Protein coil residues predict contacting residue pairs protein residues. Medical search. Frequent questions

Native states of proteins are shown to be thermodynamically stable structures that exist in physiological conditions, and are proven in experiments with ribonuclease by Christian B. Anfinsen (see Anfinsen's dogma). (wikipedia.org)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Crystal structures of protein kinases with bound substrate peptides show that substrate residues at positions -3 to +3 relative to the phosphorylated serine, threonine or tyrosine residue adopt an extended conformation and bind to a pocket in the catalytic domain of the protein kinase [ 8 ]. (biomedcentral.com)
Proteins fold from chains of amino acids, forming secondary structures, α-helices and ß-strands, that, at least for globular proteins, subsequently fold into a three-dimensional structure. (bvsalud.org)
ß-Turns are one of the most common secondary structures found in proteins. (bvsalud.org)
The structures of the spike proteins (S1 and S2) of most of the coronaviruses, including SARS-CoV-2 ( Fig. 1a(i) ), revealed that these proteins possess multiple disulfide (S-S) bonds. (rsc.org)
Profiles' of protein structures and sequence alignments can detect subtle homologies. (biopred.net)
Computational analysis is increasingly important for inferring the functions and structures of proteins [1] because the speed of DNA sequencing has long since surpassed the rate at which the biological function of sequences can be elucidated experimentally. (biopred.net)
The predicted structures of the Gimap proteins show common sequences and motifs, such as GTP-binding domains in the N-terminal half, but with differing C-terminal ends [ 2 , 3 ]. (hindawi.com)

After introducing the term in 1987, Ken A. Dill surveyed the polymer theory in protein folding, in which it addresses two puzzles, the first one being the Blind Watchmaker's Paradox in which biological proteins could not originate from random sequences, and the second one being Levinthal's Paradox that protein folding cannot happen randomly. (wikipedia.org)
Predikin now consists of two components: (i) PredikinDB, a database of phosphorylation sites that links substrates to kinase sequences and (ii) a Perl module, which provides methods to classify protein kinases, reliably identify substrate-determining residues, generate scoring matrices and score putative phosphorylation sites in query sequences. (biomedcentral.com)
Established sequence comparison algorithms detect significant similarities between known database sequences and 35-80% of new proteins, depending on the organism. (biopred.net)
analyzed the amino acid sequences of two specific intrinsically disordered proteins from different organisms to reconstruct the versions of the proteins that were likely found in their common ancestors 450-600 million years ago. (elifesciences.org)
Among the conspicuous characteristics featuring its hyperthermophilic adaptation are overrepresentation of purine bases in protein coding sequences, higher GC-content in tRNA/rRNA sequences, distinct synonymous codon usage, enhanced usage of aromatic and positively charged residues, and decreased frequencies of polar uncharged residues, as compared to those in mesophilic organisms. (biomedcentral.com)
Pairwise comparison of 105 orthologous protein sequences shows a strong bias towards replacement of uncharged polar residues of mesophilic proteins by Lys/Arg, Tyr and some hydrophobic residues in their Nanoarchaeal orthologs. (biomedcentral.com)
A phylogenetic tree based on the predicted amino acid sequences of the fibrinogen-related domains demonstrates that tenascin-C and tenascin-R are the most closely related vertebrate tenascins, with the most conserved repeat and domain organization. (biomedcentral.com)

The term was introduced by Ken A. Dill in a 1987 article discussing the stabilities of globular proteins. (wikipedia.org)

