Protease inhibitor indinavir drug therapy combination. Medical search. Frequent questions

Boosted indinavir requires two 400-mg indinavir capsules with 1 to 2 100-mg ritonavir capsules twice a day. (wikipedia.org)
Co-administration with Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir. (nih.gov)
Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naïve HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study. (hiv-guidelines.jp)
This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
There is a relationship between diabetes and re-exposure to HAART, especially among individuals under therapy with stavudine, zidovudine, didanosine, and indinavir, while the risk is reduced in case of exposure to ritonavir and nevirapine. (bvsalud.org)
regarding five various other protease inhibitors indicated that BMS-232632-resistant pathogen remained delicate to saquinavir, although it demonstrated various amounts (0.1- to 71-fold reduction in sensitivity)-of cross-resistance to nelfinavir, indinavir, ritonavir, and amprenavir. (bioxorio.com)
In reciprocal tests, the BMS-232632 susceptibility of HIV-1 variations selected in the current presence of each one of the various other HIV-1 protease inhibitors demonstrated the fact that nelfinavir-, saquinavir-, and amprenavir-resistant strains of HIV-1 continued to be delicate to BMS-232632, while indinavir- and ritonavir-resistant infections shown six- to ninefold adjustments in BMS-232632 sensitivity. (bioxorio.com)
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours. (cheapbuyorder.co.uk)
Indinavir plus ritonavir plus 2 NRTIs is one of the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis. (cheapbuyorder.co.uk)

trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. (wikipedia.org)
Crixivan (indinavir) [package insert]. (stonecottagegardens.com)

RESCRIPTOR tablets contain delavirdine mesylate, a synthetic non-nucleoside reverse transcriptase inhibitor (NNRTI) of the human immunodeficiency virus type 1 (HIV-1). (drugs.com)
EDURANT is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-naïve patients 12 years of age and older and weighing at least 35 kg with HIV-1 RNA less than or equal to 100,000 copies/mL ( 1.1 ). (guidelinecentral.com)
As few or no PI mutations are detected when a patient's first PI-based regimen fails, which is not the case with non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens and some integrase strand transfer inhibitor (INSTI)-based regimens, 1 PI based regimens may be useful for patients at risk for intermittent therapy because of poor adherence. (guidelines.org.au)

Should not be administered in combination with zidovudine (poor antiretroviral effect). (cdc.gov)
In drug combination studies of delavirdine with zidovudine, didanosine, zalcitabine, lamivudine, interferon-α, and protease inhibitors, additive to synergistic anti-HIV-1 activity was observed in cell culture. (drugs.com)
Genotypic analysis of HIV-1 isolates from patients receiving RESCRIPTOR plus zidovudine combination therapy (n = 79) showed resistance-conferring mutations in all isolates by Week 24 of therapy. (drugs.com)
In a separate study, an average of 86-fold increase in the zidovudine susceptibility of patient isolates (n = 24) was observed after 24 weeks of combination therapy with RESCRIPTOR and zidovudine. (drugs.com)
Compare the antiretroviral activity and tolerability of two regimens containing efavirenz, one with a protease inhibitor (indinavir) and the other with two nucleoside reverse transcriptase inhibitors (zidovudine and lamivudine), with a standard three-drug regimen (indinavir, zidovudine and lamivudine). (ubc.ca)
The efficacy of the regimen of efavirenz plus indinavir was similar (53 percent) to that of the regimen of indinavir, zidovudine, and lamivudine. (ubc.ca)
The combination of efavirenz, zidovudine, and lamivudine as antiretroviral therapy in HIV-1-infected adults has greater antiviral activity and is better tolerated than the combination of indinavir, zidovudine and lamivudine. (ubc.ca)
Now the mainstay of the treatment is a single fixed dose combination of Tenofovir, Lamivudine and Efavirenz per day or Zidovudine, Lamivudine and Nevirapine twice daily. (austinpublishinggroup.com)

or didanosine [ddI] and d4T) for most HIV exposures and an expanded regimen that includes the addition of a third drug for HIV exposures that pose an increased risk for transmission. (cdc.gov)
The Antiretroviral Pregnancy Registry, where clinicians should report cases of exposure to antiviral therapy in pregnancy, contains approximately 18,000 reported exposures and notes no increase in the congenital malformation rate with exposure to antiretroviral medications, even in the first trimester, with the exception of didanosine and nelfinavir . (medscape.com)
If indinavir and didanosine are administered concomitantly, they should be administered at least one hour apart on an empty stomach (consult the manufacturer's product circular for didanosine ). (wikidoc.org)

