IP(-/-) mice) exhibit increased tendency to thrombosis in response to experimentally-induced Endothelium, a result which appears to reflect, at least in part, the loss of IP's anti-platelet activity. (wikipedia.org)
By using a combination of optogenetics, in vivo electrophysiology, and machine learning analysis, we find that a subset of neurons in the ACC receives S1 inputs, and activation of the S1 axon terminals increases the response to noxious stimuli in ACC neurons. (iasp-pain.org)
Chronic pain enhances this cortico-cortical connection, as manifested by an increased number of ACC neurons that respond to S1 inputs and the magnified contribution of these neurons to the nociceptive response in the ACC. (iasp-pain.org)
Patients2
My job is to learn from the patients' samples what is required to induce our immune system to make these super-effective antibodies. (wrfseattle.org)
Most patients complain of paresthesias, numbness, or similar sensory changes. (medscape.com)
Spontaneous2
For example, miR-let-7b induces spontaneous pain via activation of Toll-like receptor 7 and transient receptor potential ion channel A1. (medscape.com)
Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms studied. (jcimjournal.com)
Inflammation5
[ 1 , 2 ] Acute pain is often elicited by acute inflammation and has biologic significance to protect the wounded tissue. (medscape.com)
Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test, carrageenan (Cg)-induced acute inflammation model, bradykinin (BK)-induced acute inflammation model, and complete Freund's adjuvant (CFA)-induced chronic inflammation model. (jcimjournal.com)
A single application of Ca cream (10% or 30%) reduced paw edema and thermal hypernociception in Cg-induced acute inflammation, corresponding with a local decrease in TNF-α. (jcimjournal.com)
Repeated applications of Ca cream also decreased CFA-induced chronic inflammation, mechanical hypernociception and histopathological changes in the paw. (jcimjournal.com)
STING-Induced Inflammation - A Novel Therapeutic Target in ALS? (leyastat.com)
Chronic1
For instance, activation of p38 mitogen-activated protein kinase in dorsal root ganglianeurons initiates peripheral sensitization by increasing transient receptor potential ion channel V1 activity in response to tumor necrosis factor [ 18 ] and also by increasing Na V 1.8 activity in response to interleukin-1β, and furthermore, this activation maintains peripheral sensitization and chronic pain by increasing transient receptor potential ion channel V1 expression. (medscape.com)
Tissue1
Furthermore, the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by captopril. (jcimjournal.com)
Role2
Recent studies suggest that central cytokines and chemokines are powerful neuromodulators and play a sufficient role in inducing hyperalgesia and allodynia after central nervous system administration. (medscape.com)
These data indicated that nonneutralizing antibodies or cellular immunity may play a more important role in vaccine-induced protection than previously believed. (bvsalud.org)
Pain2
Neuronal plasticity consists of peripheral sensitization in primary sensory neurons of dorsal root ganglia and trigeminal ganglia [ 3-5 ] and central sensitization of pain-processing neurons in the spinal cord and brain. (medscape.com)
This effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain. (jcimjournal.com)