• Versican is a member of the lectican protein family that also includes Aggrecan, Brevican, and Neurocan. (rndsystems.com)
  • Differential regulation of O-glycopeptides for proteoglycans, including brevican, neurocan, and versican, was observed for GBM subtypes vs. controls. (bu.edu)
  • Thus, it remains largely elusive whether PNN-specific chondroitin-sulfated proteoglycans (CSPGs) of the lectican family (aggrecan, brevican, neurocan, and versican) are expressed within the cochlea at all. (biomedcentral.com)
  • Versican is BIIE 0246 definitely a member from the lecticans, structurally related protein that likewise incorporate aggrecan, neurocan, and brevican. (healthyconnectionsinc.com)
  • This connection is definitely additional stabilized by hyperlink proteins itself, which binds both HA and versican (75, 76). (healthyconnectionsinc.com)
  • Lots of the adhesive properties of HA polymers rely upon the current presence of HA-binding protein, and as well as II, HCs, TSG-6, and versican donate to a powerful extracellular environment with the capacity of directing cell adhesion as well as the creation of inflammatory cytokines. (healthyconnectionsinc.com)
  • Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. (mdbioproducts.com)
  • Aggrecan belongs to the chondroitin sulfate (CS) proteoglycan family, which also includes Versican, Brevican, and Neurocan. (rndsystems.com)
  • B) In the CNS, Tenascin-R (TN-R), .2/7 Brevican (Bcan), Versican (Vcan), and Phosphacan (Phcan) are enriched in the extracellular matrix surrounding the nodes, and stabilize the nodal complex.These molecules bind NF186, NrCAM, and Contactin-1 which are expressed at CNS nodes. (emlinhibitor.com)
  • A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is an ECM-degrading enzyme that is involved in ECM remodeling by degrading proteoglycans, such as aggrecan, versican, brevican, and neurocan ( 10 , 11 ). (frontiersin.org)
  • Brevican core protein is a protein that in humans is encoded by the BCAN gene. (wikipedia.org)
  • This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. (mdbioproducts.com)
  • Background Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. (qedbio.com)
  • Little attention, however, has been paid to glycosylation of the extracellular matrix components that constitute the majority of glycosylated protein mass and presumed biological properties. (escholarship.org)
  • Specificity This antibody recognizes mouse and rat Brevican. (qedbio.com)
  • Description Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6 (56541). (qedbio.com)
  • Primary Antibody: Mouse Anti-Brevican Monoclonal Antibody (56541) at 1:100 for overnight at 4°C with slow rocking. (qedbio.com)
  • C) Brevican Antibody (D) Composite. (qedbio.com)
  • Description Western Blot analysis of Rat Brain Membrane showing detection of ~140 kDa Brevican protein using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6 (56541). (qedbio.com)
  • Primary Antibody: Mouse Anti-Brevican Monoclonal Antibody (56541) at 1:1000 for 1 hour at RT. (qedbio.com)
  • Primary Antibody: Mouse Anti-Brevican Monoclonal Antibody (56541) at 1:100 for 60 min at RT. (qedbio.com)
  • Cartilage-link protein (HAPLN1) monoclonal antibody (clone 8A4). (mdbioproducts.com)
  • Full length recombinant SARS-CoV-2 nucleocapsid Protein was used as the immunogen for this antibody. (abeomics.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Jagged 1 Protein (JAG1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (kits-elisa.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Jagged 1 Protein (JAG1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
  • The corrected sequence of rat BEHAB is identical to that reported for rat brevican (Yamada et al. (rupress.org)
  • Brevican is localised to the surface of neurons in the brain. (wikipedia.org)
  • Brevican is secreted from astrocytes and neurons as a145kDa core protein that bears up to three covalently-linked CS chains. (qedbio.com)
  • Evidence indicate that the brain-specific protein, brevican, is proteolytically cleaved during neurodegeneration, hence positioning fragments of brevican as potential blood biomarkers of neurodegenerative diseases, such as dementia. (nordicbioscience.com)
  • The results indicate that several of the proteins included in the panel may serve as synaptic biomarkers for AD. (lu.se)
  • PTP-sigma (a transmembrane protein tyrosine phosphatase) is a just lately discovered receptor for CSPGs and is essential for proper CSPG operation. (anaheimpoliceassociation.org)
  • It is expressed as a membrane-bound type II transmembrane protein [2] on various cell types including monocytes , dendritic cells and bone marrow stromal cells. (wikidoc.org)
  • obs, K. Dystrophin gene mutations that cause DMD result in either the absence of dystrophin protein production or markedly truncated proteins that cannot attach to the transmembrane protein com- plex and are rapidly catabolized. (top5binarybrokers.com)
  • [7] [8] Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone , bone morphogenetic protein , and growth differentiation factor belong to the TGF-β protein superfamily . (wikidoc.org)
  • Immunogen Fusion protein corresponding to aa 219-655 of rat Brevican (accession no. (qedbio.com)
