External Beam RadiothAdjuvant radiotherapyRecurrent prostaPost-prostatectomyFailure after radical prostatectomyBrachytherapyOncologyRadical prostatectomy for prostate cancerTreated with radicalOutcomesRecurrence after radical prostatectomySalvage radical prostatectomyUnderwent radical prostatectomyRadiation therapyLaparoscopic radical prostUrinary incontinenceSurvivalPostoperative radiotherapyHigh Risk Prostate CancerErectile dysfunctionCurative intentPelvic lymphClinicalAndrogenAdverseTreatmentsHormonal therapyProstate cancer patients treatedMETHODSWatchfulCancerTreatmentImage-guidedPhaseDoseSurgeryObservationSurgical removalMetastasisPrognosticResults
External Beam Radioth4
- RESULTS: Twenty-four men had undergone external beam radiotherapy, 11 brachytherapy, and six both. (umassmed.edu)
- There may be very special cases where technically brachytherapy is better suited than conventional external beam radiotherapy. (nethealthbook.com)
- Is moderate hypofractionation accepted as a new standard of care in north america for prostate cancer patients treated with external beam radiotherapy? (ohsu.edu)
- In reality a salvage radical prostatectomy can be considered for men with locally recurrent prostate cancer after external beam radiotherapy has failed. (malecare.org)
Adjuvant radiotherapy8
- Adjuvant radiotherapy after radical prostatectomy provided no meaningful benefit in patients with prostate cancer but increased the risk for urinary and bowel morbidity compared with men followed with observation alone, according to the latest results from the phase 3 RADICALS-RT trial. (medscape.com)
- The new findings showed no difference in the rate of 10-year freedom from distant metastases or overall survival in patients who received adjuvant radiotherapy vs those who underwent observation with salvage radiotherapy if their disease progressed and provided further confirmation of earlier results reported in The Lancet in 2020 . (medscape.com)
- Invited discussant and session co-chair Shahneen Sandhu, MBBS, said that the findings definitively confirm the value of observation with salvage radiotherapy over adjuvant radiotherapy in this patient population. (medscape.com)
- In the study, 697 patients were randomly assigned to adjuvant radiotherapy and 699 to observation with salvage radiotherapy. (medscape.com)
- However, self-reported urinary and fecal incontinence rates at 1 year were significantly higher in the adjuvant radiotherapy group vs the observation group, 60% of whom had not received salvage radiotherapy at that time. (medscape.com)
- Our study suggests that removing the prostate followed by adjuvant radiotherapy is associated with greater overall survival in men with prostate cancer. (eurekalert.org)
- Although there are clear criteria (pT3-pT4 disease and/or positive margins) for the use of adjuvant radiotherapy, no specific clinical or tumour-related criteria have yet been defined for SRT. (wjgnet.com)
- Not all adverse pathology features are equal: Identifying optimal candidates for adjuvant radiotherapy among patients with adverse pathology at radical prostatectomy. (oncologynurseadvisor.com)
Recurrent prosta3
- Reirradiation salvage radiotherapy for recurrent prostate cancer after primary low-dose brachytherapy. (urotoday.com)
- The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
- Salvage Radical Prostatectomy for Recurrent Prostate Cancer after Radiation Therapy. (malecare.org)
Post-prostatectomy2
- The Phase II, limited-participation study comparing salvage radiotherapy (SRT) with standard androgen deprivation therapy (ADT) to enhanced ADT with enzalutamide in patients with post-prostatectomy PSA recurrences with aggressive disease features was expected to enroll 170 patients, however the trial official closed to patients with 188 patients accrued. (rtog.org)
- Although SRT is a widely-accepted treatment option for patients with post-prostatectomy PSA recurrences, including those with aggressive features, up to half of the patients treated with SRT will experience disease progression," stated Edwin Posadas, MD, FACP, of Cedars-Sinai Medical Center and the Principal Investigator of the STEEL study. (rtog.org)
Failure after radical prostatectomy2
- Overall, the trial results "support the use of early salvage radiotherapy for PSA failure after radical prostatectomy rather than early adjuvant intervention, " concluded Clarke, a professor and consultant urologist at The Christie Hospital and Salford Royal Hospital, Manchester, United Kingdom. (medscape.com)
- Available at: radiotherapy for biochemical failure after radical prostatectomy with or. (ehd.org)
Brachytherapy2
- Locally advanced cervical cancer: Should intensity-modulated radiotherapy replace brachytherapy? (urotoday.com)
