PhosphotyrosineShc Signaling Adaptor Proteinssrc Homology DomainsAdaptor Proteins, Signal TransducingBinding SitesAdaptor Proteins, Vesicular TransportMolecular Sequence DataTyrosineProtein BindingAmino Acid SequencePhosphoproteinsInsulin Receptor Substrate ProteinsPhosphorylationProtein Structure, TertiarySignal TransductionCell LineProteinsSequence Homology, Amino AcidRecombinant Fusion ProteinsMutagenesis, Site-DirectedPhosphopeptidesRecombinant ProteinsProtein-Tyrosine KinasesCarrier ProteinsProtein Tyrosine PhosphatasesCloning, MolecularBase SequenceSequence AlignmentAmino Acid MotifsModels, MolecularDNA-Binding ProteinsTwo-Hybrid System TechniquesGRB2 Adaptor ProteinMutationTransfectionDNA, ComplementaryIntracellular Signaling Peptides and ProteinsCOS CellsProto-Oncogene Proteins c-cblPrecipitin TestsNerve Tissue Proteins3T3 CellsReceptor Protein-Tyrosine KinasesProto-Oncogene ProteinsProtein ConformationTranscription FactorsReceptor, InsulinPeptidesProtein Interaction Domains and MotifsCell MembraneKineticsEnzyme ActivationDNAProtein Structure, SecondaryCrystallography, X-RayEscherichia coliNuclear ProteinsLigandsDimerizationPeptide FragmentsAmyloid beta-Protein PrecursorVanadatesStructure-Activity RelationshipPhosphatidylinositol 3-KinasesMembrane ProteinsSequence DeletionBacterial ProteinsHeLa CellsPlasmidsConserved SequencePromoter Regions, GeneticElectrophoresis, Polyacrylamide GelRepressor ProteinsMolecular WeightDNA PrimersTranscription, GeneticRNA-Binding ProteinsMutagenesisCells, CulturedTrans-ActivatorsGlutathione TransferaseBinding, CompetitiveSaccharomyces cerevisiaeAmino Acid SubstitutionPoint MutationCytoplasmBlotting, WesternSubstrate SpecificityZinc FingersRNA, MessengerCricetinaeCell NucleusTumor Cells, CulturedConsensus SequenceProtein FoldingProtein Tyrosine Phosphatase, Non-Receptor Type 6Transcriptional ActivationModels, BiologicalViral ProteinsGene Expression Regulation