SuperfamilyAACTMouse Monoclonal AntibodyELISA KitTHROMBINSerumInhibitsHeparinProteolyticEndogenousSecretorySerpinsTrypsinSerine EndopeptidasesAntithrombin IIIProteinEnzymePancreaticPhysiologicalKallikreinPancreasPlasmaInactivateDetectAntigenImmunohistochemistryAntibodiesMolecular WeightAntitrypsin1998HumanNEUTROPHILSTherapeuticGlycoproteinSimilaritiesAcuteActivityCellularHistoneProstate cancerComplex
Superfamily5
- The members of serpin superfamily have instrumental roles in a variety of physiological and cellular functions and are associated with the vertebrate blood coagulation cascade, complement activation, inflammation, programmed cell death, cell development, and fibrinolysis [ 1 - 3 ]. (jgenomics.com)
- These serpin members represent the largest superfamily and most diverse family of protease inhibitors [ 3 ]. (jgenomics.com)
- Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. (wikidoc.org)
- Background Alpha 1-antichymotrypsin (alpha1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. (qedbio.com)
- 1987 ). This superfamily of proteases is defined by the presence of a Zn 2+ ion at the catalytic center, which is coordinated by three histidine residues in the zinc-binding consensus sequence HExxHxxGxxH that is present in all proteolytically active metzincins, and a characteristic, strictly conserved methionine-containing tight 1,4 beta turn forming a hydrophobic cleft for the catalytic zinc ion (Bode et al. (evelinvahter.com)
AACT5
- It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). (neobiotechnologies.com)
- AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. (neobiotechnologies.com)
- In human, the normal serum level of AACT is about one-tenth that of 伪 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. (neobiotechnologies.com)
- This MAb recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). (enquirebio.com)
- Description: A sandwich ELISA for quantitative measurement of Rat Alpha 1 Antichymotrypsin,AACT in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (tissue-cell-culture.com)
Mouse Monoclonal Antibody2
- Formalin-fixed, paraffin-embedded human liver stained with Alpha-1-Antichymotrypsin Mouse Monoclonal Antibody (SERPINA3/4187). (neobiotechnologies.com)
- 19,000 full-length human proteins using Monospecific to Alpha-1-Antichymotrypsin Mouse Monoclonal Antibody (SERPINA3/4187). (neobiotechnologies.com)
ELISA Kit3
- This Human Plasma serine protease inhibitor (SERPINA5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINA5 in samples. (abbkine.com)
- Human Plasma serine protease inhibitor (SERPINA5) ELISA Kit has high sensitivity and excellent specificity for detection of Human SERPINA5. (abbkine.com)
- Description: A sandwich ELISA kit for detection of Thrombospondin 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ksiazkiwnauce.pl)
THROMBIN4
- The physiological target proteases of antithrombin are those of the contact activation pathway (formerly known as the intrinsic pathway), namely the activated forms of Factor X (Xa), Factor IX (IXa), Factor XI (XIa), Factor XII (XIIa) and, to a greater extent, Factor II (thrombin) (IIa), and also the activated form of Factor VII (VIIa) from the tissue factor pathway (formerly known as the extrinsic pathway). (wikipedia.org)
- They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. (lookformedical.com)
- Antithrombin III is a serum protease inhibitor that inhibits the blood coagulation protease, thrombin, and is an important regulator of hemostasis. (scrippslabs.com)
- By inhibiting the coagulation proteases, especially thrombin, FXa and FIXa, AT prevents uncontrolled coagulation and thrombosis. (diapharma.com)
Serum4
- Glycoprotein found in alpha(1)-globulin region in human serum. (lookformedical.com)
- Serum alpha-1 antitrypsin in acute ischemic stroke: A prospective pilot study. (rush.edu)
- Immunogen Purified human serum alpha-1-antichymotrypsin. (qedbio.com)
- Specificity These antibodies specifically recognize human serum alpha-1-antichymotrypsin. (qedbio.com)
Inhibits3
- Protein C inhibitor is sometimes referred to as plasminogen activator inhibitor-3 (PAI3) because it also inhibits plasminogen activators (Meijers and Chung, 1991). (abbkine.com)
- A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. (lookformedical.com)
- alpha1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. (qedbio.com)
Heparin2
- Antithrombin is a serpin (serine protease inhibitor) and is thus similar in structure to most other plasma protease inhibitors, such as alpha 1-antichymotrypsin, alpha 2-antiplasmin and Heparin cofactor II. (wikipedia.org)
