• The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
  • Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)
  • PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception. (iasp-pain.org)
  • The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
  • Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). (iasp-pain.org)
  • Protein kinase C-mediated phospho. (unige.ch)
  • The expression of protein kinase C (PKC) isoenzymes and the effects of PKC activation on myocardial phospholipase A2 (PLA2) activity, platelet-activating factor (PAF) generation and eicosanoid release were studied in spontaneously beating cultured rat cardiomyocytes. (unige.ch)
  • UNLABELLED: BACKGROUND: In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBCs). (duke.edu)
  • RESULTS: To further characterize global ERK1/2-induced changes in membrane protein phosphorylation within human RBCs, a label-free quantitative phosphoproteomic analysis was applied to sickle and normal RBC membrane ghosts pre-treated with U0126, a specific inhibitor of MEK1/2, the upstream kinase of ERK1/2, in the presence or absence of recombinant active ERK2. (duke.edu)
  • Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus. (ucl.ac.uk)
  • MgATP-dependent priming was readily reversible and inhibited by a broad range of protein kinase inhibitors. (rupress.org)
  • The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)
  • An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
  • Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
  • It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
  • In this preliminary study we assessed the role of Protein kinase C (PKC) in CD47-mediated phosphatidylserine expression pathway in jurkat T cells. (scholarsresearchlibrary.com)
  • The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway was involved in this ubiquitin-proteasome-mediated degradation of PDCD4. (plos.org)
  • We further identified SYK as a critical kinase that phosphorylates MyD88, promoted MyD88-dependent signaling and mediates dermatosis in Ptpn6spin mice . (bvsalud.org)
  • Downstream of SHP1 and SYK-dependent counterregulation of MyD88 tyrosine phosphorylation , we have demonstrated that the scaffolding function of receptor interacting protein kinase 1 (RIPK1) and tumor growth factor -ß activated kinase 1 (TAK1)- mediating signaling were required to spur inflammatory disease . (bvsalud.org)
  • In addition, Fbxo3 modifies this pathway by inhibiting Fbxl2-mediated RIM1α ubiquitination, suggesting that presynaptic protein ubiquitination makes a crucial contribution to the development of neuropathic pain. (jneurosci.org)
  • Glycophorin A was the most affected protein in sickle RBCs by this ERK1/2 pathway, which contained 12 unique phosphorylated peptides, suggesting that in addition to its effect on sickle RBC adhesion, increased glycophorin A phosphorylation via the ERK1/2 pathway may also affect glycophorin A interactions with band 3, which could result in decreases in both anion transport by band 3 and band 3 trafficking. (duke.edu)
  • These findings also identify additional protein targets of this pathway other than the RBC adhesion molecule ICAM-4 and enhance the understanding of the mechanism of small molecule inhibitors of MEK/1/2/ERK1/2, which could be effective in ameliorating RBC hemorheology and adhesion, the hallmarks of SCD. (duke.edu)
  • CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)
  • Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)
  • Overall these novel data demonstrate an IKK2-dependent, predominantly G-protein-independent pathway involved in PAR-2 regulation of NFκB phosphorylation in keratinocytes. (strath.ac.uk)
  • We found that AR was ubiquitinated by an E3 ubiquitin ligase, myosin regulatory light chain interacting protein (MYLIP) and then degraded through the ubiquitin-proteasome pathway. (oncotarget.com)
  • PKC inhibition enhanced phosphatidylserine expression in CD47 receptor mediated leukaemia cells apoptotic pathway. (scholarsresearchlibrary.com)
  • This indicates that PKC may be involved in CD47-mediated PS exposure pathway in jurkat T cells. (scholarsresearchlibrary.com)
  • Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. (plos.org)
  • Marie Skepö (PI), has in collaboration with Lise Arleth and Kresten Lindorff-Larsen at University of Copenhagen, and Jens Preben Morth at University of Oslo, been awarded 6.8 MNOK for studying the structure of membrane proteins under solution conditions. (lu.se)
  • The aim is to understand how the lipid environment influences the activity of membrane proteins, using the active transporter MgtA as benchmark system, and to investigate the dynamic fluctuations between lipid and protein in solution, utilising neutron and X-ray scattering in combination with computer simulations. (lu.se)
  • Levels of phosphorylation and protein expression were determined using western blotting. (hindawi.com)
  • Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation. (duke.edu)
  • Parallel experiments showed that in both cell types, p65 NFκB phosphorylation is mediated through the selective activation of IKK2. (strath.ac.uk)
