• This report demonstrates that CETSA can not only quantitatively evaluate the drug-TE in mouse peripheral blood, but also confirm TE in animal tissues exemplified by using the receptor interacting protein 1 kinase (RIPK1) lead compound we have developed. (nature.com)
  • Receptor interacting protein 1 kinase (RIPK1) is a key mediator of not only a process of regulated necrosis, termed necroptosis, but also promotion of caspase-8-dependent apoptosis and pro-inflammatory gene expression 13 . (nature.com)
  • Involvement of protein kinase C (PKC) has been commonly assumed, but available studies were limited to nonhuman prostate smooth muscle or cell cultures. (uni-muenchen.de)
  • Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. (oregonstate.edu)
  • The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. (oregonstate.edu)
  • B7H6 induction by ER stress requires protein kinase R-like ER kinase (PERK), one of the three canonical sensors of the unfolded protein response. (iucc.ac.il)
  • The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimers disease. (idhinhibitor.com)
  • Heme-regulated inhibitor (HRI) kinase is a member of the eIF-2{alpha} kinase family. (en-academic.com)
  • Low concentrations of heme activate Heme-Regulated Inhibitor Kinase, which phosphorylates the Serine-51 of eIF-2{alpha}, and makes its interaction with eIF-2B nonproductive(eIF-2{alpha} sequesters eIF-2B). (en-academic.com)
  • Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses. (en-academic.com)
  • AMP-activated protein kinase - 5 AMP activated protein kinase or AMPK consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans, that plays a role in cellular energy homeostasis. (en-academic.com)
  • Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
  • L'analyse d'image des cartes appariées a permis d'identifier sept protéines qui étaient soit surexprimées, soit sous-exprimées : le récepteur de la protéine kinase C activée, la tubuline alpha (×2), la prostaglandine F2-alpha synthase, la protéine disulfide isomérase, une protéine du transport vésiculaire et une protéine hypothétique. (who.int)
  • Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). (abcam.com)
  • DDL-701 thus represents a drug that can immediately be repurposed and undergo clinical evaluation as a PL pro inhibitor that may be most effectively used in a protease inhibitor cocktail with an M pro inhibitor such as nirmatrelvir (Paxlovid) for the treatment of COVID-19. (biorxiv.org)
  • Hypersensitive C-Reactive Protein (CRP), tumor necrosis factor-alpha (TNF-α), and angiotensin II (ANG II) were measured using ELISA. (biomedcentral.com)
  • PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)
  • Exposure of tumor cells to the HIV protease inhibitor nelfinavir improves the recognition by B7H6-directed CAR-T. (iucc.ac.il)
  • Fullerene-treated mice had less tumor necrosis factor alpha and less interleukin-1beta production compared to the production levels for nontreated mice. (nanomedicine.com)
  • This alteration in lipid distribution results in a low-grade inflammatory response caused by increases in inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-agonists such PF-04217903 as thiazolidinediones that are used to manage diabetes produce an impetus for identifying alternative treatments that may improve insulin sensitivity. (bios-mep.info)
  • they belong to the MEROPS proteinase inhibitor family I39, clan IL. (wikipedia.org)
  • We investigated whether alpha-1 antitrypsin (AAT), a multifunctional protein with proteinase inhibitor and anti-inflammatory activities, mitigates bone loss induced by estrogen deficiency, a state with increased production of proinflammatory cytokines. (usda.gov)
  • Alpha-1antitrypsin (AAT) is a multifunctional protein with proteinase inhibitor and anti-inflammatory activities. (usda.gov)
  • If the protein is already known to have a match in malarial cDNA library, we can skip most of the above steps and PCR-amplify the cDNA of interest from the library directly. (hideyuki-ts.com)
  • Purification: This antibody is purified through a protein A column, followed by peptide affinity purification. (hatinhibitor.com)
  • The following product was used in this experiment: FceR1 alpha Monoclonal Antibody (MAR-1), Functional Grade, eBioscience™ from Thermo Fisher Scientific, catalog # 16-5898-82, RRID AB_469137. (thermofisher.com)
  • Description: The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability. (thermofisher.com)
  • Formalin-fixed, paraffin-embedded human liver stained with Alpha-1-Antichymotrypsin Mouse Monoclonal Antibody (SERPINA3/4187). (neobiotechnologies.com)
  • 19,000 full-length human proteins using Monospecific to Alpha-1-Antichymotrypsin Mouse Monoclonal Antibody (SERPINA3/4187). (neobiotechnologies.com)
  • Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (neobiotechnologies.com)
