• The chemical properties of the binding site, and the other molecule, are also important: bonding will only take place if it is chemically feasible. (wisegeek.com)
  • It has four sites that can bind to an oxygen molecule. (wisegeek.com)
  • We present the fabrication and characterization of a nano-scale sensor made of amorphous silicon (a-Si) for electronic detection of small molecule -protein binding. (nsti.org)
  • The bound drug is kept in the blood stream while the unbound component may be metabolized or excreted, making it the active part. (wisegeek.com)
  • A drug in blood exists in two forms: bound and unbound. (wikipedia.org)
  • If the protein binding is reversible, then a chemical equilibrium will exist between the bound and unbound states, such that: Protein + drug ⇌ Protein-drug complex Notably, it is the unbound fraction which exhibits pharmacologic effects. (wikipedia.org)
  • The bound portion may act as a reservoir or depot from which the drug is slowly released as the unbound form. (wikipedia.org)
  • Since the unbound form is being metabolized and/or excreted from the body, the bound fraction will be released in order to maintain equilibrium. (wikipedia.org)
  • Note: The most commonly used methods for measuring drug concentration levels in the plasma measure bound as well as unbound fractions of the drug. (wikipedia.org)
  • If the amount of plasma protein is decreased (such as in catabolism, malnutrition, liver disease, renal disease), there would also be a higher fraction unbound. (wikipedia.org)
  • If Drug B is also given, it can displace Drug A from the protein, thereby increasing Drug A's fraction unbound. (wikipedia.org)
  • Binding is often reversible and in these cases can create a chemical equilibrium, in which the chemical reaction can go backward and forward with no net change in reactants and products. (wisegeek.com)
  • Based on a theoretical model of fly-casting binding, Dr. Chang and colleagues found that temperature, an important component of the entropic term in free energy, influences the capture radius of fly-casting binding. (redorbit.com)
  • Their results indicate that the transition temperature of protein folding and unfolding is the most suitable condition for fly-casting binding, since the capture radius is greatest at that temperature. (redorbit.com)
  • Their work, entitled "Influence of temperature and diffusive entropy on the capture radius of fly-casting binding", was published in SCIENCE CHINA Physics, Mechanics & Astronomy, 2011, 54(12). (redorbit.com)
  • The recently discovered "fly-casting" mechanism allows a protein chain to unfold and extend to reach substrates a long distance away from the protein. (redorbit.com)
  • This mechanism compensates for diffusive entropy by enlarging the "capture radius" of binding process, and consequently accelerates the binding process. (redorbit.com)
  • The identity of the proteins involved and the localisation mechanism are not known. (wikipedia.org)
  • The binding of proteins to various substrates in a biological system is a basic but essential process to maintain the function of living things. (redorbit.com)
  • We use a method called contrast common pattern classifier (CCPC) to predict chemical-protein binding activity. (springer.com)
  • Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. (wikipedia.org)
  • The results demonstrate that candidate binding pockets obtain less relative Von Neumann entropy which means more random scattering of voids inside them. (springer.com)
  • This book is a passionate account of the scientific breakthroughs that led to the solution of the first protein structures and to the understanding of their function at atomic resolution. (ebooks.com)
  • The points at which the two free energy curves crosses defines the capture radius for protein binding. (redorbit.com)