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  • ritonavir
  • Protease inhibitors that have been developed and are currently used in clinical practice include: Antiretroviral HIV-1 protease inhibitors - class stem -naviramprenavir atazanavir darunavir fosamprenavir indinavir lopinavir nelfinavir ritonavir saquinavir tipranavir Hepatitis C virus NS3/4A protease inhibitors - class stem -previrasunaprevir boceprevir grazoprevir paritaprevir simeprevir telaprevir Given the specificity of the target of these drugs there is the risk, as in antibiotics, of the development of drug-resistant mutated viruses. (wikipedia.org)
  • Researchers are investigating the use of protease inhibitors developed for HIV treatment as anti-protozoals for use against malaria and gastrointestinal protozoal infections: A combination of ritonavir and lopinavir was found to have some effectiveness against Giardia infection. (wikipedia.org)
  • I have posted my hypothesis, 09/08/96, that protease inhibitors work by reducing production of DHEA, as 'Ritonavir works by reducing DHEA. (bio.net)
  • Lopinavir was developed by Abbott in an attempt to improve on the HIV resistance and serum protein-binding properties of the company's earlier protease inhibitor, ritonavir. (wikipedia.org)
  • however, like several HIV protease inhibitors, its blood levels are greatly increased by low doses of ritonavir, a potent inhibitor of cytochrome P450 3A4. (wikipedia.org)
  • peptide
  • It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. (wikipedia.org)
  • nelfinavir
  • Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs. (wikipedia.org)
  • Nelfinavir mesylate (Viracept, formerly AG1343) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection. (wikipedia.org)
  • Nelfinavir is a competitive inhibitor (2 nM) which is designed to bind tightly and is not cleaved due to the presence of a hydroxyl group as opposed to a keto group in the middle amino acid residue mimic, which would be otherwise S-phenylcysteine. (wikipedia.org)
  • AIDS
  • David Ho - AIDS researcher who pioneered the use of protease inhibitors in treating HIV-infected patients The Proteolysis Map Reverse transcriptase inhibitor Discovery and development of NS5A inhibitors "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). (wikipedia.org)
  • To date, I have not found any reports regarding protease intake for AIDS and cholesterol levels. (bio.net)
  • widely
  • The most successful methods found so far include: Heat Freezing Addition of Sulfites While trypsin inhibitors have been widely regarded as anti-nutritive factors in soy, research is currently being done on the inhibitors' possible anti-carcinogenic characteristics. (wikipedia.org)
  • bind
  • RBD exposure allows the aM protease complex to bind to clearance receptors and be removed from circulation. (wikipedia.org)
  • greatly
  • Protease inhibitors not only greatly reduce the number of new HIV copies that are made, they also make those that do manage to get produced defective in some way, so that they cannot go on and infect new cells. (encyclopedia.com)
  • family
  • The clinical phenotype of CEDS patients represented a paradox since caspase-8 was considered to be chiefly a proapoptotic protease, that was mainly involved in signal transduction from Tumor necrosis factor receptor family death receptors such as Fas. (wikipedia.org)
  • found
  • These inhibitors are primarily found in plants and in particular in the seeds of legumes, as well as in cereal grains. (wikipedia.org)
  • In soy, KTI is found in much larger concentrations than BBI is soy, however, to achieve the highest nutritional value from this ingredient, both of these inhibitors must be denatured in some way. (wikipedia.org)
  • Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex which were crucial for the induction of nuclear translocation of NF-κB. (wikipedia.org)
  • drugs
  • Inhibitors of the proteasome, such as bortezomib are now front-line drugs for the treatment of multiple myeloma. (wikipedia.org)
  • Protease inhibitors (pronounced PRO-tee-ace in-HIH-bi-ters) are a new type of drugs that slow down the spread of HIV (human immunodeficiency virus) inside a person's body. (encyclopedia.com)
  • Although not a cure for this disease, protease inhibitors have proven to be a powerful anti-HIV drug, especially when taken in combination with certain other drugs. (encyclopedia.com)
  • I suggest the connection of protease inhibitors and benzodiazepines is directly tied to effects of these drugs on the melatonin - DHEA cycle. (bio.net)
  • glucose
  • Decreased adiponectin secretion and induced expression of interleukin-6 associated with HIV protease inhibitors may also contribute to inhibition of insulin-stimulated glucose uptake. (wikipedia.org)