AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
Amino Acid SequenceBiologyMolecular Sequence DataDatabases, ChemicalSmall Molecule LibrariesDrug DiscoveryAmino AcidsEvolution, MolecularAlkynesHigh-Throughput Screening AssaysBiological ProductsDrug DesignMolecular StructureDrug Evaluation, PreclinicalPharmaceutical PreparationsModels, MolecularChemistryProteinsProtein BindingEnzyme InhibitorsSignal TransductionSystems BiologyPhylogenyDirected Molecular EvolutionDevelopmental BiologyMolecular BiologyModels, ChemicalComputational BiologyChemical PhenomenaSynthetic BiologySelection, GeneticSpecies SpecificityModels, BiologicalMultiple Chemical SensitivityBase SequenceMagnetic Resonance SpectroscopyChemical IndustryModels, GeneticChemical WarfareOrganic ChemicalsSequence Analysis, DNAGenetic VariationInorganic ChemicalsHazardous SubstancesCultural EvolutionBurns, ChemicalMutationEvolution, ChemicalSequence AlignmentAdaptation, BiologicalChemical Warfare AgentsWater Pollutants, ChemicalGenomicsEnvironmental PollutantsComputer SimulationMultigene FamilyGenomeClonal EvolutionTime FactorsKineticsAlgorithmsBinding SitesStructure-Activity RelationshipEscherichia coliProtein ConformationPrimatesPlantsMass SpectrometryFossilsMammalsPhenotypeReproductionSequence Homology, Amino AcidBacteriaProtein Structure, TertiaryNuclear Magnetic Resonance, BiomolecularDNACarcinogensXenobioticsConserved SequenceToxicity TestsAdaptation, PhysiologicalToxicologySoftwareChromatography, High Pressure LiquidAngiospermsEukaryotaEndocrine DisruptorsBacterial ProteinsFishesLikelihood FunctionsInvertebratesGene Expression ProfilingHistory, 20th CenturyGas Chromatography-Mass SpectrometryTemperatureBiogenesisModels, TheoreticalEcosystemMetabolic Networks and Pathways
BiochemistryGenesChemistrySmall moleculesMolecular evolutionSyntheticStructuralLipidsSystems biologyInteractionsBiomoleculesGenomics and evolutionary biologyNature ChemicaGeneticsDevelopmental BiologyMechanismsReactionsMoleculesEvolutionaryResearchersCharacterizationHarvard UniversityHigh-affinityMutationsBiological systemsKinasePhage-assisted continuous evolutionVariantsBiomolecularDegradationPhysico-chemicalExperimentalMetabolismAmino acidNucleic Acids ReCancerCellsGene2021ImmunityApproachesScientists2022Lund UniversityTherapeuticPhysiologyChemicallyCellDepartmentOrganicConformationalEcologyCellularGraduateMechanism
Biochemistry13
  • Insect Biochemistry and Molecular Biology, 24, 855-873. (scirp.org)
  • The department tailors a unique program of study for each graduate student in one of the following disciplines: analytical chemistry, biochemistry, inorganic chemistry, organic chemistry, physical chemistry, and chemical education research. (auburn.edu)
  • Bob Ignacio, Ph.D. candidate in chemical biology at Radboud University in The Netherlands, explains his research to Beth Habecker, Ph.D., professor of chemical physiology and biochemistry, medicine, and anesthesia and perioperative medicine, OHSU School of Medicine, during the poster session that he won. (ohsu.edu)
  • Carsten Schultz, Ph.D., professor and chair of chemical physiology and biochemistry, OHSU School of Medicine, together with his colleagues from University of Oregon, Oregon State University and OHSU, conceived of the conference - the third in a series - to further catalyze the growing synergy between the fields of chemical biology and physiology. (ohsu.edu)
  • In this course, we will cover subject matter in biochemistry, organic chemistry and structural biology. (columbia.edu)
  • The course is intended to provide a foundation of structural biology, bio-organic chemistry and biochemistry and to expose students to some emerging areas of research. (columbia.edu)
  • This course contains mainly molecular biology, biochemistry & genetic content, is based on reading research articles and requires writing a research proposal. (columbia.edu)
  • The essential biochemistry, genetics, cell biology, and metabolic pathways underlying the survival and success of all living organisms. (queensu.ca)
  • Research in our laboratories combines state-of-the-art approaches from chemistry, biochemistry, cell biology, genomics, computational modeling, and other disciplines to understand cellular and organismal physiology, predict emergent behaviors, and translate these discoveries into new technologies and therapies. (stanford.edu)
  • George Burslem is an Assistant Professor in the Departments of Biochemistry and Biophysics, and Cancer Biology. (upenn.edu)
  • The Perelman School of Medicine (PSOM) has announced the establishment of the Penn Institute for Structural Biology (ISB) , which will be led by Dr. Vera Moiseenkova-Bell , Professor in the Department of Systems Pharmacology and Translational Therapeutics and Secondary faculty in the Department of Biochemistry and Biophysics. (upenn.edu)
  • ACS Synthetic Biology is pleased to announce the winner of the 2019 Young Innovator Award to Chang Liu, Ph.D., Assistant Professor of Biomedical Engineering, Chemistry, and Molecular Biology & Biochemistry at the University of California, Irvine. (acs.org)
  • His PhD from Harvard in Biochemistry & Molecular Biology with Wally Gilbert included the first direct genomic sequencing method in 1984. (codondevices.com)
