• Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene. (wikipedia.org)
  • These data reveal two human protein complexes that differ only in the identity of the catalytic histone methyltransferase. (elsevierpure.com)
  • In vitro assays demonstrate that the Set1B complex is a histone methyltransferase that produces trimethylated histone H3 at Lys 4 . (elsevierpure.com)
  • Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
  • It is likely to act as a bioactive compound by exerting reactive oxygen species (ROS)-scavenging activity and/or binding to specific proteins such as oxidative enzymes and transcriptional factors in signal transduction pathways. (rsc.org)
  • The RAS gene family, responsible for signal transduction within the mitogen activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K) pathways, is frequently involved in carcinogenesis, and alterations in its member genes can be detected, with variable frequency, in a wide variety of solid and hematological cancers. (oaepublish.com)
  • These genes encode for closely related GTPase proteins responsible for signal transduction within two main pathways, the mitogen-activated protein kinase (MAPK) and phosphoinositide-3 kinase pathways, involved in the regulation of cell growth, survival, and differentiation. (oaepublish.com)
  • In soluble guanylyl cyclase, heme serves as a protein cofactor for fundamental cellular processes, such as as the nitric oxide sensor, and thus plays an important role in electron transport in the respiratory chain, oxidative stress re- signal transduction. (medicinelakex1.com)
  • Carboxyl methylation is a reversible post-translational event which regulates the function of several cellular proteins. (elsevierpure.com)
  • Because the human Na + -H + antiporter (NHE-1) possesses a C-terminal consensus sequence for carboxyl methylation, we examined the role of protein carboxyl methylation in the regulation of intracellular pH homeostasis. (elsevierpure.com)
  • Our data indicate that inhibition of carboxyl methylation reduces basal pH(i) and alters the kinetic properties of the Na + -H + antiporter in human platelets, suggesting that carboxyl methylation is implicated in the regulation of intracellular pH homeostasis. (elsevierpure.com)
  • Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro , small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. (biomedcentral.com)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • Gene structures and chromosomal locations of human protein prenyltransferase subunit genes. (biomedcentral.com)
  • Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. (biomedcentral.com)
  • The enzymatic activity of the type 2A protein phosphatase (PP2A) holoenzyme, a major serine/threonine phosphatase in the heart, is conferred by its catalytic subunit (PP2AC). (kingston.ac.uk)
  • A1.R-induced PP2AC translocation to the particulate fraction was abrogated by adenoviral expression of the alpha subunit (Gαt1) coupled to the transducin G-protein coupled receptor. (kingston.ac.uk)
  • protein_coding" "Cz12g19130.t1","No alias","Chromochloris zofingiensis","Clp protease proteolytic subunit /Translocation-enhancing protein TepA [Interproscan]. (ntu.edu.sg)
  • Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
  • 2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)
  • Here, we show that Nsp5 binds and cleaves human tRNA methyltransferase 1 (TRMT1), a host enzyme required for a prevalent post-transcriptional modification in tRNAs. (elifesciences.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
  • Stimulation of A1.Rs with 10 µM CPA increased the phosphorylation of protein kinase B at ser473, which was abolished by the PI3K inhibitor LY294002 (20 µM), thereby confirming that PI3K activity is upregulated in response to A1.R stimulation by CPA in ARVM. (kingston.ac.uk)
  • Some of the differentially expressed genes (DEGs) showed male bias, including serine/threonine-protein kinase ( STPK ), THUMP1 homolog and other genes. (beds.ac.uk)
  • Purification of individual SARS-CoV-2 proteins from human cells have identified a potential interaction between a catalytic-inactive version of Nsp5 with human tRNA methyltransferase 1 (TRMT1) ( Gordon et al , 2020b ). (elifesciences.org)
  • Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. (sdbonline.org)
  • Scholars@Duke publication: Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. (duke.edu)
  • Protein prenylation is the posttranslational attachment of either a farnesyl group or a geranylgeranyl group via a thioether linkage (-C-S-C-) to a cysteine at or near the carboxyl terminus of the protein. (biomedcentral.com)
  • Inducible expression of the carboxyl terminus of either Set1A or Set1B decreases steady-state levels of both endogenous Set1A and Set1B protein, but does not alter the expression of the non-catalytic components of the Set1 complexes. (elsevierpure.com)
  • In the current study, we show that the enzymatic components that regulate the carboxylmethylation status of PP2AC, leucine carboxylmethyltransferase-1 (LCMT-1) and phosphatase methylesterase-1 (PME-1) are abundantly expressed in, and almost entirely localised in the cytoplasm of ARVM. (kingston.ac.uk)
  • 55699) Ribosomal protein L15e CP001857 CDS Arcpr_0066 complement(55738. (go.jp)
  • This protein domain is also required to mediate feedback inhibition of Set1A and Set1B expression, which is a consequence of reduced Set1A and Set1B stability when not associated with the methyltransferase complex. (elsevierpure.com)
  • 38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
  • And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)
  • The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS . (lookformedical.com)
  • The genes encoding CaaX protein prenyltransferases are considerably longer than those encoding non-CaaX subunits, as a result of longer introns. (biomedcentral.com)
  • There are three different protein prenyltransferases in humans: farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) share the same motif (the CaaX box) around the cysteine in their substrates, and are thus called CaaX prenyltransferases, whereas geranylgeranyltransferase 2 (GGT2, also called Rab geranylgeranyltransferase) recognizes a different motif and is thus called a non-CaaX prenyltransferase [ 1 ]. (biomedcentral.com)
  • (b) genes encoding non-CaaX protein prenyltransferases are much shorter. (biomedcentral.com)
  • Encodes a defensin-like (DEFL) family protein. (or.jp)
  • Jasmonic acid carboxyl methyltransferase regulates development and herbivory-induced defense response in rice [J]. J Integr Plant Biol. (jipb.net)