  • To address this issue, we used whole-cell patch clamp recording in acute murine brain slices at both room and physiological temperatures to examine the effects of PKC-mediated phosphorylation on tonic inhibition. (ucl.ac.uk)
  • The inhibitory effects of PKC activation on α4β2δ GABAA R activity appeared to be mediated by direct phosphorylation at a previously identified site on the β2 subunit, serine 410. (ucl.ac.uk)
  • These results indicate that PKC-mediated phosphorylation can be an important physiological regulator of tonic GABAA R-mediated inhibition. (ucl.ac.uk)
  • Protein synthesis inhibition was observed to increase proteasome function and assembly in human primary embryonic fibroblasts, with heat shock protein chaperone machinery to contribute to the elevated proteasome assembly. (diva-portal.org)
  • Alternatively, protein synthesis inhibition increased the protein levels of specific proteasome subunits without influencing the proteasome activity in C. elegans. (diva-portal.org)
  • Pre-treatment of cells with the novel Gq/11 inhibitor YM-254890 and Gq/11 siRNA caused a similar pattern of inhibition and also reduced PAR-2-mediated NFκB transcriptional activity. (strath.ac.uk)
  • Tonic inhibition mediated by extrasynaptic GABAA receptors (GABAA Rs) is an important regulator of neuronal excitability. (ucl.ac.uk)
  • Recordings from dentate gyrus granule cells in the hippocampus and dorsal lateral geniculate relay neurons in the thalamus demonstrated that PKC activation caused downregulation of tonic GABAA R-mediated inhibition. (ucl.ac.uk)
  • Together, these results suggested that CNPY2 promoted cell growth of PC cells by inhibition of AR protein degradation through MYLIP-mediated AR ubiquitination. (oncotarget.com)
  • This peptide induces a potent and long-lasting antinociceptive effect that is mediated by the activation of peripheral opioid receptors. (iasp-pain.org)
  • The thiophosphorylation state of this protein was regulated by guanine nucleotides, Mg2+ and, most importantly, by activated formyl-peptide receptors. (eurekamag.com)
  • In this review, we summarized the current knowledge of hemocyte-mediated phagocytosis, in particular focusing on the related receptors for recognition and internalization of pathogens as well as the downstream signal pathways and intracellular regulators involved in the process of hemocyte phagocytosis. (frontiersin.org)
  • Sickle RBC treatment with U0126 decreased thirty-six phosphopeptides from twenty-one phosphoproteins involved in regulation of not only RBC shape, flexibility, cell morphology maintenance and adhesion, but also glucose and glutamate transport, cAMP production, degradation of misfolded proteins and receptor ubiquitination. (duke.edu)
  • We demonstrate that intein-mediated protein alternative splicing could be a new strategy to increase protein diversity (that is, functions) without any modification in genetic backgrounds. (aalto.fi)
  • Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. (uea.ac.uk)
  • [ 9 ] In addition, many M protein serotypes do not confer lifetime immunity. (medscape.com)
  • Trained immunity is mediated through epigenetics , the modification of gene expression without changing the genetic code. (cdc.gov)
  • Plasmid-mediated resistance is the transfer of antibiotic resistance genes which are carried on plasmids. (wikipedia.org)
  • Antibiotic resistance mediated by MDR plasmids severely limits the treatment options for the infections caused by Gram-negative bacteria, especially family Enterobacteriaceae. (wikipedia.org)
  • PKC alpha, delta and/or zeta therefore appear to play an important role in the PMA-mediated activation of cardiomyocyte PLA2, an event leading to subsequent production of PGI2, PGE2, 15-HETE, lyso-PC and PAF in this tissue. (unige.ch)
  • Evaluation of the antiaging and protein anti-aggregation effects of this bioactive compound indicated that 18α-GA promoted longevity in nematodes through proteasome-and SKN-1-mediated activation and decelerated Alzheimer'sdisease progression and neuropathology both in nematodes and neuronal cells. (diva-portal.org)
  • Furthermore, proteasome activation by means which have also pro-longevity effects decreased the protein synthesis rate both in human fibroblast cellsand nematodes. (diva-portal.org)
  • ERK1/2 is involved in activation of ICAM-4-mediated sickle RBC adhesion to the endothelium. (duke.edu)
  • Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
  • Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
  • The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)
  • Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
  • We also exploited it as a post-translational protein conformation-driven switch of protein functions (for example, as highly specific protein interference). (aalto.fi)
  • Spinal plasticity, a key process mediating neuropathic pain development, requires ubiquitination-dependent protein turnover. (jneurosci.org)
  • Nevertheless, the mechanism for ubiquitination-regulated turnover of presynaptic active zone proteins in the progression of spinal plasticity-associated neuropathic pain remains unclear. (jneurosci.org)
