• Recently, we carried out a metabolomics study to elucidate therapeutic mechanisms of α -mangostin (MAN, a mangosteen derived prenylated xanthone) on experimental arthritis and found that MAN compromised the biosynthesis of nicotinamide adenine dinucleotide (NAD) in fibroblast-like synoviocyte (FLS) via downregulation of nicotinamide phosphoribosyltransferase (NAMPT, a rate-limiting enzyme in the salvage pathway) and subsequently protected the joints from destruction (unpublished). (hindawi.com)
  • Poly[adenosine diphosphate (ADP) ribose] polymerases (PARPs) are a family of enzymes that modulate diverse biological processes through covalent transfer of ADP-ribose from the oxidized form of nicotinamide adenine dinucleotide (NAD+) onto substrate proteins. (regenerativemedicine.net)
  • The methionine repressor, MetJ, represses the transcription of genes involved in methionine biosynthesis by binding to arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence. (rcsb.org)
  • A distinct pattern of expression was identified for genes involved in the biosynthesis of paxilline. (massey.ac.nz)
  • Transcriptional Response of Structural and Regulatory Genes Involved in Isoprene Biosynthesis and its Relation to Essential Oil Biosynthesis in Response to Salicylic Acid and Abscisic Acid in Mentha piperita L. (jmp.ir)
  • Maleki S, Taheri H. Transcriptional Response of Structural and Regulatory Genes Involved in Isoprene Biosynthesis and its Relation to Essential Oil Biosynthesis in Response to Salicylic Acid and Abscisic Acid in Mentha piperita L.. J. Med. (jmp.ir)
  • Protein phosphatase 2A (PP2A) is a ubiquitous and highly conserved Ser/Thr phosphatase with broad substrate specificity and a diverse repertoire of cellular functions (reviewed in Janssens and Goris, 2001 ). (plantcell.org)
  • Copper is a trace element present in all tissues and is required for cellular respiration, neurotransmitter biosynthesis, pigment formation, and connective tissue strength. (supplementscanada.com)
  • The monoclonal antibody portion of the F16-IL2 fusion protein binds to tumor cells expressing the tumor associated antigen (TAA) tenascin-C. In turn, the IL-2 moiety of the fusion protein stimulates natural killer (NK) cells, macrophages and neutrophils and induces T-cell antitumor cellular immune responses thereby selectively killing tenascin-C-expressing tumor cells. (cancer.gov)
  • The heterotrimeric protein phosphatase 2A (PP2A) complex comprises a catalytic subunit and regulatory A and B subunits that modulate enzyme activity and mediate interactions with other proteins. (plantcell.org)
  • Multicellular eukaryotes express at least three different classes of B subunits, typically designated as B55 (or B), B′, and B″. In addition, accessory proteins and posttranslational modifications control PP2A subunit associations and activities. (plantcell.org)
  • To determine whether the radio-active sugars were being incorporated into serum proteins or into membrane protein, the solubilized in vivo-labeled proteins were treated with specific antisera to rat serum proteins or to albumin. (rupress.org)
  • The primary step in this process is the conversion of sunlight into chemical energy and is driven by four, multisubunit, membrane-protein complexes that are known as photosystem I,photosystem II, cytochrome b6f and F-ATPase. (kenyon.edu)
  • They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. (up.ac.za)
  • The cld -like cluster ( rmn cluster) was also detected in the genome of S. anulatus GM95 by searching our in-house genome databases, and the heterologous expression of the rmn cluster in S. avermitilis SUAK22 demonstrated that the rmn cluster was involved in the biosynthesis of the labdane-type bicyclic diterpene, raimonol ( 7 ). (springer.com)
  • We show that MitoQ extends lifespan, delays Aβ-induced paralysis, ameliorates depletion of the mitochondrial lipid cardiolipin, and protects complexes IV and I of the ETC. Despite its protective effects on lifespan, healthspan, and ETC function, we find that MitoQ does not reduce DCFDA fluorescence, protein carbonyl levels or modulate steadystate ATP levels or oxygen consumption rate. (nih.gov)
  • Eukaryotic lipid body proteins in oleogenous actinomycetes and their targeting to intracellular triacylglycerol inclulsions: Sudan IV stained lipid bodies in vascular cells of developing lateral roots of Bouteloua eriopoda. (yalasarat.info)
  • RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii. (yalasarat.info)
  • Lipid-transfer proteins: A puzzling family of plant proteins. (jmp.ir)
  • They showed that the Streptomyces Antibiotic Regulatory Protein (SARP), a regulator that controls the biosynthesis of antibiotics in streptomycetes, can be used as a general activator of various antibiotic gene clusters. (774292.buzz)
  • Reflecting the increased amino acid transport capacity of tumor cells, F-18 fluroethyltyrosine (F-18 FET) is actively taken up in tumor cells via amino acid transport system L, but is neither incorporated into proteins nor readily degraded, resulting in high intracellular concentrations of this imaging agent. (cancer.gov)
  • The rose OS10033701 flowers have been modified for mauve colouration through the biosynthesis and accumulation of the anthocyanin pigment delphinidin, which is not produced in non-transgenic roses. (biodiv.org)
  • N -acetylglucosamine, mannose, and galactose were only incorporated in vitro into proteins from membrane-attached polysomes and not into proteins from free polysomes. (rupress.org)
  • We make use of this approach to produce tailor-made samples for single-molecule fluorescence spectroscopy and, on the other hand, employ specific in vitro assays to investigate aspects of the protein biosynthesis. (rwth-aachen.de)
  • Collagen is one of the most abundant proteins in the human body and is essential for the proper function of all body tissues and organs. (biobodyweb.com)
  • During the bone matrix formation/maturation period (days 10-16), type I collagen expression and biosynthesis, fibronectin, TGF-β1 and osteonectin expressions were high and maximal around day 16. (elsevier.com)
  • During this maturation period, we found that the expression patterns of bone matrix proteins were two types: one is the expression pattern of type I collagen and TGFβ1, which was higher in the maturation period than that in both the proliferation and mineralization periods. (elsevier.com)
  • Heat shock protein 47kDa (HSP47) serves as a client-specific chaperone, essential for collagen biosynthesis and its folding and structural assembly. (preprints.org)
  • We selected most pathways galnt9 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. (creativebiomart.net)
  • Reduction of the TASK-3 protein biosynthesis induced characteristic changes in cell morphology, reduced the amount of DNA and decreased metabolic activity and mitochondrial function of melanoma cells when compared with control. (elsevier.com)
  • Bone formation involves several tightly regulated gene expression patterns of bone-related proteins. (elsevier.com)
  • We found that the expression patterns of bone-related proteins were regulated in a temporal manner during the successive developmental stages including proliferation (days 4-10), bone matrix formation/maturation (days 10-16), and mineralization stages (days 16-30). (elsevier.com)
  • What is responsible for the formation - the biosynthesis - of the rubber is a protein complex located on the surface of so-called rubber particles. (k-online.com)
  • If the formation of the protein is prevented - in other words, if it is non-existent in the plant - then no rubber is formed. (k-online.com)
  • The scientists assume that the protein is necessary for the formation of the rubber-producing protein complex. (k-online.com)
  • A second study, which was likewise carried out with substantial input from researchers from IME and Münster University, identifies a further important protein which plays a key role in the formation of the long polyisoprene chains. (k-online.com)
  • Chloroplast transformation into chromoplasts is caused by the destruction of the granal thylakoide structure and the formation of a new internal structure under the control of the nucleus through specific proteins encoded by it and synthesized in the cytoplasm. (biologyteach.com)
  • Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. (leibniz-hki.de)
  • Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus . (leibniz-hki.de)
  • The aim of the study was to evaluate value of certain serological assays in differential diagnosis between early and late phase of T. Elevation of superoxide production resulted in the activation of protein phosphatase 2A, a regulator of the positive element of the circadian clock. (pianolarge.gq)