Of these, 12.5% had resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 10.2% to non-NRTIs, and 2.3% to protease inhibitors. (cdc.gov)
Because LPV/r, FPV/r, unboosted ATV, and SQV/r have disadvantages, such as greater pill burden, lower efficacy, or increased toxicity, only boosted DRV and ATV in combination with two nucleoside reverse transcriptase inhibitors (NRTIs) are recommended as initial therapy in certain clinical situations. (guidelines.org.au)

Internationally, a total of 450 volunteers who had not previously been treated with lamivudine or any nonnucleoside reverse transcriptase inhibitor or protease inhibitor were enrolled in the study between January and September 1997. (ubc.ca)

The most notable changes in these guidelines reflect both the findings of clinical trials that evaluated new drug regimens for treating and preventing TB among HIV-infected persons and recent advances in the use of antiretroviral therapy. (cdc.gov)
The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)
Adding to CDC's current recommendations for administering isoniazid preventive therapy to HIV-infected persons with positive tuberculin skin tests and to HIV-infected persons who were exposed to patients with infectious TB, this report also describes in detail the use of new short-course (i.e., 2 months) multidrug regimens (e.g., a rifamycin, such as rifampin or rifabutin, combined with pyrazinamide) to prevent TB in persons with HIV infection. (cdc.gov)
Regimens are listed alphabetically within each drug class and recommendation category for initial therapy in in people who are ARV naive, so the order does not indicate a ranking of preference. (hiv.gov)
The table also indicates ARV drugs or regimens that are available in fixed-dose combination tablets. (hiv.gov)
Some Preferred drugs or regimens may have minimal toxicity or teratogenicity risks that are offset by other advantages for people with HIV who are pregnant or who are trying to conceive. (hiv.gov)
Relationship between weight gain and insulin resistance in people living with HIV switching to integrase strand transfer inhibitors-based regimens. (hiv-guidelines.jp)
Incomplete adherence to antiretroviral agents can have serious consequences, including loss of plasma HIV suppression and turn lead to disease progression, inability to suppress HIV even with very intensive regimens, and development of drug resistant HIV strains. (biomedcentral.com)
Because transmitted PI resistance is uncommon, boosted ATV or DRV-based regimens are recommended for rapid antiretroviral therapy (ART) initiation or in the setting of acute HIV infection, before resistance test results are available. (guidelines.org.au)
Treatment of HIV started as monotherapy initially, and then multiple drugs in regimens were given where patients had to consume 11-16 tablets per day. (austinpublishinggroup.com)
Currently, around 15 molecules are being used in different treatments regimens to treat HIV infections, however, issues like treatment failure due to drug resistance and toxicity remain crucial issues. (austinpublishinggroup.com)

A couple months later on January, 1987, a team of researchers consisting of Emilio Emini, Joel Huff, and Irving Sigal, kickstarted their studies by basing their project off of earlier research on the protease enzyme, renin. (wikipedia.org)
1. Shitara Y, Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. (degruyter.com)
Furthermore to these major substitutions, all five Prt inhibitors have already been proven to select for more overlapping sets of amino acid substitutions elsewhere in the enzyme. (bioxorio.com)
eliglustat (if you know you do not break down drugs that are broken down by the enzyme known as CYP2D6, you should check with your doctor if you can take this medicine). (mydr.com.au)
First, a protease (or proteolytic enzyme) is an enzyme that is the catalyst for proteolysis. (mindzymes.com)

Incident diabetes associated with integrase strand transfer inhibitor initiation. (hiv-guidelines.jp)

Dose reduction of Indinavir to 600 mg every 8 hours should be considered when administering delavirdine 400 mg three times a day. (wikidoc.org)

Efficacy and Safety of Switching to Dolutegravir/Lamivudine Versus Continuing a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Results Through Week 144 From the Phase 3, Noninferiority TANGO Randomized Trial. (hiv-guidelines.jp)

