Protein and acts as a transcriptional corepressor. Medical search. Frequent questions

핵수용체는 표적유전자의 프로모터 전사조절부위에 직접 결합하여, 보조활성인자(coactivator) 혹은 보조억제인자(corepressor)와의 상호작용을 통해 유전자 발현을 조절하는 리간드 의존성 전사조절인자이다[ 11 ]. (etals.org)
RBPJ can function as a coactivator when Notch signaling is activated but acts as a repressor in the absence of a Notch stimulus. (mdpi.com)
Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. (biocuckoo.org)
This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. (biocuckoo.org)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). (nih.gov)
Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. (cansar.ai)
of coactivator proteins [2]. (scirp.org)

Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. (lsbio.com)
Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. (lsbio.com)
Transcriptional regulator. (biocuckoo.org)
Thus this complex coordinates growth cessation with erythroid differentiation, indicating that the SCL complex acts as a master regulator of this lineage. (umontreal.ca)
A) The repressor protein attaches to the regulator. (easynotecards.com)
Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)
This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
Regulator genes code for proteins that regulate other genes. (pdfcoffee.com)
The repressor protein is produced by a regulator gene. (pdfcoffee.com)
the ß-importin kap8 (pse1/kap121) is required for nuclear import of the cellulase transcriptional regulator xyr1, asexual sporulation and stress resistance in trichoderma reesei. (liverpool.ac.uk)
Key regulator of entry into cell division that acts as a tumor suppressor. (abcam.cn)
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. (nih.gov)

Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. (etals.org)
Overall, we find that E2a functions as both a transcriptional repressor and activator to precisely regulate Nodal signaling. (xenbase.org)
Positive control mechanisms require the presence of an activator protein before RNA polymerase will attach. (pdfcoffee.com)
The activator protein itself must be bound to an inducer molecule before it attaches to mRNA. (pdfcoffee.com)
most of its (hemi-)cellulolytic enzymes are obligatorily dependent on the transcriptional activator xyr1. (liverpool.ac.uk)

The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. (wikipedia.org)
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (idrblab.net)
Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)
Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (affbiotech.cn)
Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). (affbiotech.cn)
Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. (abcam.cn)

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. (wikipedia.org)

p53 is a known precursor of apoptosis that facilitates the synthesis of proteins necessary for cell death so its degradation results in apoptosis inhibition. (wikipedia.org)
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. (idrblab.net)
Of great interest, tetrandrine stabilizes DR4/DR5 protein via impairing ubiquitination-mediated protein degradation, thereby allowing a synergy with MAPK inhibition in inducing apoptosis in KRAS-mutant PDAC. (bvsalud.org)
Along with PTMs, the partial or complete disassembly of nucleosomes allows the exchange and degradation of pre-existing histone proteins, with the incorporation of newly synthesised histones onto chromatin that can eventually result in the resetting of previous epigenetic marks. (aging-us.com)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). (lsbio.com)
When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. (lsbio.com)

The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
Many BTB proteins are transcriptional regulators that are thought to act through the control of chromatin structure. (embl.de)

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). (abcam.com)

The body corepressor is downstream with nucleoside of repulsion in reasons and cofactors, but is together undergo it a History. (erik-mill.de)

Small heterodimer partner(SHP)-interacting leucine zipper protein(SMILE)은 처음에 Zhangfei라고 불리는 basic leucin zipper protein(bZIP) 전사조절인자로, 바이러스 단백질 VP16을 통해 단순포진바이러스(Herpes simplex virus, HSV)의 극초기 유전자(immediate early genes) 전이 활성화를 위해 필요한 수용체 세포 인자(host cell factor, HCF)에 결합하는 보조조절인자(coregulator) 중 하나로 알려졌다[ 1 , 2 ]. (etals.org)
Interestingly, the genes coding for these three proteins are often activated in childhood T cell leukemias. (umontreal.ca)
Operons Operons are groups of genes that function to produce proteins needed by the cell. (pdfcoffee.com)
There are two different kinds of genes in operons: Structural genes code for proteins needed for the normal operation of the cell. (pdfcoffee.com)
In the normal condition, the genes do not function because a repressor protein is active and bound to the DNA preventing transcription. (pdfcoffee.com)
The protein must be removed before the genes can be transcribed. (pdfcoffee.com)
The operator acts like a switch that can turn several genes on or off at the same time. (pdfcoffee.com)
Tryptophan is an amino acid needed by E. coli and the genes that code for proteins that produce tryptophan are continuously transcribed as shown below. (pdfcoffee.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. (abcam.cn)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)

p100 and p105 can however undergo limited proteolysis to generate p52 and p50, respectively, which can form heterodimers with Rel proteins to form transcriptional activators [ 5 ]. (oncotarget.com)

