• In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
  • Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (medlineplus.gov)
  • The bacterial cell is able to control many protein-coding genes (green lines at bottom) with relatively few controls (yellow and purple lines). (creation.com)
  • 1 It turns out that the bacterial genome has a few high-level instructions that control a few middle-level processes, that in turn control a massive number of protein-coding genes. (creation.com)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • Sequence analysis of HFE, beta2M, and both human heme oxygenase genes failed to identify any causal mutations in nuclear NH families but our study points to the existence of a cohort of patients likely to suffer from an autosomal recessive trait. (nih.gov)
  • AceView: gene:him-8, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
  • We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
  • Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
  • The 46 human chromosomes (22 pairs of autosomal chromosomes and 2 sex chromosomes) between them house almost 3 billion base pairs of DNA that contain about 20,500 protein-coding genes. (medicinenet.com)
  • To resolve phylogenetic relationships among ries of bacterial clonal complexes by using concatenated isolates, we sequenced 68 isolates from Europe and North sequences of housekeeping genes when within-loci and America at 1 chromosomal locus (16S-23S ribosomal RNA between-loci recombinations are infrequent ( 5 ). (cdc.gov)
  • Overview of Chromosome and Gene Disorders Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)
  • The latter affects DNA causing cell toxicity and chromosome abnormalities which precipitate cancers in susceptible people. (aspartaam.nl)
  • Because chromosomes are the carriers of the genetic material, abnormalities in chromosome number or structure can result in disease. (medicinenet.com)
  • Namely, the mitosis in the absence of centrosomes took much longer, and was prone to errors, which led to a prominent increase of chromosome abnormalities (aneuploidy). (databasefootball.com)
  • High-risk types (e.g., types 16 and 18) can cause low-grade cervical cell abnormalities, high-grade cervical cell abnormalities that are precursors to cancer, and cancers ( 5 - 7 ). (cdc.gov)
  • Today, human genetics is for everyone. (refmedical.ir)
  • Once an obscure science or an occasional explanation for an odd collection of symptoms, human genetics is now part of everyday conversation. (refmedical.ir)
  • Chromosomes, distinct structures made up of DNA and protein, are located in the nucleus of each cell. (medicinenet.com)
  • Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
  • 5. Carlezon, W.A. Jr. & Wise, R.A. Rewarding actions drug to its receptor, but rather by the rats, treatments associated with aversive of phencyclidine and related drugs in nucleus ac- failure of an expected drug injection to states such as severe drug withdrawal cumbens shell and frontal cortex. (lu.se)
  • Altered responsiveness to co- oup the nucleus accumbens reflect the behavioral approaches that incorporate caine and increased immobility in the forced swim test associated with elevated cAMP response ele- memory of associations between the extinction-like processes may have effi- ment binding protein in nucleus accumbens. (lu.se)
  • Orphanet journal of rare diseases 2022 5 17 (1): 101. (cdc.gov)
  • Nigéria, en décembre 2022 et publie depuis lors des rapports mensuels. (who.int)
  • Adibalapravritta, chromosome at Xp21 locus. (who.int)
  • The relationship between lysate protein concentration from paclitaxel-treated and hydroxyurea-treated HeLa cells and the absorbance at 450 nm using the PathScan ® RP Phospho-Aurora A (Thr288) Sandwich ELISA Kit #41333 is shown in the upper figure. (cellsignal.com)
  • HeLa cells were treated with paclitaxel (100 nM) or hydroxyurea (4 mM) for 18 hr at 37°C and then lysed. (cellsignal.com)
  • In cells lacking expression of Ca 2+ -mobilizing G proteins, coexpression of human GPR40 and Gα q allowed medium- and long-chain fatty acids to elevate intracellular [Ca 2+ ]. (aspetjournals.org)
  • This was also observed when human embryonic kidney (HEK) 293 cells were transfected with a GPR40-Gα q fusion protein. (aspetjournals.org)
  • 3) It is then metabolized to formaldehyde which enters the cells and binds to the proteins and DNA (the genetic material). (aspartaam.nl)
  • Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis). (medlineplus.gov)
  • 92% were tropic HIV-1 strains into target cells [ 5-7 ]. (who.int)
  • Biotech Europe GmbH, Freiburg, Germa- cation of the virus in cells heterozygous for ny) was used to extract genomic DNA the mutation proceeded at an intermediate from white blood cells following the lysis rate [ 5 ]. (who.int)
  • We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
  • Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