  • The α subunits of protein prenyltransferases consist of tetratricopeptide repeats and are part of the tetratricopeptide repeat superfamily [ 5 ], which also includes functionally diverse proteins involved in transcription, co-chaperoning, protein transport, cell-cycle control and phosphorylation. (biomedcentral.com)
  • 9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
  • 10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
  • 13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
  • 13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
  • 19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
  • 21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
  • 23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
  • 29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
  • 29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
  • 36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
  • 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
  • 43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
  • 47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
  • 52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
  • 53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
  • Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). (thermofisher.com)
  • Experiments were conducted using human platelets and N-acetyl-S-trans,trans-farnesyl-L cysteine (AFC), a specific prenylcysteine methyltransferase inhibitor. (elsevierpure.com)
  • Twenty alpha-amino acids are the subunits which are polymerized to form proteins . (lookformedical.com)
  • Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (lookformedical.com)
  • TRAP1, a crucial member of the mitochondrial heat shock protein 90 family, is active in a variety of biological functions in various tumor types. (scientificarchives.com)
  • Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
  • Hsp90 family chaperones are molecular machines that regulate the degradation of proteins after aggregation, unfolding, or misfolding. (scientificarchives.com)
  • The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein [J]. J Integr Plant Biol. (jipb.net)
  • 1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)
  • But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
  • 4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
  • The genomic organization of the human genes that encode protein prenyltransferases is shown in Figure 1 . (biomedcentral.com)
  • Automatic comparisons of data from expressed sequence tags (ESTs) with genes (for example using the program Acembly, for which the results are available from the NCBI AceView server [ 2 ]) shows that all the human protein prenyltransferase genes have multiple alternative splice variants. (biomedcentral.com)
  • The chromosomal locations and number of exons from protein prenyltransferase genes in the major eukaryotic model organisms are shown in Table 2 . (biomedcentral.com)
  • retained genes for the last three steps of the pathway, allowing The most abundant group of heme proteins are cytochromes them to synthesize heme from their host-derived precursors (20). (medicinelakex1.com)
  • 32303) chromosome segregation and condensation protein%2C ScpB CP001857 CDS Arcpr_0039 complement(32287. (go.jp)
  • 32898) chromosome segregation and condensation protein ScpA CP001857 CDS Arcpr_0040 complement(32907. (go.jp)
  • 36314) chromosome segregation protein SMC CP001857 CDS Arcpr_0041 complement(36316. (go.jp)
  • Exposure of ARVM to 10 µM CPA increased the cellular association between PP2AC and its methyltransferase LCMT-1, but not its esterase PME-1. (kingston.ac.uk)
  • Reduced nitrogen enters the human body as dietary free amino acids, protein, and the ammonia produced by intestinal tract bacteria. (medmuv.com)
  • The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
  • Parasitic ecule because it reversibly binds to certain proteins, such as kinetoplastid flagellates represent a rare example of organisms transcription factors and ion channels, and thus modulates their that depend on oxidative metabolism but are heme auxotrophs. (medicinelakex1.com)
  • In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
  • Longman, Michael R. , Ranieri, Antonella , Avkiran, Metin and Snabaitis, Andrew K. (2014) Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory Class G-Protein coupled receptors in cardiomyocytes. (kingston.ac.uk)
  • 16 Furthermore, its oxidation products can act as electrophiles to bind specific proteins , resulting in the modification of their cellular functions. (rsc.org)
  • metabolism of this heme-free eukaryote, we searched for heme- There are only a few examples of facultatively anaerobic or containing proteins in its de novo sequenced genome and exam-ined several cellular processes for which heme has so far been con- pathogenic bacteria that do not require heme (10-12), but no sidered indispensable. (medicinelakex1.com)
  • This study used Drosophila melanogaster wing vein and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT ( Ste14 in flies). (sdbonline.org)
  • An unnatural amino acid that is used experimentally to study protein structure and function. (lookformedical.com)
  • The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
  • abstract = "We previously identified a mammalian Set1A complex analogous to the yeast Set1/COMPASS histone H3-Lys4 methyltransferase complex (Lee, J.-H., and Skalnik, D. G. (2005) J. Biol. (elsevierpure.com)
  • Data base analysis indicates that human Set1A protein shares 39% identity with an uncharacterized SET domain protein, KIAA1076, hereafter denoted Set1B. (elsevierpure.com)
  • Human cells infected with SARS-CoV-2 exhibit a decrease in TRMT1 protein levels and TRMT1-catalyzed tRNA modifications, consistent with TRMT1 cleavage and inactivation by Nsp5. (elifesciences.org)
  • Description: A sandwich ELISA kit for detection of Ubiquitin Carboxyl Terminal Hydrolase L1 from Human,Mouse,Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)
  • 6097 beta-lactamase domain protein CP001857 CDS Arcpr_0005 complement(6094. (go.jp)
  • 23029 TrkA-N domain protein CP001857 CDS Arcpr_0027 23060. (go.jp)
  • 25637 PKD domain containing protein CP001857 CDS Arcpr_0030 complement(25624. (go.jp)
  • 30270 beta-lactamase domain protein CP001857 CDS Arcpr_0037 complement(30271. (go.jp)
  • 51868 SMC domain protein CP001857 CDS Arcpr_0061 51865. (go.jp)
  • protein_coding" "Cz10g14210.t1","No alias","Chromochloris zofingiensis","DEAD/DEAH box helicase domain [Interproscan]. (ntu.edu.sg)