α-helix Notice that one of the peptides of each subunit invades the space of the other monomeric unit, and labels show the orientation of the complex within the inner mitochondrial membrane. (slimwithlynne.com)
Pyruvate dehydro1
The performance of the camera is satisfactory under the low-dose conditions used in cryo electron microscopy, as demonstrated here by the determination of a three-dimensional map at 15 A for the catalytic core of the 1.8 MDa Bacillus stearothermophilus icosahedral pyruvate dehydrogenase complex, and its comparison with the previously reported atomic model for this complex obtained by X-ray crystallography. (ox.ac.uk)
Enzymes1
The cellulosome consists of a multi-functional integrating subunit (called scaffoldin), responsible for organizing the various cellulolytic subunits (e.g., the enzymes) into the complex. (cazypedia.org)
Electron14
Our research builds on hybrid use of state-of-the-art cryo electron microscopy, X-ray crystallography and advanced optical microscopy to elucidate blueprints of dynamic protein and principles of their assembly and cellular level interplay. (unibas.ch)
bc1 complex for light-drivencyclic electron transfer. (slimwithlynne.com)
Ilicicolin inhibition and binding at center N of the dimeric cytochrome bc1 complex reveal electron transfer and regulatory interactions between monomers Raul Covian and Bernard L. Trumpower J. Biol. (slimwithlynne.com)
Gluconeogenesis Design and use of photoactive ruthenium complexes to study electron transfer within cytochrome bc1 and from cytochrome bc1 to cytochrome c. (slimwithlynne.com)
Hemoglobin During photosynthesis, the cytochrome b6f complex is one step along the chain that transfers electrons from Photosystem II to Phot… Stigmatellin, a Q(P) site inhibitor, inhibits electron transfer from iron-sulfur protein (ISP) to cytochrome c1 in the bc1 complex. (slimwithlynne.com)
All cytochrome bc1 complexes contain three electron transfer proteins which contain four redox prosthetic groups. (slimwithlynne.com)
The second electron is transferred to a The cytochrome bc1 consists of cytochrome b, FeS complex, and cytochrome c1. (slimwithlynne.com)
Aminoacid degradation and urea cycle The cytochrome bc1complex (ubiquinone:cytochrome coxidoreductase) is the central integral membrane protein in the mitochondrial respiratory chain as well as the electron-transfer chains of many respiratory and photosynthetic prokaryotes. (slimwithlynne.com)
There are two cytochrome complexes in the electron transport chain: cytochrome bc1 and cytochrome c oxidase. (slimwithlynne.com)
The reaction is analogous to the reaction catalyzed by cytochrome bc1 (Complex III) of the mitochondrial electron transport chain. (slimwithlynne.com)
Citric acid cycle During the electron transfer through the cytochrome bc(1) complex (ubiquinol-cytochrome c oxidoreductase or complex III), protons are translocated across the membrane, and production of superoxide anion radicals (O(2)(*-)) is observed. (slimwithlynne.com)
Electron Transport Complex II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
This graph shows the total number of publications written about "Electron Transport Complex II" by people in this website by year, and whether "Electron Transport Complex II" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Electron Transport Complex II" by people in Profiles. (ouhsc.edu)
Metabolism4
Major downstream targets include fatty acid and lipid metabolism, protein and nucleotide biosynthesis. (unibas.ch)
Eukaryotic lipid and fatty acid metabolism remains a critical challenge for studies at the atomic, molecular and cellular scale: In contrast to simple prokaryotic systems, fatty acid metabolism in eukaryotes builds upon large multienzymes, which integrate multiple catalytic activities into giant proteins. (unibas.ch)
Later steps of lipid metabolism are occurring in membrane space and rely on membrane-integral or -associated proteins. (unibas.ch)
Combining experimental structural studies with functional analysis, we elucidate fundamental principles of multienzyme architecture & regulation and the role of protein assemblies for spatial organization of metabolism. (unibas.ch)
Catalytic2
The cofactor regeneration system of leucine dehydrogenase (LeuDH) and glucose dehydrogenase (GDH) has showed great coupling catalytic efficiency in the synthesis of l -tle, however the multi-enzyme complex of GDH and LeuDH has never been constructed successfully. (biomedcentral.com)
Catalytic subunits contain dockerin modules that serve to incorporate catalytic modules into the cellulosome complex. (cazypedia.org)
Mitochondrial5
Complex III possesses a Fe-S protein like complex I. Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. (slimwithlynne.com)
Complex III is a multisubunit transmembrane protein encoded by both the mitochondrial (cytochrome b) and the nuclear genomes (all other subunits). (slimwithlynne.com)
Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration. (ouhsc.edu)
Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. (ouhsc.edu)
A mitochondrial protein consisting of four alpha-subunits and four beta-subunits. (bvsalud.org)
Subunits5
The two complexes share the defining core mTOR protein but employ characteristic subunits, Raptor for mTORC1 and Rictor for mTORC2, for capturing input signals controlling and localization, as well as for recognizing specific targets for phosphorylation. (unibas.ch)
