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Transcription FactorsMSX1 Transcription FactorTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceHomeodomain ProteinsTranscriptional ActivationBinding SitesTrans-ActivatorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Gene Expression Regulation, DevelopmentalRepressor ProteinsCell LineForkhead Transcription FactorsSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsMutationTranscription Factor AP-2Cell DifferentiationCell NucleusTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationYY1 Transcription FactorHeLa CellsCells, CulturedSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDPaired Box Transcription FactorsNFATC Transcription FactorsActivating Transcription Factor 3Reverse Transcriptase Polymerase Chain ReactionSp3 Transcription FactorTranscription Initiation SiteNF-kappa BZinc FingersElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingE2F1 Transcription FactorRNA Polymerase IICloning, MolecularGene ExpressionRecombinant Fusion ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPlasmidsMEF2 Transcription FactorsGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorProtein Structure, TertiaryLuciferasesSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorTranscription Factor RelAE2F Transcription FactorsPhosphorylationHelix-Loop-Helix MotifsChromatinOligonucleotide Array Sequence AnalysisModels, BiologicalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMice, KnockoutGene Expression Regulation, PlantSequence Homology, Amino AcidGATA6 Transcription FactorIn Situ HybridizationActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinProto-Oncogene ProteinsDown-RegulationMice, TransgenicTranscription Factor TFIIIABlotting, WesternTATA BoxNFI Transcription Factors
GenesPax3Evolutionarily conservedReceptorDifferentiationAmino AcidsHomeodomain transcription factorsTumorInteractionsSubunitDlx1SynthesisChromatinRegulatorsEnhancerEffectorsComplexesBasalDevelopmentalMoleculesCytoplasmicReceptorsEmbryonic developmentBHLHHistoneGene expressionMutationsCellsMyogeninNuclear FactorFamilyTranscriptional repressorPathwaysEmbryoRepressorInteractInductionHeat shock p
Genes16
  • The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. (wikipedia.org)
  • Other genes, most of which act downstream of Wnt include Msx1, Pax3, and Mesogenin 1 (Msgn1). (wikipedia.org)
  • We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
  • Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. (biomedcentral.com)
  • HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. (biomedcentral.com)
  • This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
  • [ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)
  • Although the etiology of dental agenesis The association between AXIN2 and CRC involves defects in the involved genetic and environmental factors, the genes more canonical WNT signaling pathway, which regulates and coordi- frequently associated with hypodontia in different populations are nates the AXIN complex for the degradation of β-catenin under 2,3 AXIN2, MSX1, PAX9, EDA, and WNT10. (sagepub.com)
  • nonpolyposis CRC syndrome (Lynch syndrome), involve mutations Somatic mutations in the AXIN-complex proteins associated with in germline or in repair genes. (sagepub.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • 25 The downstream target genes of MAPK signaling cascades comprise of the differentiation related transcription aspects Jun ATF2/AP1, C/EBPB and Egr one, which are known to get necessary for myeloid differentiation. (chk1inhibitor.com)
  • Proteína homeótica y factor de transcripción que se localiza en el núcleo celular donde activa la expresión de genes tiroideos específicos como el de la TIROGLOBULINA y el RECEPTOR DE TIROTROPINA. (bvsalud.org)
  • A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. (bvsalud.org)
  • Dentro de esta revisión se describe la fuerte asociación entre las fisuras orales y las mutaciones de genes Msx1, sonic hedgehog, proteínas morfogenéticas óseas y factor de crecimiento fibroblástico durante la migración de las células de la cresta neural y la modelación y formación del paladar. (bvsalud.org)
  • The results showed that among the top 20% of overexpressed genes, gene families related to protein synthesis and structural components were much more abundant in S . leurokolos compared to A . longirostris . (prelekara.sk)
  • Finally, genes related to structural proteins, immune proteins and protectants were overexpressed or positively selected. (prelekara.sk)
Pax31
  • Morphorgens such as Wnt, fibroblast growth factor (FGF), retinoic acid (RA) and bone morphogenetic protein (BMP) secreted from the paraxial mesoderm and epidermis regulates the expression of a group of transcription factors ( Pax3, Zic1, Msx1 ) whereby defines the boarder of neural crest. (biomedcentral.com)
Evolutionarily conserved2
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
Receptor10
  • Prosaposin can exhibit a neurotrophic effect through the G protein-coupled receptor (GPR), and GPR37 and GPR37L1 are its candidate receptors. (bvsalud.org)
  • The receptor of the subgroup A avian leukosis virus (ALV-A) in chicken is Tva, which is the homologous protein of human CD320 (huCD320), contains a low-density lipoprotein (LDL-A) module and is involved in the uptake of transcobalamin bound vitamin B12/cobalamin (Cbl). (bvsalud.org)
  • In embryos, chimeric variations of (mouse homologue of fused towards the ligand binding site of human being glucocorticoid receptor (GR) was utilized to activate HES-1 and MSX-1 by inducing their nuclear translocation after dexamethasone (Dex) addition. (globaltechbiz.com)
  • G protein-coupled receptor 83. (gsea-msigdb.org)
  • In vitro, Mage-D1 not only binds to p75 neurotrophin receptor (p75NTR) but also to distal-less homeobox 1(Dlx1) and msh homeobox 1 (Msx1). (researchsquare.com)
  • In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
  • Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
  • Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
  • Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
  • The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
Differentiation9
  • Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
  • Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
  • To check this hypothesis, we overexpressed inducible types of HES-1 and MSX-1 proteins in mouse ESCs and examined differentiation into Azlocillin sodium salt NC derivatives, including neural, soft muscle tissue, and chondrocyte-like cells, after activation of the transcription elements. (globaltechbiz.com)
