Protein by cdc2 kinase cell division cycle protein with kinase cell cycle. Medical search. Frequent questions

We show that changing the carbon source from glucose to lactic acid alters the functions of the cyclin-dependent kinase (CDK) Cdc2 and mitogen-activated protein kinase (MAPK) Sty1, leading to unanticipated outcomes in the behavior and fate of such cells. (bvsalud.org)
Feedback loops, both positive and negative are embedded in the Mitogen Activated Protein Kinase (MAPK) cascade. (biomedcentral.com)
Signal transduction pathways such as the Mitogen Activated Protein Kinase (MAPK) cascade responds to wide range of external stimuli to trigger growth, cell-division and proliferation[ 1 , 2 ]. (biomedcentral.com)

The fission yeast polo related kinase Plo1 is required to assemble the mitotic spindle, the prophase actin ring that predicts the site for cytokinesis and for septation after the completion of mitosis (Ohkura et al. (kent.ac.uk)
These data are consistent with the emerging theme from many systems that polo kinases participate in the regulation of MPF to determine the timing of commitment to mitosis and may indicate that pole association is a key aspect of Plo1 function. (kent.ac.uk)
It is required in higher cells for entry into S-phase and mitosis. (caslab.com)
Dephosphorylation of Rb and destruction of cyclin A nevertheless occur normally at mitosis, indicating that v-Jun enables cells to rephosphorylate Rb and reaccumulate cyclin A without exogenous mitogenic stimulation each time the mitotic "clock" is reset. (ox.ac.uk)
Therefore it would be interesting to examine the control mechanism of cell cycle progression in which RSK1 affects Myt1 in meiosis and Plk1 affects Myt1 in mitosis. (biospraysehatalami.com)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
The negative relationship between C-CDK activity and cell growth refers to the block of cell length extension in mitosis. (elifesciences.org)
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. (wikidata.org)

3. Davidson L, Muniz L, West S. (2014) 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. (guidetopharmacology.org)
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. (ox.ac.uk)
D-cyclin-cdk activity is required for Rb phosphorylation in v-Jun-transformed cells, since ectopic expression of the cdk4- and cdk6-specific inhibitor p16(INK4A) inhibits both DNA synthesis and cell proliferation. (ox.ac.uk)
In particular, hormonal activation of a conditional v-Jun-estrogen receptor fusion protein in quiescent, growth factor-deprived cells stimulates cyclin E-cdk2 activity and triggers Rb phosphorylation and DNA synthesis. (ox.ac.uk)
Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
Phosphorylation assays also revealed that at least three kinase complexes (Cdc2Ms A/B, D and F) were successively active in G2/M cells after synchronization. (bibbase.org)
however tyrosine phosphorylation was indicated in the case of Cdc2Ms A kinase and the p13suc1-bound kinase activity was increased by treatment of this complex with recombinant Drosophila Cdc25. (bibbase.org)
article{meszaros_multiple_2000, title = {Multiple cyclin-dependent kinase complexes and phosphatases control {G2}/{M} progression in alfalfa cells}, volume = {43}, issn = {1573-5028}, url = {https://doi.org/10.1023/A:1006412413671}, doi = {10/cb64mn}, abstract = {Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation. (enzolifesciences.com)
In addition studies on HeLa cells using Plk1 siRNA interference and overexpression showed that phosphorylation of RSK1 increased upon interference and decreased after overexpression suggesting that Plk1 inhibits RSK1. (biospraysehatalami.com)
You can find six phosphorylation sites in RSK1 that are crucial for its activation and its own subsequent part in substrate phosphorylation (21 22 Of the phosphorylation of Ser-380 can be very important to RSK1 activation traveling functions such as for example rules of gene manifestation and protein synthesis and cell cycle regulation as a downstream Nisoxetine hydrochloride kinase in the Mos-MAPK pathway (23). (biospraysehatalami.com)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)
Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. (arigobio.cn)
In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. (arigobio.cn)
Parallel to the phosphorylation by kinases, phosphatases present in the cellular volume dephosphorylates the phosphorylated kinases. (biomedcentral.com)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
Mitotic CDK-dependent phosphorylation of Cut3 on T19 results in nuclear translocation of the protein. (elifesciences.org)
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. (wikidata.org)
Endogenous regulation of the cell cycle depends on phosphorylation and dephosphorylation of the cyclin- cyclin-dependent kinase (CDK)-cyclin-dependent kinase inhibitor (CDKI) pathway. (jcancer.org)

Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. (caslab.com)
CRKs (cdc2-related kinases), Cyclins and CKSs (cdc2-kinase subunit) are involved in the progression through the cell cycle. (lancs.ac.uk)
Increasing numbers of sequence and biochemical data show the involvement of cyclin-dependent kinases (CDKs) and cyclins in regulation of the cell cycle progression in higher plants. (bibbase.org)
The present yeast two-hybrid analyses showed differential interaction between defined D-type cyclins and Cdc2Ms kinases functioning in G2/M phases. (bibbase.org)
CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. (umbc.edu)

The evolutionarily conserved structure of the three layer MAPK cascade consists of the MAPKKK (henceforth referred as M3K), MAPKK (henceforth referred as M2K) and MAPK (henceforth referred as MK) from yeast to human, which processes the incoming signal through a series of covalent modification cycles[ 1 ]. (biomedcentral.com)
We also found that BPTF knockdown downregulated the expression of the phosphorylated Erk1/2, PI3K and Akt proteins and induced the cleavage of caspase-8, caspase-7 and PARP proteins, thereby inhibiting the MAPK and PI3K/AKT signaling and activating apoptotic pathway. (oncotarget.com)

CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF) , which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. (caslab.com)
system_update_alt데이터시트system_update_alt안전 데이터시트Overview 개요Product Name:Human TIP49A ELISA KitProduct Code:HUFI01923Size:96 AssaysAlias:RUVBL1, TIP49a, Pontin 52, Nuclear matrix protein 238, NMP 238, INO80 complex subunit H, TIP60-associated protein. (assaygenie.kr)
BPTF, a subunit of NURF, is well known to be involved in the development of eukaryotic cell, but little is known about its roles in cancers, especially in non-small-cell lung cancer (NSCLC). (oncotarget.com)

The CKS proteins were first described as components of the cell cycle machinery in yeast and their action has been implicated in the regulation of CDK function. (lancs.ac.uk)
Key proteins as mentioned above are involved in the regulation of the signaling pathways that control cell growth, division and death. (erimos.com)
Transforming the gene sequence on DNA to an RNA message (a process called transcription) that can then be converted to protein is essential to the regulation of protein production. (erimos.com)
As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. (frontiersin.org)
Cell cycle regulation in response to biochemical cues is a fundamental event associated with many diseases. (bvsalud.org)
This study reveals unknown aspects of the metabolic regulation of cell division in Schizosaccharomyces pombe. (bvsalud.org)
Our results show that cross-talk between Cdc2 and Sty1, and the consequent Sty1-dependent regulation of Cdc2 activity, appears to be compromised and the relationship between Cdc2 activity and mitotic timing is also reversed in the presence of lactate. (bvsalud.org)
H3 is an important protein in the emerging feild of epigenetics, where its sequence varients and variables modification states are thought to play a role in the dynamic and long term regulation of gene. (microbiologynotes.org)
Philipp was trained as a hard-core biochemist and in his own lab uses extensively genetically modified mice to study cell cycle regulation and human disease. (lu.se)
Taken together these findings provide insights into the regulation of Plk1 during cell division and diapause cyst formation and the correlation between the activity of Plk1 and RSK1. (biospraysehatalami.com)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
In animals, CDK inhibitors are tightly regulated, especially by posttranslational mechanisms of which control of nuclear access and regulation of protein turnover are particularly important. (uni-bielefeld.de)
Here we address the posttranslational regulation of INHIBITOR/INTERACTOR OF CDK 1 (ICK1)/KIP RELATED PROTEIN 1 ( KRP1), an Arabidopsis ( Arabidopsis thaliana) CDK inhibitor. (uni-bielefeld.de)

