AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Cerebrospinal FluidCerebrospinal Fluid ProteinsCerebrospinal Fluid RhinorrheaCerebrospinal Fluid PressureCerebrospinal Fluid ShuntsMeningitisSpinal PunctureCerebrospinal Fluid OtorrheaMeningitis, BacterialMeningitis, ViralHydrocephalusMeningitis, AsepticTuberculosis, MeningealMeningitis, PneumococcalChoroid PlexusMeningoencephalitisSubarachnoid SpaceNeurosyphilisCisterna MagnaIntracranial PressureArachnoidCerebral VentriclesBrainMultiple SclerosisCentral Nervous System DiseasesOligoclonal BandsBlood-Brain BarrierMeningitis, FungalHydroxyindoleacetic AcidNervous System DiseasesMeningesVentriculoperitoneal ShuntPneumoencephalographyLyme NeuroborreliosisCentral Nervous System InfectionsHomovanillic AcidEncephalitisMeningitis, HaemophilusVentriculostomyBrain DiseasesEncephalitis, ViralLeukocytosisMeningitis, MeningococcalMagnetic Resonance ImagingBiological MarkersInjections, SpinalMeningitis, CryptococcalNeurocysticercosisAlzheimer DiseaseCentral Nervous System Viral DiseasesMeningeal NeoplasmsInjections, IntraventricularSensitivity and SpecificityAmyloid beta-PeptidesDura Matertau ProteinsIntracranial HypotensionSubarachnoid HemorrhageEpendymaAIDS Dementia ComplexHydrocephalus, Normal PressureEnterovirus InfectionsCerebral VentriculographyEnzyme-Linked Immunosorbent AssaySubacute Sclerosing PanencephalitisTrypanosoma brucei gambiensePseudotumor CerebriLeukoencephalopathy, Progressive MultifocalSubdural EffusionMethoxyhydroxyphenylglycolMyelographyPolymerase Chain ReactionMeningitis, ListeriaLatex Fixation TestsPhenylacetatesSyringomyeliaPneumocephalusEthmoid BoneMeningeal CarcinomatosisInfant, NewbornEncephaloceleHeadacheTime FactorsMeningoceleArachnoid CystsEnterovirusCentral Nervous SystemNeisseria meningitidisCeftriaxoneLeukocyte CountSpinal CordSphenoid SinusArachnoiditisCryptococcosisSpinal Cord DiseasesNeopterinCerebral AqueductCounterimmunoelectrophoresisPia MaterStreptococcus pneumoniae
BiomarkersSerumAlzheimer's2023Amyloid proteinDementiaGlucoseAlbuminLumbarDiagnosisFibrilOligoclonalLaboratoryPrecursor proteinPeptideConcentrationPeptidesViralAbnormalMAPTSpecimensCorrelationAnalysisMeningitisPatientsLipidsSpinal fluidMethodsExaminationLevelsSubarachnoidAcuteObtaining bloodAmplificationElectrophoresisInflammatoryRevealsResearchersPresenceDetectionAccumulationHumanBrainDemonstrateExpression
Biomarkers3
  • Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. (frontiersin.org)
  • The results indicate that several of the proteins included in the panel may serve as synaptic biomarkers for AD. (lu.se)
  • We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)
Serum4
Alzheimer's6
  • Alzheimer's disease (AD) associated proteins exist in cerebrospinal fluid (CSF). (empa.ch)
  • People with untreated type 2 diabetes developed Alzheimer's disease 1.6x faster and had more tau protein in cerebrospinal fluid (CSF). (foundmyfitness.com)
  • People with untreated type 2 diabetes developed Alzheimer's disease 1.6x faster and had more tau protein in cerebrospinal fluid (CSF) compared to people without diabetes. (foundmyfitness.com)
  • When mixed with the equivalent, normal protein, the misfolded fragments act as seeds for the formation, in the case of Aβ, of amyloid clumps like those found in the Alzheimer's brain. (sciencedaily.com)
  • Most importantly, Soto and his colleagues were able to distinguish between patients with Alzheimer's disease and those with other neurodegenerative or neurological disorders with 90% sensitivity and 92% specificity by applying their test to cerebrospinal fluid samples. (sciencedaily.com)
  • The fluid carried away toxic waste proteins, including those that form sticky plaques in Alzheimer's patients. (einsiders.com)
20231
Amyloid protein2
  • Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. (frontiersin.org)
  • Deposited amyloid protein in these patients is identical to the amyloid protein seen in sporadic cases, and the likely genetic defect is in the amyloid protein precursor protein ( APP ) gene on chromosome 21. (medscape.com)
Dementia1
