Proteasome Endopeptidase ComplexUbiquitinUbiquitinationProteolysisUbiquitin-Protein LigasesProteasome InhibitorsCysteine EndopeptidasesMultienzyme ComplexesPolyubiquitinLeupeptinsUbiquitinsProtein StabilityCell LineCysteine Proteinase InhibitorsProtein Processing, Post-TranslationalProtein BindingMolecular Sequence DataEndoplasmic Reticulum-Associated DegradationEndoplasmic ReticulumF-Box ProteinsAmino Acid SequenceCullin ProteinsCell Line, TumorProtein Structure, TertiaryHEK293 CellsMutationSignal TransductionHSP90 Heat-Shock ProteinsHeLa CellsProto-Oncogene Proteins c-mdm2beta-Transducin Repeat-Containing ProteinsImmunoprecipitationPhosphorylationUbiquitinated ProteinsProtein TransportDown-RegulationUbiquitin-Conjugating EnzymesSKP Cullin F-Box Protein LigasesUbiquitin ThiolesteraseNuclear ProteinsCells, CulturedCarrier ProteinsReceptors, Autocrine Motility FactorPolymerase Chain ReactionCOS CellsBlotting, WesternS-Phase Kinase-Associated ProteinsLysineRNA, Small InterferingModels, BiologicalAcetylcysteineTumor Suppressor Protein p53HydrolysisApoptosisRNA, MessengerImmunoblottingLactams, MacrocyclicTransfectionProtein FoldingBenzoquinonesCell Cycle ProteinsCell NucleusProtease InhibitorsGene Expression RegulationTranscription FactorsRNA InterferenceAmino Acid MotifsEndopeptidasesNAD(P)H Dehydrogenase (Quinone)Reverse Transcriptase Polymerase Chain ReactionCercopithecus aethiopsDNA-Binding ProteinsMolecular ChaperonesPeptide HydrolasesRecombinant Fusion ProteinsMembrane ProteinsTranscription, GeneticGlycogen Synthase Kinase 3Boronic AcidsBase SequenceProteinsPyrazinesAdenosine TriphosphatasesHSP70 Heat-Shock ProteinsCytosolSaccharomyces cerevisiae ProteinsProcollagen-Proline Dioxygenasevif Gene Products, Human Immunodeficiency VirusSaccharomyces cerevisiaeTime FactorsBiodegradation, EnvironmentalEnzyme InhibitorsRepressor ProteinsHypoxia-Inducible Factor 1, alpha SubunitAdaptor Proteins, Signal TransducingNIH 3T3 CellsActive Transport, Cell NucleusBinding SitesKineticsTumor Suppressor Proteins