Genes4
  • It unravels the secrets of genes, which are segments of genetic material, such as DNA, containing instructions for building proteins and controlling various cellular processes. (freescience.info)
  • By studying genes, proteins, and other molecules within cells, biologists can identify genetic mutations responsible for inherited disorders. (freescience.info)
  • This process is mediated by a complex molecular machinery known as the spliceosome, which enables the production of multiple and functionally distinct proteins from single genes. (lu.se)
  • There, I visited Dr. Mark Hahn's lab and performed functional analyses of the Atlantic salmon AHR genes and their expressed proteins in order to find out more about their role in the mediation of toxicity from dioxin exposure. (lu.se)
Chemistry28
  • Housed in state-of-the-art facilities, faculty and students collaborate on research ranging from the traditional sub-disciplines of chemistry to highly multidisciplinary investigations focused on energy, catalysis, chemical biology, and materials science. (auburn.edu)
  • This year's topics of focus include Bioinorganic Chemistry, Chemical Physiology, Imaging and Biosensors, Immune Response in Cancer, Molecular Switches, and Protein Chemistry. (ohsu.edu)
  • Multiple sponsors stepped forward, including Poster Sponsor ThermoFisher Scientific, and Gold level sponsors Advion, Royal Chemical Society, and Cascade Chemistry. (ohsu.edu)
  • The course is intended for advanced undergraduates as well as beginning graduate students in Biology, Chemistry, Physics, Engineering, and Computer Science. (columbia.edu)
  • Topics covered will include high-throughput assay development, screening, chemical library creation, high-throughput chemistry, affinity purification of target proteins and target validation, protein microarrays, molecular evolution, protein engineering and synthetic biology. (columbia.edu)
  • The course will be of interest to students at the interface between chemistry and biology, and students interested in medicine, academic chemical biology and drug discovery efforts. (columbia.edu)
  • This four and a half-credit course will present an introduction to the Biophysical Chemistry and Structural Biology of proteins and nucleic acids. (columbia.edu)
  • These clocks are highly conserved in all organisms, and in organisms separated by hundreds of millions of years of evolution," said Brian Crane, the paper's senior author and an associate professor in Cornell's Department of Chemistry and Chemical Biology. (news-medical.net)
  • This a great example of chemical biology, in that we can perturb the chemistry of a single molecule in a particular way and actually change the behavior of a complex organism. (news-medical.net)
  • Led by David R. Liu, Ph.D., professor of chemistry and chemical biology and an investigator at the Howard Hughes Medical Institute, the researchers report their work in Nature in a paper titled "A system for the continuous directed evolution of biomolecules. (genengnews.com)
  • David B. Collum, the Betty R. Miller Professor of Chemistry in the Department of Chemistry and Chemical Biology, describes his unusual entry into chemistry while an undergraduate at Cornell University, a exciting experience in graduate school at Columbia University, and his movement from organic synthesis to physical organometallic chemistry in his early days as an assistant professor at Cornell. (cornell.edu)
  • Recommended 4U Biology and Chemistry, or equivalent high school background. (queensu.ca)
  • As a postdoctoral fellow he worked at the Harvard Department of Chemistry and Chemical Biology. (uzh.ch)
  • Liu, who is joining the Wyss' Associate Faculty, integrates chemistry and evolution to illuminate biology and enable novel therapeutics. (harvard.edu)
  • Liu is also Professor of Chemistry and Chemical Biology at Harvard University, a Howard Hughes Medical Institute Investigator, and Vice-Chair of the Faculty of the Broad Institute of Harvard and MIT. (harvard.edu)
  • synthetic chemistry and chemical biology. (stanford.edu)
  • Molecular biology, a branch of science that combines biology and chemistry, is crucial for advancements in medicine, biotechnology, agriculture, and our understanding of evolution and biodiversity. (freescience.info)
  • He and others believe they can reconstruct in the lab the long pathway that led from chemicals in space, to Earth's formation, to pre-life chemistry on the planet, to early protocells, and finally to advanced cells with metabolism and protein synthesis. (harvardmagazine.com)
  • A Nobel laureate, professor of genetics at Harvard Medical School, professor of chemistry and chemical biology in the Faculty of Arts and Sciences, the Rich Distinguished Investigator at Massachusetts General Hospital (MGH), and a Howard Hughes Medical Institute investigator, he is described by others as a brilliant, driven scientist. (harvardmagazine.com)
  • The Burslem lab aims to bring the tools provided by synthetic chemistry to bear on problems in biomedical sciences, particularly in cancer biology and epigenetics. (upenn.edu)
