Protective in experimental protective agents. Medical search. Frequent questions

Previous studies in our lab revealed that chemical zinc chelation or zinc transporter 3 ( ZnT3 ) gene deletion suppresses the clinical features and neuropathological changes associated with experimental autoimmune encephalomyelitis (EAE). (mdpi.com)
IL-17 is important in the induction of autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and inflammatory bowel disease (IBD). (uwo.ca)

Although these therapeutic agents have greatly improved patient outcomes, the current treatments for AD are still not ideal and novel therapeutic strategies are required in the search for better drugs with safety and efficacy. (hindawi.com)
to review the data that support the clinical use of melatonin in the treatment of burn patients, with special emphasis on the stimulation of the oxidative defense system, the immune system, circadian rhythm of sleep/wakefulness and the reduction in the toxicity of therapeutic agents used in the treatment of burn victims. (sedaicu.it)
Study of the inflammatory process following encounter with agents that stimulate the innate immune responses such as adjuvants opens a new horizon for the discovery of therapeutic agents including those derived from microorganisms. (uwo.ca)

Study of experimental RS virus infection in cotton rats. (microbiologyresearch.org)
In our studies, laboratory rats were exposed to noise alone, selected chemical agents alone (carbon monoxide, hydrogen cyanide, and acrylonitrile), mixed exposure to chemicals and noise , and no experimental treatment (control). (cdc.gov)
In conclusion, the data obtained in our investigation confirm the protective effect of S. pachycarpa against acute exposure to CCl 4 -induced organ toxicity in rats. (biomedcentral.com)
Experimental sulfur mustard gas poisoning and protective effect of different medicines in rats and rabbits. (cdc.gov)

The German-American physician Anton Dilger established a secret biological laboratory in Chevy Chase, Maryland, with the intent to grow the causative agents of anthrax and glanders. (medscape.com)

Although several preventive strategies have been advised, yet CNRP is not entirely controlled with pharmacological agents after diagnosis. (razavihospital.ir)
This study is a review of therapeutic pharmacological agents used in various studies for post-PCI-CNRP. (razavihospital.ir)
Several pharmacological agents have been introduced for reducing the burden of adverse outcome, before or during PCI. (razavihospital.ir)
Head injury: pharmacological agents. (researchportal.be)
Efficacy and safety of pharmacological agents as neuroprotectives following severe traumatic brain injury. (researchportal.be)

The review by Corpet and Pierre (1) is thought-provoking, and their impatience with the apparent delay in the application of possibly active preventive agents is understandable. (aacrjournals.org)
4. Allium vegetables, like onion, contain cancer - preventive agents. (onions-usa.org)

In the modern experimental nursery near Hameln, we develop many products and make them ready for practical use. (neudorff.co.uk)

The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical factors. (biomedcentral.com)
Pelargonium sidoides, reinforcing the immune system, antiviral, has antibacterial properties as well as antioxidant properties.The aim of this study is to investigate the protective role of Pelargonium sidoides and Curcumin against mushroom poisoning. (arjournals.org)

The purpose of the Center is to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction and development caused by agents to which humans may be exposed. (cdc.gov)
In contrast to established clinical and experimental evidence that prostate cancer is associated with a decrease in the zinc uptake, numerous epidemiology studies and reports of the effect of dietary and supplemental zinc on the incidence of prostated cancer have provided divergent, inconsistent and inconclusive results which range from adverse effects of zinc, protective effects of zinc and no effect of zinc on the risk of prostate cancer. (europa.eu)

Melatonin is a powerful antioxidant and is a potent protective agent against damage after experimental thermal injury. (sedaicu.it)
In some instances drugs with known antioxidant potential were included to evaluate their protective effects. (cdc.gov)
The data gleaned from multiple experiments demonstrate that chemical agents capable of interfering with intrinsic antioxidant pathways do, in fact, increase noise -induced hearing loss and produce extensive outer hair cell death. (cdc.gov)
Also evaluated were the protective (antioxidant given before CsA) and reparative (antioxidant given after CsA) effects of CoQ10 and vitamin E in oxidative stress caused by CsA. (edu.pl)