An 1,800-bp fragment encompassing the protease and reverse transcriptase genes was amplified by nested polymerase chain reaction and directly sequenced with an ABI PrISM Big Dye Terminator cycle sequencing ready reaction kit (Perkin-Elmer, Roissy, France). (cdc.gov)
However, the use of rifampin with protease inhibitors or non-nucleoside reverse transcriptase inhibitors is contraindicated. (cdc.gov)
An intent to treat analysis (most conservative) showed that suppression of plasma HIV-1 RNA to undetectable levels was achieved in more participants in the group given efavirenz plus nucleoside reverse transcriptase inhibitors than in the group given indinavir plus nucleoside reverse transcriptase inhibitors (70 percent versus 48 percent). (ubc.ca)
More volunteers discontinued treatment because of adverse events in the group given indinavir and two nucleoside reverse transcriptase inhibitors than in the group given efavirenz and two nucleoside reverse transcriptase inhibitors (43 percent versus 27 percent). (ubc.ca)
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: amulticohort collaboration. (hiv-guidelines.jp)
Tenvir EM Tablets is indicated in combination with other antiretroviral agents (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors) for the treatment of HIV-1 infection in adults. (itradeeximm.com)
Tenvir Tablets belongs to a class of antiviral medications called reverse transcriptase inhibitors. (itradeeximm.com)
Indinavir is used to treat diseases caused by HIV-1 in adult patients who have not received antiretroviral therapy before or who have received antiretroviral drugs and who have contraindications or resistance to drugs - reverse transcriptase inhibitors. (happyfamilymedstore.com)
Previously antiretroviral drugs and having contraindications or resistance to drugs - reverse transcriptase inhibitors (in combination with antiretroviral drugs or as monotherapy). (happyfamilymedstore.com)

Unboosted indinavir requires a very precise dosing of 400 mg every eight hours to thwart HIV from forming drug-resistant mutations, including resistances to other protease inhibitors. (wikipedia.org)
We describe the frequency and nature of major genotypic mutations conferring resistance to antiretroviral drugs among patients treated in a routine HIV/AIDS outpatient clinic in Yaoundé, the political capital of Cameroon. (cdc.gov)
Mutations were classified as minor or major, by using the September 2004 version of the French National Agency for Research on AIDS consensus statements on antiretroviral drug resistance ( http://www.hivfrenchresistance.org ). (cdc.gov)
A susceptible strain based on absence of major drug resistance mutations by genotyping or a strain that could not be amplified for genotyping was considered nonresistant. (cdc.gov)
Combination therapy has been shown to dramatically reduce the likelihood of drug resistance (many drug-resistant mutations are mutually exclusive) and to suppress viral replication to the point that progression to AIDS is significantly slowed. (medscape.com)
Antiviral-resistance mutations often affect more than one drug simultaneously because of similar development pipelines and the ultimate molecular structure of the drug, and combination choices should account for this possibility. (medscape.com)
3'-deoxy-3'-fluorothymidine, a drug briefly tested in the 1980's, has been dusted off and retested in a cohort of patients with multiple nucleoside analog mutations. (natap.org)
As reported by Vincent Calvez, due to in vitro activity against multinucleoside resistant strains, MIV-310 7.5 mg qd was added to the therapy of 15 patients with >2 nucleoside analog mutations, and median 3.93 log copies HIV RNA. (natap.org)
The performance of protease inhibitors (PIs) is limited by the development of protease mutations that can promote resistance to the treatment. (bvsalud.org)

Dogs and rats treated with protease inhibitors develop hepatic cell necrosis 30 minutes after administration of the drug (44). (robertogiraldo.com)
6. Camenisch G, Umehara K. Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions. (degruyter.com)
Indinavir should be used with caution by patients with hemophilia, hepatic failure, children and old age (safety and efficacy is not established). (happyfamilymedstore.com)
Pharmacokinetic studies show that 810 is metabolized by glucuronidation, not the hepatic p450 system as are protease inhibitors. (natap.org)
The dosage of Indinavir should be reduced to 600 mg every 8 hours in patients with mild-to-moderate hepatic insufficiency due to cirrhosis . (wikidoc.org)
Hepatitis including cases resulting in hepatic failure and death has been reported in patients treated with Indinavir Because the majority of these patients had confounding medical conditions and/or were receiving concomitant therapy(ies), a causal relationship between Indinavir and these events has not been established. (wikidoc.org)