Functional and structural characterization of human adrenoleukodystrophy protein (ALDP). (elifesciences.org)
Here, we show that a Ramachandran-type plot focusing on the two dihedral angles separated by the peptide bond, and entirely contained within an amino acid pair, defines a local structural unit. (bvsalud.org)
Consequently, the purpose of this report is to uncover the physical phenomena encountered during protein folding that are best described by the BBM through the identification of parameters that have been recognized over the years as being strong predictors for protein folding, such as protein size, topology, structural class, and folding kinetics. (bvsalud.org)
While the BBM in its present form appears to be a good indicator of the folding times of the vast majority of the 195 proteins considered so far, this report finds that it excels for moderately large proteins that are primarily composed of locally formed structural motifs such as α-helices or for proteins that fold in multiple steps. (bvsalud.org)
Three-dimensional (3D) structural information allows structural environments to be taken into account when scoring aligned residues, and allows insertions and deletions to be expected more frequently in surface loops than in core secondary structure elements. (biopred.net)
One is faced with a number of difficult problems: what are the best ways to set the position-specific residue scores, to score gaps and insertions, and to combine structural and multiple sequence information? (biopred.net)
The common ancestor of these GHKL proteins, MutL and topoisomerase ATPase modules appears to have catalyzed structural reorganization of protein complexes and concomitant DNA-superstructure manipulations along with fused or standalone nuclease domains. (beds.ac.uk)
Choosing the right templates in the immunoglobulin superfamily (IgSF) is challenging because its members share low sequence identity and display a wide range of alternative binding sites despite structural homology.ResultsWe present a new approach to predict protein interfaces. (edu.in)
Case studies are presented to validate the method, yielding protein designs specifically focused on structural materials, but also exploring the applicability in the design of soluble, antimicrobial biomaterials. (aip.org)

The folding funnel hypothesis is closely related to the hydrophobic collapse hypothesis, under which the driving force for protein folding is the stabilization associated with the sequestration of hydrophobic amino acid side chains in the interior of the folded protein. (wikipedia.org)
The molten globule state predicted by the folding funnel theory as an ensemble of folding intermediates thus corresponds to a protein in which hydrophobic collapse has occurred but many native contacts, or close residue-residue interactions represented in the native state, have yet to form. (wikipedia.org)
The y-axis of the funnel represents the "internal free energy" of a protein: the sum of hydrogen bonds, ion-pairs, torsion angle energies, hydrophobic and solvation free energies. (wikipedia.org)
The prokaryotic and eukaryotic MORC homologs were unified to the exclusion of the other GHKL proteins by a specific GhXhhpXXRhl motif (h: hydrophobic, p: polar, X: any) in the S5-fold domain (Fig. 1 ). (beds.ac.uk)

We performed phylogenetic reconstruction, resurrection and biophysical characterization of two interacting disordered protein domains, CID and NCBD. (elifesciences.org)
AbstractMotivationMolecular-level classification of protein-protein interfaces can greatly assist in functional characterization and rational drug design. (edu.in)

Based on the structure, we performed integrative analysis of the cellular trafficking, protein thermostability, ATP hydrolysis, and the transport activity of representative mutations. (elifesciences.org)
The post-translational modification of proteins by phosphorylation of serine, threonine or tyrosine residues is a ubiquitous process in cellular regulation. (biomedcentral.com)
Protein kinases and their substrates regulate essentially all cellular processes through complex regulatory networks, in which phosphorylated proteins act as switches that tune the response of the cell to environmental stimuli. (biomedcentral.com)
Protein-protein interactions involving intrinsically disordered proteins are important for cellular function and common in all organisms. (elifesciences.org)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. (ucdavis.edu)

We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. (biomedcentral.com)
The second factor, termed peptide specificity, describes the interaction between amino acid residues in the catalytic domain of the protein kinase and the substrate residues that surround the phosphorylated residue. (biomedcentral.com)
The relative contribution of substrate recruitment and peptide specificity to protein kinase substrate specificity varies between protein kinases. (biomedcentral.com)
However, it is recognised that for many protein kinase families, particularly those that phosphorylate Ser/Thr residues, peptide specificity is the major factor that determines substrate specificity. (biomedcentral.com)
The prediction of peptide specificity is therefore the basis for most of the available computational methods aimed at predicting substrates of protein kinases. (biomedcentral.com)
We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

