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  • tumors
  • Although these mouse model lines showed that the loss of PTEN was instrumental in prostate tumorigenesis, the occurrence and progression of the generated tumors did not closely mimic the spatiotemporal features exhibited by human prostatic tumors, and their latency, penetrance, and severity were different among the various transgenic lines. (pnas.org)
  • These results suggest that the process of genetic instability coupled to clonal selection is one mechanism for the change in tumor phenotype characteristically associated with tumor progression within this system of prostatic tumors. (aacrjournals.org)
  • Though ductal adenocarcinoma most commonly occurs with synchronous usual-type acinar adenocarcinoma, little is known about the molecular phenotype of these mixed tumors. (sigmaaldrich.com)
  • urethra
  • The seminal colliculus (Latin colliculus seminalis), or verumontanum, of the prostatic urethra is a landmark near the entrance of the ejaculatory ducts (on both sides, corresponding vas deferens and seminal vesicle feed into corresponding ejaculatory duct). (wikipedia.org)
  • the openings of the prostatic ducts The verumontanum is an important anatomic landmark for pathology in a congenital anomaly known as posterior urethral valves, in which there is a developmental obstruction of the urethra in newborn male infants. (wikipedia.org)
  • The prostatic utricle, a remnant of the paramesonephric duct, arises from the urethra at the level of the verumontanum and projects posteriorly. (wikipedia.org)
  • Maxwell Smith, M Scott Lucia, Priya N Werahera and Francisco G La Rosa Carcinoid tumor of the verumontanum (colliculus seminalis) of the prostatic urethra with a coexisting prostatic adenocarcinoma: a case report Journal of Medical Case Reports 2010, 4:16 F Ikoma, H Shima. (wikipedia.org)
  • epithelial cells
  • We have generated PSA-Cre-ER T2 mice that express the tamoxifen-dependent Cre-ER T2 recombinase selectively in prostatic epithelium, thus allowing us to target floxed genes selectively in epithelial cells of fully differentiated prostate of adult mice and to modulate the number of genetically altered cells. (pnas.org)
  • It was suggested that these variations could result from differences in the genetic background of the various model lines, as well as in time and/or efficiency of PTEN ablation in prostatic epithelial cells. (pnas.org)
  • small cell carc
  • Immunohistochemically, prostatic small cell carcinoma are positive for thyroid transcription factor 1 (TTF-1), CD56, chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or rarely and weakly expressing, androgen receptor and prostate-specific antigen. (wikipedia.org)
  • P63 is also helpful in distinguishing poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma. (wikipedia.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • basal
  • They are thought to arise from a different precursor than other epithelial prostatic cells, possibly through a neurogenic lineage of their own, which is therefore distinct from the secretory and basal cells that derive from urogenital sinus. (wikipedia.org)
  • seminal
  • The margins of seminal colliculus are the following: the orifices of the prostatic utricle the slit-like openings of the ejaculatory ducts. (wikipedia.org)
  • Diseases
  • 5. Sciarra A, Di Silverio F, Salciccia S, Autran Gomez AM, Gentilucci A, Gentile V. Inflammation and chronic prostatic diseases: evidence for a link? (scielo.org.za)
  • epithelium
  • Various mouse lines aimed at exploring the molecular mechanisms underlying prostate carcinogenesis were generated over recent years by introducing targeted mutations selectively in prostatic epithelium ( 6 , 7 ). (pnas.org)
  • To control the cell specificity, the time of occurrence, and the cell extent of targeted somatic mutagenesis in the prostatic epithelium, we have generated PSA-Cre-ER T2 transgenic mice that express the tamoxifen (Tam)-dependent Cre-ER T2 recombinase ( 14 ) under the control of the human PSA promoter. (pnas.org)
  • Diagnosis
  • A rare cause of ureteric stricture, contiguous spread of prostatic adenocarcinoma, should be considered in the differential diagnosis of patients presenting with upper tract obstruction and a known history of prostatic adenocarcinoma. (canjurol.com)
  • Carcinoma, transitional cell MATERIALS AND METHODS Carcinoma cells of a prostate origin are rarely detected in urine cytology specimens.1,2 Although urine cytology is routinely performed in patients with urologic complaints, the clinical value is limited for making the diagnosis of prostate adenocarcinoma (PACa), and pathologists may not be familiar with the cytomorphology of these cells. (spotidoc.com)