  • The Chemical Biology Section of Chemistry Central Journal is pleased to receive manuscripts describing research into all and any aspects of the subject. (biomedcentral.com)
  • A small sample of the literature being produced by Chemical Biology institutes and departments around the world included articles ranging from enzymology to medicinal chemistry, and from structural biology to single cell proteomics. (biomedcentral.com)
  • It would be extraordinary for a single person to be enough of a polymath to be at the forefront of both chemistry and biology, and thus it is all too easy to do great chemistry and weak biology or vice versa. (biomedcentral.com)
  • Whatever your view of Chemical Biology as a field, there is a great deal of evidence that chemistry is uniquely placed to increase our understanding of, and ability to intervene in, biological processes. (biomedcentral.com)
  • The Division of Surface Chemistry of the Swedish Chemical Society. (lu.se)
  • Both Anna and Malin will mainly concentrate on the study of the physical chemistry of proteins. (lu.se)
  • The course consists of the following: -the environmental work at Chemistry Center and Lund University -hazards concerning chemicals -protection gear -safety regulations -laws and regulations for environmental safety -hazard evaluations -accidents. (lu.se)
  • New article published in Journal of Physical Chemistry B, January 2022: Self-Diffusive Properties of the Intrinsically Disordered Protein Histatin 5 and the Impact of Crowding Thereon: A Combined Neutron Spectroscopy. (lu.se)
Small molecules6
  • We will discuss the structure and function of both proteins and small molecules in biological systems. (columbia.edu)
  • Liu and his team have developed multiple technologies including DNA-templated synthesis, phage-assisted continuous evolution (PACE), and a variety of genome editing methods, to apply the principles that drive biological evolution to the discovery of bioactive synthetic small molecules, synthetic polymers, and proteins. (harvard.edu)
  • Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. (stanford.edu)
  • Chemical genetics, [ 1 ] which relies on selecting small molecules for their ability to induce a biological phenotype or to interact with a particular gene product, is one of the best examples of a methodological development in lead generation. (biomedcentral.com)
  • Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a large variety of proteins. (plos.org)
  • CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules. (cdc.gov)
Molecular evolution2
  • The ability to perform dozens of rounds of evolution each day with minimal researcher involvement implies that PACE is particularly well suited to address problems or questions in molecular evolution that require hundreds to thousands of generations or the execution of many evolution experiments in parallel," they note. (genengnews.com)
  • Our results highlight how molecular interactions within a protein can alter the effects of mutations, and thus explain patterns of convergence, divergence, and parallelism in molecular evolution. (uni-hamburg.de)
Synthetic13
  • The biosynthesis of high-value sustainable chemicals is a major goal of synthetic biology and securing the energy future. (energy.gov)
  • Topics covered include various high-throughput genomics technologies (genome sequencing, DNA microarrays, proteomics), quantitative modeling of transcriptional and post-transcriptional regulatory networks, synthetic biology, and the world of RNA structure, dynamics, and function. (columbia.edu)
  • PACE represents the integration and manipulation of many protein and nucleic acid components in a living system to enable the rapid generation of biomolecules with new activities, a significant example and goal of synthetic biology. (genengnews.com)
  • ACS Synthetic Biology 2021 , 10 (9) , 2359-2370. (acs.org)
  • Advantageously, differential pulse voltammetry at SPAgE-AgAP allowed highly sensitive detection of artificial nucleosides dTPT3 and d5SICS (developed to expand genetic alphabet in semi-synthetic organisms) using their catalytic hydrogen evolution signals, with limits of detection of 0.4 pmol l⁻¹. (researchgate.net)
  • Thus, we present the SPAgE-AgAP as a potent tool applicable in simple, fast, and sensitive electrochemical detection of reducible or catalytically active species, with prospective applications in hot research areas including chemical and synthetic biology. (researchgate.net)
  • The group routinely produces synthetic proteins, designing them to conform to a folding pattern called a four-helix bundle and then testing them in mutated strains of the bacterium Escherichia coli. (scholarsark.com)
  • In addition to testing the synthetic protein in living bacteria, she also mixed it directly with its iron-grabbing substrate and biochemically analyzed the ensuing reaction. (scholarsark.com)
  • This award, established in 2014, honors the contributions of a young scientist who has made a major impact on synthetic biology and/or related fields. (acs.org)
  • The award will be presented at the Synthetic Biology: Engineering, Evolution & Design (SEED) conference , June 23-27, 2019, in New York, New York. (acs.org)