  • Brevican is a member of the lectican protein family. (wikipedia.org)
  • [5] TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). (wikidoc.org)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • 5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
  • To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
  • [10] In addition, both complexes are derived from the same family of related genes and proteins but differ in their subunit composition. (wikidoc.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)
  • In order to survive when exposed to heat stress (HS), organisms activate stress response genes and repress constitutive gene expression to prevent the accumulation of potentially toxic RNA and protein products. (bvsalud.org)
  • B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
  • Figure-1: An indirect ELISA is carried out by coating nucleocapsid protein in serial dilution from 20 ng to 0.312 ng and using 100 ng of purified monoclonal antibodies 1F11.1E1. (abeomics.com)
  • Description: A sandwich ELISA kit for detection of Jagged 1 Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
  • Description: A sandwich ELISA kit for detection of High Mobility Group AT Hook Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human High Mobility Group AT Hook Protein 1 (HMGA1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
  • Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
  • CusabioAlternative Name(s): Brain-enriched hyaluronan-binding protein Short name: BEHABGene Names: BcanResearch Areas: Cell-matrix adhesionOrganism: Rattus norvegicus (Rat)AA. (joplink.net)
  • A short Serine rich stretch and a recognized nuclear localization signal are the unique features of the nucleocapsid protein of nCoV/SARS-CoV-2/COVID-19, which seems to have a little homology with the proteins of other members of this large corona virus family. (abeomics.com)
  • Purified by Protein G affinity chromatography. (qedbio.com)
  • Cartilage-link protein (LP) is a glycoprotein present in cartilage that stabilizes. (mdbioproducts.com)
  • Targeted proteomics is an attractive means of quantifying novel proteins in cerebrospinal and other fluids, and has potential to help overcome this bottleneck in biomarker development. (lu.se)
  • Glucocorticoid-induced TNFR family-related protein (GITR)-mediated activation of c-Jun N-terminal kinase (JNK) was shown to regulate the suppressive activity of naturally occurring CD4+CD25+ T regulatory cells (nTregs) in wild-type (WT) hosts. (siamtech.net)
  • We aimed to develop two assays capable of detecting the brevican N-terminal (N-Brev) and the ADAMTS4-generated fragment (Brev-A), cleaved at Ser401, in serum and to perform a preliminary assessment of their diagnostic potential in dementias. (nordicbioscience.com)
  • In conclusion, we developed the first assays detecting the N-terminal of brevican as well as an ADAMTS4-cleaved fragment of brevican in blood. (nordicbioscience.com)
  • The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. (wikidoc.org)
  • A comparison of brevican fragments in serum from individuals with AD (n = 28), other dementia (OD) (n = 41), and non-dementia-related memory complaints (NDCs) (n = 48) was conducted. (nordicbioscience.com)
  • The BLyS protein in the engineered bacteria can be as much as 50% to the bacteria's total protein content and still retains activity after a purification procedure. (wikidoc.org)
  • Panel of synaptic protein ELISAs for evaluating neurological phenotype. (utsouthwestern.edu)
  • Proteoglycans (PGs) are complex macromolecules composed of a core protein and covalently linked polysaccharide chain(s) which play a critical role in cell-cell and cell-matrix interactions. (oncotarget.com)
  • These features also suggest the involvement of nucleocapsid protein of nCoV/SARS-CoV-2/COVID-19 in different stages of viral lifecycle. (abeomics.com)
  • The protein has multifaceted activities including packing of the nCoV/SARS-CoV-2/COVID-19 viral genome into a helical ribonucleocapsid (RNP) and playing an important role in viral self-assembly causing nCoV/SARS-CoV-2/COVID-19. (abeomics.com)
  • Here, we show that a functionally distinct GA-binding transcription factor (TF) protein, CLAMP (Chromatin-linked adaptor for MSL complex proteins), is essential for repressing constitutive genes upon heat stress but not activation of the canonical heat stress pathway. (bvsalud.org)
  • Several DNA-binding motifs have been described, but here we focus on two that play prominent roles in the binding of DNA by regulatory proteins: the helix- turn-helix and the zinc finger. (binaryoptionstradinglist.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. (utsouthwestern.edu)
  • Applying this technique to AD we demonstrate differences in proteins involved in glucose metabolism and neuroinflammation that collectively have potential clinical diagnostic utility. (lu.se)
  • PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
  • Results: We found that LOH and methylation of the PTEN promoter were significantly associated with loss of PTEN protein expression, while, PTEN mutation was a rare event. (cancerindex.org)
  • In accordance, systemic injection of dopamine receptor D1 agonists in vivo promote rapid cleavage of the ECM protein brevican 16 . (nature.com)