Indinavir does not cure HIV/AIDS, but it can extend the length of a person's life for several years by slowing the progression of the disease. (wikipedia.org)
Among 128 patients routinely receiving highly active antiretroviral therapy in an HIV/AIDS outpatient clinic in Cameroon, 16.4% had drug resistance after a median of 10 months. (cdc.gov)
HIV drug resistance is a major threat to the scaling up of antiretroviral therapy (ART) in developing countries (the World Health Organization/United Nations Programme on HIV/AIDS "3 by 5" Initiative) ( 1 ), especially in Africa ( 2 ). (cdc.gov)
After more than a decade of treating and trying to prevent AIDS with antiretroviral therapies, neither individual nor public health benefits have been achieved (1,2). (robertogiraldo.com)
The toxicity of AZT, the drug now prescribed indefinitely to both healthy "HIV-positive" individuals and to AIDS patients, has been solidly documented (1,8-13). (robertogiraldo.com)
Currently, the HIV-AIDS supporters are prescribing hydroxyurea, an inexpensive drug used for chemotherapy of leukemia (38). (robertogiraldo.com)
The toxicity of the new protease inhibitors, prescribed as part of the so-called AIDS treatment "cocktails", is also well documented (39). (robertogiraldo.com)
It has even been documented that protease inhibitors can induce the development of AIDS-defining diseases such as mycobacterial infections (49). (robertogiraldo.com)
To assess the prevalence of oral manifestations in HIV/AIDS patients and a possible correlation of the development of diabetes mellitus due to highly active antiretroviral therapy (HAART). (bvsalud.org)
Therefore this study determines the magnitude and predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in Southwest Ethiopia. (biomedcentral.com)
Protease inhibitors are in the category of antiretroviral drugs and are currently in use to treat HIV/AIDS and hepatitis C virus (HCV) patients. (mindzymes.com)
Tenvir is used in combination with other antiviral medications in patients with acquired immunodeficiency syndrome (AIDS). (itradeeximm.com)
Using newer antiretroviral drugs as keyword in PubMed, DAIDS, CDC website, AIDS info FDA websites were searched thoroughly for recent updates. (austinpublishinggroup.com)
Indinavir is not a cure for HIV or AIDS. (cheapbuyorder.co.uk)
HIV/AIDS is usually treated with a combination of different drugs. (cheapbuyorder.co.uk)
Human Immunodeficiency Virus type 1 protease (HIV-1 PR) is one of the most challenging targets of antiretroviral therapy used in the treatment of AIDS-infected people. (bvsalud.org)

Maraviroc tablets are contraindicated in patients with severe renal impairment or end-stage renal disease (ESRD) (CrCl less than 30 mL per minute) who are concomitantly taking potent CYP3A inhibitors or inducers. (drugs.com)
Even a combination of some old has-beens, AZT+ddI and nevirapine, turned out to be a potent blocker of HIV. (treatmentactiongroup.org)
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. (curehunter.com)
BMS-232632 can be an azapeptide individual immunodeficiency pathogen (HIV) type 1 (HIV-1) protease inhibitor that presents potent anti-HIV-1 activity (50% effective focus [EC50], 2. (bioxorio.com)

Viracept Nelfinavir Tablet is an antiviral medication in a group of HIV medicines called protease (PRO-tee-AYZ) inhibitors. (itradeeximm.com)

Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. (medscape.com)
Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. (medscape.com)
Because statins are substrates for the cytochrome P450 isoenzyme 3A4 (CYP3A4), concomitant use of CYP3A4 inhibitors (eg, indinavir and other protease inhibitors) can increase plasma concentrations and the attendant risk for myopathy. (medscape.com)
All recommended PIs require PK boosting with either RTV or COBI to inhibit the CYP3A4 isoenzyme, which may lead to significant drug-drug interactions (see Drug-Drug Interactions ). (guidelines.org.au)

Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist the protease inhibitor. (wikipedia.org)
This fear of viral resistance caused a lot of users to be wary of the drug. (wikipedia.org)
Data on drug resistance in the routine care setting are urgently required to design large, effective ART programs. (cdc.gov)
Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. (medscape.com)
RESCRIPTOR may confer cross-resistance to other NNRTIs when used alone or in combination. (drugs.com)
Recommendations for initial antiretroviral therapy (ART) during pregnancy are intended for people who have never received ART or antiretroviral (ARV) drugs for prophylaxis (i.e., people who are ARV-naive) and show no evidence of significant resistance to regimen components (see Pregnant People With HIV Who Have Never Received Antiretroviral Drugs ). (hiv.gov)
EDURANT is indicated in combination with VOCABRIA (cabotegravir), for short-term treatment of HIV-1 infection in adults and adolescents 12 years and older and weighing at least 35 kg who are virologically suppressed (HIV-1 RNA less than 50 copies/mL) on a stable regimen with no history of treatment failure and with no known or suspected resistance to either cabotegravir or rilpivirine. (guidelinecentral.com)
Insulin resistance (IR) is common in HIV-seropositive patients, particularly among those receiving protease inhibitor (PI) and is more prevalent among those with lipoatrophy or fat accumulation in the visceral region. (bvsalud.org)
Despite such an extraordinary result, 30 to 50% of patients ultimately fail therapy, presumably because of patient nonadherence to drug schedules (because of inconvenient dosing and unwanted effects) (43), insufficient drug exposure, and resistance development. (bioxorio.com)
Therefore, additional Prt inhibitors that display greater potency, improved bioavailability, fewer unwanted effects, and distinct resistance profiles are needed. (bioxorio.com)
The overlapping sets of resistance substitutions are clearly in charge of certain patterns of cross-resistance among the currently approved Prt inhibitors. (bioxorio.com)
By convention, virus was thought to have meaningful resistance when drug susceptibility. (bioxorio.com)
Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower the risk that drug resistance will develop, and reduce morbidity and mortality. (biomedcentral.com)
Interestingly, using combinations also helps decrease the buildup of resistance to the medications. (mindzymes.com)
Also, as we stated before, using combinations reduces the patient's ability to build up resistance to the medications. (mindzymes.com)
These drugs have their own toxicities and many have reported development of resistance. (austinpublishinggroup.com)

