Prostatic cancer. Medical search. Frequent questions

Prostate Cancer and Prostatic Diseases is a quarterly peer-reviewed medical journal covering all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. (wikipedia.org)
Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. (wikipedia.org)
Over the last couple of decades there has been a significant increase in the burden of prostatic diseases, notably prostate cancer, in Asian countries. (nature.com)
In this virtual issue of Prostate Cancer and Prostatic Diseases entitled "Best of Asia", the journal's Editor-in-Chief, Dr. Stephen Freedland, along with members of the editorial board in China, Drs. Dingwei Ye and Yao Zhu, selected the top articles published by authors in Asia over the past year. (nature.com)
In 2017 and 2018, several notable advances have been made in the care of men with advanced or metastatic prostate cancer, and Prostate Cancer and Prostatic Diseases provides important insights and perspectives around each of these major advances. (nature.com)
The Editor of Prostate Cancer and Prostatic Diseases is proud to share a selection of key papers that have published in the journal to celebrate 20 years of publication! (nature.com)
Classification of benign diseases associated with prostatic pain: prostatitis or prostatodynia? (medscape.com)
After an overview of the normal anatomy the imaging features of common prostatic diseases with CT and its limitations are discussed. (ispub.com)
In this review an overview of the normal anatomy and common imaging findings in prostatic diseases is given. (ispub.com)
The odds of positive surgical margins were significantly increased 1.4-fold in patients with vs without a history of LUTS/BPH surgery, Massimiliano Creta, MD, PhD, of the University of Naples Federico II in Naples, Italy, and colleagues reported in Prostate Cancer and Prostatic Diseases . (renalandurologynews.com)

Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic enzymes of androgen metabolism, particularly 5α-reductases (i.e. (aacrjournals.org)
0.05) than castration monotherapy against androgen-responsive LNCaP cancers. (aacrjournals.org)
In contrast, no response was induced by dutasteride in nude mice bearing androgen-independent PC-3 human prostatic cancer xenografts. (aacrjournals.org)
Hormone therapy for most patients with prostate cancer aims to remove or block the function of the male hormone androgen. (jcancer.org)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/435483/all/Intermittent_versus_continuous_androgen_suppression_for_prostatic_cancer. (unboundmedicine.com)
In 1941 the beneficial effect of androgen ablation on metastatic prostate cancer was realised when Huggins and Clarence Hodges treated patients by either castration or estrogen therapy. (wikipedia.org)
Neoadjuvant androgen deprivation therapy (NADT) is systemic therapy administered after the diagnosis of prostate cancer but before locoregional therapy such as radical prostatectomy (RP) or radiation. (medscape.com)
With NADT prior to RP, the intent is to eradicate malignant androgen-dependent cells, in the hope that sufficient tumor regression will permit complete resection of residual prostate cancer, improving pathologic outcome and survival. (medscape.com)
However, a meta-analysis of the sequencing of androgen deprivation therapy with radiation therapy in localized prostate cancer concluded that adjuvant androgen deprivation therapy results in superior outcomes, compared with neoadjuvant or concurrent androgen deprivation therapy. (medscape.com)
The study aimed to compare the efficacy and safety of androgen deprivation therapy (ADT) with abiraterone or docetaxel versus ADT alone as neoadjuvant therapy in patients with very-high-risk localized prostate cancer. (frontiersin.org)

