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Blood CoagulationDisseminated Intravascular CoagulationBlood Coagulation TestsBlood Coagulation DisordersBlood Coagulation FactorsThromboplastinProthrombin TimePartial Thromboplastin TimeFactor VIIFibrinolysisArgon Plasma CoagulationThrombelastographyFactor XaWhole Blood Coagulation TimeProthrombinFactor XHemostasisCoagulation Protein DisordersFactor VIIaThrombinAntithrombin IIIFibrinogenFibrin Fibrinogen Degradation ProductsFactor IXFactor VIIIProtein CFactor XIIIFactor VLaser CoagulationFibrinBlood Coagulation Disorders, InheritedElectrocoagulationBlood Coagulation Factor InhibitorsThrombin TimeAntithrombinsAnticoagulantsFactor XIIThrombosisFactor XIIaThrombomodulinHemorrhagic DisordersCoagulantsHeparinFactor XIaHemophilia ABlood PlateletsFactor IXaHydroxyethyl Starch DerivativesProtein SPlasma SubstitutesPlatelet CountLight CoagulationFactor XII DeficiencyVitamin KFibrinopeptide AHemophilia BFactor XI DeficiencyFactor VaThrombophiliaAfibrinogenemiaHemorrhageAntifibrinolytic AgentsHemostaticsalpha-2-AntiplasminPlatelet ActivationFactor XIII DeficiencyKaolinFactor VII DeficiencyHypoprothrombinemiasHemostasis, SurgicalPrekallikreinReceptor, PAR-1Lupus Coagulation InhibitorPlasmaFactor X DeficiencyFactor V DeficiencyBlood Cell CountLipoproteinsPlatelet AggregationVitamin K Deficiencyvon Willebrand FactorFactor VIIIaRecombinant ProteinsProtein C DeficiencyFetoscopySepsisHirudinsPeptide HydrolasesCarboxypeptidase UPlasminogen Activator Inhibitor 1Serine Proteinase InhibitorsThromboembolismInflammationWarfarinBleeding TimeInternational Normalized RatioFibrinolysinBlood Loss, SurgicalTime FactorsPlasminogen
RecombinantHemostasisHemophiliaThrombinParts of the coagulationProduction of coagulationBloodCascadeProthrombin timeInflammationPathwayAmino acidsPlateletGeneEncodesDisordersDeficienciesAllergicAnticoagulantsAnalyzerInflammatoryEnzymesKinaseThrombosisAntithrombinDeficiencyPathwaysFVIIaSerine proteaseCofactorClinicalCoronaryFactorsEnzymeVitamin K-dependentSerumAntibodiesHealthcare providerFunctionalDefectTissueMedicationActivityPatients
Recombinant10
  • Coagulation Factor VIII Human, Recombinant Protein is produced in CHO cells and is a glycosylated polypeptide chain with 2322 amino acids. (ilexlife.com)
  • The technical name of Alprolix is Coagulation factor IX (recombinant), Fc fusion protein. (myhemophiliateam.com)
  • Recombinant Therapeutic Antibodies and Proteins Market Sh. (pharmiweb.com)
  • The recombinant therapeutic antibodies and proteins market is witnessing significant growth, owing to increasing approval and launch of novel products in the recent past. (pharmiweb.com)
  • For instance, according to the National Center for Biotechnology Information (NCBI) data of 2017, the U.S. Food and Drug Administration (FDA) approved over 140 recombinant therapeutic proteins for human use and several hundred are currently in development. (pharmiweb.com)
  • Several of these proteins are recombinant monoclonal antibodies. (pharmiweb.com)
  • The global recombinant therapeutic antibodies and proteins market size was valued at US$ 91.2 billion in 2017, and is expected to witness a robust CAGR of 12.2% over the forecast period (2018 - 2026). (pharmiweb.com)
  • Use of several recombinant methodologies has enhanced the half-life, functionality, and targeting ability of new therapeutic protein drugs. (pharmiweb.com)
  • Major governments around the world are focused on supporting R&D in recombinant therapeutic antibodies and proteins, which is expected to boost growth of the market. (pharmiweb.com)
  • High prevalence of rare disorders is also contributing to growth of the recombinant therapeutic antibodies and proteins market. (pharmiweb.com)
Hemostasis5
Hemophilia8
Thrombin4
Parts of the coagulation2
  • These results suggest that inflammation as well as parts of the coagulation pathway may contribute to the association between particulate air pollution and coronary events. (nih.gov)
  • Recent drug development has specifically targeted single parts of the coagulation process, such as FXa. (sciencedaily.com)
Production of coagulation2
  • Insufficient production of coagulation proteins or limited access to vitamin K by the immature neonatal liver may exacerbate a coagulation defect. (msdvetmanual.com)
  • It results from an autoimmune reaction in which the body attacks its own production of coagulation factor VIII, one of the blood factors required for normal clotting. (encyclopedia.com)
Blood40
  • RMS due to blood protein or platelet defects may come about through either of two mechanisms: (1) disorders associated with a hemorrhagic tendency or (2) defects associated with a thrombotic tendency. (medscape.com)
  • This gene encodes coagulation factor XII which circulates in blood as a zymogen. (nih.gov)
