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  • cells
  • Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways. (biomedsearch.com)
  • In the present study, we investigated the effect of proteasome inhibition in proliferating B-CLL cells. (biomedsearch.com)
  • CONCLUSION: Proteasome inhibition is highly effective in proliferating B-CLL cells and induces apoptosis using a caspase-dependent and -independent pathway. (biomedsearch.com)
  • CLDN1 is a major component in forming tight junction complexes between cells, which foster cell-cell adhesion of cell membranes. (wikipedia.org)
  • cell
  • An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes. (wikipedia.org)
  • Type 2 RIPs consist of an A chain that is functionally equivalent to a type 1 RIP, covalently connected by a single disulfide bond to a B chain that is catalytically inactive, but serves to mediate transport of the A-B protein complex from the cell surface, via vesicle carriers, to the lumen of the endoplasmic reticulum (ER). (wikipedia.org)
  • Chains
  • Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2 RIPs, also known as holotoxins, are composed of two different protein chains that form a heterodimeric complex. (wikipedia.org)
  • core
  • In structure, the proteasome is a cylindrical complex containing a "core" of four stacked rings forming a central pore. (wikipedia.org)
  • Although electron microscopy data revealing the stacked-ring structure of the proteasome became available in the mid-1980s, the first structure of the proteasome core particle was not solved by X-ray crystallography until 1994. (wikipedia.org)
  • This gene PSMB10 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. (wikipedia.org)
  • early
  • Much of the early work leading up to the discovery of the ubiquitin proteasome system occurred in the late 1970s and early 1980s at the Technion in the laboratory of Avram Hershko, where Aaron Ciechanover worked as a graduate student. (wikipedia.org)
  • Type
  • Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit beta2 (proteasome subunit beta type-7) in the immunoproteasome. (wikipedia.org)
  • mature
  • At the end-stage of complex assembly, the N-terminal fragment of beta2i subunit is cleaved, forming the mature beta2i subunit of 20S complex. (wikipedia.org)
  • The propolypeptide is cleaved within protein bodies by an endopeptidase to produce the mature ricin protein that is composed of a 267 residue A chain and a 262 residue B chain that are covalently linked by a single disulfide bond. (wikipedia.org)