MATERIALS AND METHODS: Between July 2004 and September 2007, 59 patients (mean age 66 years) with a histologic diagnosis of prostatic cancer underwent 3-T MRI with a phased-array coil. (unimore.it)
Once the diagnosis of prostatic enlargement is established and prostate cancer is ruled out, various treatment modalities are available. (patelhospital.com)
Diagnosis of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) can be difficult to differentiate. (auanews.net)
The method was developed in the context of optical cancer diagnosis (OCD). (fraunhofer.de)
In September 2007, he had received a diagnosis of laryngeal cancer, which required 2 chemotherapy treatments through a central venous catheter (CVC), the second of which he had received 6 days before his November visit. (cdc.gov)
Expressed prostatic secretion (EPS) microscopy, postmassage urine culture, or semen culture must be obtained for a precise diagnosis of chronic bacterial prostatitis (CBP). (medscape.com)
A total of 810 prostatic needle core biopsy specimens obtained from 100 patients with suspected prostatic adenocarcinoma were retrieved from the archival material at King Khalid University Hospital, Riyadh, and classified independently by 3 experienced histopathologists who were blinded to the original diagnosis. (who.int)
The diagnosis of prostate cancer re- at King Khalid University Hospital, quires the estimation of prostate-specif- Riyadh. (who.int)
The pathophysiology of MPE formation remains poorly understood, and although MPEs are routinely used for the diagnosis of breast cancer patients, their composition and biology are poorly understood. (bvsalud.org)

Prostate Cancer Prostatic Dis;26(3): 516-518, 2023 09. (bvsalud.org)

However, owing to the inaccuracy of clinical staging, approximately 50% of men with clinical stage T1 or T2 prostate cancer have tumor extension outside of the prostate capsule, and 5-40% have positive surgical margins. (medscape.com)
2.0 ml) tumor samples, not derived from the European Randomized Study of Screening for Prostate Cancer. (amsterdamumc.org)
Interestingly, chromosomal alterations that were found in previous studies to be potential biomarkers for tumor aggressiveness, ie, gain of 7pq and/or 8q, were already distinguished in the small and intermediate cancers. (amsterdamumc.org)
In conclusion, our data show that chromosomal losses, more specifically of 6q and 13q, are early events in prostatic tumorigenesis, whereas chromosomal gains, especially of 8q, appear to be late events in prostatic tumor development. (amsterdamumc.org)
Objective: To determine whether the frequency of anterior prostate lesions (APL) on multiparametric magnetic resonance imaging (mpMRI) prior to biopsy differed between African American (AA) and non-AA men and evaluate implications of race and tumor location for prostate cancer (PCa) detection. (northwestern.edu)
Association of Pretreatment Circulating Tumor Tissue-Modified Viral HPV DNA With Clinicopathologic Factors in HPV-Positive Oropharyngeal Cancer. (dana-farber.org)

PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. (nih.gov)
No objective parameters have been found so far that can predict the biological behavior of early stages of prostatic cancer, which are encountered frequently nowadays due to surveillance and screening programs. (amsterdamumc.org)

abstract = "When a non-metastatic subline from the Dunning rat prostatic cancer was transfected with the v-Ha-ras oncogene, some transfectants acquired metastatic potential. (johnshopkins.edu)

We also assessed the correlation between Irani G and A scores and clinical variables related to benign prostatic obstruction. (jgerontology-geriatrics.com)

Prostate cancer is a common disease that affects men, usually in middle age or later. (medlineplus.gov)
The signs and symptoms of metastatic cancer depend on where the disease has spread. (medlineplus.gov)
In the United States, African Americans have a higher risk of developing prostate cancer than do men of other ethnic backgrounds, and they also have a higher risk of dying from the disease. (medlineplus.gov)
In addition, despite considerable advances in prostate cancer research, high-risk, localized prostate cancer remains an extremely refractory disease. (medscape.com)
D.W.W. Newling The early recurrence of prostate cancer originally staged as locally more than T2 and nonmetastatic, cast doubts over the adequacy of the staging of this form of the disease. (karger.com)
Dr. Schoenfeld is a radiation oncologist in the head and neck and melanoma disease centers, a member of the Cancer Immunology program in the Dana-Farber/Harvard Cancer Center, and Assistant Professor of Radiation Oncology at Harvard Medical School. (dana-farber.org)
A total of 132 (96.4%) participants had very-high-risk prostate cancer, and 108 (78.8%) had locally advanced disease. (frontiersin.org)
Nevertheless, knowledge of the imaging features of prostatic disease on CT is important. (ispub.com)
Nonetheless knowledge of the imaging features of prostatic disease on CT is important for the radiologist for a variety of reasons. (ispub.com)
This strategy has been critical to revealing markers of disease progression, such as cancer and pathogen infection. (bvsalud.org)

