Protein _ human tumor cell line. Medical search. Frequent questions

Cellular transformation to neoplasm, tumor formation, and progression require an inherent crosstalk between the tumor microenvironment and the tumor. (biomedcentral.com)
The tumor microenvironment or tumor stroma comprises various cell types, including cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, and mesenchymal cells. (biomedcentral.com)
3D cell culture methods - and multicellular tumor spheroids (MCTS), in particular - are quickly becoming a valuable tool for studying the tumor microenvironment in cancer research . (corning.com)
Cancer scientists are creating increasingly complex tumor models that more accurately replicate in vivo conditions - including the tumor microenvironment, which plays a key role in tumor progression, according to a study published in BioTechniques . (corning.com)
modeling it in the tumor microenvironment, though, has been challenging. (corning.com)
Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)
In this context, miRNAs transferred by tumour derived extracellular vesicles (EVs) have previously been shown to create a favourable tumour microenvironment. (bvsalud.org)
The development of CRC is highly influenced by the tumour microenvironment. (lu.se)

Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
Kaempferol has been shown to inhibit cell growth, induce apoptosis and cell cycle arrest in several tumors, but not in renal cell carcinoma (RCC). (nih.gov)
MTT assay and colony formation assay were used to study cell growth, and flow cytometry was used to study apoptosis and cell cycles in different RCC cells treated with various doses of kaempferol. (nih.gov)
A significant inhibition on cell growth, induction of apoptosis and cell cycle arrest were observed in 786-O and 769-P cells after kaempferol treatment compared with the control group. (nih.gov)
Although studies in murine myeloid precursor cell lines indicated YPEL3 to have a role in apoptosis, human YPEL3 failed to demonstrate an apoptotic response using sub-G1 or poly ADP ribose polymerase cleavage as accepted indicators of programmed cell death. (wikipedia.org)
Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. (nih.gov)
We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would lead to survival and cell cycle arrest. (nih.gov)
Using a panel of Kras-driven, p53 restorable cell lines derived from genetically engineered mouse models of lung adenocarcinoma and sarcoma (both of which undergo cell cycle arrest upon p53 restoration), as well as lymphoma (which instead undergo apoptosis), we show that the level of mitochondrial apoptotic priming is a critical determinant of p53 reactivation outcome. (nih.gov)
Cells with high initial priming (e.g., lymphomas) lacked sufficient reserve antiapoptotic capacity and underwent apoptosis after p53 restoration. (nih.gov)
When primed by inhibition of their antiapoptotic proteins using genetic (BCL-2 or BCL-XL deletion or BAD overexpression) or pharmacologic (navitoclax) means, apoptosis resulted upon p53 restoration in vitro and in vivo. (nih.gov)
Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. (aacrjournals.org)
Furthermore, the combination of cisplatin and pirfenidone in NSCLC cells (A549 and H157 cells) leads to increased apoptosis and synergistic cell death. (biomedcentral.com)
A diagram of the synthesis of degradable nanocapsules into cell nuclei to induce apoptosis, or programmed cell death, in cancer cells. (understandingnano.com)
The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. (nih.gov)
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
Induces apoptosis in human malignant glioma cell lines. (sigmaaldrich.com)
Unexpectedly, this molecule promotes a caspase-dependent apoptosis that is unusual in the P-glycoprotein-overexpressing cells. (torvergata.it)
Interestingly, leukemia MDR1-expressing cells show lower LC50 values and a higher degree of apoptosis and caspase-3 activity than their drug-sensitive counterparts. (torvergata.it)
2006). A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells. (torvergata.it)
Inhibiting PAK1 signals induce tumor cell apoptosis (cell death). (thehealthyplanet.com)
The in vitro cell migration was also inhibited and apoptosis was induced by cabozantinib. (bvsalud.org)

It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
Tlx also plays an important role in glioblastoma, the most malignant of human brain cancers. (dkfz.de)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)
Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (origene.com)
Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
Leukemia is a malignant tumor of the hematopoietic system, mainly characterized by cell deoxyribonucleic acid mutations. (frontiersin.org)
It causes malignant proliferation of hematopoietic stem cells in the bone marrow, resulting in the production of cancerous cells that lack normal physiological functions. (frontiersin.org)
Because little to no tumor growth over time is usually observed and no evidence of malignant degeneration is reported with middle ear choristomas, conservative management with serial examinations is acceptable for those wishing to forego surgery. (medscape.com)
This chapter addresses the con- Coherence: carcinogenicity the induction of lung tumours, both cordance in studies of carcinogen- of tobacco smoke in humans benign and malignant, by cigarette icity and mechanisms between versus experimental animals smoke. (who.int)
Malignant pleural mesothelioma (MPM) is an aggressive cancer affecting the outer lining of the lung, with a median survival of less than one year. (cdc.gov)
The interactome is significantly enriched with genes differentially expressed in MPM tumors compared with normal pleura and with other thoracic tumors, genes whose high expression has been correlated with un-favorable prognosis in lung cancer, genes differentially expressed on crocidolite exposure, and ex-osomederived proteins identified from malignant mesothelioma cell lines. (cdc.gov)
[ 35 ] Tumor markers such as CA125 are not good discriminators of benign lesions from malignant lesions in premenopausal women but have better accuracy in postmenopausal women. (medscape.com)