- Antithrombin (AT) or Heparin Cofactor I is the major inhibitor of blood coagulation and is essential for effective heparin therapy. (diapharma.com)
Proteolytic3
- The proteolytic activity of PSA in blood is inhibited by the irreversible formation of complexes with proteinase inhibitors such as alpha 1 antichymotrypsin, alpha 2 macroglobulin and other acute phase proteins. (redituslabs.com)
- A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. (lookformedical.com)
- The regulations of proteolytic activity of serine proteases are critical steps to maintain balanced homeostasis and the serine protease inhibitors (serpins) possess capabilities to regulate the proteolytic activities of these serine proteases by inhibitory mechanism [ 1 ]. (jgenomics.com)
Endogenous2
- In the present study we have further analyzed plasma and peritoneal samples from the same patients to ascertain whether the aprotinin treatment affects the balance between proteases and endogenous antiproteases. (nih.gov)
- The protease-antiprotease balance was studied by measuring immunoreactive anionic trypsin (irAT), cationic trypsin (irCT), complexes between cationic trypsin and alpha 1-protease inhibitor (irCT-alpha 1 PI), leukocyte elastase and neutrophil proteinase 4 (NP4), as well as the endogenous protease inhibitors, pancreatic secretory trypsin inhibitor (PSTI), alpha 2-macroglobulin (alpha 2M), alpha 1-protease inhibitor (alpha 1 PI), antichymotrypsin (ACHY), and secretory leukocyte protease inhibitor (SLPI). (nih.gov)
Secretory1
- A surprise finding was that the patients had higher peritoneal levels of pancreatic secretory trypsin inhibitor (PSTI) after the lavage procedure. (nih.gov)
Serpins2
- Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known. (lookformedical.com)
- Human α 1 -antitrypsin shared lower sequence identities and similarities with urochordates serpins ranged from 14-29% and 30-49%, respectively. (jgenomics.com)
Trypsin2
- However it inactivates certain other serine proteases that are not involved in coagulation such as trypsin and the C1s subunit of the enzyme C1 involved in the classical complement pathway. (wikipedia.org)
- Although high-dose aprotinin given intraperitoneally to patients with severe acute pancreatitis seems to inhibit activated trypsin in the peritoneal cavity, the treatment has little effect on the balance between proteases and antiproteases. (nih.gov)
Serine Endopeptidases1
- Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES. (bvsalud.org)
Antithrombin III1
- antithrombin III, α 1 -protease inhibitor and chicken egg white albumin [ 7 ]. (jgenomics.com)
Protein4
- 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. (enquirebio.com)
- Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C.Suzuki et al. (abbkine.com)
- 1987) determined the sequence of cDNA for human protein C inhibitor (PCI). (abbkine.com)
- 2014), six have been examined in studies that meet our inclusion criteria: C-reactive protein (CRP), interleukin-6 (IL-6), and alpha-1-antichymotrypsin (ACT), fibrinogen, lipoprotein-associated phospholipase A2 (Lp-PLA2), and interleukin-1β (IL-1β). (alzrisk.org)
Enzyme4
- Protease inactivation results as a consequence of trapping the protease in an equimolar complex with antithrombin in which the active site of the protease enzyme is inaccessible to its usual substrate. (wikipedia.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Thrombospondin 1 (THBS1) in plasma, tissue homogenates and other biological fluids. (ksiazkiwnauce.pl)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Thrombospondin 1 (THBS1) in samples from plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (ksiazkiwnauce.pl)
- In_x000D_addition, the kit includes purified HDAC2 enzyme and a potent HDAC inhibitor,_x000D_Trichostatin A, for use as a positive and negative control. (gentaurtop.com)
Pancreatic1
- Although most studies have shown protease inhibitor therapy to have little or no effect on acute pancreatitis, in an earlier study we found that very high doses of the protease inhibitor aprotinin given intraperitoneally to patients with severe acute pancreatitis seemed to reduce the need of surgical treatment for pancreatic necrosis. (nih.gov)
Physiological1
- Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. (neobiotechnologies.com)
Kallikrein1
- The inhibitor also inactivates kallikrein and plasmin[citation needed], also involved in blood coagulation. (wikipedia.org)