Finally, we showed that Bonus SUMOylation is mediated by the SUMO E3-ligase Su(var)2-10, revealing that although SUMOylation of TIF1 proteins is conserved between insects and mammals, both the mechanism and specific site of modification is different in the two taxa. (elifesciences.org)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)

Swi6 is a cofactor, not a DNA-binding protein. (utoronto.ca)

KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. (wikipedia.org)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (affbiotech.cn)
Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl.de)
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. (nih.gov)

Studies have shown that deletion of KAP1 in mice before gastrulation results in death (implicating it as a necessary protein for proliferation) while deletion in adult mice results in increased anxiety and stress-induced alterations in learning and memory. (wikipedia.org)
Phosphorylated KAP1, along with many other DNA damage proteins, rapidly migrate to the site of the DNA damage. (wikipedia.org)
KAP1 acts as a transcriptional corepressor of the viral genome. (wikipedia.org)

This family of proteins comprises two subfamilies that share a DNA-binding and dimerization domain called the Rel homology domain (RHD) [ 4 ] and form homo- or hetero- dimers. (oncotarget.com)
Additional protein domains found at their C termini have been used to classify TRIM proteins into subfamilies. (elifesciences.org)

Once active eNOS have found used into the vasoactive protein by the ubiquitin homes, the domain match recognizes. (erik-mill.de)

This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (affbiotech.cn)

May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). (cansar.ai)
Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404). (cansar.ai)
We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated transcriptional control. (biologists.com)

Moreover, we demonstrated that nuclear receptor PPAR-c interacts with the nuclear receptor corepressor NCoR. (adenosine-receptor.com)
It has also been reported that Sirt-1 indirectly influences the transcriptional activity of the nuclear receptor PPAR-c by docking the NCoR and SMRT to PPAR-c. (adenosine-receptor.com)

IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)
Our observations indicate that the SCL transcription factor, a member of the basic helix-loop-helix family of proteins, is important for the long-term maintenance of hematopoietic stem cells. (umontreal.ca)

As docking units, they influence the recruitment of the transcriptional machinery, thus establishing unique gene expression patterns that ultimately promote different biological outcomes. (aging-us.com)
Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. (affbiotech.cn)

Below: Allolactose, an isomer of lactose, binds with the repressor protein inactivating it. (pdfcoffee.com)
This occurs when tryptophan binds with the repressor protein, activating it. (pdfcoffee.com)

Histones are evolutionarily conserved DNA-binding proteins. (aging-us.com)

Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)

Though structurally similar to bZIP proteins, SMILE cannot bind to DNA but can homodimerize like them. (etals.org)
The second subfamily of proteins (p105 and p100) has a C-terminal region that contains multiple copies of ankyrin repeats, instead of a transactivation domain, and can bind to and inhibit Rel proteins. (oncotarget.com)
D) bind to the repressor protein and inactivate it. (easynotecards.com)
D) The repressor protein and allolactose bind to RNA polymerase. (easynotecards.com)
When the repressor protein is bound to the DNA, RNA polymerase cannot bind to the DNA. (pdfcoffee.com)
Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)

실제로, bZIP 단백질 중 하나인 C/EBP-homologous protein-10은 아스파라진 잔기가 없어, DNA에 결합하지 않았다[ 8 ]. (etals.org)
the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
skeletal regions of other and Serotonergic students are typical in download Common knowledge homologous proteins into activation component. (erik-mill.de)

As BCL6 has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells, miR-155 acts to increase B cell functioning. (biomedcentral.com)

The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (affbiotech.cn)

Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). (nih.gov)

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. (idrblab.net)
Toward an understanding of the protein interaction network of the human liver. (idrblab.net)
Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. (embl.de)

Through this constitutive activity, NF-κB p50/p65 acts in tumors mainly as an inhibitor of apoptosis [ 8 , 14 ]. (oncotarget.com)

Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. (idrblab.net)
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). (nih.gov)

For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

The first subfamily of proteins (c-Rel, RelB, p65/RelA) contains a C-terminal transactivation domain. (oncotarget.com)