The NCI-60 cell lines represent the most common tumor diseases in nine tissues (such as brain, breast, bowel, skin, and blood tissue). (genengnews.com)
However, the researchers also found some clearly distinguishable protein profiles between the tumor cells of different tissues. (genengnews.com)
Western blotting was employed to determine NGF level in PC and paracarcinoma tissues and in PC cell lines as well as pancreatic ductal epithelial cells. (hindawi.com)
NGF level was preeminently higher in PC tissues and cell lines than in paracarcinoma tissues and normal pancreatic epithelial cell lines. (hindawi.com)
We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
We have also found that smg p25A is mainly detected inneural tissues by use of its specific monoclonal antibody, and that the levels of smg p25A mRNA increase in PC12 cells after their differentiation into neuron-like cells. (nii.ac.jp)
These results suggest that smg p21 and smg p25A can be used as potential tumor markers for tumors derived from hematopoietic and neural tissues, respectively. (nii.ac.jp)
The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
For circulating cancer cells to be able to invade tissues and settle at other sites in the body, they have to exhibit a specific polarity. (dkfz.de)
Rae-1 transcripts are expressed in mouse embryos and several tumor cell lines but are absent from most normal adult tissues. (rndsystems.com)
MAGEH1 expression was downregulated in HCC tumor tissues compared with adjacent normal liver tissues and in samples from patients with tumor recurrence. (nih.gov)
We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)
Further, we correlated γ-H2AX expression in breast cancer tumor tissues with telomere length. (rug.nl)
Further, we correlated γ-H2AX expression in breast cancer tumor tissues with telomere length.RESULTS: γ-H2AX positive breast cancer cells exhibit more mutations, and - when p53 mutated - have shorter telomeres. (rug.nl)

Glioblastoma (GBM) is one of the most aggressive primary brain tumors, with a median survival time of about 14.6 months despite maximal therapy 1 . (nature.com)
VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
Cell survival was determined 7, 8, or 9 days after RT by the sulforhodamine B test. (biomedcentral.com)
Forced BCL-2 or BCL-XL expression reduced priming and resulted in survival and cell cycle arrest. (nih.gov)
Triptolide stymied cancer growth in cell line experiments and resulted in smaller tumors and prolonged survival in mouse experiments. (weeksmd.com)
It is well known that metastasis establishment, cell survival, and progression are affected by tumour-host cell interactions where changes in the host cellular compartments likely play an important role. (bvsalud.org)

To reveal that the NGF-TrkA signaling pathway was closely associated with PC PNI, in vitro neuroinvasion model was established by using MiaPaCa-2 cells via coculturing DRG cells in Matrigel. (hindawi.com)
In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
The impact on cell death in vitro as well as tumor growth in a mouse model was determined. (biomedcentral.com)
However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. (biomedcentral.com)
The effectiveness of these enzyme inhibitors has been established by many in vitro and in vivo experiments on a variety of tumor types ( 7 - 9 ). (iiarjournals.org)
Human fibroblasts (0-20g/ml) were used to assess the predictive value of in vitro to in vivo modeling systems. (cdc.gov)
Human fibroblast monocultures were found to be insufficient to fully replicate in vivo fibrosis outcomes suggesting in vitro predictive potential depends upon more advanced cell culture in vitro models. (cdc.gov)

Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. (lu.se)
Three-hundred-seventy-five of the 10,000 proteins belong to the kinase group. (genengnews.com)
In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)
Like the endogenous HPK1, both wild-type HPK1 and its kinase-dead mutant, HPK1-M46, overexpressed in Panc-1 cells, were also targeted by proteasome-mediated degradation. (aacrjournals.org)
After MG132 withdrawal, wild-type HPK1 protein expression was markedly decreased within 24 hours, but kinase-dead HPK1 mutant protein expression was sustained for up to 96 hours. (aacrjournals.org)
Therefore, HPK1 kinase activities were required for the loss of HPK1 protein in PDAs. (aacrjournals.org)
Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both endothelial and tumor cells, are one of the key proteins contributing to cancer development, and are involved in drug resistance. (researchgate.net)
The encoded protein is a general protein kinase capable of phophorylating several known proteins. (origene.com)
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. (sigmaaldrich.com)
Protein kinase C inhibitor. (sigmaaldrich.com)
The infected cells contain the RSV-transforming protein, pp60src, which has characteristic tyrosine specific protein kinase activity. (rupress.org)
PAK-1 kinase is required for the growth of more than 70% of human cancers such as pancreatic, colon, breast and prostate cancers, and neurofibromatosis. (thehealthyplanet.com)
The p21 activated Kinase PAK1 is implicated in tumor genesis. (thehealthyplanet.com)
Transcript and protein examination after modulation of miR-138 expression showed changes in CAF phenotype-specific molecules, focal adhesion kinase axis, and TGFß1 signaling pathway. (bvsalud.org)

We found that loss of HPK1 protein expression correlated significantly with the progression of pancreatic intraepithelial neoplasias ( P = 0.001) and development of invasive PDA. (aacrjournals.org)
Conventional treatment of prostate cancer (PCa) uses androgen-deprivation therapy (ADT) to inhibit androgen receptor (AR) signaling-driven tumor progression. (duke.edu)
We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. (researchgate.net)
Andreeff and colleagues are refining the drug as a potential targeted therapy for breast cancer stem cells, which are thought to be crucial to therapy resistance, disease progression and spread to other organs. (weeksmd.com)
Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions. (nus.edu.sg)
Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. (bvsalud.org)

Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
This change from stationary epithelial cells to the mobile mesenchymal stem cells is an important step in metastasis," Mani said. (weeksmd.com)
Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ) have now reported. (dkfz.de)
Furthermore, the scientists also found that the number of freely circulating tumor cells exhibiting this special polarity correlates with the risk of developing metastasis, both in human tumor cell lines and in mice. (dkfz.de)
The ECM a researcher chooses has a significant effect on cancer cell proliferation, initiation, invasion, and metastasis, and it alters how the tumor model responds to drug therapy. (corning.com)
Collagen is the most abundant fibrous protein found in mammals' ECMs, and it plays a critical role in tumor growth and metastasis because it promotes cell adhesion and migration. (corning.com)
Spheroids have also been used to study transcoelomic metastasis in ovarian cancer, in which primary tumor cells seep into the abdominal cavity, where they form spheroids and then travel through fluids to secondary sites. (corning.com)
Here, we show that miR-146a-5p is highly expressed in human melanoma brain metastasis (MBM) EVs, both in MBM cell lines as well as in biopsies, thereby modulating the brain metastatic niche. (bvsalud.org)

Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
Other partners of the intracellular metabolism of gemcitabine in relation to the cell cycle effects and DNA repair could be more responsible for the radiosensitising effect than dCK activity. (biomedcentral.com)

