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  • Vivo
  • Because occurrence of carbonyl groups is the first step in oxidative damage of proteins, we questioned the formation of carbonylated proteins (i) in vitro: platelets exposed to oxidant hydrogen peroxide (H2O2) and agonist thrombin (in the presence/absence of antioxidants), and(ii) in vivo: during ageing progression, and in type 2 diabetes. (ad-astra.ro)
  • enzymatic
  • The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. (uniprot.org)
  • cellular
  • HD is triggered by an expansion of polyglutamine repeats in the protein huntingtin (Htt), impacting diverse cellular processes, ranging from transcriptional regulation to cognitive and motor functions. (pnas.org)
  • highly
  • Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (uniprot.org)
  • production
  • In this investigation, we have studied the production and clearance rates for skeletal muscle proteins in a rat model of acute oxidative stress over a time period of 24 h using a gel-based proteomics approach. (figshare.com)
  • We also assessed the rate of protein carbonyl production for flies kept at 2, 10, 21, 40 and 100 kPa as adults (all larvae reared in normoxia). (biologists.org)
  • known
  • For protein regions with known PDB structure, the solvent accessibility is also calculated using DSSP (baseline score of -5 means no structure/solvent-accessibility info). (missouri.edu)