Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Nausea2
Some studies have found ginger may help nausea caused by chemotherapy, but larger studies are needed to confirm these effects. (mskcc.org)
he experienced "immediate and profound" relief of his symptoms - his pain decreased dramatically, the new medicine did not induce nausea and he was able to gain back some of the weight he had lost during treatment. (aclu.org)
Cancer treatments like chemotherapy can induce menopause quickly, causing symptoms to appear shortly after or even during treatment. (globalliferejuvenation.com)
Several risk factors for developing venous thrombosis usually coexist in cancer patients including surgery, hospital admissions and immobilization, the presence of an indwelling central catheter, chemotherapy, use of erythropoiesis-stimulating agents (ESAs) and new molecular-targeted therapies such as antiangiogenic agents. (oncologynurseadvisor.com)
The immune system involves a host of cells, biological structures, and processes that protect us from disease and ill health caused by microorganisms, parasites, toxic chemicals, and diseased cells (cancer). (coconutresearchcenter.org)
In animal research, he found that fasting for 48 hours or longer protects normal, healthy mammalian cells, but not cancer cells from chemotherapy. (coconutresearchcenter.org)
In a human clinical trial, he had a group of cancer patients go on short fasts before and then soon after undergoing chemotherapy. (coconutresearchcenter.org)
Toxins2
Ellagic acid has demonstrated DNA-protecting properties, including the ability to bind to toxins and neutralize them. (nutrimedical.com)
1 According to Longo, fasting causes cells to rapidly switch to a protected mode with changes in levels of glucose, IGF-1, protein kinase A (PKA), and many other proteins and molecules, protecting the cells from various toxins, including chemotherapy drugs. (coconutresearchcenter.org)
Inhibition2
The live supporting benefits of Astragalus include stimulation of hepatic DNA synthesis, simulation of superoxide dismutase and glutathione reductase to support healthy oxidation enhancing levels of antioxidants, suppression of ethanol-induced lipid accumulation, inhibition of nucleic acid polymerases to downregulate management of healthy cell production and translation, free radical scavenging and joint health by transforming growth factor beta-1, and collagen synthesis in hepatic cells [12]. (biotanicahealth.com)
The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
Mice2
Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
He showed that short-term fasting provided complete protection to mice against the side effects of high-dose chemotherapy. (coconutresearchcenter.org)
Clinical2
Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. (mdpi.com)
In a study of 4 children, 3 children showed significant clinical improvement with bevacizumab and were able to discontinue steroid use, which, according to the authors, can have numerous side effects that significantly compromise a patient's quality of life. (medscape.com)
Combination2
However, it hasn't been used in combination with chemotherapy because of its weight-loss effect and lack of nutrition at a time when the body is in desperate need of nourishment to support immune function. (coconutresearchcenter.org)
It may be seen in greater than 90% of patients older than 60 years who have been successfully treated with combination chemotherapy and whole-brain radiation. (medscape.com)
Effect5
Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. (nutrimedical.com)
Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
If you're concerned about life in middle age and beyond, we've got great news: there are easy, proven steps that you can take to help stop the negative effect of aging. (globalliferejuvenation.com)
Anticoagulants and thromboprophylaxis can protect patients from this adverse effect. (oncologynurseadvisor.com)
A choice between adequate pain relief and gainful employment is an untenable one that no patient should ever be forced to make.Yet Wal-Mart forced Joseph to pay a stiff and unfair price for using a medicine allowed under state law that has had a life-changing positive effect for him. (aclu.org)
Patients receiving chemotherapy are instructed to increase protein and calorie intake. (coconutresearchcenter.org)
But in fact, the MMMA protects medical marijuana patients from "disciplinary action by a business. (aclu.org)
Reduce2
Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
Longo found that short-term fasting before and just after undergoing chemotherapy could greatly reduce the side effects associated with the therapy. (coconutresearchcenter.org)
Ability2
His condition has required extensive treatment and chemotherapy, interferes with his ability to speak and is a source of severe and constant pain. (aclu.org)
Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
Treatment2
Bax expression was induced and caspase-3 was activated by ellagic acid treatment. (nutrimedical.com)
Chemotherapy itself is very harsh on the body and causes significant collateral damage, including immune suppression by inducing DNA damage and cell death in both peripheral blood and bone marrow (disrupting stem cell development), which often results in long-term impairment to the immune system. (coconutresearchcenter.org)
Body2
Global Life Rejuvenation was founded to give women a new lease on life - one that includes less body fat, fewer mood swings, and more energy as you age. (globalliferejuvenation.com)
Fasting during chemotherapy was believed to be unwise because it would add more stress to the body. (coconutresearchcenter.org)
Expression2
Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
Growth2
Bacteriophages , like our EcoPhage , selectively target harmful bacteria (like E. coli ), and completely wipe them out (this was pioneered in Europe before the advent of antibiotics) 2,3,4 , leaving beneficial microbes to flourish, supporting the growth of beneficial bacteria and protecting against future infection. (bodyecology.com)
HRT, and growth hormone peptide therapies bridge the gap between your old life and the more vibrant, happier version of you. (globalliferejuvenation.com)
Goals1