Nearly all anti-tumor drugs are targeted against cellular proteins," says Bernhard Küster, Ph.D., TUM chair of proteomics and bioanalytics. (genengnews.com)
Therefore, based on the characteristics of black phosphorus two-dimensional nanomedicine, experimental designs were conducted on its nanosheet preparation, polyethylene glycol modification, and anti-tumor drug loading. (frontiersin.org)
The anti-tumor activity of cabozantinib was investigated using three human MBM cell lines. (bvsalud.org)

Rae-1 protein expression on tumor cell lines has been implicated in in vivo tumor rejection. (rndsystems.com)
The study's results confirmed previous findings that a treatment protocol of cisplatin and radiation was superior to radiation alone and confirmed the feasibility of using primary tumor cells for spheroid formation, which could yield MCTS that more closely mimic in vivo tumor behavior. (corning.com)

We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
Overexpression of TRIM13 in NCI-H1975 and SPC-A-1 cells hampered cell proliferation. (cancerindex.org)

YPEL3's role as a novel tumor suppressor and its involvement in cellular proliferation were discovered during experiments to investigate p53 dependent cell cycle arrest. (wikipedia.org)
As a part of the p53 pathway response and its anti-proliferation role, cellular senescence has gained attention for its working relationship with tumor suppressor genes. (wikipedia.org)
However, Tamoxifen Z isomer enters into the cell, competitively binding with ER to form receptor complexes, inhibiting that estrogen plays an role, and inhibiting proliferation of breast cancer cells. (lookchem.com)
MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/ml of NGF or the NGF inhibitor Tanezumab for 24 h, CCK-8 and Transwell assays were employed to test cell proliferation, invasion, and migration, respectively. (hindawi.com)
BMP-4 treatment of AtT-20 mouse corticotrophinoma cells has an inhibitory effect on ACTH secretion and cell proliferation. (unisr.it)
MAGEH1 reduced HCC cell proliferation, migration and invasion ability. (nih.gov)
In this study, we investigated the effect of VPA on cell proliferation, apoptotic activity and invasive ability in glioblastoma (U87MG), melanoma (G361) and Askin (SKNMC) tumor cells. (iiarjournals.org)

It's been difficult to identify cancer stem cells in solid tumors," Andreeff said. (weeksmd.com)
About 85 percent of all solid tumors start in the lining of an organ, called the epithelium. (weeksmd.com)
Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)

Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)
We have found that the levels of smg p21 mRNA increase in hematopoietic leukemiae cells after their differentiation into hematopoietic cells. (nii.ac.jp)
Here, we find graded ERK phosphorylation correlating with cell differentiation in patient-derived colorectal cancer organoids with and without KRAS mutations. (researchgate.net)
Since the recruitment of HDAC leads to transcriptional repression, inhibitors of this enzymatic activity can reverse aberrant repression in cancer cells and lead to re-expression of epigenetically silenced genes involved in growth and differentiation processes. (iiarjournals.org)
We demonstrated previously that valproic acid (VPA) and other short-chain fatty acids, as HDAC inhibitors, can arrest cell growth and induce differentiation in human neuroblastoma cells ( 10 ). (iiarjournals.org)
and controlling the growth, division, and maturation (differentiation) of cells. (medlineplus.gov)
These changes may impair normal cell differentiation, which leads to the overgrowth of certain cell types, causing cancer. (medlineplus.gov)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
SUAP later attained its current designation as YPEL3 (Yippee like three), after it was discovered to be one of five human genes possessing homology with the Drosophila Yippee protein. (wikipedia.org)
YPEL3 was discovered to be a possible p53 target after a screen for such genes was performed in MCF7 breast cancer cells following RNAi knockdown of p53 negative inhibitors. (wikipedia.org)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
In contrast, the previously established ER-negative TMX2-28 cell line has decreased expression of both DOK7 and ELF5 and increased DNA methylation in the transcriptional start site region of these genes. (umass.edu)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. (ed.ac.uk)
Comparing gene expression between GD2+ cells and CD44 high/CD24 low cells revealed 100 percent correlation in the expression of 231 genes. (weeksmd.com)
Alternatively, abnormal SWI/SNF complexes may disrupt the regulation of genes that help control the growth and division of cells, which leads to cancer. (medlineplus.gov)
Known PPIs of the 62 MPM associated genes were derived from Biological General Repository for Interaction Datasets (BioGRID) and Human Protein Reference Database (HPRD). (cdc.gov)

Pancreatic cancer (PC) is a relatively common malignancy of the digestive system and one of the human malignancies with the worst prognosis [ 1 ]. (hindawi.com)
Similarly, HPK1 protein was not expressed in any of eight PDA cell lines examined but was expressed in immortalized human pancreatic duct epithelial (HPDE) cells. (aacrjournals.org)
Treatment of Panc-1 cells with a proteasome inhibitor, MG132, increased the HPK1 protein levels in a dose-dependent manner, suggesting that alteration in proteasome activity contributes to the loss of HPK1 protein expression in pancreatic cancer. (aacrjournals.org)
Thus, HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. (aacrjournals.org)
PAK1 has also been implicated for maintenance of glucose homeostasis in pancreatic beta cells and skeletal muscle. (thehealthyplanet.com)

CONCLUSIONS: The distinct ELF5 methylation of PR-positive primary tumors from women who had a PR-negative recurrence indicates the possibility of stratification of women for tailored treatment in the early stages of disease. (umass.edu)
If the ossicular chain is enveloped by the tumor, it should be removed, as recurrence in up to 18% of patients may occur if the ossicles are left intact. (medscape.com)

In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)