- Brachytherapy is a modification of local radiotherapy where radioactive beads are implanted into the prostate gland and surrounding region. (nethealthbook.com)
Oncology4
- Observation with early salvage radiotherapy in cases of biochemical failure should be the standard of care, concluded study co-author Noel Clarke, MBBS, who presented the results at the European Society for Medical Oncology (ESMO) Congress 2023 in Madrid on October 20. (medscape.com)
- The congress brings together esteemed specialists and healthcare professionals from various disciplines, thanks to the collaborative efforts of the European Society for Medical Oncology (ESMO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and the European Association of Urology (EAU). (uroweb.org)
- Sparing the penile bulb in the radical irradiation of clinically localised prostate carcinoma: A comparison between MRI and CT prostatic apex definition in 3DCRT, Linac-IMRT and Helical Tomotherapy," Radiotherapy and Oncology, Vol. 93, No. 1, 2009, pp. 57-63. (scirp.org)
- According to new findings published in the journal Lancet Oncology, researchers at Princess Margaret Cancer Centre and the Ontario Institute for Cancer Research in Toronto, Ontario, Canada, have designed a genetic test that can determine which men are at the highest risk for developing prostate cancer recurrence following localized surgery or radiotherapy. (cancertherapyadvisor.com)
Radical prostatectomy for prostate cancer3
- Men with adverse pathology after radical prostatectomy for prostate cancer are a heterogeneous population with different outcomes, according to investigators. (oncologynurseadvisor.com)
- Adjuvant radiation may reduce the risk for all-cause mortality in a subgroup of men with very high-risk adverse pathologic characteristics at the time of radical prostatectomy for prostate cancer, new findings suggest. (oncologynurseadvisor.com)
- METHODS: The Regione Emilia-Romagna Italian Longitudinal Health Care Utilization Database was queried to identify a cohort of men who received radical prostatectomy for prostate cancer during 2003 to 2009, including patients who received postprostatectomy radiation therapy. (duke.edu)
Treated with radical3
- Prostate cancer is the most common cancer in men and can be treated with radical prostatectomy (RPE) or radiotherapy in the primary setting. (bvsalud.org)
- Previous research comparing patients treated with radical prostatectomy to radiotherapy-based treatments have generally included patients treated over the span of multiple decades. (ucla.edu)
- D. Prostate cancer T3 is successfully treated with radical prostatectomy. (imop.gr)
Outcomes10
- They also found there were few side effects with HIFU focal therapy, and that quality-of-life outcomes "compared very favorably" with those from studies of whole-gland treatments, such as radical prostatectomy or radiotherapy. (medpagetoday.com)
- These functional outcomes compare very favorably to patient-reported outcomes after whole-gland treatments, such as radical prostatectomy and radiotherapy, which, although effective, are associated with substantial and persistent side-effects that impact quality of life," the researchers added. (medpagetoday.com)
- Characterization of clinical outcomes after shorter course hypofractionated and standard-course radiotherapy for stage I-III curatively-treated Merkel cell carcinoma. (dana-farber.org)
- 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. (sfu.ca)
- laparoscopic prostatectomy versus open radical retropubic prostatectomy: Early outcomes from a randomised controlled phase 3 study. (sfu.ca)
- Comparison of Clinical Outcomes Stratified by Target Delineation for Patients Undergoing Stereotactic Body Radiotherapy for Spinal Metastases. (ohsu.edu)
- Our findings, in fact, show just the opposite - in this study, the patients with the best outcomes were those who received an aggressive therapy that included so-called 'extremely dose-escalated radiotherapy' along with hormonal therapy. (ucla.edu)
- Several studies have shown that increasing the dose of radiotherapy beyond standard doses (known as extreme dose-escalation), in combination with hormonal therapy, has improved short-term treatment outcomes, but no previous studies have shown a difference in mortality rates or long-term survival in any group of patients with prostate cancer. (ucla.edu)
- The STEEL study was designed to address a dire need for improved outcomes for prostate cancer patients with PSA recurrences with aggressive features following prostatectomy. (rtog.org)
- The evolving culture of cancer care, puting to radiotherapy planning (e.g. nologies undeniably contribute to and cancer medicine more broadly, deep learning to facilitate automated better outcomes for cancer patients has also played a major part in these treatment contouring and planning). (who.int)