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, a decade after its first formal description. (nih.gov)
The image shows metastatic prostatic adenocarcinoma in the testis . (webpathology.com)
This retrospective study aimed to assess the concordance and interobserver variation between histopathologists in reporting prostatic adenocarcinoma using material obtained from prostatic core biopsy specimens. (who.int)
of prostatic adenocarcinoma among 3 Analysis histopathology consultants. (who.int)

Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
However, little is known about the molecular changes that these viral agents may induce in the prostate epithelial cells that might lead to the initiation or progression of prostate cancer. (researchsquare.com)

Anti-cancer effect of cordycepin on FGF9-induced testicular tumorigenesis. (greenmedinfo.com)

Smooth muscle tone is mediated by sympathetic nervous stimulation of alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. (nih.gov)
2 Multiple studies and meta-analyses have claimed that type 2 diabetes is associated with an increased risk of cancer at several sites including liver, pancreas, endometrium, colorectum, breast, and bladder, and a decreased risk of prostate cancer. (bmj.com)
Treatment trends of muscle invasive bladder cancer: Evidence from the Surveillance, Epidemiology, and End Results database, 1988 to 2013. (creighton.edu)
Previous surgery for LUTS/BPE determines an additional difficulty in performing some key steps of RP, such as identification of bladder neck and prostatic margins, apex dissection and recognition of surgical cleavage, mostly due to widespread fibrosis and inflammation," Dr Creta noted. (renalandurologynews.com)
The base of the prostate is in continuity with the bladder neck and contains the prostatic urethra. (medscape.com)

6 Biases have been suspected, documented, or debated in observational epidemiology of cancer for multiple putative carcinogens, risk factors, biomarkers, and prognostic factors. (bmj.com)
In the Division of Cancer Epidemiology and Genetics (DCEG), investigators study a range of factors that influence risk for cancer. (cancer.gov)

Progression of prostatic cancer from no metastatic to high metastatic potential may involve the loss of a metastasis suppressor gene. (johnshopkins.edu)
Those concerns regarding prostate cancer progression have led to a renewed interest in the use of NADT prior to RP. (medscape.com)
David J. Grignon In spite of the slow progression rates common to most prostate cancers , it is well recognized that a subset of patients will experience a more aggressive course with many losing their lives to this malignancy. (karger.com)
Furthermore, EBV-positive samples exhibited a higher Gleason score suggesting a possible link between EBV and onset/progression of prostate cancers. (researchsquare.com)
However, future functional studies are required to understand the role of the EBV gene expression profile in the onset/progression of prostate cancer. (researchsquare.com)
They have utilized metabolomics to improve measurement of key epidemiologic exposures (e.g. diet), enable assessment of mediating mechanisms (e.g. intermediaries such as estrogen that are associated with both obesity and cancer risk), and identify novel pathways of cancer initiation or progression. (cancer.gov)
In therapeutic clinical trials, bone scan is the standard imaging modality to assess eligibility and progression for patients with metastatic prostate cancer. (snmjournals.org)

They monitored the prostate size and therapeutic efficacy by measuring serum prostatic acid phosphatase levels and concluded that androgenic activity in the body influences prostate cancer, at least with respect to serum phosphatase. (wikipedia.org)

The Gleason score (grade rate of prostate cancer in Saudi Arabia 810 prostatic needle biopsies obtained of malignant cases) was not, however, ranked sixth among male patients with from 100 patients from 2005 until the recorded as this parameter was outside a crude annual incidence of 5.7 per end of 2011 were retrieved from the the scope of this retrospective study. (who.int)