Several different triple combinations of AZT+3TC and a plethora of protease inhibitors could suppress viral replication to below the limit of detection of very sensitive PCR-based assays for many weeks. (treatmentactiongroup.org)

Molecular Docking performed on Wild Type, and Mutant Type HIV-1 proteases allowed the investigation of the interaction types displayed between the proteases and the ligands, Darunavir (DRV) and the new drug (ND). (bvsalud.org)

All HIV-infected persons at risk for infection with M. tuberculosis must be carefully evaluated and, if indicated, administered therapy to prevent the progression of latent infection to active TB disease and avoid the complications associated with HIV-related TB. (cdc.gov)
Effective antiretroviral therapy is the most important intervention in terms of improving longevity and preventing opportunistic infections in patients with human immunodeficiency virus (HIV) infection. (medscape.com)
Maraviroc tablet is a CCR5 co-receptor antagonist indicated in combination with other antiretroviral agents for the treatment of only CCR5-tropic HIV-1 infection in adults and pediatric patients 2 years of age and older weighing at least 10 kg. (drugs.com)
For instance, how do you study the clinical effects of triple combination therapy initiated in primary infection? (treatmentactiongroup.org)
Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs (D:A:D) study. (hiv-guidelines.jp)
Since 1996, with the advent and introduction of highly active antiretroviral therapy (HAART), a profound impact on the natural history of HIV infection was observed, with a remarkable increase in the survival of HIV-infected individuals, transforming the panorama of the disease. (bvsalud.org)
When doing your research, keep in mind that each type of drug affects distinct stages of the virus infection. (mindzymes.com)
Hazuda then leapfrogged the usual reporting of drug efficacy and toxicity studies in culture and animal systems, and revealed that the pilot compound L,870,812 was effective in a primate model of HIV infection. (natap.org)
Although the true potency of this drug might be overrepresented by its testing in the setting of acute infection, this model allowed a rapid proof of concept of antiviral activity. (natap.org)

Efficacy and Safety of Tenofovir DF vs Stavudine in Combination Therapy in Antiretroviral-Naïve Patients. (hiv-guidelines.jp)

Numerous antiretroviral combination products are available on the market to assist patients with compliance and decrease the daily number of tablets and capsules required (see Table 2, below). (medscape.com)
For this reason, combination oral contraceptives, including Enskyce™ (desogestrel and ethinyl estradiol tablets USP), should not be used by women who are over 35 years of age and smoke. (nih.gov)
Enskyce™ (desogestrel and ethinyl estradiol tablets USP) provides an oral contraceptive regimen of 21 light orange round tablets each containing 0.15 mg desogestrel (13-ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol) and 0.03 mg ethinyl estradiol (19-nor-17 alpha-pregna-1,3,5 (10)-trien-20-yne-3,17,diol). (nih.gov)
Twenty-eight (28) yellow tablets each containing 90 mcg of levonorgestrel (17α)-(-)13-ethyl-17-hydroxy-18, 19-dinorpregn-4-en-20-yn-3-one, a totally synthetic progestogen, and 20 mcg of ethinyl estradiol, (17α)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol. (rxlist.com)
Maraviroc tablets must be given in combination with other antiretroviral medications. (drugs.com)

Hormonal contraceptives are safe and effective means to avoid unintended pregnancy, but there is concern that coadministration of antiretroviral drugs may alter contraceptive efficacy. (hindawi.com)
Drugs or drug combinations are designated as Preferred for therapy during pregnancy when clinical trial data in adults have demonstrated efficacy and durability with acceptable toxicity and ease of use, and pregnancy-specific PK data are available to guide dosing. (hiv.gov)