  • Dr. Liu started his lab at the University of California, Irvine in 2013, where he does research in the fields of synthetic biology, chemical biology, and directed evolution. (acs.org)
  • Don't miss his talk at SEED 2019 on Synthetic Genetic Systems for Rapid Mutation and Continuous Evolution in vivo on Monday, June 24th from 3:00-3:30 P.M. EDT during Session 3. (acs.org)
  • Current research focuses on integrating biosystems-modeling with personal genomics & synthetic biology. (codondevices.com)
Structural13
  • Lectures on these topics will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics, and machine learning. (columbia.edu)
  • By substituting a single atom (sulphur for oxygen) on the surface of the vivid protein, the researchers were able to shut down the chain of events and prevent the structural changes on the protein's surface, thereby disrupting the regulation of carotenoid production. (news-medical.net)
  • We are a team of structural and chemical biologists aiming to answer these questions at the level of ångstroms, nanometers, and micrometers. (stanford.edu)
  • The Center for Structural Biology (CSB) at Stony Brook anchors much of the research in structural biology undertaken in the MCB program. (stonybrook.edu)
  • The Keck NMR Center for Structural Biology houses four NMR spectrometers: standard bore 700 MHz and 850 MHz spectrometers for solution NMR studies and wide bore 500 MHz and 600 MHz spectrometers for solid-state NMR studies. (stonybrook.edu)
  • Brookhaven National Laboratory (BNL) has world-class facilities for structural biology that are available to students in the BSB Program. (stonybrook.edu)
  • The National Synchrotron Light Source (NSLS-II) at BNL is one of the newest and most advanced facilities for structural biology in the world. (stonybrook.edu)
  • Kushol Gupta is a Research Assistant Professor in the department, a member of the BMB graduate group, and directs the Johnson Foundation Biophysics and Structural Biology Core (JFBSB), a departmental resource that serves Penn and the greater region. (upenn.edu)
  • The structural biology of Phenylalanine Hydroxylase, the enzyme that underlies the condition phenylketonuria (PKU) ( recent publication ). (upenn.edu)
  • The ISB will catalyze novel advances in the areas of structural biology, provide access to expertise and technology to support cryo-EM, Xray crystallography, NMR, molecular dynamics simulations and more, and promote collaborative studies across the biomedical community. (upenn.edu)
  • Structural Biology and Taxonomy is the first volume in a series authored by leading medical mycologists. (cdc.gov)
  • Pathogenic Fungi-Structural Biology and Taxonomy is an important interpretation of recent literature, a valuable addition to collections, and recommended reading for investigators seeking a broad appreciation for the current state of the art. (cdc.gov)
  • The NMX Macromolecular Diffractometer is the only instrument at ESS dedicated to structural biology - an area. (lu.se)
Lipids3
  • Saposins are a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. (wikipedia.org)
  • In this sense Gr-VHDL fraction has 98.6% of hemolymphatic proteins, and 89.3% of lipids presents in the hemolymph. (scirp.org)
  • Lipids are indispensable mobile constructing blocks, and their post-translational attachment to proteins makes them essential regulators of many organic processes. (apoptosises.com)
Systems biology8
  • Taught by research scientists active in various of systems biology, the course is highly interdisciplinary and rooted in recent research, with a soft focus on cancer. (columbia.edu)
  • The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. (stanford.edu)
  • The Chemical and Systems Biology Graduate Program trains students to explore the function of complex biological systems at a quantitative and molecular level. (stanford.edu)
  • Postdoctoral fellows are an integral part of the Chemical and Systems Biology community, playing active roles in its research and training activities. (stanford.edu)
  • Fellows join the Chemical and Systems Biology Postdoctoral Program through individual laboratories, and interested applicants should contact faculty members directly. (stanford.edu)
  • Tenure-track Assistant or Associate Professor position in the University Tenure Line in the Department of Chemical and Systems Biology at the Stanford University School of Medicine. (stanford.edu)
  • systems biology of signal transduction pathways. (stanford.edu)
  • Dr. Collins is a pioneer in systems biology - the study of the cell as a system of biological components - and a world leader in the use of nonlinear dynamical techniques to reverse-engineer gene regulatory networks. (codondevices.com)
Interactions9
  • The candidate will be trained in mRNA Display, peptide synthesis, protein expression and purification, and biophysical analysis of target-ligand interactions. (gettinghired.com)
  • The ease with which new protein interactions and assemblies can emerge implies that non-functional interactions are a burden that cells must cope with and evolve with. (weizmann.ac.il)