Prostate cancer cells express undetectable to low levels of SRD5A2 but elevated levels of SRD5A1 activity compared with nonmalignant prostatic tissue. (aacrjournals.org)
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. (dana-farber.org)
If an asymptomatic patient is found to have inflammation in the prostatic tissue, this is categorized as category IV prostatitis, ie, asymptomatic inflammatory prostatitis. (medscape.com)

These studies also suggest that a metastasis suppressor gene for rat prostatic cancer is located on chromosome 2. (johnshopkins.edu)
Across three different murine models of human prostate and breast cancer, KBU2046 inhibits metastasis, decreases bone destruction, and prolongs survival at nanomolar blood concentrations after oral administration. (nature.com)
Efficacy of KBU2046 is demonstrated across several different in vitro models and across multiple murine models of human cancer metastasis, which includes decreased metastasis, decreased bone destruction, and prolonged survival. (nature.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
More than 80% of metastatic prostate cancer patients have skeletal metastasis ( 1 ). (snmjournals.org)
Background: Prostate cancer patients with pelvic lymph node metastasis (PLNM) have poor prognosis. (lu.se)

Prostatic cancer, diagnosed 1.5 years earlier, had been treated by radiotherapy. (cdc.gov)

Two radiologists with differing experience in the interpretation of prostatic imaging used a 1-5 scale score to assess extracapsular spread, seminal vesicle and neurovascular bundle infiltration, and prostatic apex involvement. (unimore.it)

Conclusions Though type 2 diabetes has been extensively studied in relation to risk of developing cancer and cancer mortality and strong claims of significance exist for most of the studied associations, only a minority of these associations have robust supporting evidence without hints of bias. (bmj.com)
Conclusions --The effect of lowering the total PSA thresholds increases the screening at age 40 if men are at higher number of U.S. men who would be referred for screening for prostate cancer. (cdc.gov)
CONCLUSIONS: Our dataset presents the first unbiased assessment of breast cancer-associated MPEs at a single cell resolution, providing the community with a valuable resource for the study of MPEs. (bvsalud.org)

Grade and aggressiveness of prostatic inflammation were assessed by Irani G and A scores, respectively, in prostate biopsy specimens of men having undergone this procedure because of increased serum PSA and/or digital rectal examination. (jgerontology-geriatrics.com)
4 Patients with a small lesion in large prostate, anterior cancer lesion, or prior negative biopsy history are the most challenging cases for transrectal ultrasound (TRUS) SBx. (auanews.net)
Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990-2003. (ukhsa.gov.uk)
In general, a prostate percent free PSA will help guide public health policy in screening for prostate biopsy is highly recommended for total cancer. (cdc.gov)
Chronic inflammation is common after biopsy specimens have been obtained to help evaluate for prostate cancer. (medscape.com)

The life expectancy of individuals with metastatic cancer is increasing, but this group of patients is at considerable risk of having psychological and physical health problems. (bvsalud.org)

Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. (medlineplus.gov)
Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers . (medlineplus.gov)
Finally, early localized tumors, as detected by screening programs, harbor cancers with aggressive genetic characteristics. (amsterdamumc.org)
It is safe to say that in these countries the majority of prostate cancers are now being clinically diagnosed while still localized, and many organ-confined tumors. (karger.com)

Real-time PCR and enzymatic assays were used to determine the levels of SRD5A1 and SRD5A2 in normal versus malignant rat and human prostatic tissues. (aacrjournals.org)
BACKGROUND: Malignant pleural effusions (MPEs) are a common complication of advanced cancers, particularly those adjacent to the pleura, such as lung and breast cancer. (bvsalud.org)
RESULTS: We identified substantial inter-patient heterogeneity in the composition of cell types (including malignant, mesothelial and immune cell populations), in expression of subtype-specific gene signatures and in copy number aberration patterns, that captured variability across breast cancer cell populations. (bvsalud.org)
Within individual MPEs, we distinguished mesothelial cell populations from malignant cells using key markers, the presence of breast cancer subtype expression patterns and copy number aberration patterns. (bvsalud.org)