In September 1997, CDC convened a meeting of expert consultants who reviewed and considered background information about HIV-related TB in the United States and the scientific principles of therapy for both diseases (Part I of this report). (cdc.gov)
During his 25 years of diagnosing and battling complex infections related to HIV and then mastering antiviral therapy as it became available, he developed a strong clinical trial research site helping evolve entirely new therapies for the major RNA virus diseases, first HIV and now Hepatitis C. (peterruanemd.com)

The type that is widely used and created by Merck is indinavir sulfate. (wikipedia.org)
The pills are created from sulfate salts and are sold in dosages of 100, 200, 333, and 400 mg of indinavir. (wikipedia.org)
March 12, 2009 - The US Food and Drug Administration (FDA) has approved safety labeling revisions to provide new information regarding the increased risk for cardiovascular events in patients receiving long-term celecoxib therapy, warn of drug interactions between indinavir sulfate and statins, and advise of the need to monitor liver function in certain patients receiving treatment with rifampin as part of a tuberculosis regimen. (medscape.com)

The authors wish to acknowledge the many Novartis Drug Metabolism and Pharmacokinetic scientists of Basel, Switzerland, who have supported this work. (degruyter.com)
Cobicistat acts as Pharmacokinetic Enhancers (CYP3A Inhibitors) which do not have any antiviral activity. (austinpublishinggroup.com)

The toxicity of AZT can be potentialized by other DNA chain terminators such as gancyclovir and acyclovir, drugs that are frequently prescribed together with AZT in the treatment and prevention of opportunistic viral infections (36,37). (robertogiraldo.com)

If patients with severe renal impairment or ESRD receiving maraviroc (without concomitant CYP3A inducers or inhibitors) experience postural hypotension, the dose of maraviroc should be reduced from 300 mg twice daily to 150 mg twice daily. (drugs.com)
The FDA notes that there is no consistent evidence that concurrent use of low-dose aspirin mitigates the risk for thrombotic events, and concomitant use of both drugs does increase the risk for serious gastrointestinal tract adverse events. (medscape.com)
Concomitant use of indinavir with lovastatin or simvastatin is not recommended by the FDA, and interactions with pravastatin and fluvastatin have not been studied. (medscape.com)

The ARTEMIS study compared DRV/r (800 mg/100 mg once daily) with LPV/r (800 mg/200 mg once daily or 400 mg/100 mg twice daily), both administered in combination with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), in a randomized, open-label, noninferiority trial. (guidelines.org.au)

We performed a literature search of PubMed and Ovid databases of articles published between January 1980 and February 2012 to identify English-language reports of drug-drug interactions between hormonal contraceptives (HCs) and antiretroviral drugs (ARVs). (hindawi.com)
As access to both modern methods of contraception and antiretroviral drugs (ARVs) expands, women with HIV enter the largely uncharted territory of potential drug interactions. (hindawi.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
During drug development, it is an important safety factor to identify the potential of new molecular entities to become a victim of drug-drug interactions (DDIs). (degruyter.com)
Merck and Co, Inc) to warn of drug interactions with 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA) inhibitors. (medscape.com)
Isomerization occurs in vivo studies indicate an allergic reaction to a maximum shelf life to 1year ~ 22years cyp cytochrome p, fda food and drug interactions. (stonecottagegardens.com)

Worldwide, new infections among children declined 47% since 2010 as coverage of antiretroviral therapy (ART) provided to pregnant women rose 29% in the same time period. (medscape.com)
If you have very low CD4 counts, you may need to take drugs to prevent opportunistic infections in addition to taking ART. (hivtalk.net)

HMG-CoA inhibitors, also known as statins, are linked to an exposure-related risk for myopathy that presents as muscle pain, tenderness, or weakness, with elevated creatine kinase levels greater than 10 times the upper limit of normal. (medscape.com)

It is soluble white powder administered orally in combination with other antiviral drugs. (wikipedia.org)
The emergence KN-92 phosphate supplier of resistant variants results from the KN-92 phosphate supplier large numbers of genetically diverse viruses generated in infected individuals and the next RYBP collection of resistant strains in the current presence of antiviral drugs. (bioxorio.com)

The relationship between the in vitro susceptibility of HIV-1 RT inhibitors and the inhibition of HIV replication in humans has not been established. (drugs.com)

Discontinue indinavir if hemolytic anemia occurs. (cheapbuyorder.co.uk)
Acute hemolytic anemia , including cases resulting in death, has been reported in patients treated with Indinavir Once a diagnosis is apparent, appropriate measures for the treatment of hemolytic anemia should be instituted, including discontinuation of Indinavir. (wikidoc.org)