  • The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. (antibodies-online.com)
  • Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. (fishersci.com)
  • Among these, Raman spectroscopy has attracted increasing attention as a highly sensitive molecular imaging technique for studying complex biological systems, including cells, tissues, and various biological materials [ 4 ]. (medsci.org)
  • This technique allows non-destructive, label-free spectral imaging and analysis of cells, tissues, and nanoparticles [ 5 - 7 ]. (medsci.org)
  • As a new quantitative method, heavy water-labeled single-cell Raman microspectroscopy can reduce damage to cells and human interference factors. (medsci.org)
  • Human pluripotent stem cells, comprising both embryonic stem cells and induced pluripotent stem cells, possess two remarkable features: pluripotency - the ability to differentiate into a wide variety of cell types of the adult organism - and self-renewal - the ability to indefinitely divide and produce cells with unchanged potential. (databasefootball.com)
  • These properties have attracted a lot of attention during last years and made stem cells a subject of increasing scientific interest because of their potential utility in numerous biomedical applications, such as excellent in-the-dish model to study events important for human embryogenesis. (databasefootball.com)
  • In the study Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells, Renzova and colleagues blocked the function of PLK4 or STIL with the idea to put a brake on the centrosome duplication pathway and hence to prevent centrosome to duplicate in stem cells. (databasefootball.com)
  • In fact, these findings raised an alerting question if centrosome might perhaps be a completely obsolete organelle for human stem cells. (databasefootball.com)
  • Importantly, self-renewal potential of these cells was strongly compromised, the cells stopped proliferating 4-5 days after the centrosome duplication block was applied. (databasefootball.com)
  • Given that p53 has been shown to mediate consequences of centrosome loss in mice and human somatic cell lines, the team examined its role in the context of centrosome loss in human stem cells. (databasefootball.com)
  • Amount 1 Reflection of IKAP proteins and mRNA in FD cells. (bio2009.org)
  • This reduced sulfation of mucin proteins may underlie the relatively common finding of Candida infections in the gut, since the slight negative charges on Candida cells would lead to their repulsion by the negatively charged sulfate groups on normal mucins. (simplymimi.net)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • The human body has nearly 1013 cells. (cdc.gov)
  • As a developmental biologist, I'm satisfied with the idea that a human being emerges gradually from progressive interactions between cells and environment - it is not a unitary thing, and therefore doesn't have a single discrete point of appearance. (freethoughtblogs.com)
  • 5] Endothelial cells of liver are the major site of biosynthesis. (medscape.com)
  • Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
  • [ 4 ] Most circulating TFPI is bound to lipoproteins, but on the surface of endothelial cells, a second pool of TFPI is bound to heparan sulfates. (medscape.com)
  • It is not surprising that birth defects are fairly common, considering the complexities involved in the development of a single fertilized egg into the millions of specialized cells that constitute a human being. (msdmanuals.com)
  • Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
  • This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
  • We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
  • Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
  • However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
  • To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
  • Although possible, these strategies are often complicated to transfer to human cells due to technical issues (9 ), and only a few successful cases have been described ( 10, 11 ). (lu.se)
  • Here we describe how this system can be used for human embry- onic stem cells. (lu.se)
  • 5. 293T cells - must never be grown to confluency. (lu.se)
  • Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. (nih.gov)
  • At the ribosome, the processed mRNA is translated to produce proteins from amino acid units. (cdc.gov)
  • The RPS10 gene mutations that cause Diamond-Blackfan anemia are believed to result in an abnormally short, nonfunctional RPS10 protein that may impair the assembly of ribosomes, but the specific effects of the mutations are not known. (medlineplus.gov)
  • 90% of cases, mutations that from mutation in the dystrophin gene (located on short disrupt the reading frame (frame shift) lead to arm of X chromosome, Xp21). (who.int)
  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (hmdb.ca)
  • Proteins that catalyze both functions are referred to as glycogen debranching enzymes (GDEs). (wikidoc.org)