Gootee J, Patel M, Aurit S, Silberstein P. The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database. (creighton.edu)
His research focuses on the design and implementation of clinical, epidemiologic and translational studies in head and neck and skin cancers. (dana-farber.org)
Fully-automated sarcopenia assessment in head and neck cancer: development and external validation of a deep learning pipeline. (dana-farber.org)
Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers. (dana-farber.org)

A conventional PCR strategy was employed using virus-specific primers to screen EBV in 99 formalin-fixed paraffin-embedded (FFPE) prostate cancer and 33 BPH samples received for histopathological analysis during the years 2019-2020. (researchsquare.com)

In most cases of prostate cancer, these genetic changes are acquired during a man's lifetime and are present only in certain cells in the prostate. (medlineplus.gov)
A normal prostate volume for an adult male is approximately 25 cc, and continues to grow throughout a man's lifetime secondary to benign prostatic hyperplasia. (medscape.com)

He performed his medical internship at Memorial Sloan Kettering Cancer Center, then completed residency in radiation oncology in the Harvard Radiation Program and received a Master of Public Health in Clinical Effectiveness from the Harvard T.H. Chan School of Public Health. (dana-farber.org)
Univariate and multivariate discriminant analyses were performed to measure the ability of the algorithm classifier to detect PLNM and compare it with the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram score. (lu.se)

Huggins was the first to use a systemic approach to treat prostate cancer. (wikipedia.org)

Therefore, the levels of expression SRD5A1 and SRD5A2 and the antiprostatic cancer growth response to finasteride, a selective SRD5A2 inhibitor, versus the dual SRD5A1 and SRD5A2 inhibitor, dutasteride, were compared. (aacrjournals.org)
and all reported increased risks of developing cancer for participants with versus without diabetes. (bmj.com)

Early prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. (medlineplus.gov)
Having one or more of these symptoms does not necessarily mean that a man has prostate cancer. (medlineplus.gov)
In addition, studies indicate that many older men have undiagnosed prostate cancer that is non-aggressive and unlikely to cause symptoms or affect their lifespan. (medlineplus.gov)
PSA, suspicious digital rectal examination and peak flow rate but lower post-void residual urine volume, prostate volume and international prostate symptoms score than those without cancer. (jgerontology-geriatrics.com)
Indeed, patients with high-grade inflammation had greater PSA, prostate volume, post-void residual and international prostate symptoms score, suggesting high-grade inflammation to correlate with benign prostatic obstruction. (jgerontology-geriatrics.com)
Undergoing radical prostatectomy (RP) for prostate cancer after surgery for lower urinary tract symptoms due to benign prostatic hyperplasia (BPH) is associated with higher rates of positive surgical margins and lower rates of urinary continence and erectile function recovery, an updated review finds. (renalandurologynews.com)

The present study aimed to determine the relationship between grade and aggressiveness of prostatic inflammation and the risk of being diagnosed with prostate cancer. (jgerontology-geriatrics.com)

Should reporting of peri-neural invasion and extra prostatic extension be mandatory in prostate cancer biopsies? (ukhsa.gov.uk)
The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. (ukhsa.gov.uk)
Dive into the research topics of 'Should reporting of peri-neural invasion and extra prostatic extension be mandatory in prostate cancer biopsies? (ukhsa.gov.uk)
Our work highlights the molecular and cellular diversity captured in MPEs and motivates the potential use of these clinically relevant biopsies in the development of targeted therapeutics for patients with advanced breast cancer. (bvsalud.org)

Zhang KY, Aurit S, Silberstein P. Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database analysis. (creighton.edu)

