Protected from chemotherapy induced apoptosis stimuli protected from chemotherapy induced. Medical search. Frequent questions

Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
Hyperthermia alone as a cancer treatment can selectively eliminate cancer cells by facilitating molecular mechanisms such as cell cycle arrest, apoptosis, necrosis and autophagy [ 4 - 6 ], or activate NK cells or DCs which in turn stimulates anti-cancer immune responses [ 7 , 8 ]. (oncotarget.com)
These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)

Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. (frontiersin.org)
A temperature range of 42°C to 45°C is used therapeutically as a single agent or as an adjuvant to radiotherapy, chemotherapy or immunotherapy in the cancer treatment [ 2 , 3 ]. (oncotarget.com)
Hyperthermia acts as a sensitizer to radiotherapy, chemotherapy and immunotherapy, and thus, this has attracted interest in developing effective combination strategies that exploit using hyperthermia in combination with other therapies. (oncotarget.com)
Traditional chemotherapy and radiotherapy have limited effect in RCC, and molecular biomarkers are more targetable to guide treatment decisions. (medsci.org)
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
Furthermore, chemotherapy and radiotherapy have not substantially improved the survival of patients over the last several years [ 4 ]. (biomedcentral.com)

The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis. (nature.com)
Caspases, while dispensable for cell death during mitochondrial apoptosis, inhibit activation of pro-inflammatory pathways after MOMP. (nature.com)

RvD1 seems to advertise alveolar epithelial restore by stimulating ATII cells wound repair, proliferation, reducing apoptosis, and inhibiting TGF-β-induced EMT. (perfect-curve.com)
Moreover RvD1 inhibited human lung fibroblast proliferation, collagen production, and myofibroblast differentiation induced by both TGF-β and bronchoalveolar lavage fluid from acute respiratory distress syndrome (ARDS) patients. (perfect-curve.com)
Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
Protein kinase C (PKC) is a key enzyme which regulates proliferation, apoptosis and differentiation, representing a pharmacological target for tumor therapy. (endocrine-abstracts.org)
Previous evidence has shown that PKC is involved in the control of human medullary thyroid carcinoma (MTC) proliferation and survival by modulating apoptosis, with a mechanism that implicates PKCβII isoform and translocation in different subcellular compartments.In this study, we investigated the role of PKCδ. (endocrine-abstracts.org)
Growth of cancer cells is regulated by the balance between cell proliferation and apoptosis, which is a normal physiological process serving to eliminate unwanted cells and maintain homeostasis in healthy tissue. (nutraculture.com)
Downregulation of UCA1 enhanced the radiosensitivity of CCL244 cells via inhibition of the colony formation, proliferation and promotion of radiation-induced apoptosis and G2/M arrest. (bvsalud.org)
Also, a lot of studies has been conducted to investigate the effectiveness of Ginger in preventing cancer or suppressing the growth of the tumour in different cancer types like lymphoma, colorectal cancer, breast cancer, skin cancer, liver cancer, bladder cancer by mechanisms like apoptosis, reducing cell proliferation, cell-cycle arrest, and suppressing activator protein (AP-1) & NF-κB/COX-2 signaling pathways. (zenonco.io)

Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
UV irradiation represents a major challenge to genomic integrity throughout the evolution of terrestrial organisms, resulting in the development of specific mechanisms that govern the cellular response to UV-induced DNA damage. (rupress.org)
This article gives a comprehensive review of apoptosis, its mechanisms, how defects along the apoptotic pathway contribute to carcinogenesis and how apoptosis can be used as a vehicle of targeted treatment in cancer. (biomedcentral.com)
The general lack of understanding of the mechanisms of immunization, the role of dendritic cells, the ability of cancer to induce tolerance, and the identification of the most suitable antigens to use are just some examples of how the development of effective strategies is still problematic [7-10]. (biomedcentral.com)

This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)

Lower temperatures inhibit the influx of ions (noticeably calcium) into cells, avoid oxidative stress, decrease free radical production, and, finally, prevent apoptosis. (ajnr.org)
Several components of Ginger have been reported to have potent carcinogenic effects based on their ability to inhibit the TPA-induced Epstein-Barr virus (EBVEA) early antigen on Raji cells [ 7 ]. (zenonco.io)

We previously demonstrated that GH protects breast cancer cells towards the cytotoxic effects of doxorubicin, inducing chemoresistance. (endocrine-abstracts.org)
Studies have shown that xanthine dehydrogenase (XDH)-derived reactive oxygen species (ROS) accelerates tumor growth, and also induces mutations or produces cytotoxic effects concurrently. (medsci.org)

Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)

Surgery to the extent that this is feasible in terms of safety, followed by involved-field radiation therapy and concomitant and maintenance chemotherapy with temozolomide, has set the standard of care since 2005. (frontiersin.org)
Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
Due to the fact that cancer cells are particularly good at evading any action from the immune system, most anti-cancer treatments are based on other means like surgery, radiation therapy, and chemotherapy. (biomedcentral.com)

The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)

These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. (biomedcentral.com)
The mechanism of apoptosis is complex and involves many pathways. (biomedcentral.com)
This favors the development of less immunogenic and more apoptosis-resistant neoplastic cells, through a mechanism well known as immune editing [2]. (biomedcentral.com)

It is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli [ 7 ]. (biomedcentral.com)

Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)

The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. (endocrine-abstracts.org)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)

Cancer chemotherapy is based on an understanding of tumor cell growth and of how drugs affect this growth. (medscape.com)
PI3K confinement Lich Is particularly important for the growth and survival of the cell with embroidery and is an important means of cellular Transformation FF Ren, another condition Cilomilast SB-207499 known to induce the expression of NKG2D ligands for rdern. (microrna1.com)
K can From a variety of extracellular Ren stimuli Ren Ren signals such as growth factors, ligands for G-protein-coupled receptors, cytokines, and vitamin D3, the p85 subunit of regulation at the plasma membrane, such as catalytic subunit recruit p110 PI P2 4 5 PI converts 3.4, 5 P3. (microrna1.com)

Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)
Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)

Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
However, thermotolerance induced by thermosensitive genes such as the heat shock proteins can limit the efficacy of hyperthermic treatment. (oncotarget.com)
Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)

We determined in six neuroblastoma cell lines the cytotoxicity of TPZ using DIMSCAN, a digital imaging fluorescence assay, apoptosis and mitochondrial membrane potential (ΔΨ m ) by flow cytometry, and protein expression by immunoblotting. (aacrjournals.org)
Thus, TPZ cytotoxicity for neuroblastoma cell lines in hypoxia occurred via a p53-dependent mitochondrial pathway that caused induction of p53 and p21, ΔΨ m decrease, GSH depletion, and apoptosis. (aacrjournals.org)

3 When our temperature increases, hypothalamic neurons induce sweating and cutaneous vasodilation to dissipate heat. (ajnr.org)
The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
A high peak concentration may affect neurons, protected by the blood brain barrier, and stem cells in their niches. (rapamycin.news)

PI3K class I, which is essential in the regulation of cell survival, metabolism, apoptosis and cell cycle of the heterodimeric class I molecules of a catalyst composition PI3Ks regulatory subunit and are classified in class IA or IB PI3K class. (microrna1.com)

Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. (plos.org)
KEGG pathway term mTOR signaling pathway is observed to be meliorated in this tricluster and has been reported to be associated Inhibitors,Modulators,Libraries with estrogen induced breast cancer cell. (ampk-signal.com)

When associated with dacarbazine, bixin restored the sensitivity of A2058 cells to chemotherapy, enhancing its antiproliferative, anti-migratory and pro-apoptotic effects. (perfect-curve.com)
It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)

Accelerated hematopoietic cell apoptosis has been demonstrated in virtually all IBMFS. (medscape.com)

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. (biomedcentral.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Etoposide is an epipodophyllotoxin that induces DNA strand breaks by disrupting topoisomerase II activity. (medscape.com)

The aim of this study was to investigate whether or not RvD1 exerts protective results on alveolar epithelial cell perform/differentiation and protects towards fibroproliferative stimuli. (perfect-curve.com)
Instead, they release diffusable cytokines, which mediate the inflammatory reaction and resultant apoptosis of epithelial cells. (medscape.com)

After ovariectomy, expression of OPG mRNA was suppressed however that of RANKL was induced. (perfect-curve.com)