  • The current studies provide novel insights into the pharmacology of GPR40 and indicate that G protein-coupled receptors which respond to fatty acids, and potentially to other lipid ligands, can be occupied by endogenous agonists before assay and that this may mask the pharmacology of the receptor and may be mistaken for high levels of constitutive activity. (aspetjournals.org)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)
  • The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. (fishersci.com)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • The human interferon-gamma receptor. (wikidoc.org)
  • Usually, when chemical neurotransmitters are released in the central nervous system, they act at receptor proteins and are then inactivated by sulfation or by FAD-linked mono-oxygenases or alternatively are carried by transporter proteins back into the initiating neurone. (simplymimi.net)
  • The RPS10 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. (medlineplus.gov)
  • Genetic Homolog, Intraocular coccidioidal involvement Author affi liation: University of California, Germany usually occurs with widespread Los Angeles, California, USA infection ( 5 ). (cdc.gov)
  • Survival analysis using the Kaplan-Meier Plotter database revealed that KCNK2/3/4/5/12/15 were associated with overall survival (OS) in patients with thyroid cancer. (jcancer.org)
  • Although thyroid cancer, including PTC, has the advantages of high diagnostic detection rate, good therapeutic effect, and high survival rate [ 4 ]. (jcancer.org)
  • However, once distant metastasis of PTC occurs, it will seriously affect the survival time of patients, and some researchers have reported that the five year survival rate drops to about 54.1% for patients with thyroid cancer due to distant metastasis [ 5 - 7 ]. (jcancer.org)
  • 7) Changes in the genetic material is associated with cancer production in humans. (aspartaam.nl)
  • Cancer statistics also note that rates of breast and prostate cancer are 5 to 6 times higher in North American and Europe than in Asia and Africa, places where NutraSweet market penetration has so far been less. (aspartaam.nl)
  • 2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. (phosphosite.org)
  • It contains 20 exons and 19 introns and is located on chromosome 3p21 ( 1 - 3 ), a region frequently altered in certain cancer types ( 4 ). (spandidos-publications.com)
  • The identified proteins were subjected to subsequent bioinformatics analysis using the DAVID database. (molvis.org)
  • Expression of the protein is most predominant in the nervous system but occurs in many other tissues throughout the body. (wikipedia.org)
  • The blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are responsible for controlling the microenvironment within neural tissues in humans. (hindawi.com)
  • Removal of the sulfate residues leads to a protein which has a more globular structure and provides less protection for the tissues from the intestinal contents. (simplymimi.net)
  • X-linked inheritance, in which the defective gene is present on the female, or X-chromosome. (medicinenet.com)
  • The human genome is the entire 'treasury of human inheritance. (medicinenet.com)
  • Linkage of JH to chromosome lq is established in pedigrees throughout Europe. (nih.gov)
  • [5] The mechanism by which the glucosidase cleaves the α -1,6-linkage is not fully known because the amino acids in the active site have not yet been identified. (wikidoc.org)
  • The genetic abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosomal abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. (medicinenet.com)
  • Diseases may also occur because of chromosomal translocation in which portions of two chromosomes are exchanged. (medicinenet.com)
  • This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. (antibodies-online.com)
  • This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. (antibodies-online.com)
  • The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. (fishersci.com)
  • The trout TNFSF 13b predicted protein shares 54% amino acid identity with human and chicken TNFSF 13b, and 51% identity with mouse TNFSF 13b. (usda.gov)
  • Amino acid substitutions annotated to affect protein activity were collected from the Protein Mutant Database (PMD). (lu.se)
  • The Complementarity Between Protein-Specific and General Pathogenicity Predictors for Amino Acid Substitutions. (lu.se)
  • The A and B clones of Borrelia burgdorferi sensu stric- maintenance of these clonal complexes in natural bacterial to, distinguished by outer surface protein C ( ospC ) gene populations ( 3 , 4 ). (cdc.gov)
  • Prion protein contains five octapeptide repeats with sequence PHGGGWGQ (though the first repeat has the slightly-modified, histidine-deficient sequence PQGGGGWGQ). (wikipedia.org)
  • Prion protein contains 5 amino-terminal octapeptide repeats with sequence PHGGGWGQ. (wikidoc.org)
