TNF-Related Apoptosis-Inducing LigandApoptosis Regulatory ProteinsApoptosisLigandsProtein BindingMolecular Sequence DataCaspasesBinding SitesCaspase 3Fas Ligand ProteinAmino Acid SequenceBase SequenceSignal TransductionProto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsCell LineDNA-Binding ProteinsTumor Necrosis Factor-alphaCells, CulturedCell Line, TumorDNA FragmentationCarrier ProteinsTumor Cells, CulturedIn Situ Nick-End LabelingCell Survivalbcl-2-Associated X ProteinTransfectionProtein Structure, TertiaryX-Linked Inhibitor of Apoptosis ProteinTranscription FactorsRecombinant ProteinsCD40 LigandEnzyme ActivationCASP8 and FADD-Like Apoptosis Regulating ProteinRNA, MessengerBlotting, WesternRecombinant Fusion ProteinsApoptosis Inducing FactorCaspase 9Caspase InhibitorsCaspase 8Membrane GlycoproteinsTumor Suppressor Protein p53MutationMitochondriaModels, MolecularReceptors, Tumor Necrosis FactorMembrane ProteinsFlow CytometryKineticsHeLa CellsProto-Oncogene ProteinsGene Expression RegulationDNAPromoter Regions, GeneticCell ProliferationPhosphorylationNuclear ProteinsMice, Inbred C57BLCytochromes cSequence Homology, Amino Acidbcl-X ProteinBinding, CompetitiveDose-Response Relationship, DrugProteinsJurkat CellsCell DivisionAnnexin A5Down-RegulationCell CycleProtein ConformationNF-kappa BRNA, Small InterferingAntineoplastic AgentsCell NucleusTime FactorsMice, KnockoutRNA-Binding ProteinsAmino Acid Chloromethyl KetonesTranscription, GeneticEnzyme InhibitorsCloning, MolecularCysteine Proteinase InhibitorsReverse Transcriptase Polymerase Chain ReactionGene ExpressionModels, BiologicalDNA PrimersUp-RegulationReceptors, Tumor Necrosis Factor, Type IRepressor ProteinsPoly(ADP-ribose) PolymerasesEscherichia coliPlasmidsBacterial ProteinsCell DeathReactive Oxygen SpeciesMutagenesis, Site-DirectedImmunohistochemistryIntracellular Signaling Peptides and ProteinsHL-60 Cells