Initially discovered in a gene expression profiling assay of p53 activated MCF7 cells, induction of YPEL3 has been shown to trigger permanent growth arrest or cellular senescence in certain human normal and tumor cell types. (wikipedia.org)
Investigation into its function led to the discovery of YPEL3 being a novel protein whose growth suppressive activity is thought to be mediated through a cellular senescence pathway. (wikipedia.org)
Recognized hallmarks of cellular senescence include senescence associated(SA)beta galactosidase staining and the appearance of senescence-associated heterochromatic foci(SAHF) within the nuclei of senescent cells. (wikipedia.org)
Studies in U2OS osteosarcoma cells and MCF7 breast cancer cells have also demonstrated increased cellular senescence upon YPEL3 induction. (wikipedia.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD® CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
Seahorse Metabolic Analyzers service for rapid and quantitative measurement of cellular bioenergetics: Seahorse XF Analyzers measure the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a multi-well plate to interrogate key cellular functions such as mitochondrial respiration and glycolysis. (weizmann.ac.il)
Increased phosphorylation of the EGF receptor protein and of an 81,000-dalton cellular protein is dependent upon addition of EGF to the culture fluids, in both control and RSV-infected A431 cells. (rupress.org)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)
Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
In passive cellular immunotherapy, specific effector cells. (msdmanuals.com)
Novel PPIs were predicted by applying the HiPPIP algorithm, which computes features of protein pairs such as cellular localization, molecular func-tion, biological process membership, genomic location of the gene, and gene expression in microar-ray experiments, and classifies the pairwise features as interacting or noninteracting based on a random forest model. (cdc.gov)

The extremely poor prognosis of patients affected by these highly chemoresistant tumors has not significantly improved in recent decades, therefore new approaches in therapeutic regimens are mandatory. (iiarjournals.org)

MemA is a tumour marker preferentially expressed in human melanoma cell lines. (embl.de)
In the present study, we dissected the molecular mechanisms responsible for the procoagulant activity of MV3, a highly aggressive human melanoma cell line. (scielo.br)
In this study, the anticancer properties of VPA on neural crest-derived human tumor cell lines G361 melanoma, U87MG glioblastoma and SKNMC Askin tumor cells were investigated. (iiarjournals.org)
The effectiveness of HDAC inhibitors, expecially VPA, in neuroblastoma cells, prompted us to investigate the anticancer activity of VPA in other neural crest-derived malignancies, such as glioblastoma, melanoma and Askin tumor. (iiarjournals.org)
U87MG human glioblastoma and G361 human melanoma cells, obtained from Interlab Cell Line Collection (Genoa, Italy), and SKNMC Askin tumor cells, purchased from the American Type Culture Collection (Rockville, USA) were maintained in RPMI (Sigma, USA), supplemented with 10% fetal bovine serum (FBS), 2 mM glutamine, 50 U/ml penicillin and 50 μg/ml streptomycin and grown at 37°C in a humidified air with 5% CO 2 . (iiarjournals.org)

On the other hand, several studies have shown that viruses that normally infect one species can cause tumors if they are injected into a different species. (theepochtimes.com)
This new and unprecedented evidence for a link between SdhD dysfunction and p21(WAF1/Cip1) will open new avenues for the study of the mechanisms that cause tumors in Sdh mutants. (ed.ac.uk)

