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AKR murine leukemia virusLeukemia Virus, MurineMice, Inbred AKRMoloney murine leukemia virusFriend murine leukemia virusLeukemia, ExperimentalAbelson murine leukemia virusLeukemia Virus, FelineRauscher VirusRetroviridae InfectionsLeukemia Virus, BovineLeukemiaRetroviridaeCell LineVirus ReplicationMink Cell Focus-Inducing VirusesDNA, ViralGenes, ViralRNA-Directed DNA PolymeraseReceptors, VirusMolecular Sequence DataProvirusesGene Products, gagTumor Virus InfectionsGammaretrovirusBase SequenceLeukemia, Myeloid, AcuteMice, Inbred StrainsVirus IntegrationLeukemia Virus, Gibbon Ape
Viral proteinsMiceTumorEndogenousGeneticLipid bilayerStrainDiseasesTransmembraneAttenuatesSequencesReceptorTypeLatencyParticlesCellsTranscriptionTotalAbilityMouseActivityComponentsDiseaseFactorsEndogenous retrovirusesMammaryViralRecombination of endogenousPolymeraseSendaiStructuralProgeny virusReplicationMachineryGeneExpressionGroupHostDirectly
Viral proteins2
  • As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
  • The lipid bilayer contains integrated host and viral proteins studded with carbohydrate molecules. (wikipedia.org)
Mice2
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. (arjournals.org)
Tumor3
  • A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. (arjournals.org)
Endogenous3
  • MLVs include both exogenous and endogenous viruses. (wikipedia.org)
  • citation needed] The MLVs include both exogenous and endogenous viruses. (wikipedia.org)
  • The genomes of exogenous and endogenous murine leukemia viruses have been fully sequenced. (wikipedia.org)
Genetic2
Lipid bilayer1
  • Proteins associated with the inner surface of the lipid bilayer of the viral envelope. (lookformedical.com)
Strain1
Diseases2
Transmembrane2
  • These changes lead to the release of the surface glycoprotein (SU) and the conformational rearrangement of the transmembrane protein (TM). (wikipedia.org)
  • The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. (thermofisher.com)
Attenuates1
  • A newly identified protein-binding site (MLPal) located within DEN affects transcription only in T cells, and its deletion attenuates the ability of an MCF13 virus with a single enhancer repeat to induce thymic lymphoma. (archive.org)
Sequences2
  • We have identified nucleotide sequences that regulate transcription in both a cell-type-specific and general manner in the long terminal repeat of the MCF13 murine leukemia virus. (archive.org)
  • A nucleotide sequence comparison revealed that the MCF13 MLV LTR contains sequences highly homologous to the protein-binding sites identified in the Mo-MLV LTR. (archive.org)
Receptor2
  • Recognition of a virus-encoded ligand by a natural killer cell activation receptor. (arjournals.org)
  • Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
Type4
  • The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. (wikipedia.org)
  • The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
  • Its deletion from the MCF13 virus dramatically reduced the incidence of thymic lymphoma and increased the latency of disease in comparison with the wild-type virus. (archive.org)
  • The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. (thermofisher.com)
Latency1
Particles3
  • This cleavage is essential for the Env incorporation into virus particles. (wikipedia.org)
  • The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
  • The expelling of virus particles from the body. (lookformedical.com)
Cells6
  • Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
  • Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells. (duke.edu)
  • Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
  • T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. (arjournals.org)
  • Yamaoka K, Ohno S, Kawasaki H, Suzuki K. Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. (arjournals.org)
  • We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
Transcription2
  • These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell. (lookformedical.com)
  • This observation suggests that the MLPal protein-binding site contributes to the effect of the DEN region on T-cell-specific transcription and viral leukemogenicity. (archive.org)
Total2
  • A total of 97 distinct protein forms belonging to 14 families were identified. (afpm.org.my)
  • The current study successfully profiled the venom proteome of authenticated N. sputatrix, and showed that the venom is made up of approximately 64% three-finger toxins (including neurotoxins and cytotoxins) and 31% phospholipases A2 by total venom proteins. (afpm.org.my)
Ability2
  • The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Mouse1
  • Several commonly used laboratory mouse strains such as BALB/c, SJL, AKR, CBA, C3H and A do not express the NK1.1 antigen. (thermofisher.com)
Activity2
  • Substances elaborated by viruses that have antigenic activity. (lookformedical.com)