Recurrence after radical prostatectomy4
- Gerald L. Andriole Objective: To identify which patients with prostate cancer are at high risk for local or distant recurrence after radical prostatectomy. (karger.com)
- We assessed the management impact of 18 F-DCFPyL PSMA PET/CT in patients with prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP) and report early biochemical response in patients who underwent radiation treatment. (snmjournals.org)
- Prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP) for prostate cancer occurs in up to 20%-50% ( 1 , 2 ) and is defined by a PSA level of more than 0.2 ng/mL. (snmjournals.org)
- These important studies have illuminated the extent to which postoperative radiotherapy (RT) may provide benefit to patients with adverse pathologic features (extraprostatic extension, seminal vesicle invasion, or positive surgical margins) or biochemical recurrence after radical prostatectomy. (jnccn.org)
Salvage radical prostatectomy1
- BACKGROUND: To evaluate efficacy and morbidity prospectively in a contemporary multi-institutional salvage radical prostatectomy (SRP) series. (umassmed.edu)
Underwent radical prostatectomy2
- Among 8362 men who underwent radical prostatectomy at a single center from 1987-2020, 926 men had grade group 4-5 disease with pT3a or higher stage and/or lymph node invasion. (oncologynurseadvisor.com)
- Of the men who went on to receive definitive treatment after AS, 52% underwent radical prostatectomy, 34% received radiotherapy with androgen deprivation therapy (ADT), 6.0% received radiotherapy alone, 4.7% were managed with ADT alone, and 2.7% underwent radical prostatectomy and ADT. (medpagetoday.com)
Radiation therapy8
- Key eligibility criteria included the indication for radiation therapy after previous radical prostatectomy and no previous postoperative androgen-deprivation therapy. (ascopost.com)
- Dr. Lu-Yao and colleagues looked at the patients who were treated either with prostatectomy plus adjuvant radiation as one group, and compared them to another group who were treated with radiation therapy plus hormone-blocking therapy. (eurekalert.org)
- However, the proportion of men undergoing prostatectomy plus radiation therapy decreased significantly over time and there were trade-offs for the survival advantages," said Dr. Lu-Yao. (eurekalert.org)
- Patients with stage III prostate cancer are curable and have a number of treatment options, including external beam radiation therapy (EBRT) with or without hormone therapy, surgical removal of the cancer with radical prostatectomy, or active surveillance without immediate treatment. (texasoncology.com)
- Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer," The Journal of the American Medical Association, Vol. 280, 1998, pp. 969-974. (scirp.org)
- PURPOSE: Although the likelihood of radiation-related adverse events influences treatment decisions regarding radiation therapy after prostatectomy for eligible patients, the data available to inform decisions are limited. (duke.edu)
- RESULTS: A total of 9876 men were included in the analyses: 2176 (22%) who received radiation therapy and 7700 (78%) treated with prostatectomy alone. (duke.edu)
- CONCLUSION: Radiation therapy after prostatectomy is associated with an increase in gastrointestinal and genitourinary adverse events. (duke.edu)
Laparoscopic radical prost2
- a) radical retropubic prostatectomy b) radical perineal prostatectomy c) laparoscopic radical prostatectomy d) robotic prostatectomy. (nethealthbook.com)
- Anastomotic urine leak is less likely in robotic-assisted laparoscopic radical prostatectomy. (imop.gr)
Urinary incontinence2
- Men who received the combination of surgery and radiotherapy had higher rates of erectile dysfunction (28 percent vs 20 percent) and higher rates of urinary incontinence (49 percent vs 19 percent). (eurekalert.org)
- Although prostatectomy and radiotherapy yield excellent- long term survival rates for men with prostate cancer, adverse effects (erectile dysfunction and/or urinary incontinence with subsequent undesired lifestyle modifications, anxiety about the loss of intimacy, negative self-perception, and the effects of such stressors on work performance and family relationships) frequently afflict patients who have undergone these procedures. (ijpc.com)
Survival9
- The addition of 24 months of androgen-deprivation therapy to postoperative radiotherapy after radical prostatectomy provided a metastasis-free survival benefit and improved the time to salvage therapy in patients with prostate cancer, according to the preliminary results from the RADICALS-HD trial (ISRCTN40814031). (ascopost.com)
- When men are getting radiotherapy for prostate cancer as their initial treatment, we know the addition of hormone therapy improves efficacy and survival. (ascopost.com)