While investigating the p53 tumor suppressor protein, microarray studies which targeted Hdmx and Hdm2, both p53 negative regulators, revealed YPEL3 as a potential p53 regulated gene in MCF7 breast cancer cells. (wikipedia.org)
If the estrogen receptor (ER) is present in breast cancer cells, estrogen enters into tumor cells and binds with ER, promoting mRNA and DNA synthesis of tumor cells, stimulating tumor cell growth. (lookchem.com)
Scientists from the Technical University of Munich (TUM) have decoded the proteome of 59 tumor cell lines and say that they have found new ways to explain why cancer drugs do not have the same effect on all patients suffering from the disease. (genengnews.com)
The team identified over 10,000 different proteins in cancer cells. (genengnews.com)
The researchers used NCI-60 tumor cell lines which came from the U.S. National Cancer Institute. (genengnews.com)
The TUM group also showed that the protein pattern of the cells determines the effectiveness of cancer drugs. (genengnews.com)
We investigated how the cell lines react to 108 different cancer drugs and found that there are indeed proteins that indicate whether a cell will respond to certain therapeutic agents, or whether it will be resistant to the drug," explains Hannes Hahne, Ph.D. a TUM expert in mass spectrometry techniques. (genengnews.com)
Swedish Research Counsil (R.J.A.N.), National Cancer Institute (NCI) CA069246 and CA86355 (X.O.B.), and the American Brain Tumor Association (T.W.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
In another experiment in which the researchers additionally switched off the p53 protein as an important cancer brake, invasively growing glioblastomas arose from the cancer precursors. (dkfz.de)
The effects of pirfenidone alone and in combination with cisplatin on human patient-derived CAF cell lines and non-small cell lung cancer (NSCLC) cell lines were examined. (biomedcentral.com)
Therefore, a combined therapy that targets both the tumor cell and the CAFs might lead to novel therapies in cancer. (biomedcentral.com)
Devising a method for more precise and less invasive treatment of cancer tumors, a team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has developed a degradable nanoscale shell to carry proteins to cancer cells and stunt the growth of tumors without damaging healthy cells. (understandingnano.com)
In a new study, published online Feb. 1 in the peer-reviewed journal Nano Today, a group led by Yi Tang, a professor of chemical and biomolecular engineering and a member of the California NanoSystems Institute at UCLA, reports developing tiny shells composed of a water-soluble polymer that safely deliver a protein complex to the nucleus of cancer cells to induce their death. (understandingnano.com)
The process does not present the risk of genetic mutation posed by gene therapies for cancer, or the risk to healthy cells caused by chemotherapy, which does not effectively discriminate between healthy and cancerous cells, Tang said. (understandingnano.com)
This is a unique way to treat cancer cells and leave healthy cells untouched. (understandingnano.com)
This protein cargo accumulates in the nucleus of cancer cells and signals to the cell to undergo programmed self-destruction. (understandingnano.com)
The polymer shells are developed under mild physiological conditions so as not to alter the chemical structure of the proteins or cause them to clump, preserving their effectiveness on the cancer cells. (understandingnano.com)
Tests done on human breast cancer cell lines in laboratory mice showed significant reduction in tumor growth. (understandingnano.com)
Tang's group continues to research ways of more precisely targeting tumors, prolonging the circulation time of the capsules and delivering other highly sought-after proteins to cancer cells. (understandingnano.com)
ERK levels are generally higher in cancer cells adjacent to stromal cells at the invasive front and lower in more central areas of cancer specimens. (researchgate.net)
Non-small cell lung cancer (NSCLC) represents most of the diagnoses of lung cancer. (researchgate.net)
In this study, we performed Reverse Protein Phase Array (RPPA) analysis of murine lung cancer, which suggests that VEGFR2 protein is strongly positively regulated by MSI2. (researchgate.net)
cancer stem cells are being attended to - finally. (weeksmd.com)
Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of Texas MD Anderson Cancer Center report online in Journal of Clinical Investigation . (weeksmd.com)
Research in several types of cancer has shown cancer stem cells are a small subpopulation of cancer cells that are capable of long-term self-renewal and generation of new tumors. (weeksmd.com)
The breast cancer findings grew out of Andreeff's long-term research in mesenchymal stem cells, which can divide into one copy of themselves and one differentiated copy of a bone, muscle, fat or cartilage cell. (weeksmd.com)
Andreeff has shown these mobile mesenchymal stem cells home to wounds, including tumors, making them potential carriers of cancer therapy. (weeksmd.com)
In the current project, the researchers hypothesized that the cell markers expressed on the surface of mesenchymal stem cells would also be expressed on the surface of breast cancer stem cells. (weeksmd.com)
They found that GD2 expression, one such mesenchymal stem cell marker, divided the breast cancer cell lines into two distinct groups: about 4.5 percent of cells were GD2-positive and about 92.7 percent were GD2-negative. (weeksmd.com)
A known combination marker of cancer stem cells is high expression of CD44 and low expression of CD24 surface proteins. (weeksmd.com)
The researchers found 85 percent of GD2-positive breast cancer cells were CD44 high/CD24 low, while only 1 percent of GD2-negative cells shared that characteristic. (weeksmd.com)
An analysis of 12 human breast cancer tumors found an even higher correlation of 95.5 percent between GD2+ cells and CD44 high/CD24 low status. (weeksmd.com)
WC-Co was classified as "probably carcinogenic" to humans by the International Agency for Research on Cancer (IARC) in 2003. (cdc.gov)
Recent studies demonstrated that the tumor suppressor gene programmed cell death 4 (PDCD4) and its upstream regulator miR-21 have been considered as oncogenes for novel cancer prevention or anticancer therapies. (cdc.gov)
Metastatic tumors, the dreaded "daughter tumors", form when cancer cells break away from a tumor and migrate via the lymph and the bloodstream in order to finally settle at some distant site in the body. (dkfz.de)
However, the quantity of circulating cancer cells in the body is not the only factor that determines a patient's risk of developing metastatic sites. (dkfz.de)
Some patients display high quantities of circulating tumor cells and have no or only a few metastatic sites while in others who suffer from many metastases, hardly any migrating tumor cells can be found," said Mathias Heikenw lder from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg. (dkfz.de)
The team led by Heikenw lder has therefore taken a closer look at the properties of migrating cancer cells. (dkfz.de)
In human cancer cells as well as in patients with different types of cancer, and also in mice, they observed that a portion of the circulating cancer cells exhibit a specific polarity. (dkfz.de)
This polarity seems to help the free cancer cells return from the blood vessels into body tissue," explains Anna Lorentzen, who is the first author of the publication. (dkfz.de)
Collagen type I hydrogels have been used to grow MCTS from osteosarcomas, breast cancer cells, human colorectal cancer cells, prostate cancer cell lines, and primary cancer cells from colorectal cancer patients, according to the Science Advances study. (corning.com)
Personalized cancer therapy is emerging as a critical strategy for treating tumors. (corning.com)
MCTS can mimic metastatic microtumors, which form when cancer cells spread from the site of the primary tumor via intravasation into the blood circulation and via extravasation into the parenchyma of an organ. (corning.com)
These spheroids will be used as a drug screening platform with enhanced in vivo characteristics that better mimic how cancer forms and spreads in the human body. (corning.com)
Glioblastoma is the most common form of primary brain cancer and remains one of the most aggressive forms of human cancer. (bmj.com)
1 It is one of the most aggressive forms of human cancer. (bmj.com)
Taken together, our results, besides providing further evidence that VPA may represent a promising therapeutic strategy in cancer treatment, may help in the design of new protocols geared at the treatment of neural crest-derived tumors. (iiarjournals.org)
Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
In 2012, he became a member of the Canary Center at Stanford University where he has leveraged his experience in cell and preclinical studies to develop imaging modalities to track therapeutic responses against cancer as well as detecting early stage cancers. (stanford.edu)
He also has professional interests in stem cell research, the biology of aging, cancer as well as telomere and telomerase biology. (stanford.edu)
A physician who heard my lecture at one of the conferences told me that Ivermectin has anti-cancer properties and anti-cancer stem cell properties. (thehealthyplanet.com)
Cancer stem cells are the reason why cancer cells often develop resistance to chemotherapies. (thehealthyplanet.com)
These researches are telling us that a combination of chemo agents with Ivermectin is targeting cancer stem cells. (thehealthyplanet.com)
Killing cancer stem cells is the holy grail of cancer therapy. (thehealthyplanet.com)
Bauer Research Foundation published on December 12, 2012 that Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth (PloS ONE 7(12): e51721). (thehealthyplanet.com)
Taxol is a common chemo agent for ovarian cancer, breast cancer, small cell lung cancer, head and neck cancer, esophageal cancer, prostate and bladder cancer. (thehealthyplanet.com)
METHODS: We explored the association of γ-H2AX with mutation status and sensitivity to 139 different anticancer drugs in up to 41 breast cancer cell lines. (rug.nl)
RESULTS: γ-H2AX positive breast cancer cells exhibit more mutations, and - when p53 mutated - have shorter telomeres. (rug.nl)
abstract = "AIM: Here, we set out to establish whether endogenous γ-H2AX is a biomarker in triple-negative breast cancer.METHODS: We explored the association of γ-H2AX with mutation status and sensitivity to 139 different anticancer drugs in up to 41 breast cancer cell lines. (rug.nl)
We provide a quantitative ranking of more than 600 surface resident and endocytosed proteins, and their regulation by hypoxia, serving as a resource to the cancer research community. (lu.se)
This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (OSCC). (bvsalud.org)
Variants in the ARID1A gene have been found in many types of cancer, including cancers of the ovaries and lining of the uterus (endometrium) in women and cancers of the kidney, stomach, bladder, lung, breast, and brain. (medlineplus.gov)
M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)
CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. (lu.se)
The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)
CD47, as a key regulator of crosstalk between colon cancer cells and TAMs, could thus be a therapeutic target for CRC. (lu.se)
Animal studies have shown that LAK cells are more effective against cancer cells than are the original endogenous T cells, presumably because of their greater number. (msdmanuals.com)
Therefore CAR T cells and TCR T cells may represent complementary approaches to cancer therapy. (msdmanuals.com)
CAR T cell immunotherapy for human cancer. (msdmanuals.com)
Many cancer in humans, including (to var- mice and rats and tumours of the lar- of these issues result from the fact ying extents) cancers of the lung, ynx in hamsters. (who.int)
These tobacco smoke evident in laboratory ciated with risk of lung cancer, after and other aromatic amines are com- animals and epidemiological obser- correction for duration and intensity ponents of mainstream cigarette vations in humans ( Witschi, 2007 ). (who.int)
Concordance: carcinogenicity of tobacco smoke in humans pound likely to be involved in the dence from studies of haemoglobin versus carcinogenicity of etiology of lung cancer in smokers. (who.int)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