  • The chromophore captures a photon or particle of light, and the captured energy from the light triggers a series of interactions that ultimately lead to conformational changes on the surface of the vivid protein. (news-medical.net)
  • Molecular biology , a field studied by biologists, focuses on the study of biological molecules and their interactions at the molecular level. (freescience.info)
  • Of the hypotheses proposed to resolve this paradox, the 'Pink Queen speculation' emphasises the potential of antagonistic interactions to trigger fluctuating choice, which favours the evolution and upkeep of intercourse. (apoptosises.com)
  • Specifically, we are interested in post-translational modifications, changes to a protein after it's produced, which add an incredible level of diversity to the underlying proteins within a cell and can control a diverse array of processes, including protein stability, interactions, and activity. (upenn.edu)
  • The interactions between IGFs and several high-affinity IGF-binding proteins (IGFBPs) are important for IGF transport [ 4 - 6 ] from the liver to its site of biological action. (beds.ac.uk)
  • Dr. Baker uses a combination of experimental and computational approaches to understand the basic principles underlying protein folding and protein-protein interactions. (codondevices.com)
  • An online lecture by Mikael Lund about lesser-known protein-protein interactions is available. (lu.se)
Biomolecules1
Genomics and evolutionary biology1
  • Cédric Feschotte , professor of molecular biology and genetics in the College of Agriculture and Life Sciences, was chosen for his distinguished contributions to the fields of genomics and evolutionary biology, particularly for illuminating the impact of mobile genetic elements in evolution. (cornell.edu)
Nature Chemica2
Genetics8
  • Prerequisites: genetics or molecular biology. (columbia.edu)
  • chemical biology, cell signaling, and quantitative genetics. (stanford.edu)
  • Welcome to the fascinating world of molecular biology , where biologists study the intricate molecular mechanisms of biological molecules that determine our traits through genomics and mendelian genetics. (freescience.info)
  • In this article series on molecular biology, we will dive deeper into the captivating realm of genomics, where biologists study the genome and explore the fascinating world of Mendelian genetics. (freescience.info)
  • For instance, in cancer treatment, molecular biology techniques have led to breakthroughs in genomics and genetics such as personalized medicine. (freescience.info)
  • Thanks to molecular biology techniques like DNA sequencing and gene expression analysis, biologists have made significant strides in understanding genetics and genomics. (freescience.info)
  • The evolution and population genetics of 3 agents of major deep-seated mycoses, which follow, are of more general interest. (cdc.gov)
  • We are interested in various aspects of the genetics of sex differences, including sexual selection and sexual conflict, the evolution of sexual dimorphism, and sex chromosome evolution. (lu.se)
Developmental Biology2
Mechanisms5
  • In more recent years, Dr Usher has turned his attention to possible mechanisms for the prebiotic formation of the peptide bond using novel oligonucleotide templates, as a model for the origin of protein synthesis. (cornell.edu)
  • My main research focus is on protein transport mechanisms and rhomboid proteins. (queensu.ca)
  • Molecular biology, a branch of science, has revolutionized the field of medicine by providing insights into the intricate mechanisms underlying diseases at a molecular level. (freescience.info)
  • We explore how protein motions cause biological mechanisms and how proteins aggregate in neurodegenerative diseases such as Parkinson's and Alzheimer's. (stonybrook.edu)
  • Since resistance to apoptosis is a foundation of neoplastic evolution and selection of malignant transformed phenotype, we investigated the apoptosis pathway underlying the resistance its mechanisms to aid the understanding of SWCNT-induced carcinogenesis. (cdc.gov)
Reactions7
  • We aim to understand how the active site iron centers catalyze challenging chemical reactions and how catalysis is regulated by the protein structure. (auburn.edu)
  • Now, new research by Cornell and Dartmouth researchers explains the biological mechanism behind how circadian clocks sense light through a process that transfers energy from light to chemical reactions in cells. (news-medical.net)
  • The resulting chemical reactions were then studied. (universetoday.com)
  • However, the reactions resulted mostly in the formation of peptides (two or more amino acid building blocks linked together) that were closer to today's actual proteins. (universetoday.com)
  • The catalytic character of the hydrogen evolution reactions, involving reduction of high numbers of protons per a single catalytically active moiety, offers particularly high sensitivities of detection of the catalysts. (researchgate.net)
  • These specialized proteins set into motion all the cells' chemical reactions, making sure they run fast enough for life on a biochemical level to proceed. (scholarsark.com)