  • The large black area is a repeat that the human genome project skipped over (they did not yet have the technology to sequence highly repetitive DNA). (creation.com)
  • The DM2 repeat tract contains a flanking region 5' to the tract that consists of a polymorphic repetitive sequence (TG)14-25(TCTG)4-11(CCTG) n. (tmc.edu)
  • CAGG) repeat tract and the flanking sequence, as well as genetic selection assays may reveal the mechanisms responsible for the repeat instability in E. coli, and this may lead to a better understanding of the mechanisms contributing to the human disease state. (tmc.edu)
  • We identified zebrafish and Fugu TNFSF 13b homologues by genomic DNA database searches and determined that the predicted proteins share 68% and 76% sequence identity with trout TNFSF 13b. (usda.gov)
  • Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. (nih.gov)
  • The sequence of the human genome obtained by the Human Genome Project, completed in April 2003, provides the first holistic view of our genetic heritage. (medicinenet.com)
  • Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
  • Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
  • Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
  • This is a subset of the DATASET1 obtained by clustering the protein sequences based on their sequence similarity to remove close homologues. (lu.se)
  • This is a subset of the DATASET 3 extracted by clustering the protein sequences based on their sequence similarity. (lu.se)
  • PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four subunits of the 110kDa catalytic subunit of PI3K protein, which contains a regulatory region of 85kDa. (sigmaaldrich.com)
  • PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four catalytic subunits of PI3K protein, which plays an essential role in extracellular growth signaling. (sigmaaldrich.com)
  • The specific functions of the RPS10 protein and the other ribosomal proteins within these subunits are unclear. (medlineplus.gov)
  • Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH: Co-expression of human Kir3 subunits can yield channels with different functional properties. (drugbank.com)
  • And the expression levels of KCNK1/2/4/5/6/7/15 were correlated with the tumor stage. (jcancer.org)
  • Diet-induced over-expression of flightless-I protein and its relation to flightlessness in Mediterranean fruit fly, Ceratitis capitata. (cdc.gov)
  • When proteins detected in pupae A were compared with those in pupae B, 233 and 239 proteins were, respectively, under- and over-expressed in pupae B, while 167 proteins were overlapped in both pupae A and B. Differential protein profiles indicate that nutritional deficiency induced over-expression of flightless-I protein (fli-I) in medfly. (cdc.gov)
  • therapy for intraocular coccidioidal protein 2a (PBP2a) expression and org/10.1016/0039-6257(80)90056-9 infection is unclear, although 3. (cdc.gov)
  • The team subsequently focused on the examination of effects of centrosome depletion on stem cell properties to find that the centrosome loss led to downregulation of regulators of pluripotency OCT-4 and NANOG and a concomitant increase in the expression of proteins which marked the initiation of differentiation program (namely p53, PAX-6, brachyury etc. (databasefootball.com)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • Bacterial artificial chromosome clones have been isolated from a trout library to further facilitate genomic characterization. (usda.gov)
  • In 4 families there was bacterial or viral maternal infection associated with NH. (nih.gov)
  • It phosphorylates and activates protein kinase B (PKB) protein. (sigmaaldrich.com)
  • One unit of 110a/p85a kinase activity is defined as the amount of enzyme required to produce 1 pmol of Phosphoinositol-3, 4,5-Trisphosphate/min at 37°C. (sigmaaldrich.com)
  • 2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. (phosphosite.org)
  • RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
  • Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
  • HA371 trade name] is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children. (who.int)
  • The core of the centrosome is made by a pair of centrioles, barrel-shape structures embedded in a matrix of proteins termed the pericentriolar material. (databasefootball.com)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Some ribosomal proteins are involved in the assembly or stability of ribosomes. (medlineplus.gov)
  • IL-4 delta 2 is a known splice variant of IL-4. (fishersci.com)
  • The stage mutation noticed in nearly all FD individuals (>99.5%) is a modification from T to C at placement 6 of the 5 splice site (5sh) of intron 20 [7], [8]. (bio2009.org)
  • In particular, IL-4 is located in close proximity to IL13 on the chromosome. (fishersci.com)
  • Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. (fishersci.com)
  • Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome. (medlineplus.gov)
