticated genetics, biochemistry and electrophysiology with the unparalleled resolution provided by super-resolution imaging appears as one of the most efficient approaches to understanding the basic cell biological questions and the molecular complexity of life. (bvsalud.org)
  • PrLDs-containing proteins have been involved in different organisms' regulatory processes. (ibecbarcelona.eu)
  • Moreover, with advances in the computational design of protein folding and protein-protein interfaces, considerable progress has recently been made in the de novo design of protein assemblies. (springeropen.com)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • Most proteins are reoxidized by RNA Reconstitution II, ultimately a similar factors are as RNA immunity III engineers with promoting vital regions. (evakoch.com)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • The citric type, pin-pointed a available interface( complex), describes an Second subcellular transcription within a receptor path-finding. (evakoch.com)
  • Our review presents a description of the components of supramolecular protein assembly and their application in understanding biological phenomena to therapeutics. (springeropen.com)
  • In this paper, we will discuss about the component of supramolecular protein assembly and classify their conformation according to structural dimensionality. (springeropen.com)
  • We define the components of protein assembly in three aspects: folding structure unit, protein-protein interface, and assembly symmetry (Fig. 2 ). (springeropen.com)
  • Conserved proteins drive clathrin-mediated endocytosis (CME), which universally involves a burst of actin assembly. (biorxiv.org)
  • Here we use voltage-driven conditional logic interconnectivity among five distinct molecular redox states of a metal organic complex to embed a thicket of decision trees (composed of multiple if-then-else conditional statements) having 71 nodes within a single memristor. (regenerativemedicine.net)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • Each components determine the overall structure of supramolecular protein structure and their functions. (springeropen.com)
  • The development of computational power and increased protein structure databases has expanded our knowledge to understand and design folding units. (springeropen.com)
  • There are many open-source programs that can help us build α-helices or β-sheets and complex forms of building units. (springeropen.com)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. (rafinhibitors.com)
  • In this study, we report on the following two mechanisms employed by zebrafish mitogen-activated protein kinase kinase 7 (MAP2K7) to protect the host during spring viremia of carp virus (SVCV) infection: stabilization of host IRF7 and degradation of SVCV P protein. (bvsalud.org)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • Further analysis demonstrated that SVCV P protein was degraded by the ubiquitin-proteasome pathway, as the attenuation of K63-linked polyubiquitination was mediated by MAP2K7. (bvsalud.org)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • During viral infection, host defensive proteins either enhance the host immune response or antagonize viral components directly. (bvsalud.org)
  • According to the weaker antiviral capacity of map2k7+/- zebrafish than that of the control, we find that MAP2K7 reduces host lethality through two pathways, as follows: enhancing K63-linked polyubiquitination to promote host IRF7 stability and attenuating K63-mediated polyubiquitination to degrade the SVCV P protein. (bvsalud.org)