  • This paper evidences that protein aggregate morphology distinctly differs in CSF of patients with AD dementia (ADD), mild cognitive impairment due to AD (MCI AD), with subjective cognitive decline without amyloid pathology (SCD) and with non-AD MCI using liquid-based atomic force microscopy (AFM). (empa.ch)
Glucose3
  • Applying this technique to AD we demonstrate differences in proteins involved in glucose metabolism and neuroinflammation that collectively have potential clinical diagnostic utility. (lu.se)
  • Antibiotic pretreatment was associated with higher cerebrospinal fluid glucose levels with decreased neutrophils and increased lymphocytes. (nepjol.info)
  • The analysis of polymerase chain reaction (PCR), white blood cells, red blood cells, glucose, protein, and lactate in the cerebrospinal fluid (CSF) provides the first clues to the diagnosis. (bvsalud.org)
Albumin1
  • In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal fluid. (wikipedia.org)
Lumbar4
  • This study was conducted to evaluate the effect of intravenous antibiotic administration before lumbar puncture on cerebrospinal fluid profiles in children with bacterial meningitis. (nepjol.info)
  • A lumbar puncture revealed mild lymphocytic pleocytosis (8 cells/mm 3 ) and elevated protein (81 mg/dL). (cdc.gov)
  • Elevated or rising protein levels on serial lumbar punctures and 10 or fewer mononuclear cells/mm 3 strongly support the diagnosis. (medscape.com)
  • Cerebrospinal fluid and lumbar puncture: a practical review. (medscape.com)
Diagnosis5
Fibril2
  • CSF fibril length is inversely correlated with CSF amyloid beta (Aβ) 42/40 ratio and CSF p-tau protein levels (obtained from biochemical assays) to predict amyloid and tau pathology with an accuracy of 94% and 82%, respectively, thus identifying ultralong protein fibrils in CSF as a possible signature of AD pathology. (empa.ch)
  • We found that the C-terminal domain of DNAJB6 - suggested to be involved in peptide binding after dimerization - will inhibit the secondary nucleation of Aβ fibril formation as opposed to the intact protein which inhibits the primary nucleation. (lu.se)
Oligoclonal2
  • One of these eight also demonstrated oligoclonal banding on high-resolution protein electrophoresis of the CSF. (johnshopkins.edu)
  • Cerebrospinal fluid anti-GM1 ganglioside antibodies and oligoclonal band were negative and the IgG index was normal. (who.int)
Laboratory1
  • Figure 1 T2 weighted sagittal magnetic resonance image showing increased signal within the whole spinal cord and medulla oblongata mg/dL is the normal range for cerebrospinal fluid protein in our laboratory) and glu- cose content was 58 mg/dL (simultane- ous blood sugar 90 mg/dL). (who.int)
Precursor protein2
  • Here we report that nonglycosylated full-length and C-terminal truncated amyloid precursor protein (APP) accumulates exclusively in the protein import channels of mitochondria of human AD brains but not in age-matched controls. (jneurosci.org)
  • The major constituent of a senile plaque is β-amyloid (Αβ), which is a 40-43 amino acid peptide produced by the action of secretory pathway-associated proteases, namely β and γ secretases, at the C terminus of a type I membrane-spanning glycoprotein termed amyloid precursor protein (APP). (jneurosci.org)
Peptide1
  • However, peptide aggregation in vivo typically occurs in a more complex environment, surrounded by either different proteins or lipids, or both. (lu.se)
Concentration1
Peptides1
  • Identified MWCNT-responsive peptides depicted a mechanism involving aberrant fibrinolysis (fibrinopeptide A), blood-brain barrier permeation (homeobox protein A4), neuroinflammation (transmembrane protein 131L) with reactivity by astrocytes and microglia, and a pro-degradative (signal transducing adapter molecule, phosphoglycerate kinase), anti-plastic (AF4/FMR2 family member 1, vacuolar protein sorting-associated protein 18) state with the excitation-inhibition balance shifted to a hyperexcited (microtubule-associated protein 1B) phenotype. (cdc.gov)
Viral1