In patients with clinically localized prostate cancer, the National Comprehensive Cancer Network (NCCN) strongly discourages the use of NADT before RP outside of a clinical trial. (medscape.com)
To rule out the presence of prostatic abscess in selected patients, transrectal ultrasound may be performed. (medscape.com)
Transrectal prostatic sonography as a useful diagnostic means for patients with chronic prostatitis or prostatodynia. (medscape.com)
Ganti AK, Subbiah SP, Kessinger A, Gonsalves WI, Silberstein PT, Lobriza FR Jr. Association between Race and Survival of Patients with Non-Small Cell Lung Cancer in The United States Veterans Affairs Population:Clinical Lung Cancer-2014 Mar;15(2):152-8. (creighton.edu)
Treatment patterns, and survival of patients with metastatic undifferentiated pleomorphic sarcoma: A National Cancer Database (NCDB) study. (creighton.edu)
We have applied comparative genomic hybridization to routinely processed, paraffin-embedded radical prostatectomy specimens derived from patients who participated in the European Randomized Study of Screening for Prostate Cancer. (amsterdamumc.org)
Gerald L. Andriole Objective: To identify which patients with prostate cancer are at high risk for local or distant recurrence after radical prostatectomy. (karger.com)
In the patient study, to evaluate the effect on BSI reproducibility, repeated bone scans were prospectively obtained from metastatic prostate cancer patients enrolled in 3 groups (Grp). (snmjournals.org)
The odds of positive surgical margins after radical prostatectomy for prostate cancer were significantly increased 1.4-fold in patients with vs without a history of LUTS/BPH surgery. (renalandurologynews.com)
Only 35% discussed the side effects of prostate cancer treatment with their patients. (cdc.gov)
The majority of physicians recommend prostate cancer screening to their patients, with few decision-making tools used. (cdc.gov)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
There is a need to characterize the phenotypic diversity of breast cancer cell populations in the pleural microenvironment, and investigate how this varies across patients. (bvsalud.org)
METHODS: Here, we used single-cell RNA-sequencing to study the heterogeneity of 10 MPEs from seven metastatic breast cancer patients, including three Miltenyi-enriched samples using a negative selection approach. (bvsalud.org)

The Management of clinically localized prostate cancer. (upenn.edu)

Department of Urogenital Cancer, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. (bvsalud.org)

We report a case of prostatic cancer in which ketoconazole resulted in rapid and sustained reduction in serum androgens as well as rapid induction of a clinical remission. (mssm.edu)

The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. (wikipedia.org)
Commonly, chronic prostatitis is diagnosed after microscopic examination of the EPS and a positive culture finding after a prostatic massage. (medscape.com)
Finding WBCs in an EPS is not diagnostic of chronic bacterial prostatitis (CBP), because this finding is commonly associated with nonbacterial prostatitis, urethritis, prostatic stones, or recent ejaculation. (medscape.com)

Rats bearing the Dunning R-3327H rat prostate cancer and nude mice bearing LNCaP or PC-3 human prostate cancer xenografts were used as model systems. (aacrjournals.org)
0.05) inhibits growth of LNCaP human prostate cancer xenografts in intact male nude mice, but this inhibition is not as great as that by equimolar oral dosing with dutasteride. (aacrjournals.org)

This supplement presents the latest research featured at the symposium on GnRH Analogues and Prostate Cancer, sponsored by Takeda Chemical Industries Ltd, and held during the 5th International Symposium on GnRH Analogues and Cancer and Human Reproduction in February 1999 in Geneva, Switzerland. (nature.com)

J Natl Cancer Inst. (uw.edu)

A limited number of studies have shown the presence of Epstein-Barr virus (EBV) in prostate cancer tissues. (researchsquare.com)

The relationship between prostatic inflammation, benign prostatic hyperplasia and prostate cancer is controversial. (jgerontology-geriatrics.com)
Prostatic inflammation seems to be associated with benign prostatic hyperplasia rather than prostate cancer, with benign prostatic obstruction being strictly linked to the degree of inflammation. (jgerontology-geriatrics.com)