The traits potentially attributable to the symbiotic/parasitic life-style of the organism include the presence of apparently weak translational selection in synonymous codon usage and a marked heterogeneity in membrane-associated proteins, which may be important for N. equitans to interact with the host and hence, may help the organism to adapt to the strictly host-associated life style. (biomedcentral.com)

The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)

The overall objective of EuroNeut-41 was to design a vaccine that raises antibodies able to prevent HIV cell fusion by blocking the virus fusion protein gp41 in its pre-fusogenic conformation. (europa.eu)
Further, we demonstrate experimentally that the effect of a point mutation on backbone conformation and protein stability depends on the amino acid pair context, i.e., the identity of the adjacent amino acid, in a manner predictable by our method. (bvsalud.org)

We further demonstrate the usefulness of this cross-peptide-bond Ramachandran plot by showing that it captures ß-turn conformations in coil regions, that traditional Ramachandran plot outliers fall into occupied regions of our plot, and that thermophilic proteins prefer specific amino acid pair conformations. (bvsalud.org)
Consistent with a chromatin-associated role, the MORCs display fusions to several DNA- and peptide-binding domains, which are commonly found other eukaryotic chromatin proteins [ 5 ]. (beds.ac.uk)

Protein kinases, the enzymes responsible for protein phosphorylation, make up almost 2% of protein-encoding genes in the human genome [ 1 ] and an estimated 30-50% of human proteins are phosphorylated [ 2 ]. (biomedcentral.com)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
In order to learn more about their origins and relationships to each other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis , the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously characterized tenascins of amniotes. (biomedcentral.com)

Can anyone predict domain-swapping reliably? (predictioncenter.org)

J. Singh, T. Litfin, K. Paliwal, J. Singh, A. K. Hanumanthappa, and Y. Zhou, "SPOT-1D-Single: Improving the single-sequence-based prediction of protein secondary structure, back-bone angles, solvent accessibility and half-sphere exposures using a large training set and ensembled deep learning. (sparks-lab.org)
J. Singh, K. Paliwal, T Zhang, J. Singh, T Litfin, Y. Zhou, "Improved RNA Secondary Structure and Tertiary Base-pairing Prediction Using Evolutionary Profile, Mutational Coupling and Two-dimensional Transfer Learning. (sparks-lab.org)
Jpred predicted Secondary structure is shown above the alignment. (beds.ac.uk)
The model is applied to predict the secondary structure content (per-residue level and overall content), protein solubility, and sequencing tasks. (aip.org)

KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton. (ucdavis.edu)
At the heart of this network are LINC ( li nker of n ucleoskeleton and c ytoskeleton) complexes made of SUN ( S ad1 and UN C-84) proteins at the inner nuclear membrane and KASH ( K larsicht, A NC-1, and S yne h omology) proteins in the outer nuclear membrane. (ucdavis.edu)

The surface outside the well is shown as relatively flat to represent the heterogeneity of the random coil state. (wikipedia.org)

Q. Yuan, J. Chen, H. Zhao, Y. Zhou, and Y. Yang, "Structure-aware protein-protein interaction site prediction using deep graph convolutional network. (sparks-lab.org)

Altogether, these observations based on the use of the BBM support the notion that proteins fold the way they do because the LRBD of polypeptides is mostly driven by the local interactions experienced between aa's within reach of one another. (bvsalud.org)
Experiments together with molecular modeling using NMR chemical shifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-affinity complex which is optimized by modulating direct interactions as well as dynamics, while tolerating several potentially disruptive mutations. (elifesciences.org)
At multiple time points during evolution, new or modified proteins - and consequently new potential interactions between proteins - have emerged. (elifesciences.org)
The findings shed light on fundamental principles of how new protein-protein interactions emerge and evolve on a molecular level. (elifesciences.org)
A next step for the future will be to investigate how other protein-protein interactions have evolved and to identify general underlying patterns. (elifesciences.org)
A deeper knowledge of how this molecular evolution happened will broaden our understanding of present day protein-protein interactions and might aid the design of drugs that can mimick proteins. (elifesciences.org)
Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes. (biomedcentral.com)
The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. (ucdavis.edu)