- Based on the first results of the RADICALS-HD trial, 24 months of androgen-deprivation therapy with radiotherapy after radical prostatectomy improved metastasis-free survival, compared with 6 months of androgen-deprivation therapy, with a 10-year rate of metastasis-free survival of 78% vs 72%, respectively. (ascopost.com)
- However, overall survival was not improved with a long vs short course of androgen-deprivation therapy with radiotherapy after surgery. (ascopost.com)
- In this high-risk group RT + 24 months of ADT after prostatectomy improved overall survival. (prostatecancerfree.org)
- With the PSA test it is now possible to detect cancer of the prostate earlier and with the introduction of the selective radical prostatectomy excellent cure rates of 15 and 20 year survival rates are achieved, which for practical purposes can be considered a cure. (nethealthbook.com)
- However, for stage C and D where the cancer has broken through the tough prostate capsule surgery gives no survival advantage versus the radiotherapy approach. (nethealthbook.com)
- Therefore only external radiotherapy is available as an option to marginally improve survival. (nethealthbook.com)
- D espite the stage migration and concomitant improvements in prostate cancer-specific survival (PCSS) associated with widespread prostate-specific antigen (PSA) screening, approximately 1 in 3 men with clinically localized disease will develop a detectable PSA after radical prostatectomy (RP) in contemporary series. (jnccn.org)
Postoperative radiotherapy2
- 2 The argument for postoperative radiotherapy (RT) is predicated on the assumption that some patients may have residual local disease of a potentially lethal phenotype after surgery and that the delivery of secondary local therapy may interrupt the natural history of disease and prevent progression to systemic disease. (jnccn.org)
- Postoperative radiotherapy after prostatectomy: whom to treat. (canjurol.com)
High Risk Prostate Cancer1
- Men with very high-risk prostate cancer, who are treated at hospitals with a high proportion of administered radical local treatment (radiotherapy or prostatectomy), only have half of the mortality risk of men who are treated at hospitals with the lowest proportion. (news-medical.net)
Erectile dysfunction1
- The risks of prostate removal, or prostatectomy, are well known and include higher chance of developing incontinence and erectile dysfunction. (eurekalert.org)
Curative intent2
- Monotherapy with curative intent, either by radical prostatectomy or radiotherapy, results in around half. (karger.com)
- For example, a patient was just treated with curative intent with either radical prostatectomy or radical radiotherapy. (uroweb.org)
Pelvic lymph2
- Failure after salvage radiotherapy is most likely due to disease outside the prostate bed, which can include the pelvic lymph nodes, paraaortic lymph nodes, and distant metastases. (snmjournals.org)
- Before a prostatectomy is performed, patients may want to have pelvic lymph nodes removed to see if they contain cancer. (texasoncology.com)
Clinical2
- Clinical Significance of Radical Prostatectomy in Clinical Lymph Node Metastasis in Prostate Cancer. (urotoday.com)
- Clinical assessment of geometric distortion for a 0.35T MR-guided radiotherapy system. (ohsu.edu)
Androgen1
- According to the study, the time to salvage therapy was delayed with 24 months vs 6 months of androgen-deprivation therapy with radiotherapy. (ascopost.com)
Adverse1
- Outcome measures were genitourinary, gastrointestinal, and sexual adverse events after prostatectomy. (duke.edu)
Treatments2
- It compared two treatments initiated after a PSA rise to between 0.2 - 4.0 ng/mL after a prostatectomy and lymphadenectomy. (prostatecancerfree.org)
- One of the treatments applied in cancer is radiotherapy (RT), a therapeutic modality that uses ionizing radiation to induce damage in unwanted cells. (frontiersin.org)
Hormonal therapy1
- UCLA researchers have discovered that a combination of high doses of radiotherapy and hormonal therapy provides the best chance of decreasing the mortality rate of men with aggressive prostate cancer. (ucla.edu)
Prostate cancer patients treated1
- PURPOSE: We evaluated the biochemical recurrence (BCR) of prostate cancer patients treated by radical prostatectomy (RP) or radiotherapy (RT). (koreamed.org)
METHODS2
- Methods: Review of data from several historical and contemporary series of patients undergoing radical prostatectomy. (karger.com)
- Aims and background: we evaluate CT-3Tesla MRI fusion in conformal radiotherapy for localized prostate cancer.Methods: 18 consecutive patients underwent a 3T MRI scan under radiotherapy planning conditions, after the CT scan. (scirp.org)
Watchful1
- Radical prostatectomy or watchful waiting in early prostate cancer. (sfu.ca)