These therapies for men and women are effective, safe, and customized to fit your goals, so you can keep loving life as you get older. (globalliferejuvenation.com)
Brain1
A relationship between increased blood-brain barrier permeability and radiation therapy has been posited to contribute to this leukoencephalopathy and to methotrexate-induced vasculopathy. (medscape.com)
Death2
Whether in death or in life, whether for richer or poorer, the redeemed of the Lord tread upon their high places. (godsaidmansaid.com)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
Items1
Aging is inevitable, and for many, it signals the beginning of a new chapter - one where you cross off bucket list items and live life to the fullest, on your own terms. (globalliferejuvenation.com)
Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. (medscape.com)
Thus, TPEY-Tempo may be a promising adjunct in the treatment of glioblastoma with the potential to not only prolong survival but also to maintain quality of life and reduce treatment toxicity. (cdc.gov)
Thymoquinone extract may help protect cultured neurons against alpha-SN-induced synaptic toxicity, a type of pathology observed in the brains of patients with Parkinson's and dementia. (prevention.news)
Cancer7
Neutropenia is one of the most common and serious adverse effects of chemotherapy and is thus an important issue for researchers and clinicians who are working to improve the QOL of patients with cancer. (medscape.com)
St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy. (stjude.org)
We have identified a new form of housekeeping macrophage in mice that may in future be harnessed to protect against lung infections like bacterial pneumonia that remain one of the greatest threats to survival of cancer patients during chemotherapy," said senior and corresponding author Peter Murray, Ph.D., a member of the St. Jude Department of Infectious Diseases and Department of Immunology . (stjude.org)
That can lead to a dramatic reduction in white blood cells, including the neutrophils that play a central role in combating bacterial and other infections that are a common complication of cancer chemotherapy. (stjude.org)
Cameron K (2005) Review: chemotherapy plus supportive care improves survival and quality of life in advanced or metastatic gastrointestinal cancer more than supportive care alone. (springer.com)
Cancer treatments like chemotherapy can induce menopause quickly, causing symptoms to appear shortly after or even during treatment. (globalliferejuvenation.com)
The earlier the cancer is detected and managed, the bigger the chance of survival and prolonging the patient's life. (escovaccixcell.com)
Radiation4
Researchers are not sure how ViMs survive chemotherapy, but investigators ruled out mechanisms other cells use to resist radiation or certain chemotherapy drugs. (stjude.org)
Nigella sativa oil (NSO) and its active component thymoquinone may create a shield of protection around brain tissue affected by radiation-induced nitrosative stress. (prevention.news)
Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue. (prevention.news)
Likewise, chemotherapy and radiation therapy are not ideal solutions as they tend to damage the healthy cells along with the tumor cells. (escovaccixcell.com)
Additionally, RBAC has been shown to ameliorate irritable bowel syndrome and protect against liver injury caused by hepatitis or nonalcoholic fatty liver disease. (researchgate.net)
Thymoquinone may prevent chemically induced cancers of the liver. (prevention.news)
Infection1
Working in a mouse model that mimics infection in chemotherapy-treated patients, the researchers were surprised to find that vaccination protected mice from lethal Pseudomonas aeruginosa pneumonia. (stjude.org)
Significantly1
Where lipid peroxidation was induced by carbon tetrachloride, curcumin significantly decreased the level of lipid peroxidation. (curcuminhealth.info)
Drugs3
Chemotherapy drugs kill dividing cells, including cells in the bone marrow that give rise to different immune cells. (stjude.org)
The possible approaches include using drugs or signaling molecules called cytokines to induce protection in the immune-compromised host. (stjude.org)
That progress includes the development of life-preserving monoclonal antibody infusions and repurposing existing drugs , to which NIH's Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV ) public-private partnership has made a major contribution. (nih.gov)
Researchers2
Researchers called the newly recognized cell type vaccine-induced macrophages (ViMs). (stjude.org)
St. Jude Children's Research Hospital researchers have identified a new population of resident lung macrophages (pictured here), which they called vaccine-induced macrophages or ViMs. (stjude.org)
Cells2
Importantly, unlike other immune cells types, the size of the ViMs population remained stable during chemotherapy. (stjude.org)
ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. (springer.com)
Type1
This newly recognized cell type also showed enhanced anti-bacterial activity in mice that lacked neutrophils due to chemotherapy. (stjude.org)
Effect1
If you're concerned about life in middle age and beyond, we've got great news: there are easy, proven steps that you can take to help stop the negative effect of aging. (globalliferejuvenation.com)
Women4
Global Life Rejuvenation was founded to give women a new lease on life - one that includes less body fat, fewer mood swings, and more energy as you age. (globalliferejuvenation.com)
These therapies for men and women are effective, safe, and customized to fit your goals, so you can keep loving life as you get older. (globalliferejuvenation.com)
As women age, their hormones begin to go through changes that affect their day-to-day lives. (globalliferejuvenation.com)
However, for the reasons set forth in this opinion in part II under "Discussion," I also conclude that, so long as the Indiana Medicaid program pays for abortions to preserve the lives of pregnant women and where rape or incest cause pregnancy, it must also pay for abortions in cases of pregnancies that create for pregnant women serious risk of substantial and irreversible impairment of a major bodily function. (findlaw.com)
Heart1
Thymoquinone extract derived from Nigella sativa may protect against damage in the event of a heart attack. (prevention.news)