Protein acts as a transcriptional activator. Medical search. Frequent questions

Drosophila protein pannier (or DGATAa) (gene pnr) which acts as a repressor of the achaete-scute complex (as-c). (expasy.org)
Pax5 (BSAP) is essential for B cell development and acts both as a transcriptional activator and a repressor. (elsevierpure.com)
These data suggest that Daxx can affect Pax5's roles as an activator or repressor in B cells and describe a role for Daxx as a transcriptional coactivator. (elsevierpure.com)
The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. (silverchair.com)
In the absence of Hh, Ci is processed and acts as a transcriptional repressor. (silverchair.com)
ORF63 protein acts as transcriptional repressor and activator of host and viral promoters, inhibits interferon-alpha induced antiviral response (J Virol 2007. (com.hr)
It thus appears that YY1 is a bifunctional protein, capable of functioning asan activator in some transcriptional control elements and a repressor in others. (baxkyardgardener.com)
In lower multicellular fungi, the C2H2 zinc finger CreA/CRE1 protein has been shown to act as the transcriptional repressor in this process. (biomedcentral.com)

Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
The Arabidopsis genome contains an estimated 340,000 potential MADS binding sites ( de Folter and Angenent, 2006 ), leading to the intriguing question: What is the biological significance of the large number of potential MADS binding sites, and how many target genes do MADS proteins really regulate? (frontiersin.org)
Based on these studies, it appears that MADS proteins may directly regulate thousands of target genes (Figure 1 A), and may serve to integrate different biological processes. (frontiersin.org)
(A) Network representation (Cytoscape) of the reported target genes (represented by blue lines) of the four MADS proteins (yellow circles). (frontiersin.org)
The four MADS proteins share 70 target genes. (frontiersin.org)
Several of the SNF and SWI genes of Saccharomyces cerevisiae encode proteins that are involved in the regulation of transcriptional activation. (bdbiosciences.com)
The retinoblastoma protein, Rb, stimulates the transcription of a number of genes. (bdbiosciences.com)
Muchardt C, Yaniv M. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. (bdbiosciences.com)
The GATA family of transcription factors are proteins that bind to DNA sites with the consensus sequence (A/T)GATA(A/G), found within the regulatory region of a number of genes. (expasy.org)
GATA-3 [ 3 ], a transcriptional activator which binds to the enhancer of the T-cell receptor α and delta genes. (expasy.org)
Caenorhabditis elegans elt-1 and elt-2, transcriptional activators of genes containing the GATA region, including vitellogenin genes [ 6 ]. (expasy.org)
Neurospora crassa nit-2 [ 9 ], a transcriptional activator which turns on the expression of genes coding for enzymes required for the use of a variety of secondary nitrogen sources, during conditions of nitrogen limitation. (expasy.org)
Neurospora crassa white collar proteins 1 and 2 (WC-1 and WC-2), which control expression of light-regulated genes. (expasy.org)
The genome of E. coli MG1655 is 4,641,642 bp, corresponding to 4702 genes encoding 4328 proteins. (encyclopedia.pub)
The genome size of E. coli strain K-12 MG1655 is 4,641,652 bp, corresponding to 4702 genes encoding 4328 proteins, 228 RNA genes, and 146 pseudogenes. (encyclopedia.pub)
Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. (xenbase.org)
Studies on transcriptional regulation of endogenous genes by ERF2 transcription factor in tobacco cells. (gao-lab.org)
Here, we used genome-scale loss-of-function screening to establish genes critical for IFN-induced transcription, identifying all expected members of the JAK-STAT signaling pathway and a previously unappreciated epigenetic reader, bromodomain-containing protein 9 (BRD9), the defining subunit of non-canonical BAF (ncBAF) chromatin-remodeling complexes. (helmholtz-hzi.de)
It binds to downstream elements inseveral vertebrate ribosomal protein genes, where it apparently acts positively to stimulatetranscription and can act either negatively or positively in the context of the immunoglobulin k 3enhancer and immunoglobulin heavy-chain E1 site as well as the P5 promoter of theadeno-associated virus. (baxkyardgardener.com)
Tissue-specific deletion of important autophagy genes (ATG) such as for example or has uncovered that autophagy has a cytoprotective function by degrading possibly dangerous aggregated proteins and broken organelles (2C9). (careersfromscience.org)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)
A subset of these, the conserved class A ARFs, are transcriptional activators of auxin-responsive target genes that are essential for regulating auxin signalling throughout the plant lifecycle. (ofr.su)
Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. (silverchair.com)