  • Diamond Blackfan anemia: ribosomal proteins going rogue. (medlineplus.gov)
  • is determined in men when reduced testosterone production is suspected, e.g. in hypogonadism, estrogen therapy, chromosome aberrations (as in the Klinefelter's syndrome) and liver cirrhosis. (cdc.gov)
  • The process of sulfation also affects the functioning of peptides and proteins. (simplymimi.net)
  • Total serum calcium is divisible into protein-bound and ultrafiltrable (diffusible) calcium ( Fig. 6-1 ). (abdominalkey.com)
  • Approximately 40% of total calcium is bound to serum proteins, and 80% to 90% of this calcium is bound to albumin. (abdominalkey.com)
  • Variations in serum protein alter proportionately the concentration of the protein-bound and total serum calcium. (abdominalkey.com)
  • An increase in serum albumin concentration of 1 g/dL increases protein-bound calcium by 0.8 mg/dL, whereas an increase of 1 g/dL of globulin increases protein-bound calcium by 0.16 mg/dL. (abdominalkey.com)
  • Marked changes in serum sodium concentration also affect the protein binding of calcium. (abdominalkey.com)
  • Immunoassay for the in vitro quantitative determination of Sample testosterone in human serum and plasma. (cdc.gov)
  • Laboratory studies reveal conjugated hyperbilirubinemia, with total bilirubin serum levels usually in the 2- to 5-mg/dL range (but potentially as high as 25 mg/dL). (medscape.com)
  • CAGG) repeat tract in intron 1 of zinc finger protein 9 (ZNF9) in chromosome 3q21.3. (tmc.edu)
  • This protein has a wide range of physiological functions, and plays central role in multiple types of cancers. (sigmaaldrich.com)
  • This finding has been confirmed numerous times and the DNA-protein-cross-links are believed to cause cancers in experimental animals. (aspartaam.nl)
  • [ 10 ] Protein Z/ZPI's physiologic activity in the coagulation system is unclear. (medscape.com)
  • The protein can exist in multiple isoforms: the normal PrPC form, and the protease-resistant form designated PrPRes such as the disease-causing PrPSc(scrapie) and an isoform located in mitochondria. (wikipedia.org)
  • and in humans: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Sträussler-Scheinker syndrome (GSS), kuru, and variant Creutzfeldt-Jakob disease (vCJD). (wikipedia.org)
  • The protein can exist in multiple isoforms , the normal PrP C , and as Protease resistant PrP Res like the disease-causing PrP Sc(scrapie) and an isoform located in mitochondria . (wikidoc.org)
  • This DNA tract remains one of the least characterized disease-associated DNA repeats, and mechanisms causing the repeat expansion in humans have yet to be elucidated. (tmc.edu)
  • This difference in permeability has attracted motor neuron disease (MND) research, with findings suggesting that the BSCB is damaged in human and rodent ALS sufferers. (hindawi.com)
  • The gene connected with the disease was connected to chromosome 9q31 and determined as the gene. (bio2009.org)
  • Reduced sulfation has been linked with gut dysfunction in irritable bowel disease (3) and lower levels of sulfation of the ileal mucins have recently been shown to occur in children with autism (4) and in irritable bowel. (simplymimi.net)
  • Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)
  • F1 contains 876 proteins with 3257 disease-associated and 2118 benign variations. (lu.se)
  • F2 is an independent dataset, which consisted of 218 proteins with 696 disease-associated and 456 benign variations. (lu.se)
  • 2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. (phosphosite.org)
  • Robust classification of protein variation using structural modelling and large-scale data integration. (lu.se)
  • The BSCB acts as a functional equivalent of the BBB by maintaining the microenvironment for the cellular constituents of the spinal cord [ 5 ]. (hindawi.com)
  • 4. Ultracentrifugation tubes (Beckman L 60). (lu.se)
  • The mechanism for conformational conversion to the scrapie isoform is speculated to be an elusive ligand-protein, but, so far, no such compound has been identified. (wikipedia.org)
  • This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines. (cdc.gov)
  • Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
  • 4) Cytogenetic effects (changes in DNA) have been shown to result from formaldehyde exposure (5) and DNA damage occurs from formaldehyde. (aspartaam.nl)
  • For example, Down syndrome (sometimes referred to as ' Down's syndrome ') or trisomy 21 is a common genetic disorder that occurs when a person has three copies of chromosome 21. (medicinenet.com)
  • RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
  • Centrosome duplicates once per cell cycle, with proteins PLK4 and STIL playing the pivotal role in the regulation of a key step in centrosome cycle - the duplication of centrioles. (databasefootball.com)
  • Low-risk types (e.g., types 6 and 11) can cause benign or low-grade cervical cell changes, genital warts, and recurrent respiratory papillomatosis ( 4 ). (cdc.gov)