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  • tumor
  • The I3C-mediated cell cycle arrest and repression of CDK6 production were also observed in estrogen receptor-deficient MDA-MB-231 human breast cancer cells, which demonstrates that this indole can suppress the growth of mammary tumor cells independent of estrogen receptor signaling. (wellnessresources.com)
  • Furthermore, development of prostate carcinomas in TRAMP/Rosa26-FoxM1b double TG mice required high levels of FoxM1 protein to overcome sustained expression of the alternative reading frame tumor suppressor, a potent inhibitor of FoxM1 transcriptional activity. (aacrjournals.org)
  • Semaphorin 3B (Sema3B) particularly is a secreted protein that has been known to modulate proliferation and apoptosis, processes that are critical for tumor progression and development. (jove.com)
  • This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (abnova.com)
  • The drugs work by blocking the function of proteins CDK4 and CDK6, both of which drive cell multiplication, fueling tumor growth. (medicalxpress.com)
  • hematopoietic
  • We here show that cyclin‐dependent kinase 6 (Cdk6) is specifically expressed in proliferating hematopoietic progenitor cells, and that Cdk6 inhibits transcriptional activation by Runx1, but not C/EBPα or PU.1. (embopress.org)
  • inhibitors
  • The activity of CDK6 is very tightly controlled by association with D-cyclins ( 7 ) and two families of CDK inhibitors, including the CIP/KIP family and the inhibitors of CDK4 (INK4) family proteins ( 9 ). (aacrjournals.org)
  • Baculovirus
  • Die Kinase CDK6 wurde in Form verschiedener Fusionsproteine mit Hilfe des Baculovirus-Expressionsvektorsystems in hoher Ausbeute exprimiert und anschließend aufgereinigt. (tum.de)
  • tumorigenesis
  • To determine the role of CDK6 in development and tumorigenesis, we generated and analyzed knockout mice. (aacrjournals.org)
  • However, the specific role of CDK6 in thymocyte development is unclear and the effect of CDK6 loss on T-cell tumorigenesis has not been ascertained. (aacrjournals.org)
  • In the present study, we tested the role of CDK6 in murine thymocyte development and tumorigenesis by generating Cdk6 -deficient thymocytes using a knock-in approach. (aacrjournals.org)
  • therapeutic
  • The verification of these miRs and their associated targeted proteins provides new insights for further investigation into therapeutic interventions. (biomedcentral.com)
  • function
  • This study aimed to investigate the relationship of dosing, renal function, plasma levels of oxypurinol and granulysin (a cytotoxic protein of SJS/TEN), the disease severity and mortality in allopurinol-SCAR. (jove.com)
  • evidence
  • Several lines of evidence have established the evolutionary conserved RNA-binding protein Musashi1 as a marker of adult stem cells, including those of the intestinal epithelium , and revealed its roles in stem cell self-renewal and cell fate determination. (nih.gov)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)