  • Variations in Alpha-1-Antichymotrypsin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
  • Tissues from cancer patients, for instance, have their own distinct pattern of Alpha-1-Antichymotrypsin expression as measured by anti-Alpha-1-Antichymotrypsin antibody immunohistochemical staining. (enquirebio.com)
  • Cells were lysed in RIPA lysis buffer made up of protease inhibitor and analyzed on 10% SDS-PAGE followed by Western blotting with SRF C-terminus antibody (Santa Cruz) or adiponectin antibody (R&D systems). (bios-mep.info)
  • Background: Chuk acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. (hatinhibitor.com)
  • PERK phosphorylates eIF2 alpha, which regulates protein synthesis and gene expression. (iucc.ac.il)
  • α2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β. (wikipedia.org)
  • In the human prostate, doxazosin mesylate antagonizes phenylephrine (alpha 1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha 1c adrenoceptor. (nih.gov)
  • However, cobalamin immediately binds to R-protein. (vin.com)
  • For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29. (neobiotechnologies.com)
  • Derive the 50% inhibition concentration (IC 50 ) for rhKininogen by plotting RFU/min (or specific activity) vs. concentration with 4-PL fitting. (rndsystems.com)
  • This LA-dependent increase in Akt phosphorylation was accompanied by inhibition of LPS-induced NF-kappaB DNA binding activity and up-regulation of TNFalpha and monocyte chemoattractant protein 1. (oregonstate.edu)
  • Lipoic acid-dependent Akt phosphorylation and inhibition of NF-kappaB activity were abolished by the PI3K inhibitors LY294002 and wortmannin. (oregonstate.edu)
  • Cerulenin inhibition of glucose effects was concentration dependent, with a 50% inhibitory concentration (IC50) of 5 microg/ml and complete inhibition at 100 microg/ml. (diabetesjournals.org)
  • The concentrations required to produce 50 percent inhibition ranged from 0.000124 millimoles for methyl-alpha-D-glucoside (97303) to 12.80 millimoles for isopropanol (67630). (cdc.gov)
  • Some authors propose that serum thyroid hormone abnormalities are due to inhibition of thyroid hormone binding to proteins, thus preventing tests from appropriately reflecting free hormone levels. (medscape.com)
  • Importantly, inhibition of miR-146a-3p upregulated SIRT1 protein and suppressed M1 polarization in PM 2.5 treated RAW264.7 cells. (medsci.org)
  • Inhibition of endothelial cell gamma-GT at the blood-brain barrier likely enhances the uptake into brain of thioether metabolites of MDA and MDMA, such as 5-(glutathion-S-yl)-alpha-MeDA and 2,5-bis-(glutathion-S-yl)-alpha-MeDA, by increasing the pool of thioether conjugates available for uptake via the intact GSH transporter. (mdma.net)
  • Blockade of the alpha 1 receptor decreases urethral resistance and may relieve the obstruction and BPH symptoms. (nih.gov)
  • FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. (thermofisher.com)
  • Through screening of a custom clinical compound library, we identified eltrombopag (DDL-701), a thrombopoietin receptor agonist, as having PL pro inhibitory activity that is sustained in the presence of the M pro inhibitor nirmatrelvir. (biorxiv.org)
  • Impact of Inhibitors, μ Opioid Receptor/MOR Activator drug Organic Solvent, and Surfactant and Oxidizing Agents around the Protease Activity. (achrinhibitor.com)
  • The transient receptor potential melastatin 4 (TRPM4) protein is an intracellular Ca 2+ -activated non-selective cation channel, which is impermeable to Ca 2+ . (frontiersin.org)
  • Serum insulin, adipocytokines and plasminogen activator inhibitor-1 (PAI-1) concentrations were measured using a customized multiplex Luminex assay. (biomedcentral.com)
  • It is demonstrated that manipueira is devoid of lectins, serine proteinase inhibitors and chitinase activity, although very low levels of alpha-amylase inhibitory activity were detected. (europa.eu)
  • In consequence, protein turnover of WT-TRPM4 and TRPM4 variants overexpressed in HEK293 cells was analyzed using cycloheximide, an inhibitor of protein biosynthesis. (frontiersin.org)
  • Here, we examined the effects of the PKC inhibitors Go6983 and GF109203x on contractions of human prostate tissues. (uni-muenchen.de)
  • The delta variant also accumulates at high concentrations in host tissues and has caused waves of lethal disease. (elifesciences.org)
  • This binding inhibitor can be present both in the serum and in body tissues and might inhibit uptake of thyroid hormones by cells or prevent binding to nuclear T3 receptors, thus inhibiting the action of the hormone. (medscape.com)
  • We were unable to detect Alpha-1-Antichymotrypsin in other tissues. (enquirebio.com)
  • The FXa-inhibitory activity of TFPIα is synergistically stimulated by FV-Short and protein S. The circulating FV-Short/protein S/TFPIα complex concentration is normally low (≈0.2 nM) but provides an anticoagulant threshold. (lu.se)