  • Spinal RIM1α-associated allodynia was mediated by Fbxo3, which abates Fbxl2-dependent RIM1α ubiquitination. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Ubiquitination is a well known process required for protein degradation. (jneurosci.org)
  • Studies investigating pain pathology have demonstrated that ubiquitination contributes to chronic pain by regulating the turnover of synaptic proteins. (jneurosci.org)
  • To focus the investigation on B cell:CD4 T cell interactions in vivo and in vitro, we previously developed a B cell-dependent, Ab-independent experimental autoimmune encephalomyelitis (EAE) mouse model driven by a peptide encompassing the extracellular domains of myelin proteolipid protein (PLPECD). (listlabs.com)
  • We therefore conclude that PLPECD-induced EAE features a required pathogenic B cell-mediated Ag presentation function, providing for investigable B cell:CD4 T cell interactions in the context of autoimmune demyelinating disease. (listlabs.com)
  • The spike protein is the largest structural component of the virus and mediates interactions essential for infection, including with the primary angiotensin-converting enzyme 2 (ACE2) receptor. (cam.ac.uk)
  • Members of the benzothiazole aniline (BTA) family of compounds are characterized as a class of small molecules that have shown great promise in preventing Aβ-protein interactions. (jneurosci.org)
  • a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
  • The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
  • water-mediated interactions resulted in severely [email protected] reduced af®nities for trp repressor (Joachimi ak et al. (lu.se)
  • We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts. (nature.com)
  • Adenine forms several biological compounds involved in a variety of cellular physiological processes such as adenosine triphosphate (ATP) in cellular respiration and deoxyribonucleic acid (DNA) in protein synthesis. (hindawi.com)
  • A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a complex with both mutant and wild-type p53 protein has been characterized, purified, and identified. (nih.gov)
  • Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. (diva-portal.org)
  • Additionally, the crosstalk between protein synthesis and proteasome-mediated protein degradation was analyzed in eukaryotic organisms under various cellular conditions. (diva-portal.org)
  • During the past few decades, hemocyte-mediated phagocytosis, as one of the most important innate cellular immune function, has also received great attention in crustacean, and a good progress in elucidating the involvement of hemocyte-mediated phagocytosis, as well as its protective roles and mechanisms, against bacterial and viral infections has been achieved. (frontiersin.org)
  • A substantial number of proteins that are involved in the heat-acclimatization process such as the proteins related to cellular redox status and heat shock, are already altered in the type-A arr mutants without a prior exposure to stress conditions. (frontiersin.org)
  • While recent publications have shown promising results reducing mutant huntingtin toxicity by lowering huntingtin levels using antisense oligonucleotides, there is some concern regarding unwanted side effects caused by lowering huntingtin protein levels too much. (bmj.com)
  • In our study we reduce mutant huntingtin toxicity by modifying the huntingtin protein to prevent proteolytic cleavage and subsequent formation of toxic N-terminal huntingtin fragments. (bmj.com)
  • 3,3',4,4',5'-Pentachlorobiphenyl (PCB126) is a carcinogenic environmental pollutant and its toxicity is mediated through binding with aryl hydrocarbon receptor (AhR). (cdc.gov)
  • Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy. (ox.ac.uk)
  • Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. (nature.com)
  • Resistance genes are ones that give rise to proteins that modify the antibiotic or pump it out. (wikipedia.org)
  • DNA wraps around proteins called histones such that some genes can be accessed easily by cell proteins that "read" the gene, increasing gene expression, while others are less accessible, decreasing gene expression. (cdc.gov)
  • The student will be responsible for improving the annotations, especially for the untranslated regions that lie up and downstream of protein coding genes. (lu.se)
  • This review summarizes key aspects of tetraspanin proteins, with a focus on the functional relevance and structural features of these proteins and how they are organized into a novel type of membrane microdomain. (nih.gov)
  • used protein biochemistry, structural biology and genetics to uncover how the IDA hormone activates HAESA. (elifesciences.org)
  • The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
  • Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins. (rupress.org)
  • Finally, we recorded mCherry-Arc interaction with presynaptic protein Bassoon in mCherry-negative surrounding neurons at close proximity to mCherry-positive spines of edited neurons. (lu.se)