Pancreas1
- A protease of broad specificity, obtained from dried pancreas. (lookformedical.com)
Plasma3
- Plasma levels of leukocyte proteases were high in all the patients, indicating leukocyte activation to be an important feature of the pathophysiology of severe acute pancreatitis. (nih.gov)
- The control group had lower plasma levels of SLPI and analysis of peritoneal fluid showed the reduction of irCT-alpha 1 PI to be more pronounced in the aprotinin group. (nih.gov)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Thrombospondin 1 (THBS1) in samples from plasma, tissue homogenates or other biological fluids. (ksiazkiwnauce.pl)
Inactivate1
- The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion. (bvsalud.org)
Detect1
- We were unable to detect Alpha-1-Antichymotrypsin in other tissues. (enquirebio.com)
Antigen1
- 2001. Value of prostate specific antigen α1-antichymotrypsin complex for the detection of prostate cancer in patients with a PSA level of 4.1-10.0 ng/mL: comparison with PSA-related parameters. (neobiotechnologies.com)
Immunohistochemistry2
- Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined. (neobiotechnologies.com)
- Variations in Alpha-1-Antichymotrypsin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
Antibodies1
- Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. (qedbio.com)
Molecular Weight1
- It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. (lookformedical.com)
Antitrypsin4
- alpha 1-Antitrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- This graph shows the total number of publications written about "alpha 1-Antitrypsin" by people in this website by year, and whether "alpha 1-Antitrypsin" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "alpha 1-Antitrypsin" by people in Profiles. (rush.edu)
- They do not cross-react with alpha-1-antitrypsin. (qedbio.com)
19982
- 1998 Aug;24(1):9-17. (nih.gov)
- 1998). "Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. (wikidoc.org)
Human3
- enQuire Bio's Alpha-1-Antichymotrypsin Anti-Human Monoclonal is available for Research Use Only. (enquirebio.com)
- Which of these reactions are physiologically or pathophysiologically relevant is often not clear, although studies on knockout animals, human genetic and epigenetic, as well as biochemical studies using natural or synthetic inhibitors have provided insight to a great extent. (evelinvahter.com)
- Human TNFa Immunoassay KitEA 9,360.00 766Singulexmillipore 03-0024-00ReagentsActive GLP-1 Immunoassay Kit AssemblyEA 9,360.00 766Singulexmillipore 03-0024-01ReagentsActive GLP-1 Immunoassay KitEA 14,040.00 766Singulexmillipore 03-0024-02ReagentsActive GLP-1 Immunoassay KitEA 14,040.00 766Singulexmillipore 03-0024-03ReagentsErenna? (thesixteendigital.com)
NEUTROPHILS1
- A serine protease found in the azurophil granules of NEUTROPHILS. (lookformedical.com)
Therapeutic1
- This has stimulated a flurry of studies into MMP inhibitors as therapeutic agents, as well as into measuring MMP levels as diagnostic or prognostic markers. (evelinvahter.com)
Glycoprotein1
- PSA is a 27-kD glycoprotein that is produced by prostate epithelial cells and with chymotrypsin-like serine protease activity. (mlo-online.com)
Similarities1
- Plasminogen activator inhibitor-1 (PAI1) has structural similarities to PCI. (abbkine.com)
Acute1
- In fractions 1-4 from newborn CF piglets an additional cluster containing acute phase proteins was observed, suggesting an early inflammatory response in CF piglets. (biomedcentral.com)
Activity1
- Description: The Fluorogenic HDAC Assay Kit is a complete assay system_x000D_designed to measure histone deacetylase (HDAC) class 1 activity for screening_x000D_and profiling applications. (gentaurtop.com)
Cellular1
- They form a covalent complex with SERINE PROTEASES and can mediate their cellular internalization and degradation. (lookformedical.com)
Histone1
- We identify the histone acetyltransferase MYS-1, as a critical regulator of this metabolic-epigenetic axis. (knoblauchpublishing.com)
Prostate cancer1
- 1,2 Many more cases of prostate cancer do not become clinically apparent, as demonstrated in autopsy series, where prostate cancer is identified in one-third of men under the age of 80 and in two-thirds of men older than 80. (mlo-online.com)
Complex1
- The formation of an antithrombin-protease complex involves an interaction between the protease and a specific reactive peptide bond within antithrombin. (wikipedia.org)