  • Active colicins can be produced with lysates containing molecular chaperones and coproduction of immunity proteins in cell-free protein synthesis reactions. (bvsalud.org)
Molecules5
  • Small organic molecules function in energy production and creating building blocks for the components of cells and can also be used to perturb the functions of proteins directly. (columbia.edu)
  • His research is focused on protein engineering and directed evolution, especially of antibodies, engineered binding molecules and membrane proteins. (uzh.ch)
  • How did amino acids, the chemical building blocks of life, come together roughly four billion years ago to create the first protein molecules? (universetoday.com)
  • For decades, scientists have had theories about how the first amino acids came together to form protein molecules. (universetoday.com)
  • Their research in evolutionary biology and cell biology contributes to advancements in medicine, agriculture, and biotechnology by unlocking the mysteries of biological molecules and developing new therapies. (freescience.info)
Evolutionary3
  • His work is tied to human evolution, including evolutionary adaptation and the evolutionary processes that lead to genetic disease. (buffalo.edu)
  • The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology , vol. 294, no. 4, Wiley Online Library, 2011, pp. 567-79. (evolutionnews.org)
  • The emergence of cooperation is a central question in evolutionary biology. (cdc.gov)
Researchers7
  • After the discovery of a natural circularly permuted protein, researchers looked for a way to emulate this process. (wikipedia.org)
  • Researchers addressed this challenge by developing a cell-free DNA assembly and protein synthesis platform, allowing researchers to rapidly screen 1000's of sequence defined enzyme mutants in iterative design-build-test-learn cycles. (energy.gov)
  • The researchers studied a protein called vivid, which contains a chromophore -- a light-absorbing molecule. (news-medical.net)
  • For instance, a team of researchers from the Georgia Institute of Technology's Center for Chemical Evolution (CCT) recently conducted a study that showed how some of the earliest predecessors of the protein molecule may have spontaneously linked up to form a chain. (universetoday.com)
  • Unfortunately, when asked to define Chemical Biology, most researchers seem to be lost for an apt description. (biomedcentral.com)
  • Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. (stackexchange.com)
  • However, little is known about the contribution of the non-mutated splicing factors in tumor evolution," explain the researchers. (lu.se)
Characterization1
Harvard University1
  • The Harvard University team that has developed the technique claims it will allow scientists to rapidly generate new proteins or nucleic acids with desired properties. (genengnews.com)
High-affinity1
Mutations2
  • We investigated the effects of these insertions in combination with other mutations at nearby sites in the protein and found that they can either produce or diminish resistance to these toxins depending on whether another mutation was present. (uni-hamburg.de)
  • begingroup$ @Mithoron If mutations are random, then the median protein can mutate to 10^487 different new proteins. (stackexchange.com)
Biological systems3
  • We will discuss approaches for discovering and optimizing chemical tools for measuring and perturbing biological systems. (columbia.edu)
  • By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies. (stanford.edu)
  • It is this partnership, which allows cutting edge chemical concepts and tools to be brought to bear on previously impenetrable biological systems, that is the essence of Chemical Biology. (biomedcentral.com)
Kinase1
  • A further chapter discusses how surface membrane G-protein receptors in C. albicans and other fungi transmit external stimuli through 2 major protein kinase cascades. (cdc.gov)
Phage-assisted continuous evolution1
  • The new system, called phage-assisted continuous evolution, or PACE, is based on the continuous culture and selection of the M13 filamentous bacteriophage commonly used in phage display. (genengnews.com)
Variants4
  • The CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. (wikipedia.org)
  • The three PACE experiments executed 45-200 rounds of evolution in 1.5-8 days and yielded T7 RNAP variants with activities on their target promoters or templates that exceeded or matched the activity of the wild-type enzyme transcribing the wild-type T7 promoter both in cells and in vitro," the team states. (genengnews.com)
  • Gokcumen's research examines the role that genomic variants, especially deletions and duplications, play in human disease and biology. (buffalo.edu)
  • Analysis of 6,515 Exomes Reveals the Recent Origin of Most Human Protein-Coding Variants. (evolutionnews.org)
Biomolecular3
  • Topics covered include introductions to biomolecular structure, physico-chemical tools used to probe biomolecular structure and dynamics, intermolecular forces that govern these structures and dynamics, and experimental and computational approaches for studies of biomolecular folding and function. (columbia.edu)