  • Around 30% of all proteins in eukaryotic organisms have recently been shown to belong to intrinsically disordered proteins (IDPs) involved in many central biological processes and diseases. (lu.se)
  • We have recently started a follow-up study to assess the longitudinal phenotypical effect of antisense oligonucleotide-mediated exon skipping in YAC128 HD mice. (bmj.com)
  • Importantly, we identified B cell-mediated Ag presentation as the critical mechanism explaining B cell dependence in PLPECD-induced EAE, where bone marrow chimeric mice harboring a B cell-restricted MHC class II deficiency failed to develop EAE. (listlabs.com)
  • We report here that BTA-EG 4 decreases Aβ levels, alters cell surface expression of amyloid precursor protein (APP), and improves memory in wild-type mice. (jneurosci.org)
  • In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
  • Here, we found that the spinal presynaptic active zone protein Rab3-interactive molecule-1α (RIM1α) participates in neuropathic pain development by binding to and upregulating the expression of Ca V 2.2. (jneurosci.org)
  • The enhancement in binding of [ 14 C]HCP to microsomal protein in the presence of epoxide hydrase inhibitors was consistent with the formation of HCP arene oxides or structurally related species. (aspetjournals.org)
  • Receptor-stimulated guanine-nucleotide-triphosphate binding to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
  • The data thus provide evidence for an essential difference between GTP[S] and p[NH]ppG binding to guanine-nucleotide-binding regulatory proteins and suggest that, in addition to the nucleotide-exchange reaction, a (thio)phosphate-group-transfer process via guanine-nucleotide-binding regulatory protein beta subunits is involved in the receptor-stimulated binding of guanine nucleotide triphosphates to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
  • MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis. (ozgene.com)
  • Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic Treg cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. (ozgene.com)
  • We discovered that in addition to ACE2, expression of LRRC15 also causes spike protein binding. (cam.ac.uk)
  • IDA binding to HAESA allows another receptor protein called SERK1 to bind to HAESA, which results in the release of signals inside the cell that trigger the shedding of organs. (elifesciences.org)
  • Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. (uea.ac.uk)
  • Protein binding was suspected to be a major factor for the high liver concentration of PCB126 despite its high lipophilicity. (cdc.gov)
  • Unfavorably high temperature causes heat stress in all organisms and leads to disintegration of membrane lipids, protein misfolding and denaturation, oxidative burst, and increased membrane fluidity. (frontiersin.org)
  • The biological roles of protein splicing still remain elusive because inteins neither provide any clear benefits nor have an essential role in their host organisms. (aalto.fi)
  • Changes in gene expression mediate growth and development in all living organisms. (lu.se)
  • The protein was identified as a product of the murine double minute 2 gene (mdm-2). (nih.gov)
  • Here, we use a reporter gene-based screen in Saccharomyces cerevisiae for the discovery of antifungal inhibitors of GPI-anchoring of proteins, and identify the oligocyclopropyl-containing natural product jawsamycin (FR-900848) as a potent hit. (nature.com)
  • Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)
  • To reveal static and dynamic properties of intrinsically disordered proteins (IDPs) to provide a deeper understanding of the mechanism of action and the static as well as dynamic structure-function relationship. (lu.se)
  • Presynaptic active zone proteins have a crucial role in regulating vesicle exocytosis, which is essential for synaptic plasticity. (jneurosci.org)
  • Here, after research involving Sprague Dawley rats, we reported that spinal nerve ligation (SNL), in addition to causing allodynia, enhances the Rab3-interactive molecule-1α (RIM1α), a major active zone protein presumed to regulate neural plasticity, specifically in the synaptic plasma membranes (SPMs) of the ipsilateral dorsal horn. (jneurosci.org)
  • The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
  • These microdomains now provide a context in which to evaluate tetraspanins in the regulation of growth factor signaling and in the modulation of integrin-mediated post-cell adhesion events. (nih.gov)
  • Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. (cipsm.de)
  • Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis. (cipsm.de)
  • However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling. (biologists.com)
  • This report suggests that Canopy FGF signaling regulator 2 (CNPY2) controls AR protein levels in PC cells. (oncotarget.com)
  • From structure and mutagenesis studies, we are beginning to understand functional subregions within tetraspanins, as well as the levels of connections among tetraspanins and their many associated proteins. (nih.gov)