it acts as an enhancer that recapitulates the posterior expression pattern of gt (Berman, 2002). (sdbonline.org)
Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. (utsouthwestern.edu)

Ustilago maydis urbs1 [ 7 ], a protein involved in the repression of the biosynthesis of siderophores. (expasy.org)
Emericella nidulans areA [ 8 ], a transcriptional activator which mediates nitrogen metabolite repression. (expasy.org)
In addition, we found CRE1-repression of nitrogenous substances uptake, components of chromatin remodeling and the transcriptional mediator complex, as well as developmental processes. (biomedcentral.com)

The decreased expression and inhibition of nuclear transfer of GLI1 downregulated macrophage M1 polarization and osteoclast activation, the effect of which was achieved by modulation of DNA methyltransferases (DNMTs) via transcriptional regulation and protein interactions. (elifesciences.org)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. (xenbase.org)
Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways mediated by ethylene, that seems to depend on a protein kinase cascade, and to be influenced by methyl-jasmonate. (gao-lab.org)
Wounding leads to a both local and systemic expression, independently of ethylene, and through a de-novo-protein-synthesis-independent regulation. (gao-lab.org)
The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)

Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)
Drosophila box A-binding factor (ABF) (also known as protein serpent (gene srp)) which may function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. (expasy.org)
In invertebrates, such as Drosophila , Hh binds its receptor Patched (Ptc) and thereby activates Smoothened (Smo),another transmembrane protein. (silverchair.com)

GW9 encodes a nucleus-localized protein containing both C2H2 zinc finger (C2H2-ZnF) and VRN2-EMF2-FIS2-SUZ12 (VEFS) domains, serving as a negative regulator of grain size and weight. (bvsalud.org)
Transcriptional regulator. (biocuckoo.org)
A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. (bvsalud.org)

STAT2 (AAH51284, 742 a.a. ~ 851 a.a) partial recombinant protein with GST tag. (abnova.com)
Mechanistically, BRD9 acts at the level of transcription, and its IFN-triggered proximal association with the ISG transcriptional activator, STAT2, suggests a functional localization at selected ISG promoters. (helmholtz-hzi.de)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Acts as a transcriptional activator and may be involved in disease resistance pathways. (gao-lab.org)
We integrated the SARS-CoV-2 RNA interactome with changes in proteome abundance induced by viral infection and linked interactome proteins to cellular pathways relevant to SARS-CoV-2 infections. (helmholtz-hzi.de)

Hb, Kr, and Kni are zinc-finger gap proteins that act primarily as repressors in specific embryonic domains. (sdbonline.org)

A component of promyelocytic leukemia protein nuclear bodies, Daxx has been implicated in apoptosis and characterized as a transcriptional corepressor. (elsevierpure.com)
This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. (biocuckoo.org)

Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. (wikipedia.org)

Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)

Transfected Brm, expressed in cells lacking endogenous protein, can cooperate with the glucocorticoid receptor (GR) in transcriptional activation. (bdbiosciences.com)
Singh P, Coe J, Hong W. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. (bdbiosciences.com)
The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. (utsouthwestern.edu)
mTORC1 suppresses autophagy and in parallel promotes cell development via the activation of eIF4E and ribosomal S6 proteins kinase (S6K) (15). (careersfromscience.org)

