• Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent. (phosphosite.org)
  • We previously revealed increased oxidative stress and high expression of antioxidant proteins in culture cell lines established from lesional lung tissues with IPF (Kabuyama Y, Oshima K, Kitamura T, Homma M, Yamaki J, Munakata M, Homma Y. Genes Cells 12: 1235-1244, 2007). (scialert.net)
  • ACADSB Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. (phosphosite.org)
  • These mutants have defects in peroxins, which disrupt peroxisomal biogenesis or import, or in proteins acting within the peroxisome matrix, affecting specific pathways including fatty acid -oxidation and valine catabolism. (umsl.edu)
  • It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. (wikipedia.org)
  • Since the complex proteomes consist of a number of proteins with diversified functions, they pose a challenge for quantitative proteomics analysis. (hindawi.com)
  • It first binds glutaryl-CoA substrate to the oxidized form of the enzyme and abstracts the alpha-proton of the substrate by the Glu370 catalytic base. (wikipedia.org)
  • Thus, this allows for the decarboxylation of glutaconyl-CoA, an enzyme-bound intermediate, by breaking the Cγ-Cδ bond, resulting in formation of a dienolate anion, a proton, and CO2. (wikipedia.org)
  • The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. (genecards.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • freeQuant supports label-free quantitative analysis which makes full use of tandem mass spectrometry (MS/MS) spectral count, protein sequence length, shared peptides, and ion intensity. (hindawi.com)
  • Delivery of peroxisome-targeted matrix proteins depends on the PEX5 receptor docking with PEX13 at the peroxisomal membrane, and we found severely reduced import of matrix proteins and less organelle-associated PEX5 in pex13-4 seedlings. (deepdyve.com)
  • Calmodulin-like protein AtCML3 mediates dimerization of peroxisomal processing protease AtDEG15. (deepdyve.com)
  • Two peroxisomal targeting signals (PTS), the C-terminal PTS1 and the N-terminal PTS2, mediate the translocation of proteins into the organelle. (deepdyve.com)
  • Khan, B.R. and Zolman, B.K. (2010) pex5 mutants that differentially disrupt PTS1 and PTS2 peroxisomal matrix protein import in Arabidopsis. (umsl.edu)
  • Zolman, B.K., Silva, I.D., and Bartel, B. (2001) pxa1 , an Arabidopsis -oxidation mutant, is defective in a protein required for the peroxisomal import of both fatty acids and indole-3-butryic acid. (umsl.edu)
  • They use alternative metabolic pathways and have anaplerotic effects due to propionyl-CoA production by the thiolytic cleavage of odd carbon ketone bodies. (clinicaltrials.gov)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • Because previously described Arabidopsis pex13 alleles either are lethal or confer only subtle defects, the pex13-4 mutant provides valuable insight into plant peroxisome receptor docking and matrix protein import. (deepdyve.com)
  • PIQED: automated identification and quantification of protein modifications from DIA-MS data. (nih.gov)
  • Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates. (nih.gov)
  • Identification and characterization of AckA-dependent protein acetylation in Neisseria gonorrhoeae. (nih.gov)