In tumor necrosis factor (TNF)-alpha-stimulated human aortic endothelial cells, beta-sitosterol was found to significantly inhibit vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression. (drugs.com)
Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
Moreover, we found that glioblastoma cells, notorious for their VEGF production, elicited a similar response when co-cultured with endothelial cells [11] . (plos.org)
Both in culture and in mice, the manipulated cells were no longer able to attach efficiently to endothelial cells. (dkfz.de)

Two types of border configurations contributed to tumor cell spreading through distinct invasion patterns: an invasive margin that executes slow but directed invasion, and a diffuse infiltration margin with fast but less directed movement. (nature.com)
Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
NGF promoted MiaPaCa-2 and CFPAC-1 cell invasion and migration, while Tanezumab treatment showed the opposite results. (hindawi.com)
TrkA blocking-up could restrain NGF induced PC cell migration and neural invasion. (hindawi.com)
In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)
ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its effects on their phenotype and invasion of adjacent OSCC cells. (bvsalud.org)
Ectopic miR-138 expression reduced fibroblasts' motility and collagen contraction ability and suppressed invasion of suprajacent OSCC cells, while its inhibition resulted in the opposite outcome. (bvsalud.org)

In the present study, we investigated the effects of kaempferol and the underlying mechanism(s) on the cell growth of RCC cells. (nih.gov)
Moreover, the results clearly showed that kaempferol causes a strong inhibition of the activation of the EGFR/p38 signaling pathways, upregulation of p21 expression and downregulation of cyclin B1 expression in human RCC cells, together with activation of PARP cleavages, induction of apoptotic death and inhibition of cell growth. (nih.gov)
YPEL3 has growth inhibitory effects in normal and tumor cell lines. (wikipedia.org)
p53 is a tumor suppressor protein encoded by the human gene TP53 whose function is to prevent unregulated cell growth. (wikipedia.org)
The parent (MCF-7) and tamoxifen-selected cell lines were characterized for protein expression of ER, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) using immunohistochemistry (IHC). (umass.edu)
To further investigate the physiological processes 40 underlying GBM cell movement, this study aimed to image and analyze distinct GBM invasive growth patterns found in vivo , similar to those observed in patients. (nature.com)
Addition of epidermal growth factor (EGF) to the cells induces further phosphorylation of this protein. (rupress.org)
The effect of VPA on cell growth, apoptotic activity and invasive ability were evaluated. (iiarjournals.org)
Firstly, VPA induced cell growth inhibition and apoptotic activity, as demonstrated by sulforhodamine B protein assay, annexin V assay and by Western blot analysis for Bcl2 and Bax expression levels, in all three cell lines. (iiarjournals.org)
Through the development and initiation of individual cancers, the TGF-signaling pathway includes a dual function, originally suppressing tumor development but with raised degrees of TGF- marketing the growth, development and metastatic pass on of set up tumors. (accessibletech4all.org)

More than 5,000 of the 10,000 proteins identified are present in varying abundances in tumor cell lines of all types of tissue. (genengnews.com)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
It is what is called the subventricular zone, a tissue structure lining the lateral ventricles. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
Moreover, the biological factors that determine the tissue-specificity of these tumors have not been identified. (ed.ac.uk)
It was observed that tumor cells strongly accelerate plasma coagulation as a result of: i) expression of the blood clotting initiator protein, a tissue factor, as shown by flow cytometry and functional assays (factor Xa formation in the presence of cells and factor VIIa), and ii) direct activation of prothrombin to thrombin by cells, as evidenced by hydrolysis of the synthetic substrate, S-2238, and the natural substrate, fibrinogen. (scielo.br)
Tissue factor (TF) is a 47-kDa membrane-bound protein that serves as a receptor and co-factor for the enzyme factor VIIa (FVIIa), with subsequent formation of the extrinsic tenase complex that converts factor X (FX) to FXa (2). (scielo.br)
Subsequently, the pole is shifted to the side facing the attachment site and the tumor cell migrates through the endothelial layer into the tissue. (dkfz.de)
However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)

This resulted in activation of tumour-promoting cytokines (IL-6, IL-8, MCP-1 and CXCL1). (bvsalud.org)

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. (nih.gov)
Pirfenidone alone induced apoptotic cell death in lung CAFs at a high concentration (1.5 mg/mL). (biomedcentral.com)
The combined treatment induced significant mitotic arrest and activated the apoptotic cascades, tumor cell death. (thehealthyplanet.com)

