Proteasome Endopeptidase ComplexAcetylcysteineProteasome InhibitorsCysteine Proteinase InhibitorsCysteine EndopeptidasesMultienzyme ComplexesLeupeptinsUbiquitinBoronic AcidsPyrazinesProtease InhibitorsEndopeptidasesNeprilysinCell LineUbiquitinsOligopeptidesLactonesSerine EndopeptidasesThiorphanUbiquitinationPeptide HydrolasesApoptosisProteolysisInfusions, IntralesionalPHEX Phosphate Regulating Neutral EndopeptidaseCell Line, TumorAmino Acid SequenceMolecular Sequence DataHydrolysisAntineoplastic AgentsEnzyme InhibitorsProtein Processing, Post-TranslationalBlotting, WesternNF-kappa BDown-RegulationTumor Cells, CulturedUbiquitinated ProteinsMultiple MyelomaPolyubiquitinEndoplasmic ReticulumSubstrate SpecificityCells, CulturedTransfectionMetalloendopeptidasesUbiquitin-Protein LigasesChymotrypsinI-kappa B ProteinsHeLa CellsSignal TransductionDose-Response Relationship, DrugDipeptidesCalpainProtein BindingCaspasesEnzyme ActivationDrug SynergismProtein SubunitsRNA, MessengerProteinsProtein Synthesis InhibitorsMutationLactams, MacrocyclicKineticsCell SurvivalPeptide FragmentsBrefeldin ARecombinant ProteinsLysosomesPhosphorylationBenzoquinonesTime FactorsCytosol