Cancer14
- The approach of early salvage radiotherapy spared morbidity [from] radiation in the vast majority of patients, and further bowel and bladder toxicity is reduced in the setting of salvage radiotherapy," said Sandhu, an associate professor and consultant medical oncologist at Peter MacCallum Cancer Centre, Victoria, Australia. (medscape.com)
- The aim of the RADICALS-RT study was to clarify the optimal timing for radiotherapy after radical prostatectomy in men with prostate cancer, which previously had been uncertain. (medscape.com)
- Stereotactic Radiotherapy after Radical Prostatectomy in Patients with Prostate Cancer in the Adjuvant or Salvage Setting: A Systematic Review. (bvsalud.org)
- presented in "Long-term Hormone Therapy May Increase Other-Cause Mortality in Men with Prostate Cancer Receiving Early Salvage Radiotherapy. (prostatecancerfree.org)
- Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. (frontiersin.org)
- Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
- González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)
- If the lymph nodes contain cancer, usually the surgeon will not proceed with a radical prostatectomy. (texasoncology.com)
- Overall the statistics show that about 85% of stage A and B prostate cancer patients can have a successful selective radical prostatectomy, in other words only 15% lose their potency. (nethealthbook.com)
- However, the danger is that some of the prostate cancer could stay behind, which would not be the case with a selective radical prostatectomy. (nethealthbook.com)
- Radical prostatectomy versus observation for localized prostate cancer. (sfu.ca)
- G. Ingrosso, A. Carosi, E. Ponti, P. Bove and R. Santoni, "Three-Tesla Magnetic Resonance and Computed Tomography Imaging in Three-Dimensional Conformal Radiotherapy for Localized Prostate Cancer," Open Journal of Radiology , Vol. 1 No. 1, 2011, pp. 1-8. (scirp.org)
- Prostate cancer researchers have developed a genetic test to identify which men are at highest risk for their prostate cancer to come back after localized treatment with surgery or radiotherapy. (cancertherapyadvisor.com)
- C. Prostate cancer T3 progresses within 5 years after radical prostatectomy in 40% of cases. (imop.gr)
Treatment3
- Prostatectomy is an unpopular treatment," said Lu-Yao. (eurekalert.org)
- In an elderly man who may soon die of a stroke or a heart attack this might still be the treatment of choice as a selective radical prostatectomy is a certain surgical risk. (nethealthbook.com)
- Active treatment is mostly recommended for patients with localised disease and a long life expectancy with radical prostatectomy (RP) shown to be superior to WW in a prospective randomised trial. (nih.gov)
Image-guided1
- The first group of men were treated with image-guided radiotherapy and were followed for 7.8 years, on average. (cancertherapyadvisor.com)
Phase1
- Performance of a Genomic Classifier (GC) Within a Phase 3 Randomized Trial of Dose Escalated Salvage Radiotherapy (SRT) After Radical Prostatectomy (RP). (cdc.gov)
Dose2
- Radiotherapy Dose in Patients Receiving Immunotherapy. (dana-farber.org)
- The dose-volume histogram (DVH) analysis shows a significant reduction of the dose received by the rectum and the penile bulb in MRI-plans compared to CT-plans.Conclusions: 3 Tesla MRI scan under radiotherapy planning conditions along with bowel preparation significantly improves the definition of the target volume sparing normal tissue irradiation. (scirp.org)
Surgery3
- However, when men are getting radiotherapy after surgery, we have much less data about the role of hormone therapy. (ascopost.com)
- It's not just the risk of side effects.For some men, especially those who are not fit enough for the surgery, prostatectomy is not an option. (eurekalert.org)
- The test will help determine who will need chemotherapy or hormone therapy in addition to radiotherapy or surgery. (cancertherapyadvisor.com)
Observation1
- Patients in the observation arm received salvage radiotherapy if they experienced two consecutive PSA increases ≥ 0.1 ng/mL or three consecutive rises. (medscape.com)
Surgical removal1
- Radical prostatectomy involves surgical removal of the prostate gland and a small amount of surrounding normal tissue. (texasoncology.com)
Metastasis1
- 18. For patients who presented biochemical relapse after radical prostatectomy, which of the following factors are related more to local relapse than to remote metastasis? (imop.gr)
Prognostic1
- 2) Spratt concluded: "Pre-salvage radiotherapy PSA is both a prognostic and true predictive biomarker for benefit of hormone therapy combined with salvage radiation. (prostatecancerfree.org)
Results1
- Salvage radiotherapy, most commonly to the prostate bed, results in 5-y biochemical control of 56% ( 3 ). (snmjournals.org)