The aim of this in vitro study was to assess the remineralization process of human enamel, using two commercial pastes (containing calcium, phosphates, hydroxyl-apatite and sodium fluoride) and an experimental gel (obtained from fruit extract). (ubbcluj.ro)

Neurological pathologies in which a neuroprotective action of AEDs has been demonstrated in specific experimental models include: cerebral ischemia, Parkinson's disease, and Alzheimer's disease. (unipg.it)

The BSL-3 facility is required by federal regulations to necessitate specific training for preventing the loss, release, or theft of an infectious agent. (northwestern.edu)
Delivery of an infectious agent or intervention to the respiratory tract mirrors natural routes of exposure and allows for the evaluation of clinically relevant therapeutic administration. (cdc.gov)

In addition, although protective functions are well documented for AMP-activated protein kinase (AMPK), paradoxically, disease-promoting effects have also been demonstrated for this enzyme. (mdpi.com)
There is a clear need to evaluate the preventive effects of additional combinations of these agents, identified perhaps from the Corpet and Pierre review (D. E. Corpet and F. Pierre, Cancer Epidemiol. (aacrjournals.org)
Some actions of melatonin as a potential supportive pharmacologic agent in burn patients include its: role as a scavenger of both oxygen and nitrogen-based reactants, stimulation of the activities of a variety of antioxidative enzymes, reduction in proinflammatory cytokines, inhibition of adhesion molecules, chronobiotic effects and reduction in the toxicity of the drugs used in protocols to treat thermal injury patients. (sedaicu.it)
This article gives a general overview of the sources and occurrence of exposure to biological agents in workplaces, and of the health effects of such exposures. (europa.eu)
AIHA ERPG-2 (maximum airborne concentration below which it is believed that nearly all persons could be exposed for up to 1 hour without experiencing or developing irreversible or other serious health effects or symptoms that could impair their abilities to take protective action) = 3 ppm. (cdc.gov)
Degradation of CWAs using decontamination agents is one of the few ways to protect human health against the harmful effects of CWAs. (preprints.org)
Among these agents, antiepileptic drugs (AEDs), both the old and the newer generations, have shown to exert protective effects in different experimental models. (unipg.it)
The data to support instillation or inoculation volumes are important both for optimal experimental design and to minimize or avoid effects of diluent alone, which may compromise both data interpretation and animal welfare. (cdc.gov)
Although the etiological role of microorganisms in the pathogenesis of this disease is clear, the host's immune-inflammatory response can lead to protective and/or destructive effects on periodontal tissues 1 . (bvsalud.org)

DATA EXTRACTION AND SYNTHESIS: Experimental and clinical evidence from the medical literature relevant to the airway propagation hypothesis and its consequences. (healthpartners.com)

CCL4 is one of the most commonly used agents to induce chronic and acute liver failure in experimental animals at doses of 0.5-2.5 mL/kg. (biomedcentral.com)
Microbial agents such as Bacille Calmette-Guérin (BCG) or Freund's adjuvant (CFA) that induce a Th17 response are protective in models of autoimmune diseases particularly EAE and type 1 diabetes (T1D). (uwo.ca)
Thus, carcinogens nogenic are polycyclic aromatic hy- to induce DNA damage, it can be may act not only by producing DNA drocarbons and benzene, which by cal ed a genotoxicant or a genotox- damage directly but also by altering themselves are relatively inert chem- in, and if it is shown that the agent the processes that control normal ical y. (who.int)

What's especially alarming is that in many appliances, there's no additional wash cycle to remove the remaining rinse aid,' explained Dr Cezmi Akdis, UZH professor of experimental allergology and immunology and director of the SIAF, who led the study. (bariatricnews.net)

They suggest that agents with preventive activity with little or no toxicity should be evaluated in clinical intervention studies without delay. (aacrjournals.org)
Studies have demonstrated that, in the form of alcoholic extracts, decoctions, and infusions, C. verbenacea exhibits important anti-rheumatic, anti-inflammatory, analgesic, and healing properties which are related to a protective effect on the gastric mucosa, as well as very low toxicity when orally or topically administered 12-17 . (bvsalud.org)