  • Scientists claim to have developed a new phage-based approach to biomolecular evolution that is about 100 times faster than conventional laboratory evolution techniques and far less labor intensive. (genengnews.com)
  • Matthew DeLisa , the William L. Lewis Professor of Engineering in the Smith School of Chemical and Biomolecular Engineering, was recognized for solving complex problems in biology and medicine by engineering the protein machinery of bacteria. (cornell.edu)
Degradation2
  • We have shown, using our mathematical model, how complex degradation can potentially be exploited to target a chemical to a particular tissue, and how the level of the active chemical depends on factors such as the diffusion coefficients and degradation/production rates of each species. (beds.ac.uk)
  • We believe that adjusting the rate of degradation of the complex may well provide a generic mechanism for tuning tissue exposure to various chemicals in the body. (beds.ac.uk)
Physico-chemical1
  • Characteristics of individual transport pathways, including their geometry, physico-chemical properties and dynamics are instrumental for understanding of structure-function relationships of these proteins, for the design of new inhibitors and construction of improved biocatalysts. (plos.org)
Experimental2
  • As such, the primary purpose of this position is to provide experimental leadership and support for research projects at the scientific interface between MRI engineering, multi-modality imaging, computer science, cancer biology, animal models, and clinical translation. (gettinghired.com)
  • There are a lot of theories about the origins of proteins but not so much experimental laboratory support for these ideas. (universetoday.com)
Metabolism1
  • Molecular biology techniques, such as DNA sequencing and genotyping, have facilitated the identification of genetic variations that impact drug metabolism and efficacy. (freescience.info)
Amino acid4
  • From this, the team hypothesized that prefabricated amino acid chains that are useful in living systems evolved before life had found a way to make proteins. (universetoday.com)
  • We found that chinchillas and sandgrouse have independently evolved single amino-acid insertions in the same region of their sodium-potassium pump proteins. (uni-hamburg.de)
  • No life, no endless pool of 375 amino acid long proteins. (stackexchange.com)
  • L-Tryptophan is an essential amino acid that is necessary for making proteins. (medlineplus.gov)
Nucleic Acids Re1
  • Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)
Cancer2
  • these substrates range from bacteria, viruses, and cancer cells to drugs and protein toxins. (stanford.edu)
  • In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
Cells5
  • This molecule carries energy all through the body, and most cells and proteins require ATP to perform their various roles. (elifesciences.org)
  • On a young, rocky planet, how might chemicals have come together in just the right way to form the very first cells? (harvardmagazine.com)
  • We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. (stanford.edu)
  • DNA microarray and Western blot analyses of key apoptosis-regulatory proteins in the transformed cells revealed FLICE-inhibitory protein (FLIP) as an important target of regulation by SWCNT. (cdc.gov)
  • Microorganisms often cooperate by producing a chemical resource (a public good) that benefits other cells. (cdc.gov)
Gene2
  • Next, start and stop codons are introduced at corresponding locations in the duplicated gene, removing redundant sections of the protein. (wikipedia.org)
  • Molecular biology techniques are instrumental in designing safe and effective gene delivery systems for the manipulation of DNA and genome. (freescience.info)
20212
  • Chemical & pharmaceutical bulletin 2021 0 0. (cdc.gov)
  • Accounts of chemical research 2021 0 0. (cdc.gov)
Immunity1
  • Immunity or digestion: glucanase activity in a glucan-binding protein family from lepidoptera. (mpg.de)
Approaches2
  • Bio Reimagining liquid waste streams as resources can lead to recovery of valuable products and more efficient, less costly approaches to reducing harmful discharges to the environment. (stanford.edu)
  • Moreover, the speed of the phage lifecycle means that progeny phage production starts about 10 minutes after infection of the bacteria, so PACE can effectively mediate many generations of selective phage replication much faster than other laboratory evolution approaches. (genengnews.com)
Scientists1
  • Before this, scientists had an idea of the proteins that are found in the mouth, but we didn't have a complete picture of where they were coming from. (buffalo.edu)
20221
  • Chemical science 2022 0 0. (cdc.gov)
Lund University1
  • I got an MSc degree in Biology from Lund university (1999) and I continued to finish my PhD at the Department of Ecology, division of Animal Ecology in 2004. (lu.se)
Therapeutic4
  • Molecular biology aids in drug discovery by identifying potential therapeutic targets and evaluating their efficacy in DNA. (freescience.info)