Phenotypic analyses of isolates from patients treated with RESCRIPTOR as monotherapy showed a 50- to 500-fold reduced susceptibility in 14 of 15 patients by Week 8 of therapy. (drugs.com)
The clinical relevance of the phenotypic and the genotypic changes associated with therapy with RESCRIPTOR has not been established. (drugs.com)

Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
Any drug regimen that makes you spew projectile vomit can't be all good for you. (treatmentactiongroup.org)
What's more, when used in a medication regimen for hepatitis C virus protease inhibitors actually play their part in curing hepatitis C! (mindzymes.com)

All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
[ 9 ] Antiretroviral drug classes and agents within each class are listed in Table 1, below (see individual medication tables for more detail). (medscape.com)

These drugs were found to be orally bioavailable and inhibit 50% of HIV replication in culture at a concentration of 0.25 M. This respectable IC50 (inhibitory concentration 50%) was found in the presence of 50% human serum. (natap.org)

Thus, correct and timely prediction of the cleavage site of HIV-1 protease can significantly speed up and optimize the drug discovery process of novel HIV-1 protease inhibitors. (bvsalud.org)
In this work, we built and compared the performance of selected machine learning models for the prediction of HIV-1 protease cleavage site utilizing a hybrid of octapeptide sequence information comprising bond composition, amino acid binary profile (AABP), and physicochemical properties as numerical descriptors serving as input variables for some selected machine learning algorithms. (bvsalud.org)

The ECCCS represents a powerful tool to anticipate the DDI potential of victim drugs based on in vitro drug metabolism and transport data. (degruyter.com)
Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs. (degruyter.com)

For situations where discontinuation of therapy with one of the active agents of this medicine, or dose reduction is necessary, separate preparations of rifampicin and/or isoniazid should be used. (who.int)
In addition to adequate hydration, medical management in patients who experience nephrolithiasis / urolithiasis may include temporary interruption (e.g., 1 to 3 days) or discontinuation of therapy. (wikidoc.org)
If signs or symptoms of nephrolithiasis / urolithiasis occur, (including flank pain , with or without hematuria or microscopic hematuria ), temporary interruption (e.g., 1-3 days) or discontinuation of therapy may be considered. (wikidoc.org)

Can be taken at the same time as other HIV medications except for the protease inhibitors (PIs) Aptivus, Prezista, and Reyataz. (clinicalgate.com)

The hepatotoxicity of protease inhibitors has also been documented (43). (robertogiraldo.com)

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive use. (nih.gov)
Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. (nih.gov)

Drug users must significantly increase their water intake due to indinavir's low solubility that can cause it to crystallize. (wikipedia.org)

The session opened with impressive back-to-back presentations by Daria Hazuda and Stephen Young of the Merck HIV Integrase Inhibitor Discovery Team. (natap.org)
Young then expanded on the properties of L,870,810, the drug selected for first human testing (Merck is cleverly developing two top candidates in parallel, so that there is a back-up ready if one gets tripped up). (natap.org)

contraindications=*Indinavir is contraindicated in patients with clinically significant hypersensitivity to any of its components. (wikidoc.org)

LDL-C level, risk factors for coronary artery disease, and the patient's response to current cholesterol-lowering treatment will be taken into account when starting therapy or adjusting the dose. (stellapharm.com)
Pediatric usual dose: In combination with other antiretrovirals: 90 mg per m2 of body surface area every 12 hours. (cdc.gov)
If you are more than 2 hours late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. (cheapbuyorder.co.uk)
Patients should not alter the dose or discontinue therapy without consulting their physician. (cheapbuyorder.co.uk)
Dose reduction of Indinavir to 600 mg every 8 hours is recommended when administering itraconazole 200 mg twice daily concurrently. (wikidoc.org)
Dose reduction of rifabutin to half the standard dose (consult the manufacturer's product circular for rifabutin ) and a dose increase of Indinavir to 1000 mg every 8 hours are recommended when rifabutin and Indinavir are coadministered. (wikidoc.org)

Several combination products that contain tenofovir alafenamide (TAF) are now approved in the United States. (medscape.com)