  • RC5: data virus de Epstein Barr y se identificó el genoma viral en el líquido cefalorraquídeo, a través de la prueba de reacción en cadena management. (bvsalud.org)
Abnormal2
  • The synucleinopathy Parkinson's disease (PD), is a neurodegenerative disease characterized by abnormal accumulation of the alpha-synuclein (α-Syn) protein in the brain. (nature.com)
  • This short reference guide provides generic information that may guide initial interpretation of cerebrospinal fluid (CSF) studies but should not be used alone for determination of normal or abnormal results. (medscape.com)
MAPT1
  • Genetics plays an important role in PD, with disease-susceptibility loci including more than 90 genes, including SNCA (Synuclein Alpha), LRRK2 (Leucine Rich Repeat Kinase 2), GBA (Glucosylceramidase Beta) , and MAPT (Microtubule Associated Protein Tau) [ 4 ]. (nature.com)
Specimens1
  • He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)
Correlation2
  • Their correlation seems to be essential in protein-folding simulation. (medscimonit.com)
  • however, correlation between fluids was limited. (cdc.gov)
Analysis5
  • The clinicopathological analysis revealed leukocytosis, and increased haptoglobin and C-reactive protein consistent with severe flogistic process. (hindawi.com)
  • osteopontin and cystatin C. In an independent multivariate orthogonal projection to latent structures discriminant analysis (OPLS-DA), these proteins were also identified as major contributors to the separation between AD and non-AD in both cohorts. (lu.se)
  • The confirmation of an inflammatory origin is made by cerebrospinal fluid (CSF) analysis. (vin.com)
  • Thus, we aimed to identify a biomarker directly from protein analysis and relate it with transcriptomic data to validate in larger cohorts. (quanterix.com)
  • Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults. (uib.no)
Meningitis1
  • Objectives: To assess the diagnostic role of CSF C-reactive protein quantitatively in acute meningitis and to evaluate the efficacy of CSF C-reactive protein in differentiating pyogenic meningitis from non-pyogenic meningitis. (medresearch.in)
Patients8
  • Researchers can detect tiny, misfolded protein fragments in cerebrospinal fluid taken from patients, according to a new study. (sciencedaily.com)
  • Researchers have shown that they can detect tiny, misfolded protein fragments in cerebrospinal fluid taken from patients. (sciencedaily.com)
  • Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma. (nel.edu)
  • Tung J, Tsao T, Chen S, Tai C, Shen S, Cheng Y, Jiang M. Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma. (nel.edu)
  • Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica. (nel.edu)
  • Jiang Y, Yang Y, Zhang B, Peng F, Bao J, Hu X. Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica. (nel.edu)
  • Reverse-phase protein array and microarray data of these patients were analyzed. (quanterix.com)
  • Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients. (uib.no)
Lipids1
  • Further, the effect of Aβ in the presence of both lipids and other proteins was investigated. (lu.se)
Spinal fluid1
  • Here, we examine the cerebral spinal fluid (CSF)-derived peptidomic fraction as a reflection of neuropathological alterations induced by pulmonary carbon nanomaterial exposure. (cdc.gov)
Methods1
  • MATERIAL/METHODS: The polypeptide chains of all the proteins in the Protein Data Bank were transformed into their early-stage structural forms. (medscimonit.com)
Examination1
  • At two-month follow-up evaluation, the cerebrospinal fluid examination was normal and the computed tomography of the brain showed no abnormalities except for the stable aneurysm. (hindawi.com)
Levels6
  • however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously. (nih.gov)
  • CSF is derived from blood plasma and is largely similar to it, except that CSF is nearly protein-free compared with plasma and has some different electrolyte levels. (wikipedia.org)
  • On this basis, we hypothesized that TBI leads to increases in the brain levels of clusterin protein, and consequently, increased plasma clusterin levels. (nature.com)
  • Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech. (medscimonit.com)
  • Accumulation of APP across mitochondrial import channels, which varied with the severity of AD, inhibited the entry of nuclear-encoded cytochrome c oxidase subunits IV and Vb proteins, which was associated with decreased cytochrome c oxidase activity and increased levels of H 2 O 2 . (jneurosci.org)
  • Pretreatment did not modify total cerebrospinal fluid white blood cell count and cerebrospinal fluid protein levels. (nepjol.info)
Subarachnoid2
Acute1
  • Lipocalin-2 (LCN2) is an acute phase protein able to bind iron when complexed with bacterial siderophores. (bvsalud.org)
Obtaining blood1
Amplification1
  • Their protein misfolding cyclic amplification (PMCA) technology works by amplifying existing misfolded proteins and then breaking them up into smaller pieces. (sciencedaily.com)
Electrophoresis1
  • protein measurement and electrophoresis were performed within 48 hours on centrifuged specimen and cell differential count after cytospin. (vin.com)
Inflammatory1
  • An inflammatory marker, HMGB1 protein, was found to be strongly involved in long term repair and defense programs in cerebral ischemia. (scienceopen.com)
Reveals1
Researchers1
Presence1
  • The cerebrospinal fluid study showed hyperproteinuria and a Epstein Barr predominantly lymphocyte count of 450 cells with preserved glycorrhachia, without the presence of bacteria. (bvsalud.org)
Detection1
  • In the new study, Soto and his colleagues applied a technology they developed earlier for detection of the misfolded proteins responsible for prion diseases including mad cow disease. (sciencedaily.com)
Accumulation1
  • Accumulation of the α-Syn protein in the brain occurs rather late in the disease. (nature.com)
Human1
  • The elimination of [ 125 I]hAβ(1-40) was significantly inhibited by human receptor-associated protein (RAP) and the elimination was attenuated in either anti-low-density lipoprotein receptor-related protein (LRP)1 antibody-treated or RAP-deficient mice, suggesting that a member(s) of the low-density lipoprotein receptor gene family is involved in the elimination of hAβ(1-40) from CSF. (elsevierpure.com)
Brain6
  • Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. (wikipedia.org)
  • Our previous mRNA-seq data revealed a 1.8-2.5 fold increase in clusterin mRNA expression in lesioned brain areas in rats with lateral fluid-percussion injury (FPI)-induced TBI. (nature.com)
  • Interstitial fluid and solutes drain from brain to cervical lymph nodes along basement membranes of capillaries and arteries powered by the pulsatile flow in these vessels (reverse transport). (medscape.com)
  • CSF protein is normally derived by filtration from the plasma across the blood brain barrier. (ouh.nhs.uk)
  • They discovered a system of pipes and fluid-filled channels that can "spout" waste products out of the brain, flushing them away into the bloodstream. (einsiders.com)
  • The cerebrospinal fluid (CSF) surrounding the brain was most active during deep sleep. (einsiders.com)
Demonstrate1
  • In addition, we demonstrate that certain mitochondrial pro-apoptotic proteins such as caspases 3, 8, and 9, and p53 were unexpectedly overexpressed in tumors, suggesting that they possess additional non-apoptotic functions. (pdbwiki.org)
Expression4
  • To alter the cross-talk between the mitochondria and the nucleus, we used specific siRNA to silence the expression of VDAC1 in glioblastoma (GBM) U87-MG and U118-MG cell-derived tumors, and then monitored the nuclear localization of mitochondrial proteins and the methylation and acetylation of histones. (pdbwiki.org)
  • Immunohistochemistry revealed a marked increase in extracellular clusterin protein expression in the perilesional cortex and ipsilateral hippocampus (7d to 1 month post-TBI), and ipsilateral thalamus (14d to 12 months post-TBI). (nature.com)
  • Protein Isl-1 RNA interference and over expression in early chicken embryo dorsal root ganglia (DRG) were used to investigate t. (nel.edu)
  • Protein Expression and Purification. (lu.se)