Gene cloning and physiological and biochemical experiments reveal that sts is a novel mutant allele of Mitogen-activated protein Kinase Kinase 4 (OsMKK4), which controls the grain size, and has recently been found to be related to salt tolerance in rice. (bvsalud.org)
Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
EGCG significantly inhibited phosphorylation of the MAPKs p38 and c-Jun N-terminal kinase (JNK), and NFκB and AP-1 transcriptional activities. (molvis.org)

This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
GS9 acts as a transcriptional activator to regulate rice grain shape and appearance quality. (github.io)
The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. (nottingham.ac.uk)

More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. (enzolifesciences.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
GATA-2 [ 2 ], a transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. (expasy.org)
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. (expasy.org)
The levels of CD44 mRNA and protein expression were greatly increased by EGF and by TGF-α in SKBR3 and BT474 breast cancer cells. (iiarjournals.org)
Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. (xenbase.org)
This purified protein, which is homologous to human DNA-binding protein YB-1, recognizes some feature of the 110-bp promoter region of hns and acts as a cold shock transcriptional activator of this gene since it stimulates the expression of CAT activity and of cat transcription in in vitro systems programmed with plasmid DNA carrying the hns-cat fusion. (unicam.it)
Levels of cel5D mRNAs in the mutant were 16 fold lower than that of the wild-type strain suggesting that GlyR2 acts as an activator of cel5D expression. (nottingham.ac.uk)
This protein belongs to the rel proto-oncogene and NF-KB transcriptional factor family and acts by controlling zygotic gene expression. (silverchair.com)

Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. (biocuckoo.org)

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. (novusbio.com)

LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
Some other proteins contain a single zinc finger motif highly related to those of the GATA transcription factors. (expasy.org)

Upon transient transfection assay of Daxx in B cells expressing endogenous Daxx and Pax5, we observed not only transcriptional corepression but also, unexpectedly, coactivation in M12.4.1 and A20 mouse B cell lines. (elsevierpure.com)

ZNF398 (NP_065832.1, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. (novusbio.com)
Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. (novusbio.com)
Antibody Reactive Against Recombinant Protein. (abnova.com)

Through this constitutive activity, NF-κB p50/p65 acts in tumors mainly as an inhibitor of apoptosis [ 8 , 14 ]. (oncotarget.com)

ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. (biocuckoo.org)
show, by investigating chromatin modifications and accessibility, that loci encoding these proteins are constitutively open for transcription. (ofr.su)

Activated and released IRE1α acts as an RNase to initiate transcription of XBP1 mRNA and it becomes a transcriptional activator for unfolded protein response (UPR) gene targets, such as BiP and calreticulin ( 10 ). (spandidos-publications.com)

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. (thermofisher.com)
a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)

ORF63 protein is 278 amino acids long tegument protein expressed with an immediate-early kinetics (J Gen Virol 1986. (com.hr)

Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)
Saccharomyces cerevisiae DAL81 (or UGA43), a negative nitrogen regulatory protein. (expasy.org)
Saccharomyces cerevisiae GLN3, a positive nitrogen regulatory protein. (expasy.org)

The hormone auxin is a key signal for plant growth and development that acts through the AUXIN RESPONSE FACTOR (ARF) transcription factors. (ofr.su)

Using RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. (helmholtz-hzi.de)

Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
The second subfamily of proteins (p105 and p100) has a C-terminal region that contains multiple copies of ankyrin repeats, instead of a transactivation domain, and can bind to and inhibit Rel proteins. (oncotarget.com)
In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. (abnova.com)
It codes for a 'b-HLH' DNA-bind-ing protein which can dimerize and bind to DNA in vitro and to polytene chromosomes in vivo. (silverchair.com)

Autophagy is a vesicular trafficking pathway that regulates the degradation of aggregated protein and damaged organelles. (careersfromscience.org)

C. elegans homeobox protein ceh-14. (embl.de)
C. elegans homeobox protein unc-97. (embl.de)

Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)

The SARS-CoV-2 RNA-protein interactome in infected human cells. (helmholtz-hzi.de)

