Prostate tumor autologous tumor cells antigen of tumor. Medical search. Frequent questions

Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)
Cancer immunotherapy with mRNA-transfected dendritic cells. (nova.edu)
Immunotherapy is being investigated more and more for the treatment of prostate cancer, and although not many of these therapies are currently FDA-approved, mounting data shows promise. (urologytimes.com)
At the 15th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies, Susan F. Slovin, MD, PhD , gave a presentation on immunotherapy in advanced prostate cancer, 1 reiterating the significant impact that this mode of treatment has had on patients with this disease. (urologytimes.com)
Please highlight the main points from your talk on immunotherapy in advanced prostate cancer. (urologytimes.com)
What is very challenging about any sort of immunotherapy, and in particular the checkpoint inhibitors, is that you need to get the treating product or the immune cells into the tumor microenvironment, which in the case of prostate cancer, happens to be the bone. (urologytimes.com)
In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. (asmepress.com)
As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. (asmepress.com)
As the most important cancer vaccine based on monocytes, it is the only prostate cancer therapeutic vaccine approved by the US Food and Drug Administration at present, which plays an extremely important role in the immunotherapy of prostate cancer. (asmepress.com)
Currently, the complexity of immunotherapy and the specificity of prostate cancer mean that other prostate cancer vaccines have not shown expected clinical benefits in large randomized phase II and III trials, and further in-depth studies are still needed. (asmepress.com)
In the past decades, immunotherapy has been used to treat prostate cancer through anti-tumor effects driven by immune response. (asmepress.com)
Pembrolizumab has become an important therapeutic tool for prostate cancer immunotherapy [7, 8]. (asmepress.com)
As an important part of immunotherapy, cancer vaccines have unique and significant advantages against prostate cancer, including monocyte vaccines and dendritic cells,accines, viral vaccines, peptide vaccines and DNA/mRNA vaccines [9]. (asmepress.com)
Among them, Sipuleucel-T plays a great role in promoting prostate cancer immunotherapy. (asmepress.com)
Sipuleucel-T (Provenge®, Dendreon, USA) is an active immune cell-based immunotherapy that induces an immune response against prostate acid phosphatase (PAP). (asmepress.com)
He has successfully translated his findings from the laboratory to the clinics and has conducted and led several large national immunotherapy clinical trials for brain tumors. (stanfordhealthcare.org)
Dr. Lim is a world leader in immunotherapy for brain tumors. (stanfordhealthcare.org)
In addition to being invited world-wide to give lectures and seminars, he has given platform presentations on the topics of immunotherapy for brain tumors, neurosurgical techniques and management of brain tumors at the American Society of Clinical Oncologists, American Academy of Neurological Surgeons, Radiological Society of North America, Annual Symposium on Brain and Spine Metastases, Congress of Neurological Surgeons, and other meetings. (stanfordhealthcare.org)
Whether it's working on our own immunotherapy trials for solid tumors, or partnering with companies to find novel medicines, City of Hope is committed to transforming cancer care for our patients and beyond. (wkrn.com)
Here we tested whether a tumor-derived antigen source called DRibbles®, which contain a pool of defective ribosomal products (DRiPs), long-lived and short-lived proteins (SLiPs) and danger-associated molecular patterns (DAMPs), can be used to identify tumor-associated antigen (TAA)-specific responses in patients before or after immunotherapy treatment. (providence.org)
Rocapuldencel-T is an autologous dendritic cell immunotherapy for patients with metastatic renal cell carcinoma about which we have written previously. (shu.edu)
Vaccine strategies for cancer immunotherapy depend on the induction of dendritic cells (DC) in close proximity to T cells. (shu.edu)
However, post-immunotherapy the patient received six cycles of mitoxantrone, an 'antineoplastic' or 'cytotoxic' chemotherapy drug, from July 2017 to October 2017, as he had an advanced hormone-refractory prostate cancer due to hormonal therapy failure earlier in the treatment history. (immucura.com)
The current case report suggests autologous DC immunotherapy could form a safe, feasible and efficacious therapy in combination with the systemic chemotherapy drug mitoxantrone, providing a step forward toward an evolving chemoimmunotherapy approach for cancer treatment. (immucura.com)
SEAL BEACH, Calif.-( BUSINESS WIRE )-Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, today announced publication of results from its PROCEED registry, which evaluated real-world use of PROVENGE ® (sipuleucel-T) in men with asymptomatic or minimally symptomatic metastatic castrate-resistant prostate cancer (mCRPC). (gabio.org)
PROVENGE is the only FDA-approved immunotherapy made from a patient's own immune cells for the treatment of prostate cancer. (gabio.org)
PROVENGE is an autologous cellular immunotherapy indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant (hormone-refractory) prostate cancer. (gabio.org)
IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Immunotherapy offers great promise for ovarian cancer patients who have already failed or relapsed following treatment with platinum-based chemotherapies because it uses the patient's own immune cells to kill cancer cells," said Susie Jun, M.D., Ph.D., ArsenalBio's Chief Medical Officer. (arsenalbio.com)
Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
Compared to viral-based methods, this method serves as an alternative and versatile way of generating T cells with tumor-targeting receptors for cancer immunotherapy. (cartherics.com)
Provenge is unlike other prostate cancer treatments because it is a form of immunotherapy, which means it is designed to utilize and work with a man's immune system to fight prostate cancer. (prostate.net)
In this sense, this drug is sometimes referred to as a prostate cancer vaccine because vaccines are also a form of immunotherapy. (prostate.net)
Provenge is an autologous cellular immunotherapy, which means it uses a man's own immune cells (autologous) to battle prostate cancer. (prostate.net)
The main reason Provenge differs from other treatments for prostate cancer is that it is the only prostate cancer immunotherapy approved by the Food and Drug Administration (FDA) and the first in a new class of therapy to use this approach. (prostate.net)
After unsatisfactory efforts and explicit clinical failures, the field of cancer immunotherapy has received a significant boost, thanks mainly to the development in 2010 of an autologous cellular immunotherapy, sipuleucel-T, for the treatment of prostate cancer [3] and the approval of the anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) antibody ipilimumab (2011) and anti-programmed cell death protein 1 (PD1) antibodies (2014) for the treatment of melanoma [4]. (biomedcentral.com)