The specific order of amino acids in a protein determines its shape and structure, which in turn controls what the protein can do. (elifesciences.org)

The ancestral proteins were then 'resurrected' by recreating them in test tubes and their characteristics and properties analyzed with experimental and computational biophysical methods. (elifesciences.org)

Individuals acquire infection with coronaviruses primarily through direct contact with virus-positive individuals via aerosols. (rsc.org)
Using contextual information from conserved gene neighborhoods we show that these proteins primarily function in restriction-modification systems, in conjunction with diverse superfamily II DNA helicases and endonucleases. (beds.ac.uk)

New features in Predikin include the use of SQL queries to PredikinDB to generate predictions, scoring of predictions, more reliable identification of substrate-determining residues and putative phosphorylation sites, extended options to handle protein kinase and substrate data and an improved web interface. (biomedcentral.com)
The most accurate protein interface predictions rely on finding homologous proteins with known interfaces since most interfaces are conserved within the same protein family. (edu.in)

ii) How can a protein fold so quickly despite a vast number of possible conformations (the Levinthal's Paradox)? (wikipedia.org)
Also I noted that some other servers had also predicted this same J-shaped fold. (predictioncenter.org)

Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)

Yet, these proteins play important roles in many processes that require the protein to interact with a number of other proteins. (elifesciences.org)
The provenance and biochemical roles of eukaryotic MORC proteins have remained poorly understood since the discovery of their prototype MORC1, which is required for meiotic nuclear division in animals. (beds.ac.uk)

Further analysis of the proposed sulphate and predicted CSA-binding site indicates either none or very low level of conservation among the critical interacting residues. (biomedcentral.com)
Next, based on the similarity of residue level conservation scores derived from the evolutionary profiles, a query protein is hierarchically clustered with all available template proteins in its superfamily with known interface definitions. (edu.in)

8 The SARS-CoV-2 spike protein S1 is composed of three domains, the receptor binding domain (RBD) that contains 4 S-S bridges, the N-terminal domain (NTD) that contains 3 S-S bridges and the S1/S2 cleavage site that contains 3 S-S bridges ( Fig. 1a(iii) ). (rsc.org)
Some C-terminal regions are consistent with transmembrane domains as in the case of Gimap1 and Gimap5, while others, as in Gimap9 and Gimap4, predict coiled coil domains [ 3 , 14 ]. (hindawi.com)
Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA. (biomedcentral.com)
This gene encodes a large protein with an estimated molecular weight of 350 kDa, and can be divided into six Duffy-binding-like domains (DBL 1-6) based on several conserved cysteines. (biomedcentral.com)
In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. (ucdavis.edu)

During the past year, applications of these powerful new HMM-based profiles have begun to appear in the fields of protein-structure prediction and large-scale genome-sequence analysis. (biopred.net)
An increase of a single percentage point may mean learning something useful about an additional 700 human proteins by the time elucidation of the sequence of the human genome nears completion round about the year 2002. (biopred.net)
In this review, I will explain what HMMs are, describe their strengths and limitations, and highlight how HMM-based profiles are beginning to be used in protein structure prediction and large-scale genome sequence analysis. (biopred.net)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
These epigenetic mechanisms are mediated by chemical modifications of DNA, proteins (most commonly histones), and RNA. (activemotif.com.cn)
Similarly, how the mechanisms by which reduced Gimap5 transcript levels and the absence of the Gimap5 protein [ 2 , 7 , 8 ] contribute to lymphopenia and T1D are still being elucidated [ 9 - 13 ]. (hindawi.com)

These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)

Engineered resonance energy transfer (RET) between a mTurquoise2 fluorescent protein and FMN-bound As LOV2 increases switch sensitivity. (nature.com)
The results showed that the ancestral proteins created weaker bonds between them compared to more 'modern' ones, and were more flexible even when bound together. (elifesciences.org)

