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  • cathepsin
  • Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. (ucsf.edu)
  • These activities were caused by an intracellular cysteine protease not associated with the lysosome and having an optimum activity at neutral pH, which clearly distinguished it from the cathepsin family of proteases. (wikipedia.org)
  • microarrays
  • The materials presented in this chapter examine the recent developments in the field of peptide microarrays with special emphasis on the generation and applications of high-density arrays of peptides on glass slides. (springer.com)
  • The assay principle of peptide microarrays is similar to an ELISA protocol. (wikipedia.org)
  • Peptide microarrays can be used to study different kinds of protein-protein interactions, specially those involving modular protein substructures called peptide recognition modules or, most communly, protein interaction domains. (wikipedia.org)
  • assays
  • Our scientific team has extensive experience in developing pharmacologically sensitive assays for various drug target classes that include GPCRs , kinases, and proteases . (genscript.com)
  • If you can't find protease of interest in ready catalog assays, please feel free to contact us for support. (genscript.com)
  • cyclic peptide
  • Once a cyclic peptide is identified with a biological activity of interest, it may also be possible to identify the target of the peptide (a gene that encodes a protein with which it interacts) by functional complementation, facilitating a better understanding of its mechanism of action. (wikipedia.org)
  • bioactive
  • Agyei D, Danquah MK (2011) Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. (springer.com)
  • By drawing attention to how proteolysis serves as an additional irreversible mechanism by which cells could achieve control over biological processes, they outlined the necessity of studying proteases for their functional relevance in processing bioactive molecules. (wikipedia.org)
  • Novel
  • The discoveries of novel roles for proteases and breakthroughs in protease-substrate discovery would be summarized later by Dr. Carlos Lopez-Otin and Dr. Chris Overall, introducing degradomics on a system-wide scale. (wikipedia.org)
  • GPCRs
  • Depending upon their scope and design, chemical libraries can also be classified as diverse oriented, Drug-like, Lead-like, peptide-mimetic, Natural Product-like, Targeted against a specific family of biological targets such Kinases, GPCRs, Proteases, PPI etc. (wikipedia.org)
  • synthetic
  • The structure of the synthetic amidated peptide Hb 33-61a [ 21 ] as well as its truncated analogues [ 22 ] was elucidated by H 1 -NMR in micelles of SDS. (biomedcentral.com)
  • Whereas peptides spotted can undergo quality controls that include mass spectrometer analysis and concentration normalization before spotting and result from a single synthetic batch, peptides synthesized directly on the surface may suffer from batch-to-batch variation and limited quality control options. (wikipedia.org)
  • targets
  • Diamond SL, Greenbaum D. Proteases' prime targets revealed . (upenn.edu)
  • To speed up the drug discovery process that involves protease targets, GenScript has developed a protease assay panel for compound screening. (genscript.com)
  • Moreover, custom assay development service is available to facilitate your drug screening against protease targets of your interest. (genscript.com)