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  • effector genes
  • CREB triggers a gene expression cascade with a group of IEGs coding for transcription factors such as zif/268, c-fos, c-jun, junB, and junD that in turn lead to transcription of late effector genes coding for proteins critical for establishing long-term memory (Abraham et al. (supermemo.com)
  • Recently, we found epigenetic silencing of the Ras effector genes NORE1B and/or RASSF1A in 97% of the hepatocellular carcinoma (HCC) investigated. (aacrjournals.org)
  • We recently found epigenetic inactivation of the Ras effector genes NORE1B and RASSF1A in the majority of HCC due to CpG-site hypermethylation in the promoter regions. (aacrjournals.org)
  • PRKCH
  • Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan. (nih.gov)
  • genomes
  • Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. (genetics.org)
  • Since the structure of bacterial genomes is relatively simple, containing ca. 4,000 genes and few repetitive sequences, DNA arrays can monitor transcript levels of an entire genome in a single hybridization with high sensitivity. (asm.org)
  • E-CELL provides a unified, object-oriented framework for modeling and simulation of the complex interactions among the gene products of completed genomes. (keio.ac.jp)
  • phenotypes
  • These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity. (genetics.org)
  • Identification of variant genes that contribute to the development of hypertension is further complicated because the cardiac output and peripheral resistance, are controlled by other intermediary phenotypes. (japi.org)
  • phospholipid
  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. (genecards.org)
  • Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. (keio.ac.jp)
  • susceptibility
  • Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population. (nih.gov)
  • Type 2 diabetes has a substantial genetic component, but the polygenic nature of this disease has complicated the identification of susceptibility genes ( 1 ). (diabetesjournals.org)
  • Accordingly, RASSF1A knockout mice show enhanced tumor susceptibility, and loss of function of the NORE1 gene is linked to a familial form of kidney cancer ( 15 , 16 ). (aacrjournals.org)
  • phosphorylate
  • PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. (nih.gov)
  • orthologs
  • In applying this test to several thousand human-chimpanzee gene orthologs, I show that such variation clusters are not generally caused by relaxed selection. (genetics.org)
  • I also identify multiple new human-chimpanzee orthologs subject to positive selection, among them genes that are involved in reproductive functions, immune defense, and the nervous system. (genetics.org)
  • activates
  • In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. (genecards.org)
  • In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. (genecards.org)
  • 1997) . DAG activates protein kinase C (PKC) (Riedel et al. (supermemo.com)
  • isoform
  • Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. (uth.edu)
  • Inhibition of protein kinase C βII isoform ameliorates methylglyoxal advanced glycation endproduct-induced cardiomyocyte contractile dysfunction. (nih.gov)
  • Transcription
  • The factors causing it to transition from benign resident of the gut microbiome to virulent pathogen are not well understood, but a combination of horizontal gene transfer (HGT) of virulence genes and differential transcription of endogenous genes are clearly involved. (frontiersin.org)
  • It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. (nih.gov)
  • Gene expression in bacteria has been traditionally analyzed by transcriptional or translational fusions to promoterless "reporter" genes (e.g., lacZ , cat , and gus ) or by direct detection of transcripts using Northern blotting or reverse transcription-PCR (RT-PCR). (asm.org)
  • Functional
  • The CRISPR-Cas system is a multi-functional system described in prokaryotes that may be involved in control both of HGT and of gene regulation. (frontiersin.org)
  • In CLL samples compared with normal B cell samples, differentially expressed miRNAs (DEMs) were identified via the GEO2R instrument of GEO and differentially expressed genes (DEGs) were obtained via the limma package of R. Functional enrichment analysis of the DEGs was performed via the Database for Annotation, Visualization and Integrated Discovery. (spandidos-publications.com)
  • Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. (keio.ac.jp)
  • Polymorphisms in two of these genes, namely angiotensinogen and ACE, have been associated with functional differences in the encoded gene products with measures of "sodium sensitivity", as measured by blood pressure response to changes in sodium intake. (japi.org)
  • regulation
  • We have developed an antisense oligonucleotide microarray for the study of gene expression and regulation in Bacillus subtilis by using Affymetrix technology. (asm.org)