The company develops P-PSMA-ALLO1, an autologous chimeric antigen receptor T cell (CAR-T) product candidate that is in Phase I trial for the treatment of patients with metastatic castrate resistant prostate cancer (mCRPC). (seekingalpha.com)
We are seeing a tremendous amount of interest in using chimeric antigen receptor T [CAR T] cells as an immune approach in prostate cancer. (urologytimes.com)
So, among the challenges that everybody's looked at, with regard to chimeric antigen receptor T cells, or armored CAR T cells, which we like to call them sometimes, is that they need to be stable. (urologytimes.com)
ONCT-808 is an investigational autologous chimeric antigen receptor T (CAR T) cell therapy that targets Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) using the binding domain from zilovertamab. (oncternal.com)
Baxalta, the biopharmaceutical spinoff of Baxter, entered into a $1.7 B deal with Precision BioSceinces for 6 CAR-T (Chimeric Antigen Receptor T-cell) projects, and Saronic Biotechnology announced positive data in preclinical studies of its autologous dendritic cell vaccine for hepatocellular carcinoma. (shu.edu)
Their modifications include adding a chimeric antigen receptor specific for B7-H3 and partnering with Fate Therapeutics to make four genetic modifications to these cells. (urotoday.review)
What we've done is we've been able to engineer natural killer cells and then we've added a chimeric antigen receptor specific for B7-H3. (urotoday.review)
A Phase 1b-2, open-label study of JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) therapy directed against BCMA in subjets with relapsed or refractory multiple myeloma. (biosafety.be)
BNT211 is a potential first-in-class therapeutic approach which comprises a synergistic combination of two of the Company's proprietary drug products, an autologous chimeric antigen receptor (CAR) T cell therapy targeting the oncofetal antigen Claudin-6 (CLDN6) and a CLDN6-encoding CAR-T cell amplifying RNA vaccine (CARVac). (jacksonnewsreporter.com)
Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)
Manufacture of chimeric antigen receptor (CAR)-T cells usually involves the use of viral delivery systems to achieve high transgene expression. (cartherics.com)