  • Manifestation of Hes1 and Msx1 in Wild-type Sera Cells in Pluripotent Circumstances and after NC Differentiation To investigate the part of and in the differentiation of mESCs into neural crest cells, we utilized the stromal cell-inducing activity of Pre-adipose 6 (PA6) cells for 5 times [17], accompanied by the addition of BMP4, which commits cells to differentiate into NC derivatives [6]. (globaltechbiz.com)
  • Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
  • We observed that the protein levels of Brd4 decreased upon differentiation together with global histone H4 acetylation. (biomedcentral.com)
  • Inhibition of Brd4:histone H4 interaction by the BET domain inhibitor (+)-JQ1 in ESCs results in enhanced differentiation to the endodermal lineage, by disrupting the protein abundance dynamics. (biomedcentral.com)
  • They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
  • This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. (cancer-genetics.org)
Amino Acids1
  • Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). (nih.gov)
Homeodomain transcription factors1
  • Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
Tumor2
  • We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit. (molcells.org)
  • Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
Interactions5
  • Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
  • Of particular interest are the protein interactions that occur between Hox proteins and general transcription factors (GTF) from the RNA Pol II basal transcription machinery. (biomedcentral.com)
  • Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
Subunit4
Dlx11
  • p75NTR, Dlx1, and Msx1 seem to be closely related to the underlying mechanism of Mage-D1 action. (researchsquare.com)
Synthesis1
  • The resulting decrease in protein synthesis, proliferation and survival leads to a drastic reduction of cranial neural crest cells early in fetal development and a loss of most facial structures in the absence of either protein. (bvsalud.org)
Chromatin2
Regulators2
  • As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Enhancer1
  • Msgn1 activates SNAI1 by binding to its enhancer and activating SNAI1 to induce EMT. (wikipedia.org)
Effectors1
Complexes3
  • Once activated, R-Smads accumulate in the nucleus where they associate with Smad4, a common partner for all R-Smads, to form transcription complexes. (biomedcentral.com)
  • Here we report Antennapedia (Antp) Hox protein-protein interaction with the TATA-binding protein (TBP) and the formation of novel trimeric complexes with TFIIEβ and Extradenticle (Exd), as well as its participation in transcriptional regulation. (biomedcentral.com)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
Basal2
  • Here, we focused on the interplay between Antp and the basal transcription machinery and show the direct interaction of Antp with TBP through the poly-glutamine (PolyQ) regions of both proteins. (biomedcentral.com)
  • They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)
Developmental3
  • Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
  • We observed that, as skeletal muscle progressed from perinatal to postnatal and adult developmental stages, MSY3 protein became gradually dephosphorylated and accumulated in the nucleus. (biomedcentral.com)
  • These proteins are transcription factors that control developmental pathways. (nih.gov)
Molecules1
  • Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
Cytoplasmic1
  • To further define which neurons express Eph, antibodies were generated to the cytoplasmic portion of the Eph protein. (sdbonline.org)
Receptors2
  • Smads 1, 5 and 8 are mainly activated by BMP and GDF receptors, while Smads 2 and 3 are substrates for TGF-β, activin and Nodal receptors. (biomedcentral.com)
  • IMPORTANCE Retroviruses bind to cellular receptors through their envelope proteins, which is a crucial step in infection. (bvsalud.org)
Embryonic development1
  • Snail is a family of transcription factors that promote the repression of the adhesion molecule E-cadherin to regulate epithelial to mesenchymal transition (EMT) during embryonic development. (wikipedia.org)
BHLH1
Histone3
  • Histone acetylation is bound by bromodomain-containing proteins. (biomedcentral.com)
  • A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. (childrensmercy.org)
  • A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. (childrensmercy.org)
Gene expression2
  • In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
Mutations1
Cells5
  • We found that transcripts were increased in MGR cells, whereas coactivation of HGR+MGR caused a significant increase in (-found that some of the transcription factors associated with the development of the NC are coexpressed with pluripotency factors at the blastula and gastrula stages. (globaltechbiz.com)
  • The growth of individual tissue compartments is mainly related to the proliferation of the cells that comprise that compartment, whereas intercellular communication mediated by various morphogens and growth factors is responsible for coordination of growth between neighboring tissue compartments. (molcells.org)
  • In cells receive the WNT signal, β-catenin is stabilized and joins the addition, AXIN2 has also been independently associated with DNA-bound T-cell factor family of transcription proteins for tooth agenesis and non-syndromic cleft lip palate (NSCLP). (sagepub.com)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
Myogenin1
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
Nuclear Factor3
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
Family3
Transcriptional repressor2
  • When the prostaglandin signaling pathway is compromised, SNAI1 transcriptional repressor activity decreases, increasing E-cadherin protein levels during gastrulation. (wikipedia.org)
  • MSY3 is a DNA binding protein, which acts as a transcriptional repressor. (biomedcentral.com)
Pathways1
Embryo2
  • The nuclear protein encoded by this gene is structurally similar to the Drosophila Snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. (wikipedia.org)
  • In the embryo, zygotic transcription of Eph is confined to the nervous system. (sdbonline.org)
Repressor1
Interact1
  • Studies have confirmed that Mage-D1 can interact with a variety of proteins through its three domains 11 . (researchsquare.com)
Induction2
  • These coordinates are achieved through the induction of specific sets of transcription factors in response to a variety of extrinsic cues. (biomedcentral.com)
  • Nevertheless, many experimental techniques are designed inside a nonregulated style, precluding evaluation at different period factors during NC Rabbit Polyclonal to C-RAF induction. (globaltechbiz.com)
Heat shock p1