  • The rapid and impressive advancements in chemical biology during the last decade have clearly demonstrated that solutions for a vast majority of medical problems rely on the understanding of the molecular basis of diseases, therapeutic targets, drug actions, and drug resistance. (stonybrook.edu)
  • In many biological and therapeutic contexts, it is highly desirable to target a chemical specifically to a particular tissue where it exerts its biological effect. (beds.ac.uk)
  • A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. (bvsalud.org)
Physiology4
  • 22 is the third offering of a biennial international conference series focused on the growing intersection of Chemical Biology and Physiology. (ohsu.edu)
  • Gretchen Fujimura, a bachelor's of science student at Oregon State University, came to the OHSU Chemical Biology and Physiology Conference to trade ideas. (ohsu.edu)
  • Kathrine Rush, Ph.D., postdoc in the lab of Ninian Blackburn, OHSU School of Medicine, gives a short talk at the Chemical Biology and Physiology Conference. (ohsu.edu)
  • He said he'd imagined some tropical location with a poster session beneath the palm trees, but when he came across the April 28 - May 1 Chemical Biology and Physiology Conference at OHSU, he knew this would do. (ohsu.edu)
Chemically2
  • In 1983, David Goldenberg and Thomas Creighton were able to create a circularly permuted version of a protein by chemically ligating the termini to create a cyclic protein, then introducing new termini elsewhere using trypsin. (wikipedia.org)
  • The latter acids, which are not found in proteins today, had the potential to chemically react just as well (or better than) the biological ones. (universetoday.com)
Cell6
  • A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
  • We insert barcodes to study evolution, cell-by-cell. (stonybrook.edu)
  • His own research focuses on one segment of the pathway to life: the protocell, "a really, really simple primordial cell that could assemble from chemicals that were around early on, on the surface of Earth," Szostak explains. (harvardmagazine.com)
  • Cell-free protein synthesis provides a flexible platform for the production of difficult-to-express proteins, because maintaining cell viability is unnecessary. (bvsalud.org)
  • The molecular architecture of fungal walls remains elusive because of difficulty in correlating chemical composition with the ultrastructural layers and uncertainty concerning the linkages connecting major cell wall polymers: glucans, mannan, and chitin. (cdc.gov)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
Department6
  • His interest in the Origin of Life is broad, and includes collaborative research with Jonathan Lunine of Cornell's Department of Space Sciences, investigating possible chemical evolution on Saturn's moon Titan. (cornell.edu)
  • I am a Professor in the Department of Biology at Queen's University. (queensu.ca)
  • Other facilities include a Scanning Transmission Electron Microscope (STEM) in the Department of Biology. (stonybrook.edu)
  • We do research in different research groups at the Department of Biology. (lu.se)
  • Between 2004 and 2006 I was a Postdoctoral Scholar at the Biology Department, Woods Hole Oceanographic Institution, MA, USA. (lu.se)
  • I am now employed at the Center for Environmental and Climate Research (CEC) and have my research group at the Department of Biology in the Ecology Building. (lu.se)
Organic2
  • 1974. The industrially significant organic chemicals -- Part 2. (cdc.gov)
  • The largest subset of articles (22/39) examined the effects of toxic exposures or toxicogenomic effects of chemicals, such as polychlorinated biphenyls, dioxins, heavy metals, and organic solvents. (cdc.gov)
Conformational1
  • We can now show that this conformational change in the protein is directly related to its function in the organism," said Brian Zoltowski, the paper's lead author and a graduate student at Cornell in chemical biology. (news-medical.net)
Ecology2
  • Our research is primarily focused on the ecology and evolution of animal flight. (lu.se)
  • Our research lies at the interface of development, ecology, and evolution. (lu.se)
Cellular2
  • Proteins are the primary class of biological macromolecules and serve to carry out most cellular functions. (columbia.edu)
  • And, how is nutrient sensing integrated with other chemical signals, such as hormones, to determine cellular decisions, especially the decision: to grow or not to grow? (stanford.edu)
Graduate2
  • Ever since Bob Ignacio became a graduate student in chemical biology at Radboud University in The Netherlands, he's wanted to attend a conference in a place far away. (ohsu.edu)
  • I have been teaching a variety of courses here at Queen's for over 20 years, from introductory biology to the commercialization of biological research at the graduate level. (queensu.ca)
Mechanism3
  • The earliest model proposed for the evolution of circular permutations is the permutation by duplication mechanism. (wikipedia.org)
  • For example, some favorite modifications can lead to the protein being degraded which provides a mechanism to get rid of proteins which cause disease. (upenn.edu)
  • I wonder if any known mechanism can explain this selection of protein varieties. (stackexchange.com)