Daily oral treatment of rats with the SRD5A2 selective inhibitor, finasteride, reduces prostate weight and DHT content but did not inhibit R-3327H rat prostate cancer growth or DHT content in intact (i.e., noncastrated) male rats. (aacrjournals.org)
Prostate cancer and bone metastases: medical treatment. (wheelessonline.com)
This property suggested that ketoconazole might be useful in the treatment of prostatic cancer. (mssm.edu)
Ketoconazole may be a valuable agent in the treatment of prostatic cancer. (mssm.edu)
Prostate cancer : new questions about screening and treatment : hearing before the Committee on Oversight and Government Reform, House of Representatives, One Hundred Eleventh Congress, second session, March 4, 2010. (upenn.edu)
Urological Cancer Treatment by a Multidisciplinary Team throughout the Covid-19 Pandemic: What Have We Learned? (thieme-connect.com)
This became specifically true in the Covid-19 pandemic in which choices for urological cancer treatment are influenced by many factors. (thieme-connect.com)
Polyunsaturated fatty acids may have a preventive and thereapeutic role in the treatment of testicular cancer. (greenmedinfo.com)

Cancers occur when genetic variants (also known as mutations) build up in critical genes, specifically those that control cell growth and division or the repair of damaged DNA. (medlineplus.gov)
Less commonly, genetic changes present in essentially all of the body's cells increase the risk of developing prostate cancer. (medlineplus.gov)
The pathophysiology of prostate cancer involves both genetic and acquired factors, including pathogens, such as viruses. (researchsquare.com)
The pathophysiology of prostate cancer involves both genetic and acquired factors. (researchsquare.com)

Eligibility criteria Meta-analyses or systematic reviews of observational studies in humans that examined the association between type 2 diabetes and risk of developing or dying from cancer. (bmj.com)

this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)
As with any therapy, the ultimate benefit of NADT in prostate cancer will be determined only through properly designed trials with long-term follow-up. (medscape.com)
Compared with ADT alone, neoadjuvant therapy with ADT plus docetaxel or abiraterone could achieve better pathological outcomes (pCR or MRD) for very-high-risk localized prostate cancer. (frontiersin.org)

These results document that testosterone is not as potent as DHT but does stimulate prostate cancer growth, thus combining castration with dutasteride enhances therapeutic efficacy. (aacrjournals.org)
We hypothesized that we could use them to identify novel and selective sites that regulate cancer cell motility and that such sites would constitute high-value therapeutic targets. (nature.com)

3 The observed associations between type 2 diabetes and cancer could be either causal (for example, caused by hyperglycaemia or hyperinsulinaemia) or because of confounding from common risk factors such as adiposity. (bmj.com)

About 1 in 7 men will be diagnosed with prostate cancer at some time during their life. (medlineplus.gov)
While most men who are diagnosed with prostate cancer do not die from it, this common cancer is still the second leading cause of cancer death among men in the United States. (medlineplus.gov)

Anatomy14

Organisms6

Diseases55

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology1

Phenomena and Processes39

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups2

Health Care27

Geographicals5

Diseases10

Androgen10

Diagnosis9

20231

Tumor6

Stages of prostatic2

Abstract1

Related to benign1

Disease10

Adenocarcinoma4

Epithelial cells2

Tumorigenesis1

Bladder5

Epidemiology2

Progression7

Acid phosphatase1

Gleason1

Tissue3

Metastasis6

Radiotherapy1

Apex1

Conclusions3

Biopsy5

Metastatic cancer1

Tumors4

Malignant4

Neck4

20201

Man's lifetime2

Memorial Sloan2

Systemic1

Versus2

Symptoms6

Aggressiveness1

Biopsies4

Neoplasia1

Patients14

Clinically1

Oncology1

Clinical1

Prostatitis3

Human prostate2

19991

Natl Cancer Inst1

Tissues1

Inflammation2

Treatment8

Genetic4

Systematic1

Therapy3

Therapeutic2

Risk Factors1

Diagnosed with prostate cancer2