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  • complications
  • This metabolic derangement in turn leads to increased production of a reactive glucose-derived substance, methylglyoxal (MG), that is elevated in diabetes and linked to vascular complications, including damage to blood cells, kidneys, retina and nerves in arms and legs. (nutritionreview.org)
  • Together these processes contribute to blood vessel damage linked to the development of vascular complications associated with diabetes. (nutritionreview.org)
  • Type 2 diabetes mellitus (T2DM) significantly increases risk for vascular complications. (hindawi.com)
  • Youth with T2DM had higher rates of all complications than nondiabetes subjects, and an overall 6.15-fold increased risk of any vascular disease [ 2 ]. (hindawi.com)
  • Although application of drugs and changing life style had been widely promoted to control the complications, unfortunately, the preventive of the development and progression of vascular complications in the diabetic patients remains unoptimistic [ 4 ]. (hindawi.com)
  • Therefore, an effective approach to prevent and/or delay the development and progression of diabetic vascular complications urgently needs to be developed. (hindawi.com)
  • There was also increasing evidence indicating that the increased production of reactive oxygen and/or nitrogen species (ROS and/or RNS) is the major pathogenic factor responsible for the development and progression of vascular complications in diabetic patients, although several other mechanisms are also proposed [ 8 - 10 ]. (hindawi.com)
  • It was suggested by many researchers to use angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor antagonists to limit the size of atherosclerotic lesion and hence to reduce its vascular complications [ 2 , 3 ]. (omicsonline.org)
  • inhibitors
  • The robust protection conferred by one-time local delivery of kenpaullone suggests that CDK2 inhibitors may transform the clinical prevention and treatment of cisplatin- and noise-induced hearing loss in patients," Zuo says. (brightsurf.com)
  • researchers
  • 3) And in tests where researchers induced a temporary state of low acid (pH greater than 4.0) all subjects experienced bacterial overgrowth in the proximal small intestine. (nutritionreview.org)
  • While the link between exercise and alleviating symptoms of depression isn't clear, researchers have found that regular exercise -- 30 to 60 minutes of moderate exercise most days of the week -- can lift mood, reduce stress and boost self-esteem as well as protect against heart disease , high blood pressure and cancer. (howstuffworks.com)
  • damage
  • In this review we will describe the mechanisms of resistance, and how they may be overcome to improve the survival of GBM patients by implementing novel chemotherapy drugs, new drug combinations and new approaches relating to DNA damage, angiogenesis and autophagy. (mdpi.com)
  • And currently, it's being studied for its ability to reduce symptoms of PMS, altitude sickness, chemotherapy-induced end-organ vascular damage and symptoms of depression. (howstuffworks.com)
  • vessels
  • Local cold applications are used to steer chemotherapy away from certain areas by constricting the vessels in that area, minimizing blood flow through them. (tracywalton.com)
  • humans
  • Although different types of chemotherapy affect the immune system differently, this research suggests that humans undergoing chemotherapy may be able to enhance the function of their leucocytes with taurine. (alignlife.com)
  • bacteria
  • Removal of pyruvate induces a physiological change in biofilm bacteria that causes them to disassemble the biofilm structure, rendering biofilm bacteria more susceptible to antibiotics. (nutritionreview.org)
  • immune
  • While it may not be the common cold cure we all hope for, it does help protect us from cancer , stroke and cardiovascular disease, and it is beneficial to our eye health and boosts our immune system. (howstuffworks.com)
  • New research has revealed that taurine deficiency can compromise the immune system, while supplemental taurine can boost white blood cell count even during chemotherapy. (alignlife.com)
  • thus
  • At this point, only proteins that were endocytosed remain protected from L-glutathione and thus remain biotinylated. (jove.com)
  • Thus, CB 1 receptor antagonists may offer a new cardioprotective strategy against DOX-induced cardiotoxicity. (onlinejacc.org)
  • high
  • People receiving chemotherapy face a high risk for developing infections, and they are less able to fight off infections once they develop. (alignlife.com)
  • proteins
  • Hydrochloric acid (HCl) is an important gastric secretion that enables the body to break down proteins, activate important enzymes and hormones, and protect against bacterial overgrowth in the gut. (nutritionreview.org)
  • Endocytosis of biotinylated plasma membrane proteins is induced by incubation at 37 ºC. (jove.com)
  • The biotinylated proteins protected from L-glutathione are those that did not recycle to the plasma membrane. (jove.com)
  • clinical
  • Given that 100-dB noise is in the range of noise insults commonly experienced by people in our society, kenpaullone could have significant clinical application in treating noise-induced hearing loss," says Zuo. (brightsurf.com)
  • affect
  • For massage therapists working with clients before, during, or after chemotherapy infusion, how do these new technologies affect your approach? (tracywalton.com)
  • function
  • These results suggest that sulforaphane is able to upregulate aortic Nrf2 expression and function and to protect the aorta from T2DM-induced pathological changes. (hindawi.com)
  • Journal
  • Overexpression of Two Different GTPases Rescues a Null Mutation in a Heat-induced RRNA Methyltransferase Journal of Bacteriology. (jove.com)
  • normal
  • LSCs reside in the same niche as healthy HSCs and, on one side, they benefit from BM niche support and, on the other side, they modify the BM niche in order to induce a favorable environment for leukemic growth hampering normal hematopoiesis [ 5 ]. (hindawi.com)