There are restrictions on what sorts of food may be eaten concurrently with the unboosted indinavir treatment. (wikipedia.org)
In a recent study in public and private health care clinics in Douala, the economic capital of Cameroon, we found that the clinical and biological follow-up and drug supply were irregular and that many patients interrupted their treatment ( 6 ). (cdc.gov)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
Recent efforts have largely focused on expanding access to HIV diagnosis and counseling, as well as treatment with highly-active antiretroviral therapy (HAART). (hindawi.com)
For the treatment of type 2 diabetes mellitus in combination with diet and exercise. (pdr.net)
The first order of business seems to make sure we adequately study these new combinations and treatment strategies before mounting an antiretroviral Marshall Plan. (treatmentactiongroup.org)
Pfizer, Inc) to include new study data regarding the risk for cardiovascular (CV) thrombotic adverse events in patients receiving long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDS). (medscape.com)
That refers to the fact that most medical professionals prescribe three or more drugs for the treatment of HIV from at least two major classes. (mindzymes.com)
Even with the approval of new drug therapies, he expects that still better treatment options will come rapidly through ongoing trials and most importantly, that all patients with Hepatitis C are curable. (peterruanemd.com)
Treatment of HIV with medicines is called as Highly Active Anti- Retroviral Therapy (HAART). (austinpublishinggroup.com)

Avoid or substitute another drug for these medications when possible. (medscape.com)
Clinicians may need to consider additional factors when initiating ART in patients who previously received ART or ARV drugs for prophylaxis (see Pregnant People With HIV Who Have Previously Received Antiretroviral Medications but Are Not Currently on Antiretroviral Medications and Table 7 ). (hiv.gov)
In today's world of HIV medications, you will hear reference to cART which stands for combination antiretroviral therapy. (mindzymes.com)
Clarithromycin can be used in combination with other medications to kill H. pylori, a bacteria known to cause ulcers in the digestive tract. (medbroadcast.com)
Persons who engage in behaviors that result in frequent recurrent exposures that would require sequential or near-continuous courses of antiretroviral medications (eg, multiple sex partners who rarely use condoms or injection-drug users who often share injection equipment) should not receive nPEP. (medscape.com)

The patients had to pay for their drugs (US $23-$100 monthly) and laboratory tests (US $58-$85 per viral load assay and $19-$27 per CD4 cell count). (cdc.gov)
Other factors that relate to the perpetrator's HIV status and may increase the risk of HIV transmission include a high plasma HIV viral load, advanced HIV disease, and failing antiretroviral therapy. (medscape.com)

Indinavir is an HIV protease inhibitor used in combination with other medicines to manage human immunodeficiency virus (HIV). (cheapbuyorder.co.uk)
Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body. (cheapbuyorder.co.uk)

If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. (medscape.com)
Patients and providers should make shared decisions about which ARV drugs to use during pregnancy after discussing the known and potential risks to pregnant people and their fetuses (see Appendix C: Antiretroviral Counseling Guide for Health Care Providers and Recommendations for Use of Antiretroviral Drugs During Pregnancy: Overview ). (hiv.gov)
This class of drugs suppresses viral replication to a larger extent compared KN-92 phosphate supplier to the RT inhibitors in HIV-1-infected patients (12, 13, 24, 25, 27, 28, 42). (bioxorio.com)
Antiretrovirals are a group of drugs specifically developed for HIV patients. (mindzymes.com)
offLabelAdultNoGuideSupport=There is limited information regarding Off-Label Non-Guideline-Supported Use of Indinavir in adult patients. (wikidoc.org)
Adequate hydration is recommended in all patients treated with Indinavir. (wikidoc.org)

In earlier days, when used as monotherapy this drug was not better than ZDV, caused low platelet counts, and so fell by the wayside. (natap.org)

Diseases2

Chemicals and Drugs9

Phenomena and Processes1

Health Care1

Ritonavir9

Crixivan2

NNRTI3

Zidovudine8

Didanosine3

NRTIs2

Nonnucleoside reverse transcrip1

Regimens11

Enzyme5

Integrase strand transfer inhibitor1

Delavirdine1

Lamivudine1

Reverse transcriptase9

Mutations9

Hepatic6

AIDS16

Potent4

Nelfinavir1

CYP3A44

Resistance16

Suppress viral replication1

Darunavir1

Infection9

Stavudine1

Tablets5

Efficacy2

Diseases2

Sulfate3

Pharmacokinetic2

Toxicity1

Concomitant3

Emtricitabine1

Interactions6

Infections2

Exposure1

Antiviral drugs2

Inhibition1

Hemolytic anemia2

Rescriptor2

Regimen3

Antiretroviral drug2

Orally1

Cleavage-site2

Vitro2

Discontinuation3

Aptivus1

Hepatotoxicity1

Increases2

Significantly1

Merck2

Contraindications1

Dose6

Tenofovir alafenamide1

Treatment11

Medications5

Viral load2

Human Immun2

Patients6

Monotherapy1