  • Increased production of all proteins means α2-macroglobulin concentration increases. (wikipedia.org)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • The brain uptake of 5-GSyl-alpha-MeDA is decreased by glutathione (GSH), but sharply increases in animals pretreated with acivicin, an inhibitor of gamma-glutamyl transpeptidase (gamma-GT) suggesting competition between intact 5-GSyl-alpha-MeDA and GSH for the putative GSH transporter. (mdma.net)
  • In addition, glial fibrillary acidic protein (GFAP) expression increases in the striatum of acivicin and MDA (10 mg/kg) treated rats, but remains unchanged in animals treated with just MDA (10 mg/kg). (mdma.net)
  • Thus, increases in gastric pH-which may be age-related (such as with atrophic gastritis) or drug-related (such as with proton pump inhibitors)-can decrease calcium absorption and increase the risk of constipation. (msdmanuals.com)
  • Serum albumin decreases and alpha 1-acid glycoprotein increases with age, but the clinical effect of these changes on serum drug binding varies with different drugs. (msdmanuals.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • The ability of protein A affinity chromatography to achieve 95% purity in one simple step was the runway that got recombinant immunotherapy off the ground and made it available to millions. (bioprocessintl.com)
  • When the rare tRNAs are depleted to produce the recombinant protein, proliferation of the host cells is restricted, leading to low yield. (hideyuki-ts.com)
  • Human recombinant protein fragment corresponding to amino acids 31-267 of human IL15RA produced in E.coli. (thermofisher.com)
  • enQuire Bio's Alpha-1-Antichymotrypsin Anti-Human Monoclonal is available for Research Use Only. (enquirebio.com)
  • It functions as an inhibitor of coagulation by inhibiting thrombin. (wikipedia.org)
  • In patients with an acute disorder or malnutrition, rapid reductions in serum albumin may enhance drug effects because serum concentrations of unbound (free) drug may increase. (msdmanuals.com)
  • The cellular thermal shift assay (CETSA) has recently been reported to monitor the binding of ligand to its target protein in cells and tissue samples. (nature.com)
  • In FV-Short, the truncated B domain exposes a high-affinity binding site for tissue factor pathway inhibitor alpha (TFPIα), and together with protein S a high-affinity trimolecular complex is generated. (lu.se)
  • In contrast, when pancreatic tissue is inflamed an increased amount of trypsinogen and trypsin leak into the vascular space increasing serum TLI concentrations. (vin.com)
  • Outline an expression and purification strategy, using both traditional and high-throughput methods, to produce a sample suitable for protein crystallography. (hideyuki-ts.com)
  • The expression and purification strategies depend on the characteristics of the protein of interest, such as size, shape, intrinsic solubility, requirement of post-translational modifications and/or cofactors, presence of disulfide bridges, in vitro stability. (hideyuki-ts.com)
  • The structure of some homologous proteins might have been solved previously and we can refer to their expression and purification strategies, which might prevent some waste of time on trial-and-errors. (hideyuki-ts.com)
  • Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha 1 subtype of alpha adrenergic receptors. (nih.gov)
  • In 1993, MSAD-C 60 was found effective against HIV-1 and HIV-2 with 50% effective concentration (EC50) averaging 6 x 10 -6 M in acutely or chronically infected human lymphocytes, and with selective activity against HIV-1 protease [ 732 ]. (nanomedicine.com)
  • Secretory leukoprotease inhabitor is thought to be the most critical anti-elastase in the upper airways whereas alpha-1-antitrypsin is thought to be less important, although more important at the alveolar level protecting against the development of emphysema. (gla.ac.uk)
  • Patients with homozygous PiZ alpha-1-antitrypsin deficiency have decreased circulating (15-20% normal) and alveolar concentrations of alpha-1-antitrypsin which facilitate the development of early onset and rapidly progressive emphysema. (gla.ac.uk)
  • Patients with chronic bronchitis without alpha-1- antitrypsin deficiency showed a negative correlation between FEV1 (% predicted) and myeloperoxidase, interlexikin 8 and leukotriene B4, and bronchial protein leak. (gla.ac.uk)
  • The third study assessed upper airways inflammation in patients with chronic bronchitis with and without PiZ alpha-1-antitrypsin deficiency in the stable clinical state, to determine the importance of alpha-1-antitrypsin in the upper airways and the effects of continued smoking. (gla.ac.uk)
  • The final study assessed upper airways inflammation in patients with and without alpha-1-antitrypsin deficiency during an acute exacerbation. (gla.ac.uk)