This study characterizes the expression of hormone receptors, and the mRNA and DNA methylation levels of docking protein 7 (DOK7), and E74-like factor 5 (ELF5), in 21 novel tamoxifen-resistant cell lines and extends the findings to primary and recurrent human breast tumors. (umass.edu)
The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. (theepochtimes.com)
The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. (theepochtimes.com)
However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. (theepochtimes.com)
There was no difference in HPK1 mRNA levels in PDA cell lines or primary PDA compared with those in HPDE cells or ductal epithelium in chronic pancreatitis and normal pancreas, respectively. (aacrjournals.org)
Right here, we investigate the systems where TGF- adversely regulates TRIII messenger RNA (mRNA) manifestation in the transcriptional level in both breasts and ovarian tumor model systems. (accessibletech4all.org)

The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)

The importance of functioning p53 in the regulation of the cell cycle is evident in that 55% of human cancers exhibit p53 mutations. (wikipedia.org)
The researchers based their work on the premise that it is proteins, and not mutations in DNA per se, that are ultimately responsible for changing somatic cells into cancerous ones. (genengnews.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Shain AH, Pollack JR. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. (medlineplus.gov)

MCTS mimic many of the features that tumors exhibit in the human body, including extracellular matrix (ECM) deposition between cells, gradients in nutrient concentration, and strong cell-cell junctions. (corning.com)

Besides, NGF binding to TrkA receptors encouraged the intracellular Warburg effect in PC and DRG cells. (hindawi.com)
TGF- elicits its mobile effects via relationship with three cell surface area receptors, the sort I, II and III changing development factor-beta ST3932 receptors (TRs). (accessibletech4all.org)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)

Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticle s in JB6 cells involves ROS-mediated MAPK pathways. (cdc.gov)
What pathways are this gene/protein implicaed in? (cancerindex.org)

Taken together, there is only moder- nested case-control studies within as 4-aminobiphenyl and 2-naphthyl- ate concordance between the carci- prospective cohorts, biomarkers of amine as human bladder carcino- nogenic and mechanistic effects of PAH and NNK exposure were asso- gens (IARC, 1987, 2012a) . (who.int)

miR-21-5p inhibitor could abolish the facilitative effect of NGF on PNI in MiaPaCa-2 cells. (hindawi.com)
We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)
AtT-20 cells stably transfected with a dominant-negative form of the BMP-4 signal cotransducer Smad-4 or the BMP-4 inhibitor noggin have increased tumorigenicity in nude mice, showing that BMP-4 has an inhibitory role on corticotroph tumorigenesis in vivo. (unisr.it)
The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol- 4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. (torvergata.it)

As further possible evidence to its function, reduced expression of YPEL3 has been observed in ovarian, lung, and colon tumor cell lines. (wikipedia.org)
Cells with low initial priming (e.g., lung adenocarcinoma and sarcoma) survived and proceeded to arrest in the cell cycle. (nih.gov)
The present study explored the expression and potential role of TRIM13 in non-small-cell lung carcinoma (NSCLC). (cancerindex.org)
Lately, we have proven that TRIII manifestation is considerably downregulated at both message and proteins levels in a wide spectrum of human being malignancies, including malignancies of the breasts, lung, ovary, pancreas and prostate (11C15). (accessibletech4all.org)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
The A/J mouse, which relatively high concentrations, pro- is highly susceptible to lung tumour duces avoidance reactions, stress, development, appears to present weight loss, and other indicators of a relatively reproducible system for toxicity that are widely different from Part 1 · Chapter 5. (who.int)

Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. (nature.com)
Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
Form five times as many tumors when 10 cells of each type are transplanted into mice. (weeksmd.com)
Recent findings show that encountered in the workplace include toluene diisocya- sensitized mice develop airway hyperreactivity and inflammation, nate (TDI), diphenyl-methane diisocyanate and hexam- reflective of human disease. (cdc.gov)

Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. (nus.edu.sg)
Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM), the most common and aggressive brain tumor in adults. (lu.se)

DNA methylation of a CpG island near the YPEL3 promoter as well as histone acetylation may represent possible epigenetic mechanisms leading to decreased gene expression in human tumors. (wikipedia.org)
16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
Expression of DOK7 and ELF5 is significantly up-regulated in half of the tamoxifen-selected cell lines as compared to the parental MCF-7. (umass.edu)
TrkA expression was knocked down in MiaPaCa-2 and dorsal root ganglion (DRG) cells treated with NGF to determine its effect on the Warburg effect. (hindawi.com)
Mechanistically, NGF could upregulate TDE-miR-21-5p levels, and DRG cells took up TDE to activate the Warburg effect and stimulate nociceptor gene expression. (hindawi.com)
These findings displayed that NGF/TrkA encouraged the neuroinvasive potential of PC cells by activating the Warburg effect in DRG cells through upregulation of TDE-miR-21-5p expression. (hindawi.com)
Furthermore, restoring wild-type HPK1 protein in PDA cells led to the increase in p21 and p27 protein expression and cell cycle arrest. (aacrjournals.org)
Flow cytometric analysis of CD36 expression on human peripheral blood platelets. (bdbiosciences.com)
In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal adenohypophysis and its expression is reduced in corticotrophinomas obtained from Cushing's patients compared with the normal pituitary. (unisr.it)
Indeed, retinoic acid induces both BMP-4 transcription and expression and its antiproliferative action is blocked in Smad-4dn- and noggin-transfected Att-20 cells that do not respond to BMP-4. (unisr.it)
We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)
Conclusions: Despite its heterogeneous expression, miR-138 in OSCC-derived CAFs exhibits a tumor-suppressive function. (bvsalud.org)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)
IL-8 and LTD4 could induce CD47 expression in CRC cells. (lu.se)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)

Kinetic data indicate a similar NBDHEX membrane permeability between multidrug resistance cells and their sensitive counterpart revealing that NBDHEX is not a substrate of the P-glycoprotein export pump. (torvergata.it)