  • ARHGEF11 is 1 of 85 activators of Rho GTPases that play a fundamental role in G protein signaling and therefore many aspects of cellular regulation ( 9 , 10 ), including β-cell apoptosis, insulin secretion ( 11 - 13 ), insulin signaling ( 14 - 18 ), and lipid metabolism ( 19 , 20 ). (diabetesjournals.org)
  • Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. (keio.ac.jp)
  • The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. (keio.ac.jp)
  • Through its modulation of salt and water homeostasis, the reninangiotensin system (RAS) is a major regulator of blood pressure.4 Since role of RAS is involved in BP regulation, the genes that encode the components of RAS have been suggested to be promising candidate for understanding the pathophysiology of hypertension. (japi.org)
  • differential
  • These tests included optimization of the labeling and hybridization conditions, determination of the linear dynamic range of gene expression levels, and assessment of differential gene expression patterns of known vitamin biosynthetic genes. (asm.org)
  • Synapsins Ia (706 amino acids) and Ib (670 amino acids) are derived from one gene by differential splicing of the mRNA and differ from each other only at their carboxy‐termini. (embopress.org)
  • As a result of alternative splicing and/or differential promoter usage RASSF1 codes for RASSF1A and six further isoforms (RASSF1B-G), whereas NORE1 gives rise to NORE1A and NORE1B (also called RAPL). (aacrjournals.org)
  • genome
  • Although other Wnt genes are present in the fly genome, they do not appear to have major roles in development (reviewed in L ogan and N usse 2004 ). (genetics.org)
  • Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. (uth.edu)
  • chromosome
  • Rho guanine nucleotide exchange factor 11 (ARHGEF11), located on chromosome 1q21, is involved in G protein signaling and is a pathway known to play a role in both insulin secretion and action. (diabetesjournals.org)
  • Genomics
  • The challenge created by genomics is to understand how all the cellular proteins work collectively as a living system. (keio.ac.jp)
  • HUMAN
  • For human populations, candidates include genes mediating adaptations to UV exposure or pathogens, such as malaria. (genetics.org)
  • DGKB Full-Length MS Protein Standard (NP_004071), Labeled with [U- 13C6, 15NL-Arginine and [U- 13C6, 15NL-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. (creative-proteomics.com)
  • Human fecal carriage of Enterobacteriaceae possessing mobilized colistin resistance genes ( mcr-1 and mcr-2 ) remains obscure in Hong Kong. (springer.com)
  • To the best of our knowledge, this is the first study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in Hong Kong. (springer.com)
  • biosynthetic
  • In addition, we were able to monitor the transcript level of known biosynthetic genes regulated by riboflavin, biotin, or thiamine. (asm.org)
  • We show that the microarray can monitor gene expression changes in response to transition from the exponential to the stationary growth phases and exposure to three different vitamins that repress expression of biosynthetic genes. (asm.org)
  • calcium
  • It is a calcium-independent and phospholipids-dependent protein kinase. (nih.gov)
  • Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol. (genecards.org)
  • calcium flowing into the cell as a result of depolarization and a result of its release from intracellular stores takes part in activation of calmodulin-dependent CAM kinase II (CAMKII) (Kelly, 1991 Muller et all. (supermemo.com)
  • The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. (utsouthwestern.edu)
  • Variation
  • Variation in this gene has been associated with bipolar disorder. (genecards.org)
  • The test detects significant deviations from this expectation in the form of variation clusters, highly localized groups of amino acid changes in a coding region. (genetics.org)
  • expression
  • Understanding CRISPR/Cas function in B. fragilis will elucidate their role in gene expression, DNA repair and ability to survive exposure to antibiotics. (frontiersin.org)
  • The miRNA expression dataset GSE62137 and mRNA expression dataset GSE22529 were downloaded from National Center of Biotechnology Information Gene Expression Omnibus database. (spandidos-publications.com)
  • Negrini et al revealed that miRNAs whose expression was distinctive of cases with mutated vs. unmutated IGHV genes or cases with 13q, 11q, and 17p deletions and trisomy 12 and miR26a, miR532-3p, miR146-5p , and miR29c * were strongly associated with progression-free survival in CLL ( 20 ). (spandidos-publications.com)
  • Possible consequences of such intervention include cell death, changes in growth rate, and an increase or decrease in the expression of specific genes. (keio.ac.jp)
  • Our modeling approach described in this paper attempts to link diverse cellular processes such as gene expression, signaling and metabolism, to construct a cell model for conducting experiments in silico . (keio.ac.jp)