  • In human, the normal serum level of AACT is about one-tenth that of 伪 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. (neobiotechnologies.com)
  • 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. (enquirebio.com)
  • Contractions were induced by electric field stimulation (EFS), alpha(1)-adrenergic agonists (noradrenaline, phenylephrine, methoxamine), thromboxane A(2) analog U46619, endothelin-1, or calcium chloride in an organ bath. (uni-muenchen.de)
  • Polyunsaturated fatty acids which act as agonists for both PPARand PPARinhibitor GW9962 (1.5?inhibitor GW9662 (Sigma). (bios-mep.info)
  • To mediate viral entry, the S protein is processed into S1 and S2 subunits by the S priming proteases (SPP), including TMPRSS2, cathepsin L (CTSL), and, to a lesser degree, FURIN. (elifesciences.org)
  • Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. (thermofisher.com)
  • Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. (thermofisher.com)
  • The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. (thermofisher.com)
  • Because eIF2 alpha is phosphorylated by several kinases following different stress conditions, the program downstream to eIF2 alpha phosphorylation is called the integrated stress response (ISR). (iucc.ac.il)
  • Nelfinavir and lopinavir, two clinically approved HIV protease inhibitors, promote eIF2 alpha phosphorylation by different mechanisms. (iucc.ac.il)
  • Even more striking is that roasting may even increase the function of Ara h 2 as a trypsin inhibitor, essentially preserving the integrity of itself and other allergens. (medscape.com)
  • Cobicistat is a mechanism-based inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family. (rxlist.com)
  • It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and haemostasis system. (relmedlab.com)
  • For crystallography studies, a protein sample with high purity, solubility and yield must be obtained. (hideyuki-ts.com)
  • We found that ovariectomy decreased wet uterus weight, caused significant bone loss, and increased serum leptin concentrations in mice compared to sham. (usda.gov)
  • When we know the sequence of GOI, we can do a BLAST to find possible homologous proteins, and study any relavant scientific literature. (hideyuki-ts.com)
  • Under normal cellular conditions, eIF-2{alpha} productively interacts with eIF-2B, giving rise to guanine-nucleotide exchange activity that is essential for protein translation. (en-academic.com)
  • The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
  • ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
  • If the coding sequence of the protein is unknown but the protein is purified, mass spectrometry (or chemical methods such as Edman degradation) can be used to determine the amino acid sequence of the protein, which can then be used to search for the the corresponding DNA sequence. (hideyuki-ts.com)
  • Recent evidence indicates that altered degradation rate of mutant proteins represents a pathogenic mechanism underlying genetic diseases. (frontiersin.org)
  • In conclusion, we find that the diabetes mellitus patients infected with COVID-19 suffer from a high increase of inflammatory proteins and parameters associated with diabetes compared to other patients infected with COVID-19 only, making them more susceptible to disease and more deaths compared to other people. (bsmiab.org)
  • Activation of PPAR-gamma receptors regulates insulin-responsive gene transcription involved in glucose production, transport, and utilization, thereby reducing blood glucose concentrations and reducing hyperinsulinemia. (medscape.com)
  • In addition to its critical role in viral replication, PL pro removes post-translational modifications like ubiquitin and interferon-stimulated gene product 15 (ISG15) from host proteins through its deubiquitinase domain, leading to host immunosuppression and increased ability of the virus to evade the host antiviral immune response. (biorxiv.org)
  • To achieve this goal, maintaining compound concentrations in vivo is a key factor because reversible compounds leave the target protein when the concentration is less than the binding affinity between the compound and the target through the sample preparation processes. (nature.com)
  • The latter low-affinity site functions in conjunction with the active site of MMP-2 to generate a tight enzyme-inhibitor complex. (uea.ac.uk)
  • By 1998, computational models for optimizing the binding of fullerene inhibitors of the HIV-1 protease led to the synthesis and testing of two C 60 -derived ligands for the HIV protease active site that displayed ~50-fold increase in affinity compared to previously tested fullerene compounds [ 735 ]. (nanomedicine.com)
  • PM 2.5 decreased the protein level of SIRT1 but not the mRNA expression in vitro and in vivo experiments. (medsci.org)