  • The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. (nih.gov)
  • This gene encodes coagulation factor XI of the blood coagulation cascade. (nih.gov)
  • This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. (nih.gov)
  • Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. (nih.gov)
  • Proteine mit Einfluss auf die Blutgerinnung [Proteins influencing the blood coagulation]. (unil.ch)
  • Coagulation factors are proteins in your blood. (medlineplus.gov)
  • A coagulation factor test is used to find out if you have a problem with any of your clotting factors that may cause too little or too much blood clotting. (medlineplus.gov)
  • Coagulation factor tests are also used to monitor people who have a known problem with clotting factors or who take medicine called blood thinners to lower the risk of blood clots. (medlineplus.gov)
  • A prospective panel study was conducted to study the early physiologic reactions characterized by blood biomarkers of inflammation, endothelial dysfunction, and coagulation in response to daily changes in air pollution in Erfurt, Germany. (nih.gov)
  • However, not all of the blood markers of endothelial dysfunction and coagulation increased consistently in association with air pollutants. (nih.gov)
  • This also activates protein kinase C which stimulates platelet aggregation and therefore blood coagulation further down the pathway. (wikipedia.org)
  • It is exposed to flowing blood during injury or inflammation, binds FVIIa, and initiates the extrinsic coagulation pathway. (merckvetmanual.com)
  • Recombinate (clotting factor) is a naturally occurring protein in the blood. (drugs.com)
  • By Lisa Fratt The Hemochron Response whole blood coagulation system is a future-oriented system based on International Technidyne Corp's (ITC) decades of experience in point-of-care coagulation monitoring. (clpmag.com)
  • Coagulation factor VIIa is a man-made protein similar to a natural protein in the body that helps the blood to clot. (cigna.com)
  • It was not until 1965, however, that another doctor discovered a way to separate the protein factors from the liquid part of blood plasma by a freeze-drying process. (encyclopedia.com)
  • The coagulation factors in the blood interact with the platelets and other chemicals in the blood to form a network or web that holds the clot in place. (encyclopedia.com)
  • Both vitamin K1 and vitamin K2 produce proteins that help the blood clot. (medicalnewstoday.com)
  • Blood clotting or coagulation prevents excessive bleeding internally and externally. (medicalnewstoday.com)
  • Idelvion belongs to a group of drugs called blood coagulation factors. (rxwiki.com)
  • Nephrotic syndrome is a group of symptoms that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. (rxwiki.com)
  • Agglutinin is an antibody or sugar-binding protein found in the blood. (differencebetween.net)
  • An initial step in detecting liver damage is a simple blood test to determine the level of certain liver enzymes (proteins) in the blood. (medicinenet.com)
  • Blood protein extravasation through a disrupted blood-brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. (nature.com)
  • However, how blood proteins polarize innate immune cells remains largely unknown. (nature.com)
  • Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)
  • Deletion of the blood coagulation factor fibrinogen largely reversed blood-induced microglia neurodegenerative signatures. (nature.com)
  • Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals. (nature.com)
  • However, how microglia integrate extracellular signals at sites of cerebrovascular damage and the specificity of blood proteins controlling innate immune cell polarization in disease remain poorly understood. (nature.com)
  • We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
  • Moreover, our study provides a resource for the investigation of the immunology of blood proteins in inflammatory, autoimmune and neurodegenerative diseases. (nature.com)
  • To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
  • is a protein present in blood plasma that is essential in blood clotting. (proprofs.com)
  • Explanation a protein essential in blood clotting. (proprofs.com)
  • Whole blood and tissues were harvested for analysis of mRNA transcripts related to inflammation and coagulation. (cdc.gov)
  • Interestingly, whole blood showed similar gene expression induction of macrophage-inflammatory protein-2 (MIP-2) and tumor necrosis factor alpha (TNFá) following LPS by pharyngeal aspiration or IP injection. (cdc.gov)
  • In conclusion, lung inflammation results in activation of inflammatory and coagulation biomarkers associated with cardiovascular diseases and blood gene expression studies can identify biomarkers which predict cardiovascular outcomes in occupational-related respiratory exposures. (cdc.gov)
