• Impairment in ubiquitin-proteasome system (UPS) has recently been implicated in Parkinson's disease, as demonstrated by reduced proteasomal activities, protein aggregation and mutation of several genes associated with UPS. (biomedsearch.com)
  • A major challenge of modern biology is to understand the networks of interacting genes regulating complex traits, and the subset of these genes that affect naturally occurring quantitative genetic variation. (biomedcentral.com)
  • Expression profiling is a powerful method for identifying networks of pleiotropic genes regulating complex traits, but the relationship between variation in transcript abundance among lines used to map QTLs and genes affecting variation in quantitative traits is complicated. (biomedcentral.com)
  • Advances in medicine, agriculture, and an understanding of adaptive evolution depend on discovering the genes that regulate these complex traits, and determining the genetic and molecular properties of alleles at loci that cause segregating genetic variation in natural populations. (biomedcentral.com)
  • Discover related pathways, diseases and genes to Proteasome 20S alpha 6. (novusbio.com)
  • Discover related pathways, diseases and genes to Proteasome beta 1. (novusbio.com)
  • CONCLUSION: These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer. (cnrs.fr)
  • Now EC 3.4.19.1, acylaminoacyl-peptidase EC 3.4.14.4: dipeptidyl-peptidase III EC 3.4.14.5: dipeptidyl-peptidase IV EC 3.4.14.6: dipeptidyl-dipeptidase EC 3.4.14.7: Deleted entry: tetralysine endopeptidase EC 3.4.14.8: Transferred entry: tripeptidyl peptidase. (wikipedia.org)
  • Thus, our study demonstrates that distinct selective autophagy pathways contribute to host immunity and bacterial pathogenesis during Pst infection and provide evidence for an intimate crosstalk between the proteasome and autophagy system in plant-bacterial interactions. (nih.gov)