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  • apoptosis induced
  • In apoptosis induced by γ-irradiation and cisplatin, two antitumor treatments that are cell-cycle phase-nonspecific agents, both Bcl-XL and Bcl-2 conferred similar protection against γ-irradiation, but Bcl-XL provided better protection than Bcl-2 against cisplatin. (bloodjournal.org)
  • Initial studies suggested that Bcl-XL protected better than Bcl-2 against apoptosis induced by the immunosuppressant drugs cyclosporin A, FK-506, and rapamycin. (bloodjournal.org)
  • Analysis of antiapoptotic protein expression revealed that IL-4 stimulation resulted in up-regulation of cellular (c) FLIP/FLAME-1 and Bcl-x L . Exogenous expression of cFLIP/FLAME-1 inhibited apoptosis induced by CD95 and to a lesser extent by chemotherapy, while tumor cells transduced with Bcl-x L were substantially protected both from CD95 and chemotherapeutic drug stimulation. (jimmunol.org)
  • survival
  • The BCR is a key signaling molecule that triggers pathways that can induce B-cell proliferation, survival, differentiation, anergy, and apoptosis (for a review, see Niiro and Clark 12 ). (bloodjournal.org)
  • Medical therapies (chemotherapy, hormone therapy, and target therapy) are adopted to improve the disease-free ratio, overall survival ratio, and patients' quality of life. (hindawi.com)
  • Resection of tumors with or without adjunctive chemotherapy is the only00000 known strategy for long-term survival. (spandidos-publications.com)
  • The high levels of ferritin in TAMs may protect them from iron-induced damage, stimulate survival, proliferation, and angiogenesis ( 11 ). (spandidos-publications.com)
  • Glutathione
  • 2006) Glutathione can facilitate the detoxification and excretion of many chemotherapy agents. (pinestreetfoundation.org)
  • Three hours after IT administration, the ileum glutathione concentration dropped significantly. (herbs.org)
  • Green tea polyphenols significantly affected the glutathione:glutathione disulfide ratio but not lipid peroxidation, macrophage inflammatory protein-2 levels, myeloperoxidase activity, or nuclear factor-κB activation. (herbs.org)
  • The combination has been shown to significantly increase glutathione synthesis, insulin sensitivity and mitochondrial fuel oxidation and to decrease NEFA levels, lipid peroxidation and F2 isoprostanes. (blogspot.fi)
  • ligation
  • Ligation of the BCR with sol-IgM induced incomplete responses in both CLL subsets, resembling the pattern described for tolerant B cells. (bloodjournal.org)
  • Moreover, analysis of early signaling events induced by IgM ligation indicate that the 2 subsets may also differ in their capacity to transmit BCR-derived stimuli. (bloodjournal.org)
  • alleviate
  • In conclusion, RUT may be a possible adjuvant therapeutic intervention to alleviate cognitive and other complications associated with DOX chemotherapy. (dovepress.com)
  • Cycles
  • This study provides compelling evidence that administering Neulasta in the first and subsequent cycles of moderately myelosuppressive chemotherapy can significantly reduce the risk of potentially life-threatening infections that can result in hospitalizations and require IV antibiotics," said Schwartzberg. (amgen.com)
  • Cognitive dysfunction was induced in Wistar rats by administering ten cycles of DOX (2.5 mg/kg, intraperitoneal, once in 5 days), as we observed significant impairment of episodic memory in ORT. (dovepress.com)
  • By outlining how prolonged fasting cycles - periods of no food for two to four days at a time over the course of six months - kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders . (fightaging.org)
  • Even after WBCs are severely suppressed or damaged as a consequence of chemotherapy or aging, cycles of PF are able to restore the normal WBC number and lineage balance, suggesting that the organism may be able to exploit its ability to regenerate the hematopoietic system after periods of starvation, independently of the cause of the deficiency. (fightaging.org)
  • Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system. (nutritionreview.org)
  • cells
  • Prior exposure to RUT at 100 µM protected IMR32 cells from DOX (1 µM) neurotoxicity. (dovepress.com)
  • DOX exposure resulted in increased cellular death, apoptosis, and intracellular ROS generation with inhibition of neurite growth in differentiated IMR32 cells, which was significantly ameliorated by RUT. (dovepress.com)
  • The blood count, including white blood cells, platelets, and hemoglobin, and serum levels for SCF and granulocyte-macrophage colony-stimulating factor were assessed before (pretest) and 6 weeks after (posttest) the participants' first course of chemotherapy. (greenmedinfo.com)
  • CP injection significantly increased apoptosis by increasing cleaved caspase-3 expression, which was obviously inhibited by HQQD, accompanied by the improvement of cells viability. (hindawi.com)
  • therapeutic
  • VEGF also exerts potent therapeutic effects in chemotherapy-induced sensory neuropathies, which have been attributed to its vessel growth and perfusion-promoting effects. (kuleuven.be)
  • To test whether the therapeutic effect of VEGF is due to a direct effect on sensory nerves, VEGF was subplantarly delivered to rats with Taxol-induced neuropathy. (kuleuven.be)
  • etoposide
  • Using four M-phase specific chemotherapeutic agents, Bcl-XL and Bcl-2 provided similar protection against vincristine and vinblastine whereas Bcl-XL afforded as much as 50% greater cell viability than Bcl-2 against etoposide and teniposide-induced cell death. (bloodjournal.org)
  • clinical
  • The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V H ) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. (bloodjournal.org)
  • No substantial clinical research has emerged to support the assertion that antioxidants are contraindicated during chemotherapy. (pinestreetfoundation.org)
  • Green tea polyphenols supplied orally protected against oxidation in our experimental model and could be one approach to reducing the risk of chemotherapy induced side effects in a clinical setting. (herbs.org)
  • rats
  • Prophylactic treatment with daily doses of NR (200 mg/kg) for seven days before chemotherapy was started and continued for 24 days after the chemotherapy ended prevented the hypersensitivity to touch in the rats. (qualitycounts.com)
  • assay
  • Diarylheptanoids showed stronger antioxidant effects, in comparison to hydroxyphenylalkanes, as demonstrated by DPPH assay and amelioration of CCl 4 -induced disturbed intracellular GSH/GSSG balance. (mdpi.com)
  • incidence
  • Neulasta was also associated with a significantly lower incidence of hospitalizations with one percent of patients (6/463) requiring hospitalization versus 14 percent of patients receiving placebo (64/465). (amgen.com)
  • novel drug
  • It is therefore important that we improve our ability to identify patients who will benefit from adjuvant chemotherapies and to discover novel drug targets for those patients resistant to current chemotherapeutics. (biomedcentral.com)
  • tissue
  • Immunosuppression and normal tissue injury are the major limitations of chemotherapy [ 2 ], which give rise to numerous side effects [ 3 , 4 ]. (hindawi.com)
  • effects
  • The positive effects of VEGF were counteracted by TSA and Tubacin, which suggests that VEGF protects sensory neurons in these Taxol models at least partly via HDAC6. (kuleuven.be)