Its clinical product candidates also include BPX-603, an autologous dual-switch GoCAR-T product candidate, which is in Phase 1/2 clinical trials for the treatment of solid tumors expressing human epidermal growth factor receptor 2 antigen. (marketbeat.com)
ONCT-534 is a dual-action androgen receptor inhibitor (DAARI) with preclinical activity in prostate cancer models against both unmutated androgen receptor (AR), and against multiple forms of AR aberrations. (oncternal.com)
A novel T cell receptor transgenic animal model of seborrheic dermatitis-like skin disease. (southernbiotech.com)
Another challenge is the cell entry of oncolytic adenovirus, which is mainly mediated by the Coxsackie-Adenovirus receptor and this receptor is downregulated in various cancer cells. (helsinki.fi)
It is a bispecific humanized monoclonal antibody against CD3, a T-cell surface antigen, and GPRC5D (human G-protein coupled receptor family C group 5 member D), a tumor-associated antigen with potential antineoplastic activity. (medscape.com)
Quizartinib and its active metabolite (AC886) inhibit FLT3 kinase activity, preventing autophosphorylation of the receptor, thereby inhibiting downstream FLT3 receptor signaling and blocking FLT3-ITD-dependent cell proliferation. (medscape.com)
CTLA-4 is related to the T cell co-stimulatory receptor CD28, and acts to suppress T cell function by competing with CD28 for binding to CD80 and CD86 on antigen presenting cells and recruiting inhibitory molecules into the TCR signaling synapse. (sanguinebio.com)
A second article in the same issue of The Journal of Experimental Medicine by Bulliard et al also explored the role of FcgR engagement on the effects of Ipilimumab as well as an agonistic antibody (DTA-1) targeting the T cell activating receptor GITR (TNFR glucocorticoid-induced TNFR-related protein), which is also expressed on both activated T cells and T REG s. (sanguinebio.com)
For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
This binding process leads to the release of IL-1α and activation of IL-1 receptor, promoting chemokines production and attracting other innate immune cells to kill AdV infected MFs [61]. (genemedi.com)

Bellicum Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering and developing novel cellular immunotherapies for the treatment of hematological cancers and solid tumors in the United States and internationally. (marketbeat.com)
NSCLC without driver mutations is one of the most heavily mutated of human cancers [ 8 ], thus it is likely that NSCLC cells harbor neoantigens to which the host would not be tolerant, and against which the immune system could mount a strong, destructive immune response. (biomedcentral.com)
This review describes the use of mRNA-encoded tumor antigens as a form of antigen loaded onto DCs, including our early experience from clinical trials in urological cancers. (nova.edu)
and P-MUC1C-ALLO1 that is in Phase I trial for treating a range of solid tumors, including breast, colorectal, lung, ovarian, pancreatic, and renal cancers. (seekingalpha.com)
Prostate acid phosphatase (PAP) is expressed in approximately 95% of prostate cancers and is mainly limited to prostate tissue, which is a target for prostate cancer tumor vaccine development. (asmepress.com)
And what's really interesting about B7-H3 is that it's very highly expressed on prostate cancers and fortunately many other cancers as well, but in the context of there's very low PD-L1 and checkpoint inhibitor expression on these same cancers. (urotoday.review)
4 Four years later, the FDA approved two autologous CAR-T cell therapies for patients with certain types of hematologic cancers: relapsed or refractory ALL and relapsed or refractory large B cell lymphoma. (cellandgene.com)
Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens. (nih.gov)
P-MUC1C-ALLO1 is an allogeneic CAR-T product candidate targeting solid tumors derived from epithelial cells, including breast and ovarian cancers. (poseida.com)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)
To date, first generation T cell-based technologies have failed to drive deep and durable responses in solid tumors, leaving a large unmet need for effective immunotherapies across many types of solid tumor cancers. (arsenalbio.com)
Following our AB-1015 study, we plan to initiate subsequent clinical studies to explore the use of our ICT cell technology in other solid tumor cancers with high unmet medical need including kidney and prostate cancers. (arsenalbio.com)
While CAR-T cell therapy has had remarkable success against most types of blood cancers, its application to T cell cancers is limited. (cartherics.com)
CAR-T cell therapies face a range of barriers against T cell cancers. (cartherics.com)
The use of CAR-T cells for the treatment of blood cancers has been revolutionary with unparalleled responses observed in some patients. (cartherics.com)
Solid cancers are able to create an environment that supports cancer growth and 'protects' cancer cells from elimination. (cartherics.com)
Designing a delivery system that shields CAR-T cells from the impact of the cancer environment may improve outcomes of CAR-T therapy in solid cancers. (cartherics.com)
Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)