CONCLUSIONS: The diffuse injury that characterizes acute respiratory distress syndrome is often considered a process that begins synchronously throughout the lung, mediated by inhaled or blood-borne noxious agents. (healthpartners.com)

The potential spectrum of bioterrorism ranges from hoaxes and actual use of agents by individuals or groups against others, to state-sponsored terrorism that employs biological warfare (BW) agents and delivery systems that can produce mass casualties. (medscape.com)
Aerosolized Y pestis, causing primary pneumonic plague, has been recognized by bioterrorism experts as having one of the highest potentials as a bioterrorism agent due to its extremely high mortality, its high uptake into enzootic and epizootic animals as well as humans, and its ability to be spread over a large area. (medscape.com)
It has been classified as a Category A, or high priority, bioterrorism agent by the Centers for Disease Control and Prevention (CDC). (medscape.com)
The ability for plague to be spread by aerosols makes Y pestis a potential agent of bioterrorism. (medscape.com)

Risk assessment and management of biological agents in workplaces is a legal requirement, but the process may be complicated because of the diversity of such agents, as they have unique properties which differentiate them from other dangerous substances. (europa.eu)
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (ucdenver.edu)
It is a strong oxidizing agent and can react explosively or form explosive compounds with many common substances. (cdc.gov)

Organophosphorus nerve agents are amongst the most toxic chemicals known to human beings. (preprints.org)

Moreover, drugs that can reduce free radicals are protective against the promotion of noise -induced hearing loss by chemicals. (cdc.gov)

With the evolution of toxic chemicals continuing to progress, developing methods for the destruction of chemical warfare agents (CWAs) has become an increasingly important research topic. (preprints.org)

overcome the protective mechanisms (Borrelli & Izzo, 2000). (researchgate.net)
First-principles approximations of the intrinsic catalytic reaction mechanisms towards different agents in Zr-MOFs are summarized, and developments in the structure-property relationships governing Zr-MOF design rules for efficient degradation in the aqueous and solid phases are discussed. (preprints.org)

Effectiveness of Two Methods for Preparation of Autologous Platelet-Rich Plasma: An Experimental Study in Rabbits. (jsurgmed.com)

Agent: HIVs Including HTLV-III, LAV, HIV-1, and HIV-2 In the period 1984-1986, several health-care workers (HCWs) who had no recognized risk behavior for acquired immunodeficiency syndrome (AIDS) were reported to have HIV infection (10-15). (cdc.gov)
IgG was the first class of virus-specific immunoglobulin to be detected in the lungs of infected animals after experimental infection. (microbiologyresearch.org)
We therefore assessed the squirrel monkey ( Saimiri sciureus ) as an experimental model of NiV infection. (cdc.gov)

The protective effect appears to be related to the presence of organosulfur compounds and mainly allyl derivatives, which inhibit carcinogenesis in the forestomach, esophagus, colon, mammary gland, and lungs of experimental animals. (onions-usa.org)
Similar protective layers are also present on the skin and in the lungs. (bariatricnews.net)

Biological agents such as microorganisms are omnipresent and in many cases useful as well. (europa.eu)

This has been supported by animal experimental studies, case control and cohort studies. (nih.gov)
Some of the volunteers exhibited symptoms at the time of exposure to these agents but long-term follow-up was not planned as part of the DoD studies. (wikipedia.org)
391-400, 2003) have reviewed the prevention studies made with the azoxymethane rat and Min mouse colon cancer models, and have shown that many agents reduce the numbers of these experimental tumors. (aacrjournals.org)
Corpet and Pierre (1) have reviewed the many animal studies that have tested dietary and pharmaceutical agents for their ability to prevent colon cancer. (aacrjournals.org)
The point of Corpet and Pierre (1) is that these agents should be tested quickly for their activity in clinical intervention studies. (aacrjournals.org)
No adequate experimental animal studies are available to evaluate the carcinogenicity of zinc compounds in humans. (europa.eu)
Clinical and experimental studies have established that zinc levels are decreased in prostate cancer and support a role of zinc as a tumor suppressor agent. (europa.eu)
Laboratory animal studies as well as occupational epidemiological studies demonstrate that a broad range of chemical agents can increase the vulnerability of subjects to noise exposure. (cdc.gov)
Experimental chemotherapy studies. (jax.org)
By the way, although there have been numerous studies on different agents capable of lessening the noreflow phenomenon, yet there is no exact guideline for choosing the most appropriate drug. (razavihospital.ir)
This paper reviews experimental and computational studies on CWA removal by MOFs, with a special emphasis on nerve agent (GB, GD, and VX) removal via hydrolysis and sulfur mustard (HD) removal via selective photooxidation. (preprints.org)