  • Recent research indicate that significant health advantages relating to the regulation of signaling proteins derive from the intake of omega-3 polyunsaturated essential fatty acids (agonist DHA. (bios-mep.info)
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • In contrast, cerulenin did not attenuate insulin release elicited by nonnutrient secretagogues, such as a depolarizing concentration of K+, activators of protein kinases A and C, and mastoparan. (diabetesjournals.org)
  • Other fullerene-based inhibitors of E. coli growth have been investigated [ 5236 ]. (nanomedicine.com)
  • Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
  • 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. (neobiotechnologies.com)
  • After depolarization in calcium-free solution, calcium chloride-induced concentration-dependent contractions, which were inhibited by GF109203X and Go6983. (uni-muenchen.de)
  • Toxicity may develop slowly because concentrations of chronically used drugs increase for 5 to 6 half-lives, until a steady state is achieved. (msdmanuals.com)
  • e.g., thrombin when bound to thrombomodulin activates protein C. Another example is factor V (FV), which in addition to being a procofactor to FVa has emerged as an anticoagulant. (lu.se)
  • Taking alpha-lipoic acid by mouth for up to 4 years seems to lower total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol in people with or without hyperlipidemia. (medlineplus.gov)
  • MCP-1 monocyte chemoattractant protein type 1 workplace. (cdc.gov)
  • The concentration of α2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. (wikipedia.org)
  • α2-Macroglobulin levels are increased when the serum albumin levels are low, which is most commonly seen in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. (wikipedia.org)
  • Increased concentrations are associated with patients with some Chronic liver diseases, Nephrotic syndrome, and Diabetes. (relmedlab.com)
  • In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. (rndsystems.com)
  • In contrast, in SIBO microorganisms in the small intestine synthesize folic acid, which can lead to an increase in folate absorption and in turn to an increased serum folate concentration. (vin.com)
  • Taking alpha-lipoic acid by mouth with or without standard hydration therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents. (medlineplus.gov)
  • We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. (oregonstate.edu)
  • Overexpression of miR-146a-3p downregulated the expression of SIRT1 protein in untreated RAW264.7 cells. (medsci.org)
  • We show that nelfinavir and lopinavir sustainably instigate B7H6 expression at their pharmacologically relevant concentrations. (iucc.ac.il)
  • In conclusion, decreased or increased protein expression of several TRPM4 variants linked to cardiac conduction disorders or ventricular arrhythmias were found to be caused by altered TRPM4 half-life compared to the WT form. (frontiersin.org)
  • IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2. (thermofisher.com)
  • Phenytoin and warfarin are examples of highly protein-bound drugs with a higher risk of toxic effects when the serum albumin level decreases. (msdmanuals.com)
  • In the resulting αM-protease complex, the active site of the protease is sterically shielded, thus substantially decreasing access to protein substrates. (wikipedia.org)
  • and finally FEV1 (% predicted) and myeloperoxidase, interleukin 8 and leukotriene B4, secretory leukoprotease inhibitor, and bronchial protein leak. (gla.ac.uk)
  • Elastase activity that exceeded 50nM was associated with decreased levels of secretory leukoprotease inhabitor and increased levels of bronchial protein leak. (gla.ac.uk)
  • Dietary cobalamin is bound to dietary protein. (vin.com)
  • In this fundamental process of life, the ribosome builds proteins according to the information encoded on the mRNA. (en-academic.com)
  • For drugs absorbed in the upper small intestine, such as acetaminophen, slowed gastrointestinal motility can delay the absorption and onset of action and reduce peak drug concentrations and pharmacologic effects. (msdmanuals.com)
  • Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. (diabetesjournals.org)
  • In isolated rat pancreatic islets, cerulenin inhibited the glucose augmentation of Ca2+-stimulated insulin release evoked by a depolarizing concentration of K+ in the presence of diazoxide and Ca2+-independent insulin release triggered by a combination of forskolin and phorbol ester under stringent Ca2+-free conditions. (diabetesjournals.org)
  • The R-protein in turn is digested by pancreatic proteases in the small intestine. (vin.com)
  • Therefore, severe and longstanding disorders of the distal small intestine as well as exocrine pancreatic insufficiency will lead to depletion of cobalamin body stores and to a decreased serum cobalamin concentration. (vin.com)