T. Zhang, J. Singh, T. Litfin, J. Zhan, K. Paliwal, and Y. Zhou, "RNAcmap: A fully automatic pipeline for predicting contact maps of RNAs by evolutionary coupling analysis. (sparks-lab.org)

Studies during the 1980s focused on models that could explain the shape of the energy landscape, a mathematical function that describes the free energy of a protein as a function of the microscopic degrees of freedom. (wikipedia.org)
Protein structure, both at the global and local level, dictates function. (bvsalud.org)
Gimap proteins may therefore have similar function, but different subcellular locations. (hindawi.com)
S. Liang, Z. Li, J. Zhan, and Y. Zhou, "De novo protein design by an energy function based on series expansion in distance and orientation dependence. (sparks-lab.org)
This S5 domain usually provides a conserved basic residue, which might function similar to the arginine or lysine finger observed in various phosphohydrolase reactions [ 6 ]. (beds.ac.uk)

On the side of the protein, free energy is further lowered by favorable energetic contacts: isolation of electrostatically charged side chains on the solvent-accessible protein surface and neutralization of salt bridges within the protein's core. (wikipedia.org)

The folding funnel hypothesis is a specific version of the energy landscape theory of protein folding, which assumes that a protein's native state corresponds to its free energy minimum under the solution conditions usually encountered in cells. (wikipedia.org)
Except in specific cases where protein translocation or other visualised downstream phenomena are targeted, it is hard to know whether an actuator has been switched. (nature.com)
Pairwise sequence comparison methods such as BLAST and FASTA generally assume that all amino acid positions are equally important even though a great deal of position-specific information is usually available for a protein or protein family of interest. (biopred.net)
A 'profile' (defined as a consensus primary structure model consisting of position-specific residue scores and insertion or deletion penalties) is an intuitive step beyond the pairwise sequence alignment methods. (biopred.net)

The 3 × 10 −4 G 0 level is attributed to a single SARS-CoV-2 protein connecting to the two STM Au nano-electrodes from the receptor binding domain (RBD) subunit and the S1/S2 cleavage site. (rsc.org)

The protein folding problem is concerned with three questions, as stated by Ken A. Dill and Justin L. MacCallum: (i) How can an amino acid sequence determine the 3D native structure of a protein? (wikipedia.org)
And (iii) is it possible to create a computer algorithm to predict a protein's native structure based on its amino acid sequence alone? (wikipedia.org)
That would mean even residues at very different positions in the amino acid sequence will be able to come into contact with each other. (wikipedia.org)
The method, named Predikin, identifies key conserved substrate-determining residues in the kinase catalytic domain that contact the substrate in the region of the phosphorylation site and so determine the sequence surrounding the phosphorylation site. (biomedcentral.com)
The heptapeptide sequence from -3 to +3 that best binds to the pocket is determined by the physicochemical nature of the residues in the catalytic domain that line the pocket and contact the substrate. (biomedcentral.com)
A series of reports published in the last 3 years has illustrated that a blob-based model (BBM) can predict the folding time of proteins from their primary amino acid (aa) sequence based on three simple rules established to characterize the long-range backbone dynamics (LRBD) of racemic polypeptides. (bvsalud.org)
Multiple alignments of protein sequence families indicate residues that are more conserved than others, and the points at which insertions and deletions are more frequent. (biopred.net)
To unravel the provenance and relationships of the MORC family, we initiated sequence profile searches using the PSI-BLAST program seeded with eukaryotic MORC proteins. (beds.ac.uk)

A lower 4 × 10 −6 G 0 conductance is attributed to the spike protein connecting to the STM electrodes from the RBD subunit and the N-terminal domain (NTD). (rsc.org)
For example, the spike proteins (S1 and S2) of SARS-CoV-2 contain 14 S-S bonds in well-defined regions, with 10 S-S bridges in the S1 subunit. (rsc.org)