Genes Cells. (wikipedia.org)
Gene Ontology (GO) enrichment analysis of differentially expressed genes between wild type plants and STTM159 transgenic plants showed that genes involved in cell division, auxin, cytokinin (CK) and brassinosteroids (BRs) biosynthesis and signaling are significantly down-regulated in STTM159 plants. (biomedcentral.com)
Further analysis from the RNA-seq data showed that the decreased cell divisions in STTM159 transgenic plants may result, at least partly from the lower expression of the genes involved in cell cycle and hormone homeostasis, which provides new insights of rice miR159-specific functions. (biomedcentral.com)
A set of cdc2-related genes (cdc2Ms A, B, D and F) was expressed in G2 and M cells. (bibbase.org)
It selectively reduces transcription of genes that have promoters controlled by the Sp1 factor, such as survivin, cdc2 and VEGF. (erimos.com)
The specificity of terameprocol in cancer cells is derived from being able to access those genes that are highly active in cancer (through their "open" DNA conformation) to repress their expression through Sp1 binding inhibition, while normal cells do not have the same gene expression profile or DNA conformation accessible to terameprocol binding. (erimos.com)
Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
This domain occurred 376 times on human genes ( 869 proteins). (umbc.edu)
Uncontrolled cell proliferation is the hallmark of cancer, and genes that directly regulate the cell cycle are typically damaged in tumor cells ( 10 ). (jcancer.org)

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes-like. (umbc.edu)
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 1 (CDK1) subfamily, catalytic (c) domain. (umbc.edu)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
STP, serine/threonine protein phosphatase. (rupress.org)

The homothallic fission yeast Schizosaccharomyces pombe undergoes sexual differentiation when starved, but sam (skips the requirement of starvation for mating) mutants such as those carrying mutations in adenylate cyclase (cyr1) or protein kinase A (pka1) mate without starvation. (bvsalud.org)

So far limited research efforts have been devoted to the functions of phosphatases in the control of plant cell division. (bibbase.org)
The phosphatases P1, P2 and P3 dephosphorylate the kinases M3K, M2K and MK respectively. (biomedcentral.com)
Although the importance of kinases in this process has long been recognized, an appreciation for the complex and fundamental role of phosphatases is more recent. (rupress.org)
Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

Cancer cells then redirect the cellular systems to allow for uncontrolled cell growth, replication, and resistance to programmed cell death (apoptosis). (erimos.com)
Caspases are essential for apoptosis and are deemed the "executioner" proteins for their roles in the cell. (erimos.com)
Apoptosis is regulated by the inhibitor of apoptosis protein (IAP) family of proteins, through their inhibition of caspase-induced cell death. (erimos.com)
In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. (umbc.edu)
Weighed against its homologs Plk1 (and its own connected signaling pathway) offers attracted much interest because overexpression of Plk1 can be firmly correlated with carcinogenesis (10 11 Furthermore inhibition of Plk1 using RNA disturbance (RNAi) or particular little molecule inhibitors causes development arrest or apoptosis in tumor cells (12-14). (biospraysehatalami.com)
Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Knockdown of BPTF by siRNA significantly inhibited cell proliferation, induced cell apoptosis and arrested cell cycle progress from G1 to S phase. (oncotarget.com)

Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. (umbc.edu)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. (arigobio.cn)
The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle. (ptgcn.com)
Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
Cyclin-dependent kinase (CDK) 10, is reported to play an essential role in the progression from the G2 to M phase of the cell cycle. (jcancer.org)
Deregulation of cell cycle progression is considered to be critical for carcinogenesis ( 9 ). (jcancer.org)

CDK1, also named as CDC2, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily.CDC2 plays a key role in the control of the eukaryotic cell cycle. (caslab.com)
The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. (umbc.edu)
Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. (arigobio.cn)
Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. (arigobio.cn)
CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. (arigobio.cn)

The functional complementation between the CKS proteins of two evolutionary distant organisms supports the role of Tcp12CKS1 as a key regulator in T. cruzi cell cycle. (lancs.ac.uk)
Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. (bvsalud.org)

CDK9 (cyclin-dependent kinase 9) is a member of the cyclin-dependent protein kinase family. (thermofisher.com)

In oocytes, caffeine induces the dephosphorylation of MPF by inhibiting the transcription factor Myt1 and activity of the G2 checkpoint kinase Wee1, converting inactive MPF into its active form. (molcells.org)

Nucleosome consists of DNA wrapped around 8 histone protein called histone octamer. (microbiologynotes.org)
Each histone protein gathered to create 1 octameric nucleosome core particle and 147 base of DNA wrap around this core particle. (microbiologynotes.org)
H1 is the main among 5 histone protein which have a components of chromatin in eukaryotes. (microbiologynotes.org)
All the histone protein are chemically modified. (microbiologynotes.org)

