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  • experiments
  • Stillman and postdoctoral investigator Manzar Hossain, Ph.D., today publish in eLife the results of experiments demonstrating precisely how Cyclin E expression is kept in balance in normal cells by the opposing actions of two proteins. (eurekalert.org)
  • Further experiments confirmed that while APC/C-Cdh1 targets cyclin F and thus shuts down SCF/cyclin F, the latter reciprocally targets Cdh1 and thus shuts down APC/C-Cdh1. (phys.org)
  • molecule
  • a long, thread-like molecule made of the chemical called DNA (deoxyribonucleic acid) that is held together with special proteins and is visible (with strong microscopes) during cell division. (asu.edu)
  • This active form of TGF β is synthesized from a large inactive precursor molecule, called latent TGF β . (hindawi.com)
  • Each TGF β subunit is synthesized as a large inactive precursor molecule bound to accessory proteins (LAP and LTBP). (hindawi.com)
  • cells
  • Cells that have temporarily or reversibly stopped dividing are said to have entered a state of quiescence called G0 phase. (wikibooks.org)
  • It is also suggested that a certain type of stem-like cells is responsible for the initiation of cancer, so-called cancer stem cells (CSCs). (springer.com)
  • The daughter cells from mitosis are called diploid cells. (asu.edu)
  • Lymph: Colorless, watery fluid that carries white blood cells called lymphocytes through the lymph system. (cigna.com)
  • Also called B cells. (cigna.com)
  • NETs, which are also called carcinoid tumors, can occur in many parts of the body because they begin in the neuroendocrine cells, which are widely disbursed and responsible for producing hormones. (curetoday.com)
  • Whereas in G1 phase the cell merely ramps up its production of proteins and other key molecules so that the two future daughter cells will have enough to live. (phys.org)
  • When we looked at cells going through the cell cycle , we saw cyclin F levels starting to increase right at the G1/S transition, and at the same time the levels of Cdh1 were decreasing. (phys.org)
  • pathway
  • CDK inhibitors can block the impact of cyclin E/CDK action, helping to restore the beneficial effects of the TGF-beta/SMAD3 pathway, and thus facilitating cancer cell death. (news-medical.net)
  • known
  • Arath;CycB1;4, while homologous to Arath;CycB1;2, has some features that make it different from other known mitotic-like cyclins. (deepdyve.com)
  • Standing guard at this boundary between phases is a molecular machine known as APC/C, which comprises more than a dozen separate proteins including an enzyme component. (phys.org)
  • another
  • it serves as a target-recognition device for another disposal-tagging E3 ubiquitin ligase, in this case one called SCF. (phys.org)
  • Scientists
  • Published today in Nature Communications , a study by scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis--the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals. (eurekalert.org)
  • shown
  • As shown in Figure 1 , latent TGF β is composed of a TGF β dimer in a noncovalent complex with the TGF β propeptide or latency-associated peptide (LAP) that remains bound to TGF β after secretion, retaining TGF β in an inactive form and the latent TGF β -binding protein (LTBP) which is linked to LAP by a disulfide bond [ 12 ]. (hindawi.com)
  • group
  • Arath;CycB1;3 is most homologous to the plant CycB1group cyclins and contains a conserved motif that is typical of this group. (deepdyve.com)
  • function
  • The article is titled "Therapeutic Delivery of Cyclin A2 Induces Myocardial Regeneration and Enhances Cardiac Function in Ischemic Heart Failure. (rxpgnews.com)
  • In biology, if two practically indistinguishable phenotypes are obtained, it is an indication that the proteins have the same function and that they may work together. (eurekalert.org)
  • process
  • The process then repeats in what is called the cell cycle. (asu.edu)
  • ORC1 is one of the main protein components of the machine called the Origin Recognition Complex, or ORC, which determines where along the chromosomes the process of duplicating the DNA begins. (eurekalert.org)
  • patients
  • If an intestinal NET causes too much of a hormone called serotonin to be released, for example, patients can get flushing or diarrhea. (curetoday.com)