Its reaction mechanism is initiated by the binding of a quinol molecule to an active site, followed by a series of charge transfer reactions between the quinol and protein subunits. (slimwithlynne.com)
Cohesin modules are the major building blocks of scaffoldins, which are responsible for organizing the cellulolytic subunits into the multi-enzyme complex. (cazypedia.org)
Several different types of scaffoldins have been described: the primary scaffoldins incorporate the various dockerin-bearing subunits directly into the cellulosome complex, adaptor scaffoldins increase the repertoire or number of components into the complex, and the anchoring scaffoldins attach the complex to the bacterial cell surface. (cazypedia.org)
Vivo1
Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo? (cnrs.fr)
Bacterial2
Studies of bacterial protein-DNA complexes (Portsmouth)All bacterial species have an 'immune system', whereby their own DNA can be distinguished from foreign DNA. (ukri.org)
Bacterial cellulosomal systems can be categorized into two major types: simple cellulosome systems contain a single scaffoldin and complex cellulosome systems exhibit multiple types of interacting scaffoldins. (cazypedia.org)
Selective1
All taken together, these observations underline the complexity of the mechanisms responsible for the selective destruction of proteins within cells. (cnrs.fr)
Regulate1
Deuteration will be used to study how key protein complexes work to regulate the formation of chromatin structure, and which genes are expressed (transcribed into RNA and protein).9. (ukri.org)
Lipid1
Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
Binding2
We later identified PIAS (protein inhibitor of activated STAT)xalpha as a DJ-1-binding protein, and found that DJ-1 restored androgen receptor (AR) transcription activity that was repressed by PIASxalpha. (nih.gov)
To further characterize the function of DJ-1, we cloned cDNA encoding a novel DJ-1-binding protein, DJBP, by a yeast two-hybrid system. (nih.gov)
Multi-enzyme complex1
It is the first report about the fusion of GDH and LeuDH as the multi-enzyme complex to synthesize l -tle and reach the highest space-time yield up to now. (biomedcentral.com)
Degradation1
These findings suggest an ubiquitin-independent mechanism of proteasomal degradation for alpha-synuclein and other natively unfolded proteins. (ox.ac.uk)
Structural2
Our structural studies have revealed the intricate interlinking, coupling and crosstalk between domains that result in emergent properties beyond the functionality of their isolated building blocks and shed light on the evolution of this family of multienzymes (Maier et al. (unibas.ch)
Structural studies of human ferroportin (King's College London)Ferroportin is a protein that is involved in transferring dietary iron from intestines to blood. (ukri.org)
Oxidase2
The second cytochrome complex c oxidase consists of cytochrome a and cytochrome a3. (slimwithlynne.com)
A flavoprotein oxidase complex that contains iron-sulfur centers. (ouhsc.edu)
Cytochrome2
Complex III (cytochrome bc1) accepts two electrons from ubiquinol and shuttles them to cytochrome c. (slimwithlynne.com)
The cytochrome bc 1 complex (also known as ubiquinol-cytochrome c oxidoreductase or complex III) is a multi-subunit dimeric integral membrane protein complex. (slimwithlynne.com)
Factors1
The c-Fos and c-Jun oncoproteins and the p53 tumor suppressor protein are short-lived transcription factors. (cnrs.fr)
Membrane1
The bc 1 complex is an important enzyme involved in the conversion of energy into a proton gradient across the cellular membrane in photosynthetic bacteria, and cellular respiratory systems in higher organisms. (slimwithlynne.com)
Symptoms1
Diagnosis is complicated because the symptoms may be varied and complex. (medscape.com)
Disorders1
Mutations in Complex III cause exercise intolerance as well as multisystem disorders. (slimwithlynne.com)
Study2
NMR/neutron studies of a mechanosensitive channel protein (Oxford) We will study a 'mechanosensitive' protein from membranes that controls cell shape and size in different environments. (ukri.org)
Neutron scattering studies of a multienzyme complex (Glasgow)We will study how a particular set of proteins is put together to make a specialised 'molecular machine' of medical importance that controls a key step in the pathway that converts glucose into energy.5. (ukri.org)
Formation2
Furthermore, a co-immunoprecipitation assay showed that the formation of a ternary complex between DJ-1, DJBP, and AR occurred in cells in which DJ-1 bound to the AR via DJBP. (nih.gov)
Metabolic reactions are spatially organized not only into organelles but also by the transient formation of localized protein assemblies in the cytosol. (unibas.ch)
Functions1
The mTOR kinase exerts its functions in two functionally and structurally distinct complexes, mTORC1 & 2. (unibas.ch)
Studies2
Neutron diffraction studies of DNA and drug-DNA complexes (Reading)DNA is not always the beautiful double helix of popular imagination. (ukri.org)
NMR and neutron studies of chromatin structure (Cambridge)DNA within the cell is packaged into bundles with proteins to give a structure called chromatin. (ukri.org)
Cells1
It was found that DJBP repressed a testosterone-dependent AR transactivation activity in monkey Cos1 cells by recruiting histone deacetylase (HDAC) complex, including HDAC1 and mSin3, and that DJ-1 partially restored its repressed activity by abrogating DJBP-HDAC complex. (nih.gov)