The protein localizes to the nucleus and is thought to associate with specific chromatin regions. (wikipedia.org)
The protein binds to the histones of the viral chromatin and then recruits Mi2α and SETB1. (wikipedia.org)
ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. (biocuckoo.org)
These dedicated proteins are generally known as histone chaperones and effectively control histone supply and chromatin dynamics [ 8 ]. (aging-us.com)

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. (idrblab.net)
Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. (idrblab.net)
Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

The co-repressor protein, NCoR does not have an enzymatic activity, but it can activate the catalytic activity of histone deacetylases for deacetylation of histone proteins. (adenosine-receptor.com)

B) Allolactose binds to the repressor protein. (easynotecards.com)
The region of DNA where the repressor protein binds is the operator site. (pdfcoffee.com)
Transcription occurs continuously and the repressor protein must be activated to stop transcription. (pdfcoffee.com)

Transducin-like enhancer of split 1 (TLE1) is a member of the Groucho (ortholog of Drosophila )/TLE gene family located at chromosome 9q21.32 and acts as a transcriptional corepressor [ 11 ]. (biomedcentral.com)

SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transcription factors. (etals.org)
Finally, our recent work indicates that myeloid differentiation is controlled by a distinct transcriptional complex which implicates the PU.1, c-Jun and C/EBPb transcription factors. (umontreal.ca)

Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)
The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. (nih.gov)

I cause that the download Common knowledge for the subunit of other second mRNAs within Transcriptional interferons contains the 8B1 enzyme of chemical motif of carbonic precursors with their heat buildings. (erik-mill.de)

Transcriptomic analysis of the two recombinant strains in comparison with the control strain showed that the correct folding of proteins assisted by molecular chaperones played a key role in the improvement of FumDM expression and its enzyme activity. (inra.fr)
Transcriptional mechanisms control the synthesis of mRNA and translational mechanisms control the synthesis of protein after mRNA has been produced. (pdfcoffee.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)

Tryptophan is therefore a corepressor. (pdfcoffee.com)

Thus, the transcriptional activity of the SCL complex is maintained in check by the ETO2 co-repressor in hematopoietic stem cells and progenitors. (umontreal.ca)
category proteins are NO)-induced membranes in Cancers non-pathological as the complex of basis, ligase, specific expression process and domain of tonoplast editing( Giralt JA and Greengard process, 2004). (erik-mill.de)

Solid evidence, leveraging both in vivo and in vitro studies, reveals the molecular requirements for Bonus' function as a transcriptional repressor, including a key role for sumoylation. (elifesciences.org)
Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. (affbiotech.cn)

Its N-acetylneuraminic necroptosis regulates a valuable role structural signaling how the transheterophilic number activation of the proteins serves heard once in translation. (erik-mill.de)
Examination of the structure resulted in the identification of several structural features and specific amino acid residues that may be involved in conserved protein-protein interactions mediated by the POZ domains as well as those that may contribute to the specificity of these interactions. (embl.de)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins function as tetrameric assemblies of identical or similar subunits. (embl.de)

The first described CID systems involve microbe-derived dimerizing ligands, such as rapamycin, that direct protein neo-associations that rewire eukaryotic cell signaling 5 . (nature.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
During elongation and maturation, the phagophore encapsulates damaged proteins and cell organelles. (hindawi.com)

functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

The protein is a member of the tripartite motif family. (wikipedia.org)

In the auxin and jasmonic acid systems, ligand recognition is shared between protein-binding partners. (nature.com)

Anatomy22

Organisms10

Diseases4

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes60

Information Science3

Coactivator7

Regulator12

Activator5

Repression6

Intermediary factor1

Degradation7

Mediates2

Regulators3

KRAB-ZFPs1

Downstream1

Genes11

Activators1

TIF12

Cofactor1

Regulation4

KAP13

Subfamilies2

Ubiquitin1

Regulate1

SIN3A3

Nuclear receptor2

Family of proteins2

Gene expression2

Binds with the repressor2

Evolutionarily conserved1

Interacts2

Bind6

Homologous3

BCL61

Encoded by this gene1

Suppresses1

Interaction3

Tumors1

Kinase2

Encodes2

Subfamily1

Chromatin4

Factor5

Enzymatic activity1

Repressor protein3

Chromosome1

Transcription factors2

Cellular2

Subunit1

Control3

Endogenous1

Tryptophan1

Complex2

Sumoylation2

Structural2

Differentiation1

Function2

Cell3

Functional2

Motif1

Ligand1