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High-grade prostaticIntraepithelial neoplasiaBenignEpithelial cellsBiopsyNucleoliBasal cellCytoplasmSituFeaturesArchitectureCells

High-grade prostatic2

• Prostate xanthomas may mimic high-grade prostatic acinar adenocarcinoma with foamy cytoplasm, as well as adenocarcinoma with posthormonal therapy effect, particularly androgen deprivation therapy. (medscape.com)
• High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). (wikipedia.org)

Intraepithelial neoplasia5

• It may be referred to simply as prostatic intraepithelial neoplasia (PIN). (wikipedia.org)
• We investigated the cellular localization of CART in normal human prostate, benign prostatic hyperplasia, prostatic intraepithelial neoplasia and acinar adenocarcinoma. (bvsalud.org)
• CART expression was markedly diminished and, in some cases, entirely absent in tissues of prostatic intraepithelial neoplasia and adenocarcinoma. (bvsalud.org)
• In addition to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and angiogenesis have a critical role in the initiation and progression of prostate cancer. (bvsalud.org)
• GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. (bvsalud.org)

Benign5

• Other patterns include arrangement of the histiocytes in cords or single cells that percolate between benign prostatic glands. (medscape.com)
• HGPIN is diagnosed from tissue by a pathologist, which may come from:[citation needed] a needle biopsy taken via the rectum and, surgical removal of prostate tissue: transurethral resection of the prostate - removal of extra prostate tissue to improve urination (a treatment for benign prostatic hyperplasia), radical prostatectomy - complete removal of prostate and seminal vesicles (a treatment for prostate cancer). (wikipedia.org)
• Benign pathology of the prostate gland, and prostate histology and anatomy are dealt with in the ''[[prostate gland]]'' article. (librepathology.org)
• CART expression also was increased in both neuroendocrine and glandular epithelial cell populations from samples of benign prostatic hyperplasia as validated by IHC, ISH and RTqPCR. (bvsalud.org)
• Owing to loss of CART expression in adenocarcinoma and its increase in benign prostatic hyperplasia, CART may prove to be an important prostate marker. (bvsalud.org)

Epithelial cells1

• We found cellular expression of CART in both normal prostatic luminal secretory epithelial cells neuroendocrine cells (NEC) of both ducts and acini. (bvsalud.org)

Biopsy2

• however, cases have been discovered mostly in prostate core biopsy specimens, which suggests that prostatic xanthomas occur in men in the same age range as those with prostate cancer. (medscape.com)
• No specific clinical findings have been reported for xanthoma of the prostate other than an elevation in the serum level of prostate-specific antigen (PSA), which prompts the prostatic biopsy. (medscape.com)

Nucleoli1

• Its cytologic features are that of prostatic adenocarcinoma: presence of nucleoli, increased nuclear-to-cytoplasmic ratio and, increased nuclear size. (wikipedia.org)

Basal cell1

• Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)

Cytoplasm4

• and abundant, finely vacuolated, foamy cytoplasm with no mitotic figures. (medscape.com)
• Prostatic xanthoma comprises collections of histiocytes with finely vacuolated, lipid-laden cytoplasm. (medscape.com)
• Foamy gland carcinoma of the prostate features cells with abundant finely vacuolated cytoplasm and pyknotic hyperchromatic nuclei. (medscape.com)
• They may show abundant clear-to-vacuolated, foamy cytoplasm with hyperchromatic nuclei without nucleolar prominence. (medscape.com)

Situ3

• It is considered to be a pre-malignancy, or carcinoma in situ, of the prostatic glands. (wikipedia.org)
• Because it is thought to be a premalignant state, PIN is often considered the prostate equivalent of what is called carcinoma in situ (localized cancer) in other organs. (wikipedia.org)
• However, PIN differs from carcinoma in situ in that it may remain unchanged or even spontaneously regress. (wikipedia.org)

Features1

• No information on the molecular and genetic features of prostatic xanthoma is currently available. (medscape.com)

Architecture2

• The architecture of the glands and ducts remains normal. (wikipedia.org)
• Micro = major criteria: abnormal architecture (increased gland density, usu. (librepathology.org)

Cells2

• If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
• Tumor cells usually retain prostatic epithelial antigenicity, and immunohistochemical stains can be used for their identification. (medscape.com)