Although most of these agents have shown a remarkable effect on post-PCI CNRP incidence reduction, and it seems more powerful are still needed for a better validation of the results. (razavihospital.ir)
of demineralizing agent and the effect on the organic and inorganic dentine. (karger.com)
ATR-FTIR (Jasco-610, Japan) was employed to verify the protective effect of the remineralizing products on enamel. (ubbcluj.ro)
Protective Effect of Platelet Rich Plasma on Experimental Ischemia/Reperfusion Injury in Rat Ovary. (jsurgmed.com)
One ingredient in particular found in commercial rinse agents has a toxic effect on the gastrointestinal tract. (bariatricnews.net)
This inspired the research team under Akdis to investigate what effect the components of commercial-grade detergents and rinse agents have on the epithelial barrier in the gut - the layer of cells that lines the intestinal tract and controls what enters the body. (bariatricnews.net)

The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. (wikipedia.org)

It is also used in protective coatings, reinforced glass fiber, agricultural products, and as a food additive. (cdc.gov)
This product is primarily used as a curing agent for coatings and adhesives. (dpta.vip)
Handling of coatings or adhesives containing activated polyisocyanates and residual monomeric HDI requires appropriate protective measures, see safety data sheet. (dpta.vip)

We selected these New World monkeys because of their availability, reliability as a primate model with which to study infectious diseases ( 11 ), and suitability as experimental animals in BSL-4 conditions. (cdc.gov)
Philipp Kanzow This study aimed to analyse if the erosion -protective potential of the salivary pellicle is different between female and male subjects. (karger.com)
For the study groups, the remineralization agent differed: GC Tooth Mousse, Recaldent, Remin Pro (Voco) and an experimental gel made by "Raluca Ripan" Chemistry Institute (Cluj Napoca, Romania). (ubbcluj.ro)

Safety first: Wear protective gloves, a lab coat, and goggles. (science-on-stage.eu)

Prohibition by many countries around the world cannot disguise the 11 remaining presence of nerve agents in stockpile storage and governmental deployment, 12 highlighting the dire need for an efficient catalyst to degrade and detoxify nerve agents by 13 hydrolysis. (preprints.org)
Modern Reticular Chemistry fosters the design and 15 synthesis of well-defined crystalline MOFs with open Lewis acidic metal sites that can catalytically 16 hydrolyze nerve agents both in aqueous solution and in solid state systems, unveiling unparalleled 17 potential for MOF-based personal protection gears. (preprints.org)

The use of biological agents is not a new concept, and history is replete with examples of biological weapons use. (medscape.com)
This was the first multilateral agreement that extended prohibition of chemical agents to biological agents. (medscape.com)
Biological agents have a ubiquitous presence in the environment and are found in many sectors. (europa.eu)
There is a lack of standardised measurement methods and there are generally no established occupational exposure limits for biological agents. (europa.eu)
Anyone using biological agents has to be aware of their hazard potential. (europa.eu)
The GESTIS Biological Agents Database contains a wealth of information ranging from the classification in risk groups through to occupational safety and health measures. (europa.eu)

Residue from rinse agents left behind on dishes after they are cleaned in professional-grade dishwashers, damages the natural protective layer in the gut and can contribute to the onset of chronic diseases, according to researchers working with organoids at the Swiss Institute of Allergy and Asthma Research. (bariatricnews.net)

The result was that high doses of rinse agents killed the intestinal epithelial cells and lower doses made it more permeable. (bariatricnews.net)

Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. (nih.gov)