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. (enzolifesciences.com)
Cells were then followed and monitored for their Cut3-tdTomato nuclear/cytoplasmic (N/C) ratio (C-CDK activity) and C-CDK-YFP level using fluorescence time-lapse microscopy (see Materials and methods). (elifesciences.org)

In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)

Due to their high survivin expression, tumor cells are prevented from entering the caspase-induced cell death pathway that would lead to their destruction. (erimos.com)
Increased sub-G1 population and annexin-V binding, activation of caspases 9 and 3, cleavage of poly(ADPribose) polymerase (PARP), and a decrease of mitochondrial membrane potential (MMP) indicated involvement of the mitochondrial apoptotic pathway in terpinen-4-ol-treated A549 and CL1-0 cells. (hindawi.com)

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. (wikipedia.org)
Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
They are found inside the nucleus of eukaryotic cell. (microbiologynotes.org)
The cdc25 gene product is a tyrosine phosphatase that acts as an initiator of M-phase in eukaryotic cell cycles by activating p34 cdc2 . (biologists.com)

It is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. (caslab.com)

The PCM is an ordered lattice that anchors a large number of microtubule (MT)-associated proteins, many of which bear putative coiled-coil domains, a tertiary structure known to facilitate protein-protein interactions [ 4 ]. (biomedcentral.com)

Histones are a collection of proteins that link with DNA in the nucleus and help to condense it into chromatin. (microbiologynotes.org)
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. (biomedcentral.com)
Centrosomes are animal-specific non-membranous organelles that localize in close proximity to the cell nucleus for the duration of interphase. (biomedcentral.com)
Further we demonstrate that ICK1/KRP1 is an unstable protein and degraded by the 26S proteasome in the nucleus. (uni-bielefeld.de)

End of the chromosome a) Shorten by how much following cell division? (freezingblue.com)
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. (lookformedical.com)
In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1). (lookformedical.com)

This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. (wikipedia.org)

Analysis of the effectiveness of caffeine and MG132 for improving somatic cell nuclear transfer (SCNT) technology using cryopreserved eggs showed that supplementation did not improve the blastocyst formation rate of cloned mouse eggs. (molcells.org)

The respiratory chain in aerobic organisms is composed of a number of membrane-bound protein complexes that link electron transfer to proton translocation across the membrane. (bvsalud.org)

Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)
CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. (thermofisher.com)

Mol Cell Biol , 35 (2): 468-78. (guidetopharmacology.org)
J Cell Biol (2000) 150 (2): F57-F62. (rupress.org)
J Cell Biol, 72 (3). (cshl.edu)
Mol Biol Cell, 26 (8). (cshl.edu)
J Cell Biol, 167 (1). (cshl.edu)

Molecular Biology of the Cell, 10 (8). (kent.ac.uk)
After being promoted to Senior Investigator, he moved to Singapore where he worked at the Institute of Molecular Cell Biology (IMCB/A*STAR/National University of Singapore). (lu.se)
Journal of Cell Biology, 83 (2 PART). (cshl.edu)
Journal of Cell Biology, 95 (2). (cshl.edu)
Molecular Biology of the Cell, 19 (7). (cshl.edu)
Nature Cell Biology, 9 (5). (cshl.edu)

CDK9 is a member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex. (thermofisher.com)
The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. (thermofisher.com)

The antibody is specific to the 2 isoforms of CDC2. (caslab.com)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Western blot of Knockout validated Cyclin D1 antibody in HepG2, SW 1990, and NIH/3T3 cell lines with 60186-1-Ig at a dilution of 1:10000 incubated at room temperature for 1.5 hours. (ptgcn.com)

In G1 phase, cells have a single centrosome consisting of two centrioles joined by cohesion fibers. (biomedcentral.com)
Each cell inherits one centrosome after the completion of cytokinesis. (biomedcentral.com)
Centrosome duplication is tightly regulated and limited at once per cell cycle through a mechanism that prevents re-duplication. (biomedcentral.com)

Avoid freeze-thaw cycles. (novusbio.com)
Store at -20°C. Avoid freeze / thaw cycles. (caslab.com)
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. (abcam.cn)