Most peaks, clearly enriched for CArG-box sequences, are present in upstream promoter regions close to the transcriptional start site, though some are also found in introns and 3′-UTR regions. (frontiersin.org)

Using a yeast two-hybrid assay to identify potential coregulators of Pax5, we identified Daxx, a protein that is highly conserved, ubiquitously expressed, and essential for embryonic mouse development. (elsevierpure.com)
The Hedgehog (Hh) family of secreted proteins plays an important role during embryonic development in regulating growth, patterning and morphogenesis of many tissues ( Ingham and McMahon, 2001 ). (silverchair.com)
Thus, the first events of embryonic development along the D/V axis are controlled at the transcriptional level. (silverchair.com)

Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)

Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. (thermofisher.com)

The primary antibody is intended for laboratory professional use in the detection of the corresponding protein in formalin-fixed, paraffin-embedded tissue stained in manual qualitative immunohistochemistry (IHC) testing. (thermofisher.com)
Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)

Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)
This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (utsouthwestern.edu)
The precise function of PtdIns(3)P in autophagy is normally unclear, but research claim that PtdIns(3)P recruits particular effector proteins such as for example Atg18/WIPI (22, 23) and DFCP1 (dual FYVE domain-containing proteins 1) (19), both which may are likely involved in autophagosome formation. (careersfromscience.org)

The human Brm protein has been reported to be a 180 kDa nuclear factor that acts as a transcriptional activator when fused to a heterologus DNA binding domain. (bdbiosciences.com)
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)

Several transcriptional and post-transcriptional regulatory mechanisms control the preferential use of glucose over other sugars. (encyclopedia.pub)

Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (PubMed:14602201). (proteopedia.org)

Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES. (bvsalud.org)

Induction by purified xylanase from Trichoderma viride (TvX) and another elicitor from Phytophthora infestans (PiE), that appears to be mediated by both protein kinases and protein phosphatases. (gao-lab.org)
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (abnova.com)

Fission yeast protein GAF2. (expasy.org)

Tissue culture supernatant is purified by either protein A/G or affinity purification methods. (bdbiosciences.com)

Alternative translocations include EWS-ERG t(21;22), EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. (medscape.com)

As a consequence, processing of Cubitus interruptus (Ci) is inhibited and Ci enters the nucleus to act as a transcriptional activator. (silverchair.com)

Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)

Coactivation apparently involves recruitment of the CREB binding protein (CBP), because we precipitated complexes containing Pax5, Daxx, and CBP in B cell lines. (elsevierpure.com)

We demonstrated by genetic perturbation that cellular nucleic acid-binding protein (CNBP) and La-related protein 1 (LARP1), two of the most strongly enriched viral RNA binders, restrict SARS-CoV-2 replication in infected cells and provide a global map of their direct RNA contact sites. (helmholtz-hzi.de)

The identification and characterization of the transcriptional regulatory networks governing the physiology and adaptation of microbial cells is a key step in understanding their behaviour. (biomedcentral.com)

Anatomy12

Organisms19

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes80

Technology, Industry, Agriculture1

Information Science3

Repressor8

Genes23

Enhancer4

Repression3

Regulation8

Drosophila3

Regulator3

STAT22

Pathways3

Repressors1

Corepressor2

Promoters1

Binds1

Activation4

Kinase3

Regulate3

Expression9

Coactivator1

C2H21

Zinc4

Endogenous1

Recombinant Protein3

Apoptosis1

Chromatin2

MRNA1

Differentiation3

Amino acids1

Saccharomyces3

Transcription factors1

Human proteins1

Bind5

Regulates1

Elegans2

Inhibition1

Interactome1

Promoter regions1

Embryonic3

Vertebrate3

Helix-loop-1

Antibody2

Function4

Nuclear3

Glucose1

Lipid1

Receptors1

Kinases2

Yeast1

Purification1

Family protein1

Nucleus1

Sequence3

Complexes1

Genetic1

Identification1