METHODS: Twenty-one tamoxifen-selected cell lines were developed through cloning by limiting dilution of an MCF-7 cell culture treated with 1 μM tamoxifen for 6 months. (umass.edu)
The method achieved satisfactory performance using the Institute for Reference Materials and Measurements (IRMM) lyophilized human serum reference material ERM-DA470k, which has a certified AGP value of 0.617 g/L as measured by various methods using ERM-D470 as calibrant. (cdc.gov)

The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to the cytotoxic effect of dFdC. (biomedcentral.com)
T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)

But a disadvantage is that those who have been exposed to natural forms of the adenovirus have antibodies to the virus that will likely block the synthesis of the spike protein, and therefore not afford protection against SARS-CoV-2. (theepochtimes.com)
Just as in the case of antibiotic resistance, new strains evolve within an infected immune-compromised person's body that produce a version of the spike protein that no longer binds with the acquired antibodies. (theepochtimes.com)
In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)
When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)

The wide variety of kinases shows how different these mechanisms are in human cancers. (genengnews.com)
A study published in Anticancer Research on head and neck cancers charted the development of a method for generating MCTS from tumor biopsies, the first step toward creating a method of assessing individual susceptibility to chemotherapy drugs and radiation therapy. (corning.com)
While multiple systems potentially take into account the increased loss of TRIII manifestation in these human being malignancies, including lack of heterozygocity from the gene and epigenetic rules (11C13), we'd also determined TGF-1-mediated repression of TRIII message amounts inside a breasts cancers model (11). (accessibletech4all.org)
Human being breasts cancers MDA-MB-231 cells had been cultured in Improved Eagle's Moderate, supplemented with nonessential proteins, sodium pyruvate and 10% fetal bovine serum. (accessibletech4all.org)
Cells had been infected using the ALK5QD-expressing adenovirus 100.A Stream of human being ESTs using the 1st coding exon of TRIII revealed the current presence of 80 ESTs, 75 which contained sequences homologous towards the proximal 5 UTR (A). message and proteins amounts in ovarian (Ovca420) and breasts cancers (MDA-MB-231) cell lines in both a dosage- and time-dependent way. (accessibletech4all.org)

Thus MCT models are particularly useful, according to Science Advances, for developing therapies that target metastatic cells. (corning.com)
He has also examined the cooperativity of Withaferin A with other interventions that are known to inhibit gliomas such as combination therapies of Withaferin A with temozolomide, with other ginsenosides and with alternating electric fields (known as tumor treating fields or TTFields). (stanford.edu)
Clinical trials of LAK cells in humans are ongoing but this approach has not gained widespread use and is generally considered less effective than other cell therapies. (msdmanuals.com)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)

This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. (dkfz.de)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)

The mean recovery of AGP in ERM-DA470k spiked into CFAS protein material was 96.8% (1:2 dilution), 94% (1:4 dilution), and 92.5% (1:8 dilution) during 2 measurements performed in 2020 and 2021. (cdc.gov)

Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]. (nih.gov)
As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)

The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)

Furthermore, ATO dysregulated microtubule polymerization via the CLIP170/LIS1/NDEL1/dynein signaling pathway in Cal27 cells as a functional consequence of CLIP170 zinc finger disruption. (nih.gov)
The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. (nih.gov)

Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell. (origene.com)

Source of all serum proteins is from USDA inspected abattoirs located in the United States. (bdbiosciences.com)
Human being ovarian tumor Ovca420 cells had been taken care of in RPMI moderate supplemented with 10% fetal bovine serum. (accessibletech4all.org)
Cells had been serum starved for 3 h unless in any other case indicated and treated with TGF-1 (R&D Systems, Minneapolis, MN) with indicated concentrations. (accessibletech4all.org)
Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
Many studies are using a combination of ultrasound, serum CA125 testing, and other tumor markers. (medscape.com)

Blocks estradiol-stimulated VEGF production in breast tumor cells. (sigmaaldrich.com)

Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)

The paper states Ivermectin synergizes with chemo agents cytarabine and daunorubicin to induce cell death in leukemia cells. (thehealthyplanet.com)

The relationship between hormone receptor status and promoter methylation of DOK7 and ELF5 was further examined using available methylation array data (Illumina HM450) from a set of paired primary and second breast tumors from 24 women. (umass.edu)
Rae-1 alpha, beta, gamma, δ and epsilon (retinoic acid early transcript 1) comprise a family of closely related (88‑95% amino acid identity) GPI-linked cell surface proteins that function as ligands for mouse NKG2D, an activating receptor expressed on NK and T cells. (rndsystems.com)
Furthermore, recent studies possess broadened the jobs of TRIII, including regulating TGF- receptor amounts through relationships with GAIP-interacting and -arrestin2 proteins, C terminus (GIPC) and possibly signaling individually (9,10). (accessibletech4all.org)

Further, exosomes were extracted from PC cells and identified by examining the levels of specific markers for exosomes. (hindawi.com)

Anatomy24

Organisms10

Diseases50

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

Health Care1

Microenvironment9

Apoptosis23

Malignant14

Tissues14

Survival6

Vitro7

Kinase15

Progression6

Metastasis10

Metabolism2

Anti-tumor3

Vivo tumor2

Overexpression2

Proliferation7

Solid tumors3

Differentiation10

Genes10

Pancreatic5

Recurrence2

Acts as a tumor1

Cellular12

Prognosis1

Melanoma5

Cause tumors2

Cancer73

Endothelial cells4

Invasion8

Growth10

Tissue9

Cytokines1

Apoptotic3

MRNA6

Necrosis factor2

Mutations4

Extracellular1

Receptors3

Pathways2

Biomarkers1

Inhibitor4

Lung6

Mice4

Aggressive2

Expression18

Membrane Permeability1

Methods2

Cytotoxic2

Antibodies5

Cancers5

Therapies3

Genetics1

Neural2

20211

Antigen2

Synthesis1

Pathway2

Recombinant1

Serum5

VEGF1

Inhibits1

Induce1

Receptor3

Markers1