  • The diagnostic assessment in idiopathic pulmonary artery hypertension (IPAH) includes a variety of blood studies, coagulation studies, tests for collagen-vascular disease, and imaging studies, as well as a variety of other tests and procedures. (medscape.com)
Cascade3
  • This study showed that FXa activity, an important part of the coagulation cascade that is the target of drug treatments, could be quantitatively assessed by DBCM, a method that is easy to use and may be readily used in clinical treatment. (sciencedaily.com)
  • This complicated series of chemical reactions is called the coagulation cascade. (encyclopedia.com)
  • Recently several reports have cleotide (designated as 0/10 bp) in the pro- focused on the association between the moter region of the gene at position -323 factor VII of the cascade coagulation and [ 13,14 ]. (who.int)
Prothrombin time1
Inflammation1
  • Highly expressed in platelets and endothelial cells, PAR1 plays a key role in mediating the interplay between coagulation and inflammation, which is important in the pathogenesis of inflammatory and fibrotic lung diseases. (wikipedia.org)
Pathway4
  • this pathway results in the stimulation of protein kinase C (PKC) which impacts platelet activation. (wikipedia.org)
  • The TF-FVIIa complex (extrinsic tenase) activates FX, triggering the intrinsic coagulation pathway (in vitro). (merckvetmanual.com)
  • Furthermore, transcriptomic analysis of the liver tissues displayed that the peroxisome proliferator activated receptor-1α (PPAR) and AMP-activated protein kinase (AMPK) signaling pathway genes ( Pparaa, Cpt1a, Prkaa1, Prkab1, Prkaa2 , and Ppargc1a ) were upregulated in those groups supplemented with UPF. (frontiersin.org)
  • In FV-Short, the truncated B domain exposes a high-affinity binding site for tissue factor pathway inhibitor alpha (TFPIα), and together with protein S a high-affinity trimolecular complex is generated. (lu.se)
Amino acids4
  • The use of amino acids, proteins and peptides is not expected to have any environmental impact. (janusinfo.se)
  • According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00),vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)
  • Either at genomic or at proteomic level, mutations have significant impact on normal gene or protein function, and human diseases could be associated with mutations like nonsynonymous single-nucleotide variations (nsSNVs) on amino acids. (hindawi.com)
  • The aminotransferase enzymes catalyze chemical reactions in which an amino group from one amino acid (amino acids are building blocks of proteins) is transferred from a donor molecule to a recipient molecule, hence, the name 'aminotransferases. (medicinenet.com)
Platelet3
  • Signal Peptide-Cub-Epidermal growth factor domain-containing protein-1 (SCUBE1) is secreted under hypoxia and inflammatory conditions from platelet alpha granules. (nih.gov)
  • Additionally, both PAR1 and PAR4 can couple to G-protein q which stimulates intracellular movement for Calcium ions that serve as second messengers for platelet activation. (wikipedia.org)
  • Platelet agglutination is either artificially done as a diagnostic tool or it refers to a part of the coagulation process. (differencebetween.net)
Gene4
  • Factor V (Coagulation Factor Five) is a 330kDa protein of the coagulation system encoded by the F5 gene. (rndsystems.com)
  • methylation at certain residues of histones can regulate gene expression [ 4 ], and glycosylation is responsible for targeting substrates and changing protein half-life [ 2 ]. (hindawi.com)
  • Yet how gene mutations affect protein activities through posttranslational modification sites have not been widely studied. (hindawi.com)
  • The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
Encodes1
  • Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. (ilexlife.com)
Disorders3
Deficiencies1
Allergic5
  • You should not use this medicine if you have ever had a severe allergic reaction to Recombinate, or if you are allergic to mouse or hamster proteins. (drugs.com)
  • You should not use the brand Recombinate if you are allergic to beef proteins. (drugs.com)
  • You should not receive coagulation factor VIIa if you are allergic to it. (cigna.com)
  • if you are allergic to mouse, hamster, or cow proteins. (cigna.com)
  • Allergic reactions may occur with coagulation factor IX . (rxwiki.com)
Anticoagulants3
  • Previous studies illustrated that several factors contribute to excessive bleeding after cardiac surgery, including preoperative drugs (including anticoagulants and antiplatelet drugs), cardiopulmonary bypass (CPB), coagulation factors, hyperfibrinolysis, and residual heparin effects. (researchsquare.com)