Furthermore, it introduces the legislation, and discusses general measures that may be applied to control and prevent exposure for these agents in the workplace. (europa.eu)

Claude Bernard in his book "Experimental Medicine" discusses from this point of view the relative nature of the work of a physiologist, who establishes a gastric fistula in an animal, with that of Dr. Beaumont on the stomach of Alexis St. Martin, whose fistula was produced by a point blank gun shot in the left hypochondrium. (animalresearch.info)
At that time, it was one of the first German firms to produce plant protective agents and animal care products. (neudorff.co.uk)
Plant protective agents, pest control agents and animal care products were all being produced already by the mid-1920s. (neudorff.co.uk)
The facility houses one ABSL-3 room and one BSL-3 room fully equipped for agent expansion and animal housing including CO2 incubators, biosafety cabinets, centrifuges, microisolator cage rack, etc. (northwestern.edu)

This chemical bonds strongly to the cellulose in cotton, making it difficult to wash off, unlike current self-cleaning agents. (neatorama.com)
Unlike some other experimental agents that have been applied to cotton, it does not affect the properties of the fabric. (neatorama.com)

guidelines for treatment and prophylaxis of anthrax will be published in detail in other CDC publications and are available on CDC's website at http://www.bt.cdc.gov/agent/anthrax/index.asp . (cdc.gov)

Guidance on personal protective equipment (PPE) to be used by healthcare workers during management of patients with confirmed Ebola or persons under investigation (PUIs) for Ebola who are clinically unstable or have bleeding, vomiting, or diarrhea in US healthcare settings, including procedures for donning and doffing PPE. (bmj.com)
The highest risk facing healthcare workers when looking after infected patients is inadvertently touching their own faces or neck under the face shield during patient care, and removing (doffing) personal protective equipment (PPE). (bmj.com)
Additionally, the tunable networks of MOFs allow their chemical functionalities to be customized for various applications and operating conditions, making them practicable in personal protective equipment and adjustable to dynamic environments. (preprints.org)
Hands-on training for each user includes the proper use and decontamination of laboratory equipment, non-aerosolizing pipetting techniques, record keeping, waste disposal, emergency procedures, doffing, and donning of personal protective equipment etc. (northwestern.edu)

Matthias Hannig While the ultrastructure of the enamel pellicle and its erosion protective properties are well studied, the dentin pellicle is still neglected in dental research. (karger.com)

Examples of direct-acting elec- all have an impact on the outcome trophilic carcinogens are formalde- The term "genotoxic" refers to an of this proces s (Arana and Kunkel, hyde, sulfur mustard, and ethylene agent that induces DNA damage, 2010) . (who.int)

These Guidelines are based on combinations of standard and special practices, equipment, and facilities recommended for use in working with infectious agents in various laboratory settings. (cdc.gov)
Another section contains specific agent summary statements, each consisting of a brief description of laboratory-associated infections, the nature of laboratory hazards, and recommended precautions for working with the causative agent. (cdc.gov)

Our data, however, may support a protective role of calcium and antioxidants on new adenoma formation. (nih.gov)
I think that the decision to proceed to a clinical trial is more complex, and involves an understanding of the safety of the agent and of the strength and consistency of the preclinical data. (aacrjournals.org)
These experimental results allow to create the sapphire optical discs for long-term data storage. (spie.org)
Although the whole of experimental data indicating that neuroprotection can be achieved is remarkable and encouraging, no firm data have been produced in humans so far and, at the present time, neuroprotection still remains a challenge for the future. (unipg.it)

However, I am also impressed by the wide range of agents that have been found to affect the development of colon cancer in animals. (aacrjournals.org)
The agents documented and list- ed that carcinogens commonly show tween tumour sites in humans and ed as carcinogenic to humans one or more of 10 key characteristics experimental animals. (who.int)

Moreover, the authors investigated whether two important lipophilic antioxidants, coenzyme Q10 and vitamin E, could be considered as protective or reparative agents in free radical processes caused by CsA. (edu.pl)

