A nerve pathology is an injury to the nervous system that causes sensory, motor, autonomic, or neurocognitive dysfunction. (lakesfootankle.com)
Patients7
My job is to learn from the patients' samples what is required to induce our immune system to make these super-effective antibodies. (wrfseattle.org)
More than 75% of patients with breast cancer treated with chemotherapy experience cognitive impairments (eg, memory and attention problems), commonly known as chemo-brain . (researchprotocols.org)
However, clinical trials testing the impact of exercise interventions on chemotherapy-induced cognitive decline in patients with cancer are lacking, and the mechanisms through which exercise could improve cognitive function are unclear. (researchprotocols.org)
The objective of the Improving Cognitive Function Through High-Intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy trial is to examine the effects of HIIT on cognitive function in patients with breast cancer undergoing chemotherapy. (researchprotocols.org)
This 2-arm, single-center, pilot randomized controlled trial will randomize 50 patients with breast cancer undergoing chemotherapy to HIIT or attention control. (researchprotocols.org)
If positive, our findings will establish the pilot efficacy of HIIT on chemotherapy-induced cognitive function in patients with breast cancer, providing the foundation for future larger phase-II and phase-III trials to confirm the findings and potentially establish HIIT as a standard of care for women undergoing chemotherapy for breast cancer. (researchprotocols.org)
Depending on the extent of surgery required and the potential need for reconstruction, patients may require a temporary nasogastric feeding tube and/or tracheostomy tube in order to maintain adequate nutrition and protect the airway. (medscape.com)
Experience1
Pain is an integrated sensory and affective experience. (iasp-pain.org)
Multiagent1
as a component of multiagent adjuvant chemotherapy for treatment of women with axillary lymph node involvement following resection of primary breast cancer (1.1) . (nih.gov)
Neuropathy4
Getting patients with breast cancer to wear frozen gloves and socks for 90 minutes while receiving weekly paclitaxel chemotherapy significantly reduces objective and subjective assessments of chemotherapy-induced peripheral neuropathy (CIPN) across at least 12 treatment cycles, a self-controlled, prospective study indicates. (medscape.com)
Chemotherapy-Induced Neuropathy, which can greatly decrease the ability for patients to receive a full dose of life-saving or prolong treatments. (cenexelresearch.com)
Chemotherapy-Induced Neuropathy symptoms most commonly begin farthest away from the head, starting in the hands and feet, and move closer in time. (cenexelresearch.com)
Significantly reduces1
Although chemotherapy significantly reduces symptoms caused by cancer and prolongs survival, it often causes significant side effects in patients. (cenexelresearch.com)
Severe2
Chemotherapy-Induced Neuropathic Pain may impact daily activities and result in severe pain episodes as well as limit the ability for cancer patients to receive a full series of chemotherapy. (cenexelresearch.com)
If severe, Chemotherapy-Induced Neuropathic Pain may cause more serious problems: falls, difficulty breathing, changes in blood pressure and heart rate, paralysis, and organ failure. (cenexelresearch.com)
Functional1
Researchers have found in mice that supporting cells in the inner ear, once thought to serve only a structural role, can actively help repair damaged sensory hair cells, the functional cells that turn vibrations into the electrical signals that the brain recognizes as sound. (nih.gov)
Factors like age, other medical conditions, drug frequency and dose, additional medications, family history and dosage may influence the longevity of Chemotherapy-Induced Neuropathic Pain. (cenexelresearch.com)
Treatment4
Chemotherapy is a proven treatment to eliminate the cancer cells either in conjunction with surgical intervention or as a standalone method. (cenexelresearch.com)
As a systematic drug treatment, chemotherapy is administered throughout the entire body either intravenously or orally. (cenexelresearch.com)
Symptoms may begin anytime during the first chemotherapy treatment and usually worsen with additional administrations of the drugs. (cenexelresearch.com)
Learn more about treatment of Chemotherapy-Induced Neuropathic Pain here. (cenexelresearch.com)
Drug2
In an accompanying editorial , Dawn Hershman, MD, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York City, cautions that the pathophysiology of CIPN may vary depending on the chemotoxic agent used, and it is not clear whether cryotherapy can prevent CIPN induced by a drug such as oxaliplatin, which also causes a lot of CIPN. (medscape.com)
These include some antibiotics and the chemotherapy drug cisplatin. (nih.gov)
Prevent1
Learn methods thought to prevent Chemotherapy-Induced Neuropathic Pain here. (cenexelresearch.com)
Damage4
In addition, about 15 percent of Americans between the ages of 20 and 69 have noise-induced hearing loss, which also results from damage to the sensory hair cells. (nih.gov)
Neuropathic pain is caused by damage or disease that impacts the a diverse sensory system made of receptors and processing sensors that produce sensations such as touch, temperature, body position, and pain. (cenexelresearch.com)
Some of the drugs in chemotherapy treatments can damage nerves. (cenexelresearch.com)
Because chemotherapy drugs kill cancer cells by different mechanisms, and the nerve damage can result in different ways, treating Chemotherapy-Induced Neuropathic Pain is difficult. (cenexelresearch.com)
Drugs1
Once destroyed or damaged by noise or drugs, sensory hair cells in the inner ears of humans don't grow back or self-repair, unlike the sensory hair cells of other animals such as birds and amphibians. (nih.gov)
Clear1
It is not clear whether familial renal glucosuria protects towards T2DM, while SGLT2 deletion in animal models appears to improve glucose homeostasis and protect pancreatic cell function.63 We didn't discover any recorded proof of an increased disposition to urinary tract or vulvovaginal infections, though identification and research of these topics is tricky resulting from the rarity of your sickness. (c-metinhibitors.com)
Made2
This has made exploring potential pathways to protect or regrow hair cells in humans a major focus of hearing research. (nih.gov)
Advancements in Vaccines: Bridging the Past and Future - by Nelia Sanchez-Crespo, MD The history of vaccines is a testament to the incredible progress we've made in protecting humanity against infectious diseases. (cenexelresearch.com)
Cell2
If you're looking to protect hair cells, you should be looking at supporting cells," said senior author Lisa Cunningham, Ph.D. , whose laboratory of sensory cell biology at the National Institute on Deafness and other Communication Disorders (NIDCD), a component of NIH, led the study. (nih.gov)
When utricles that had not undergone heat shock were placed in the same culture as heat-shocked utricles, the hair cells in the untreated utricle were protected from cell death after exposure to an ototoxic antibiotic. (nih.gov)