  • The notion that the activity of this downstream region is mediated by transactivating factors is supported by the observations that protein binding occurs to analogous sites in the Friend and MCF13 MLV LTRs (32, 58). (archive.org)
Components1
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
Disease1
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
Factors1
  • Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (lookformedical.com)
Endogenous retroviruses2
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Radiation-induced murine leukemias and endogenous retroviruses: the time course of viral expression. (microbiologyresearch.org)
Mammary1
  • different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. (liverpool.ac.uk)
Viral4
  • As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
  • The lipid bilayer contains integrated host and viral proteins studded with carbohydrate molecules. (wikipedia.org)
  • Different serotypes of B-tropic murine leukemia viruses and association with endogenous ecotropic viral loci. (microbiologyresearch.org)
  • Specific motifs in viral proteins called late assembly domains (L-domains) are responsible for recruiting the host ESCRT machinery directly or via ESCRT-associated proteins like ALIX. (expasy.org)
Recombination of endogenous1
  • Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (microbiologyresearch.org)
Polymerase1
  • From 5' to 3' (typically displayed as "left" to "right"), the genome contains gag, pol, and env regions, coding for structural proteins, enzymes including the RNA-dependent DNA polymerase (reverse transcriptase), and coat proteins, respectively. (wikipedia.org)
Sendai4
  • PMID- 6299951 TI - Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. (nih.gov)
  • AB - The pneumotropism of Sendai virus in mice was studied in relation to the activation and replication of the virus in the lung. (nih.gov)
  • Inactive Sendai virus grown in LLC-MK(2) cells, which possessed an uncleaved precursor glycoprotein, F, and was noninfectious to tissue culture cells, neither grew nor caused pathological changes in the lung of mice. (nih.gov)
  • The overall results suggest that some activating mechanism for the progeny virus of wild-type Sendai virus exists in the lung of mice and the principle (activator) responsible for this phenomenon has a character similar to trypsin. (nih.gov)
Structural1
Progeny virus3
  • The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
  • In this case, the progeny virus was produced in the activated form and multiple-cycle replication occurred successively. (nih.gov)
  • The progeny virus, however, remained inactive, and the replication was limited to a single cycle, which resulted in the limited lung lesion. (nih.gov)
Replication1
  • When trypsin treatment was made which cleaved F into F(1) and F(2) subunits, the virus became activated so that it could initiate replication in the bronchial epithelium of the lung. (nih.gov)
Machinery2
  • PPxY motif enlists members of the NEDD4 family of ubiquitin ligases through interactions with WW domains, although the precise link between the NEDD4-like proteins and the ESCRT machinery is still unknown. (expasy.org)
  • YP(x)n L binds the adaptor protein ALIX , which in turn binds and recruits the ESCRT machinery. (expasy.org)
Gene2
  • It is also nuclear, but is neither as polymorphic nor as ubiquitous as the pp53 - found only in SV-transformed cells, It appears to be a cellular protein whose expression is related to expression of A gene, The proteins secreted by normal and transformed proteins reported previously by Hynes lab were reviewed. (nih.gov)
  • Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
Expression1
  • Protein expression levels were detected by Western blotting. (bvsalud.org)
Group1
Host1
  • It appears to be a polymorphic protein, variant from species to species, barely detectable (if at all) in normal ac cells (except for undifferentiated EC cells), induced by SV4O transformation and, it turns, out , by other forms of oncogeneisis, as well: Jay has found t what is proabaly the a same protein in a host of m neoplastic cells by using antibodies raised against various MCAinduced tumors. (nih.gov)
Directly2
  • It also appears in normal cells during early G . The protein is phosphorylated and can be precipitated either directly by antisera or by virtue of its apparent ability to bind to T antigen. (nih.gov)
  • src These could explain the "perinuclear" location of pp60 claimed by Rohrschnieder, since Kasamatsue found antibodues against the proteins in random tumor antisera, but not in normal sera, THE EARLY REGION OF ADENOVIRUS Presentations foa focused on the transcription, Splicing and regulation of ths region and, in the words of no less than Phil Sharp, "bewildering", and certainly provided no d information beariang directly on the main topic of the meeting. (nih.gov)