Localization of Cdc2Ms F kinase to the preprophase band (PPB), the perinuclear ring in early prophase, the mitotic spindle and the phragmoplast indicated a pivotal role for this kinase in mitotic plant cells. (bibbase.org)
Protein which spindle fibers attatch to? (freezingblue.com)
system_update_alt데이터시트system_update_alt안전 데이터시트Overview 개요Product Name:Human SPAG5(sperm associated antigen 5) ELISA KitProduct Code:HUFI03067Size:96 AssaysAlias:Astrin, Deepest, Mitotic spindle-associated protein p126, MAP126Detection method:Sandwich. (assaygenie.kr)

BPTF knockdown by siRNA also upregulated the cell cycle inhibitors such as p21 and p18 but inhibited the expression of cyclin D, phospho-Rb and phospho-cdc2 in lung cancer cells. (oncotarget.com)

The transition of a healthy cell to a precancerous or cancerous cell is initiated by the disruption of these regulatory pathways. (erimos.com)

Polo kinases execute multiple roles during cell division. (kent.ac.uk)

Intended Use Human CDC2L5 ELISA Kit allows for the in vitro quantitative determination of CDC2L5 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids. (biobool.com)

While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated. (novusbio.com)
This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. (wikipedia.org)
We show that v-Jun enables cells to express cyclin A and cyclin A-cdk2 kinase activity in the absence of growth factors and that deregulation of cdk2 is required for S-phase entry. (ox.ac.uk)
Endothall elevated the kinase activity of p13suc1-bound fractions in G2-phase alfalfa cells. (bibbase.org)
Functional communication of Cdc2 with Sty1 is known to be an integral part of the cellular response to aberrant Cdc2 activity in S. pombe. (bvsalud.org)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
Cell size and C-CDK concentration dictate probability of division and CDK activity in C-CDK WT and C-CDK AF cells. (elifesciences.org)
i ) Time-lapse quantification of CDK activity in asynchronous cells. (elifesciences.org)

The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. (enzolifesciences.com)

This is the first report, however, that cyclin E-cdk2, rather than D-cyclin-cdk, is likely to be the critical Rb kinase target of v-Jun. (ox.ac.uk)

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. (wikidata.org)

The passage of a cell through the cell cycle is controlled by proteins in the cytoplasm. (ptgcn.com)

Interaction between alfalfa mitotic cyclin (Medsa;CycB2;1) and a kinase partner has been reported previously. (bibbase.org)
Next, protein-protein interaction (PPI) networks were used to further explore the biomarkers with the most interactions in gene modules. (biomedcentral.com)

Another mechanism by which tumor cells grow uncontrollably is by deregulating their cell cycle process. (erimos.com)
Survivin especially is almost exclusively present in tumor cells and terameprocol can inhibit its production by accessing the promoter region of the survivin gene to prevent Sp1 binding. (erimos.com)
The main goal of RT consists in delivering a precise dose of radiation in a target volume, such as tumor, promoting the tumor cells eradication with as minimal damage as possible in surrounding normal tissues ( 13 ). (frontiersin.org)

1990). Significantly, Plo1 associates inappropriately with the interphase SPB of stf1.1 cells. (kent.ac.uk)

Anatomy18

Organisms12

Chemicals and Drugs143

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes64

Disciplines and Occupations1

Information Science3

Health Care1

Mitogen-activa3

Mitosis9

Phosphorylation24

Cyclins5

MAPK2

Subunit3

Regulation14

Genes9

Serine4

Fission yeast1

Phosphatases7

Apoptosis13

Progression7

Cdk16

Regulator2

Cyclin-dependent protein1

Wee11

Histone4

Cytoplasmic2

NONSMALL CELL LUNG CANCER2

Pathway2

Eukaryotic4

Phosphorylates1

Putative1

Nucleus5

Chromosome3

CDC71

Nuclear1

Complexes1

Differentiation2

Biol5

Biology6

Cdk92

Antibody3

Centrosome3

Freeze-thaw cycles3

Spindle3

Inhibitors1

Regulatory1

Roles1

CDC2L51

Activity8

Abl11

CDK21

Phase1

Cytoplasm1

Interaction2

Tumor cells3

Interphase1