  • During several decades, the knowledge base of the natural anticoagulants has greatly increased and we have also learned about antiinflammatory and cytoprotective activities expressed by antithrombin and activated protein C (APC). (lu.se)
  • proteins C and S are anticoagulants. (msdmanuals.com)
Analyzer4
  • The Coagulation Analyzer survey is available as a downloadable pdf - you will need Adobe Acrobat reader to view this. (clpmag.com)
  • New applications and extended medication times drive the growing coagulation analyzer market. (clpmag.com)
  • Dade Behring Inc has announced that it has introduced the capability to connect the Sysmex® CA-7000 Coagulation Analyzer to the StreamLAB® Analytical Workcell, one of the company's customized automation solutions for the clinical laboratory. (clpmag.com)
  • Dade Behring Receives Marketing Clearance for Its Newest Coagulation Analyzer The Sysmex® CA-560 has received marketing clearance from the US Food and Drug Administration. (clpmag.com)
Inflammatory1
  • Cardiopulmonary bypass (CPB) may induce an inflammatory response, which may be involved in the coagulation process. (researchsquare.com)
Enzymes1
  • Enzymes are proteins that are present throughout the body, each with a unique function. (medicinenet.com)
Kinase1
  • For example, PAR1 in conjunction with PAR4 can couple to and activate G-protein G12/13 which in turn activates Rho and Rho kinase. (wikipedia.org)
Thrombosis1
  • The discovery of APC resistance, caused by FVLeiden, as a thrombosis risk factor resulted in the identification of FV as an APC cofactor working in synergy with protein S in the regulation of FVIIIa in the Xase complex. (lu.se)
Antithrombin1
Deficiency2
  • In a severe deficiency or functional defect of coagulation proteins, clinical signs appear at an early age. (msdvetmanual.com)
  • If a person has a vitamin K deficiency, that means the person's body cannot produce enough of these proteins, increasing the risk of excessive bleeding. (medicalnewstoday.com)
Pathways1
FVIIa1
Serine protease1
Cofactor1
  • Unlike most other coagulation factors, Factor V is not enzymatically active but functions as a cofactor. (rndsystems.com)
Clinical1
  • Because you will receive coagulation factor VIIa in a clinical setting, you are not likely to miss a dose. (cigna.com)
Coronary3
  • Can C-reactive protein predict coagulation in off pump coronary artery bypass grafting? (researchsquare.com)
  • To evaluate whether preoperative C-reactive protein (CRP) can be a novel marker of postoperative bleeding in patients having off-pump coronary artery bypass grafting (CABG). (researchsquare.com)
  • CRP may become a novel coagulation index in coronary artery atherosclerotic disease. (researchsquare.com)
Factors3
Enzyme1
  • This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. (nih.gov)
Vitamin K-dependent2
  • The actions of vitamin K-dependent proteins require calcium. (msdmanuals.com)
  • The vitamin K-dependent proteins, osteocalcin and matrix gamma-carboxy-glutamyl (Gla) protein, may have important roles in bone and other tissues. (msdmanuals.com)
Serum1
Antibodies1
  • Abcam: antibodies, proteins, kits. (abcam.com)
Healthcare provider1
  • What should I discuss with my healthcare provider before receiving coagulation factor VIIa? (cigna.com)
Functional1
  • Fourier transform infrared spectroscopy was used to identify the functional groups of protein, and the surface morphology was observed by SEM-EDS. (degruyter.com)
Defect1
Tissue1
  • In this zone there is irreversible tissue loss due to coagulation of the constituent proteins. (bmj.com)
Medication1
  • Coagulation factor VIIa may also be used for purposes not listed in this medication guide. (cigna.com)
Activity4
  • If activity of any particular coagulation protein is 5%-10% of normal, the neonate may survive, but signs usually appear before 6 months of age. (msdvetmanual.com)
  • Initial and sequential levels of ATIII (activity), PC (antigen and activity), PS (total and free), and C4b binding protein (C4bBP) were compared according to the outcome in patients with DIC. (qxmd.com)
  • Therefore, the aim of study was to evaluate the coagulation activity of NaCl extract from Leucaena leucocephala and Sesbania grandiflora seeds on the removal of turbidity for water purification. (degruyter.com)
  • The FXa-inhibitory activity of TFPIα is synergistically stimulated by FV-Short and protein S. The circulating FV-Short/protein S/TFPIα complex concentration is normally low (≈0.2 nM) but provides an anticoagulant threshold. (lu.se)
Patients1
  • The anticoagulant properties of FV were discovered during investigations of individual patients and follow the great tradition of bed-to-bench and bench-to-bed research in the coagulation field. (lu.se)