Neurologic abnormalities induced by heat stroke involve the brain (especially the basal ganglia and thalami), cerebellum, anterior horn cells in the spinal cord, and peripheral nerves. (ajnr.org)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. (oncotarget.com)
Similar findings were made in bone marrow cells from gene-targeted mice lacking Bim and/or Puma infected with FLT3-ITD and treated with inhibitor, where loss of Puma only provided transient protection from apoptosis, but loss of Bim preserved clonal survival upon FLT3-ITD inhibition. (ashpublications.org)
46% of cells in p53-functional cell lines but failed to cause apoptosis in p53 nonfunctional cell lines. (aacrjournals.org)
The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)
Although the intended target is the malignant cells of Hodgkin lymphoma, the effects of chemotherapy on normal cells of the body are considerable and account for the adverse effects observed with these agents. (medscape.com)
This difference allows normal cells to recover more quickly than malignant ones after chemotherapy and is the rationale behind current cyclic dosage schedules. (medscape.com)
C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
Gesamtverm Gens MCMV infection PI3K/Akt our data, based on data with HCMV and that this activation to induce signaling through PI3K p110a RAE RAE first required significant induction in cells infected with MCMV There are three classes obtained enzymes in the superfamily of PI3K class I, II and III. (microrna1.com)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. (biomedcentral.com)

In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)

Nutraculture™ Phycocyanin™ is a natural dietary supplement dedicated to assisting individuals who are undergoing cancer therapies including chemotherapy and radiation. (nutraculture.com)

We conclude that Tip60 enables UV-induced DDR signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1. (rupress.org)

Immunoprecipitation revealed that pulsatile shear stress induced the coupling of ubiquitin with PDCD4 expression. (plos.org)
Atherosclerosis plaques preferentially develop at arterial branches and curvatures under low and oscillatory or even static shear stress induced by disturbed blood flow as opposed to in straight parts, featuring protective unidirectional pulsatile shear stress [14] , [15] . (plos.org)

N -Acetylcysteine inhibited TPZ-mediated ΔΨ m loss and GSH depletion, but neither N -acetylcysteine nor Boc-d-fmk inhibited apoptosis caused by TPZ. (aacrjournals.org)

Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)

Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)

An analysis of an interactome for apoptosis factor, Ei24/PIG8, using the inducible expression system and shotgun proteomics. (nih.gov)

Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)

Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
Puzzlingly, rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose. (rapamycin.news)
Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)
Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)

Int J Radiat Oncol Biol Phys 51:650659 Herth FJ, Annema JT, Eberhardt R et al (2008) Endobronchial ultrasound with transbronchial needle hankering respecting restaging the mediastinum in lung cancerAnn Surg 234:758768 Neoptolemos JP, Stocken DD et al (2004) A randomized endeavour of chemoradiotherapy and chemotherapy after resection of pancreatic cancerThaw on ice the Phusion High-Fidelity PCR Check Mix with HF Buffer, cDNA die, and primer stocks. (ka35.ru)

Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)
Understanding apoptosis in disease conditions is very important as it not only gives insights into the pathogenesis of a disease but may also leaves clues on how the disease can be treated. (biomedcentral.com)

Since our data suggest that required to induce early events of viral infection RAE 1, we have a situation where. (microrna1.com)
The pathophysiology of erythema multiforme (EM) is still not completely understood, but it is probably immunologically mediated and appears to involve a hypersensitivity reaction that can be triggered by a variety of stimuli, particularly bacterial, viral, or chemical products. (medscape.com)

Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)

When we get cold, the hypothalamus does the opposite and induces shivering that increases heat production. (ajnr.org)

OBJECTIVE: The aim of this study was to test whether acupuncture could modify the threshold of tolerance to thermal and electrical stimuli. (daneurope.org)

Usually, when one thinks about the word vaccine, the first thought that comes into the mind is related to an artificial administration of a stimulus that instructs the immune system to fight against the cause of a particular pathological state (the pathogen). (biomedcentral.com)
Nowadays, however, it is clear that the various arms of the immune system play an essential role in protecting humans from cancer. (biomedcentral.com)

Anatomy9

Organisms3

Diseases61

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology5

Phenomena and Processes27

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science2

Health Care21

Autophagy5

Radiotherapy6

Mitochondrial apoptosis3

Proliferation11

Mechanisms7

Fragmentation1

Inhibit2

Cytotoxic effects2

Chemotherapeutic agents1

Radiation therapy3

Immunotherapy1

Mechanism5

Necrosis1

Oxidative stress2

Tumor cells2

Growth3

Hallmarks2

Proteins4

Cytotoxicity2

Neurons4

Metabolism1

Pathway3

Apoptotic2

Hematopoietic1

Cellular2

Etoposide1

Epithelial2

MRNA1

Cells14

Cancers1

Therapies1

Suppresses1

Shear2

Depletion1

Phenotype1

Doxorubicin1

Inducible1

Malignancies1

Resistance4

Pancreatic1

Pathogenesis2

Viral2

Cell survival1

Increases1

Tolerance1

Immune2