  • Immunoelectrophoresis of the 14 C-labeled leucine membrane and cisternal proteins showed that the membranes contained radioactive serum glycoprotein but no albumin, while the cisternal fraction contained all of the radioactive albumin and some glycoproteins. (rupress.org)
  • Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. (string-db.org)
  • Genome mining of cyslabdan-producing Streptomyces cyslabdanicus K04-0144 revealed that a set of four genes, cldA , cldB , cldC , and cldD (the cld cluster), which formed a single transcriptional unit, were involved in the biosynthesis of cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus . (springer.com)
  • Western blot analysis with our new anti-fls485 antibodies revealed at least two fls485 proteins. (courtfield.ml)
  • Protein expressions in tissues and cells were examined with immunohistochemical and immunoblotting methods, respectively. (hindawi.com)
  • Effects of preliminary adaptation to short-term stress or to regular hypoxia on disturbances of DNA biosynthesis were studied in liver and heart tissues under conditions of emotional-painful stress (EPS). (saladgaffe.ga)
  • In particular, upon entry into the stationary growth phase (which is often the consequence of starvation in one of the major cell metabolite supplies: carbon, nitrogen or phosphorus), we observed that polyamine biosynthesis was much affected, in parallel with the expression of S-adenosylmethionine decarboxylase [ 2 ]. (biomedcentral.com)
  • The bshA and bshB1 genes are embedded within a seven-gene operon additionally including mgsA , encoding methylglyoxal synthase, and the essential genes cca and birA , encoding tRNA nucleotidyltransferase (CCA transferase) and biotin-protein ligase, respectively. (microbiologyresearch.org)
  • As the researchers have been able to demonstrate, using the example of Russian dandelion, there is one special protein (a so-called rubber transferase activator) which plays a key role. (k-online.com)
  • Janina Epping, Nicole van Deenen, Eva Niephaus, Anna Stolze, Julia Fricke, Claudia Huber, Wolfgang Eisenreich, Richard M. Twyman, Dirk Prüfer and Christian Schulze Gronover (2015): A rubber transferase activator is necessary for natural rubber biosynthesis in dandelion. (k-online.com)
  • The protein encoded by this gene was expressed in bacteria and a baculovirus-based expression system. (saladgaffe.ml)
  • S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria. (microbiologyresearch.org)
  • In bacteria, this compaction is governed by the family of nucleoid-associated proteins (NAPs). (pianolarge.gq)
  • Specific deletion of each of the neo8, neo15 and neo16 genes confirmed that they are all essential for neomycin biosynthesis. (courtfield.tk)
  • Usually, metal ions are embedded in protein scaffold to form active centers of proteins in order to catalyze a broad array of chemical transformations, which are essential in supporting the biological processes mentioned above. (cmu.edu)
  • These results suggest that, in addition to the effect of altered isoprene availability on terpenoid biosynthesis, increased quality and quantity of essential oil components in M. piperita upon SA and ABA were mediated by other mechanisms. (jmp.ir)
  • The presence of alternative carbon sources also affected the rate of paxilline production and preliminary results indicate that biosynthesis of paxilline may be under carbon catabolite repression by glucose. (massey.ac.nz)
  • Such assessments of vimentin mechanics generally use a GFP-tagged vimentin protein in a transgenic system such that the protein can be visualized in vivo. (stem-cell-marker.com)
  • They were able to identify two unique genes for carotenoid biosynthesis using in vivo functional complementation experiments. (kenyon.edu)
  • Vimentin is a type III intermediate filament (IF) protein present in many eumetazoan cell types of mesodermic origin, such as the mesenchyme and fibroblasts, as well as some ectodermal cells, including neural stem cells and some cancers . (stem-cell-marker.com)
  • Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. (string-db.org)
  • Production systems analysis, based on public data, is considered with account for all transformation stages: biosynthesis, bioconversion, and technical conversion, including deep technical conversion (proteins modification) right up to end products. (e-notabene.ru)
  • In conclusion, the results indicate SP-G as a new surfactant protein which represents an until now unknown surfactant protein class. (saladgaffe.ga)