The new fabric has potential applications in biological and chemical protective clothing for health care, food processing and farmworkers, as well as military personnel," said Ning Liu, who conducted the work as a doctoral student in Professor Gang Sun's group in the UC Davis Division of Textiles and Clothing. (neatorama.com)
Specific chemical agents were selected based both upon their common use in occupational settings and their potential to produce oxidative stress. (cdc.gov)
Bernhardt SM, Borges VF, Schedin P. Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer. (ucdenver.edu)
A ferrate Fe(VI) based potential chemical warfare agent decontaminant was studied for degradation of persistent nitrogen mustard (tris(2-chloroethyl)amine, HN3). (preprints.org)

Prevention and treatment of injury from chemical warfare agents. (cdc.gov)

A more detailed analysis showed that one component of the rinse agent - alcohol ethoxylates - was responsible for this reaction. (bariatricnews.net)

Dietary calcium and antioxidants have been suggested as protective agents against colorectal cancer. (nih.gov)

Dr. Rosenstock spoke favorably about CVOTs during his introduction, stating that the current FDA regulatory approval process provides the opportunity to better assess long-term efficacy, durability, and safety of new agents. (closeconcerns.com)

The HIV agent summary statement does not specifically address safety measures for collecting and handling clinical specimens. (cdc.gov)

This technology continues to result in substantial clarification of the role of established agents in the pathogenesis of previously undocumented disease sequelae. (vin.com)

Often, the experimental characterization of the immunopathological response of a specific Ehrlichia sp. (vin.com)
Use of the BSL-3 Core Lab Facility will require approval of an experimental plan by the Institutional Biosafety Committee and all users of the facility will be required to undergo BSL-3 specific training. (northwestern.edu)

The general public can now see at every turn the enormous benefits to mankind that have come from experimental research. (animalresearch.info)
Whilst in previous years we spent time actively defending our research, we can count the blessings we and our fellow men have secured as the result of the wide adoption of experimental science and offer up thanks for our good fortune in being allowed to use this method. (animalresearch.info)
The Northwestern University BSL-3 Core Lab Facility is a newly commissioned biocontainment level three (BSL-3) facility constructed and designed to support research, both in vitro and in vivo, with infectious agents requiring a higher level of biosafety containment. (northwestern.edu)

The classic examples of necessarily be processed by the cel replication fidelity can confer strong chemical agents that require met- into a mutation (see Chapter 12, by mutator phenotypes that result in ge- abolic activation to become carci- DeMarini). (who.int)

Thiago S. Carvalho Casein and mucin have been shown to improve the erosion -protective properties of the pellicle when applied in combination. (karger.com)

Mitochondria isolated from human placenta were used as the experimental model. (edu.pl)

It is evident that many agents inhibit colon carcinogenesis in one or both models. (aacrjournals.org)

The protective action of mercap" by R J. Rutman, F S. Lewis et al. (jax.org)
The protective action of mercaptoalkylamines against alkylating agents. (jax.org)

To achieve wide dissemination modulating factors mentioned by the acteristics that distinguish them as and assessment, these key char- Workshop participants is meant to carcinogenic agents. (who.int)

Anatomy11

Organisms11

Diseases9

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes26

Technology, Industry, Agriculture6

Information Science2

Health Care4

Autoimmune encephalomyelitis2

Therapeutic agents3

Rats4

Causative agents1

Pharmacological agents5

Preventive agents2

Modern experimental1

Investigate the protective2

Adverse2

Antioxidant4

Extract1

Alzheimer's1

Infectious agent2

Effects9

Evidence1

Induce3

Immunology1

Toxicity2

Acute1

Bioterrorism4

Substances3

Organophosphorus1

Drugs1

Chemicals1

Mechanisms2

Rabbits1

Infection3

Lungs2

Microorganisms1

Studies11

Effect6

Evaluate1

Coatings3

Study3

Wear1

Nerve agents2

Biological agents6

Chronic1

Doses1

Liver1

Exposure1

Animal4

Unlike2

Anthrax1

Personal protectiv4

Enamel1

Sulfur1

Laboratory2

Data4

Animals2

Coenzyme1

Potential4

Prevention1

Alcohol1

Calcium1

Efficacy1

Safety1

Role1

Specific2

Research3

Chemical agents1

Shown1

Human1

Colon1

Action2

Participants1