Dill pulled the idea from the Blind Watchmaker into his metaphor for protein folding kinetics. (wikipedia.org)
The sole use of LRBD to predict protein folding times with the BBM represents a radical departure from all other prediction methods currently applied to determine protein folding times, which rely instead on parameters such as the structure content, folding kinetics, chain length, amino acid properties, or contact topography of proteins. (bvsalud.org)

SARS-CoV-2 spike proteins have peripheral disulfide bonds (S-S), which are common in all spike proteins of SARS-CoV-2 variants, in other types of coronaviruses ( e.g. (rsc.org)
Here, we demonstrate that S-S bonds in the spike S1 protein of SARS-CoV-2 react with gold (Au) and silicon (Si) electrodes. (rsc.org)
The two conductance states are governed by the S-S bonds reaction with Au which controls the orientation of the protein in the circuit, and via which different electron pathways are created. (rsc.org)
Fig. 1a(ii) ), 5-7 MERS-CoV contains 11 S-S bonds, and HCoV-229E spike protein contains 13 S-S bonds. (rsc.org)

Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

The native state of protein can be achieved through a folding process involving some small bias and random choices to speed up the search time. (wikipedia.org)

In this view humes problem induction, we will contact that the early Crop confers nonlinearly Quaternary in the bifurcation frequency-doubling, by honoring the 4(3 human Biogeography of the ranges of the tumour. (mooreamusicpele.com)

DNA in chromatin is organized in arrays of nucleosomes 1 .Two copies of each histone protein, H2A, H2B, H3 and H4, are assembled into an octamer that has 145?147 base pairs (bp) of DNA wrapped around it to form a nucleosome core (of relative molecular mass 206K). (nature.com)

How does the protein know what conformations not to search? (wikipedia.org)
As protein folding process goes through a stochastic search of conformations before reaching its final destination, the vast number of possible conformations is considered irrelevant, while the kinetic traps begin to play a role. (wikipedia.org)
The stochastic idea of protein intermediate conformations reveals the concept of an "energy landscape" or "folding funnel" in which folding properties are related to free energy and that the accessible conformations of a protein are reduced as it approaches native-like structure. (wikipedia.org)

Defects in these networks result in a variety of disease states making protein kinases important targets for drug design [ 3 ]. (biomedcentral.com)
Proteins are an important building block of life and are vital for almost every process that keeps cells alive. (elifesciences.org)
The var2CSA gene, which is a member of the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family, may have an important role in PAM disease and immunity. (biomedcentral.com)

Furthermore, the built-in modularity of the BBM enables the parametrization and inclusion of new phenomena affecting the LRBD of polypeptides, while its conceptual simplicity makes it an interesting new mathematical tool for studying protein folding. (bvsalud.org)

We identify the prokaryotic MORCs and establish that the MORC family belongs to a larger radiation of several families of GHKL proteins (paraMORCs) in prokaryotes. (beds.ac.uk)

The variability will distinguish given to non-contact gravity laboratory. (mooreamusicpele.com)

The new features significantly enhance the ability of Predikin to analyse protein kinases and their substrates. (biomedcentral.com)

Further trained on inverse tasks, the model is rendered capable of designing proteins with these properties as target features. (aip.org)
Predicting the properties of materials based on a flexible description of their structure, environment, or process, is a long-standing challenge in multiscale modeling. (aip.org)

We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)

Z. Zhang, P. Xiong, T. Zhang, J. Wang, J. Zhan, and Y. Zhou, "Accurate inference of the full base-pairing structure of RNA by deep mutational scanning and covariation-induced deviation of activity. (sparks-lab.org)

Anatomy10

Organisms10

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Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes79

Disciplines and Occupations5

Technology, Industry, Agriculture1

Information Science10

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Structures9

Sequences7

Globular proteins1

Structural9

Hydrophobic4

Characterization2

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Membrane-associated1

Orthologs1

Conformation2

Peptide2

Genes5

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