  • The observations from this study identify CD47 and PKC as novel functional proteins in jurkat T cells with promising therapeutic potential. (scholarsresearchlibrary.com)
  • Heat shock proteins (HSPs) and antioxidant enzymes are the two major classes of functional proteins that are induced during HSR. (frontiersin.org)
  • Thus, a product of the mdm-2 oncogene forms a tight complex with the p53 protein, and the mdm-2 oncogene can inhibit p53-mediated transactivation. (nih.gov)
  • Intrathecal injection of nNOS antisense oligonucleotides (nNOS-AS) inhibited the increase of Fos protein and NMDA(1A)R mRNA expression in the rat spinal cord during morphine withdrawal and decreased the scores of morphine withdrawal symptoms. (unboundmedicine.com)
  • Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. (nature.com)
  • GPI biosynthesis is a conserved process, required for anchoring proteins to the plasma membrane of fungi and thus essential for the integrity of the fungal cell wall in yeasts and molds 4 . (nature.com)
  • AR protein levels are controlled by both transcriptional regulation [ 4 , 5 ] and post-transcriptional regulation [ 6 ]. (oncotarget.com)
  • Marie Skepö has received a grant from Carl Trygger, https://www.carltryggersstiftelse.se , to partly cover the experimental work of the project: Histatins: Saliva proteins with important functions for our innate immune system. (lu.se)
  • Marie Skepö (PI) in collaboration with Oxana Klementieva, Medical Faculty, Ann Terry, MAX IV, and Judith Houston, ESS, have received a two year grant from NanoLund, https://www.nano.lu.se/start , for studying Histatins: Saliva proteins with important functions for our innate immune system. (lu.se)
  • Curiously, DDC have gone undetected in studies of cultured cells using the alkaline elution (AE) technique, whereas chromium-mediated DNA-protein crosslinks (DPC) were readily detected by AE. (duke.edu)
  • We performed two independent cell-based systematic screens to determine whether there are additional proteins by which the spike protein of SARS-CoV-2 can interact with human cells. (cam.ac.uk)
  • However, its role has not been evaluated in hypoxic choroidal endothelial cells (CECs), the precursor of VEGF-mediated choroidal angiogenesis. (molvis.org)
  • A receptor protein called HAESA is found on the surface of the cells that surround a future break point on the plant. (elifesciences.org)
  • En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
  • Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
  • When inducing long-term potentiation (LTP) in the hippocampus, we observed an increase of Arc protein highly correlated with an increase in fluorescent intensity and the number of mCherry-positive cells. (lu.se)
  • The BCG vaccine has been shown to increase methylation of one of the histone proteins, resulting in increased cytokine production in certain immune cells. (cdc.gov)
  • The antibodies bind with high affinity in the central region of the surface-bound M protein. (lu.se)
  • Precursor of AMP + diphosphate + 4-coumaroyl- protein. (cdc.gov)
  • Remarkably, this antibody primarily interacts through a bivalent dual-Fab cis mode, where the Fabs bind to two distinct epitopes in the M protein. (lu.se)
  • Thin-layer chromatography of dinitrophenyl derivatives prepared from Pronase-digested microsomal protein and sodium dodecyl sulfate-polyacrylamide disc gel electrophoresis of solubilized microsomes indicated that the radiolabeled products were covalently bound to amino acid residues of microsomal protein. (aspetjournals.org)
  • 12/15 shared amino acids) and the protein sequences have 70%-82% homology. (cdc.gov)
  • Amino acid position is in a conserved region compared to other Aspergilli (26/31 shared amino acids) and the protein sequences have 84% homology. (cdc.gov)
  • Also, R-factors can be taken up by "DNA pumps" in their membranes via transformation, or less commonly through viral mediated transduction, or via bacteriophage, although conjugation is the most common means of antibiotic resistance spread. (wikipedia.org)
  • Measurements of orthologous coronavirus spike proteins implied the interaction was functionally restricted to SARS-CoV-2 by accessibility. (cam.ac.uk)
  • We now report protein alternative splicing, in which new protein sequences can be produced by protein recombination by intermolecular domain swapping of inteins, as elucidated by NMR spectroscopy and crystal structures. (aalto.fi)
  • They are different from mutations that give bacteria resistance to antibiotics by preventing the antibiotic from getting in or changing the shape of the target protein. (wikipedia.org)
  • A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. (cdc.gov)
  • The high prevalence of ertapenem nonsusceptibility at a tertiary care hospital in Egypt was predominantly attributed to K. pneumoniae carbapenemase-mediated resistance mechanisms in K. pneumoniae isolates. (who.int)
  • Protein sequences are diversified on the DNA level by recombination and mutation and can be further increased on the RNA level by alternative RNA splicing, involving introns that have important roles in many biological processes. (aalto.fi)