A preparative regimen is needed to remove any inhibitory immune cells, ie, regulatory T cells (Tregs) that may contribute to a hostile tumor microenvironment, thereby providing an intratumoral milieu that blocks immune cell penetration. (urologytimes.com)
In addition, a deeper understanding of the complex interplay of cells in the tumor microenvironment will lead to therapies directed at the specific mechanism of immune suppression in a specific patient. (genengnews.com)
Ipilimumab functions to increase the ratio of effector T cells to T REGS in the tumor microenvironment and has been shown to require binding to both types of T cells for maximal anti-tumor effectiveness. (sanguinebio.com)
and a module containing synthetic short hairpin RNAs designed to pharmacologically modulate gene expression thus enabling enhanced T cell function in the tumor microenvironment. (arsenalbio.com)

Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Prostate cancer is one of the most common malignant tumors of the urinary system. (asmepress.com)
Dr. Lim's clinical interests include the treatment of benign and malignant brain tumors, with special interest in gliomas, meningiomas, metastatic tumors, and skull base tumors. (stanfordhealthcare.org)
These therapeutic methods, including but not limited to oncolytic virus therapies, T-cell therapies and cancer vaccines, are based on the body's ability to recognize mutated antigen peptides presented on the cell surface by MCH-receptors (also known as HLA-receptors in humans) and the disposal of the malignant cells by cytotoxic T-cells. (helsinki.fi)
Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
CTCL is a blood cancer caused by malignant T cells. (cartherics.com)
However, since both the malignant T cell and the therapy may share the target, CAR-T cells could kill healthy cells in the patient. (cartherics.com)
Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)
In the same way a "traditional" vaccine works, a cancer vaccine can promote the eradication of malignant cells during their initial transformation from safe to harmful cells. (biomedcentral.com)

Provenge is an adoptive cell-transfer therapy in which a patient's antigen-presenting target autologous prostate cancer tissue. (wikipedia.org)
Entering clinical development with our first adoptive cell therapy program is a significant step for Immatics, and highlights the ability of the XPRESIDENT platform to identify novel and true tumor antigens directly from a patient's tumor," said Harpreet Singh, PhD, chief scientific officer and CEO at Immatics US. (pharmacytimes.com)
CAR-T cell therapy aims to target and kill cancer cells, and boost a patient's immune system to fight cancer. (cartherics.com)
The patient's prostate cancer has worsened since undergoing treatment with drugs that stop the production of hormones. (prostate.net)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)

Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)

Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
DRibble vaccine given with GM-CSF appeared safe and capable of inducing an immune response against tumor cells in this small, pilot study. (biomedcentral.com)
The striking observation from two phase I clinical trials, in patients with prostate cancer immunized with prostate-specific antigen mRNA-transfected DCs and patients with renal cancer immunized with autologous tumor RNA-transfected DCs, was that the majority of patients exhibited a vaccine-induced T-cell response. (nova.edu)
Therefore, this article reviews the latest progress on prostate cancer vaccine, especially Sipuleucel-T vaccine based on mononuclear cells. (asmepress.com)
Figure 1 shows that general view of vaccine for prostate cancer. (asmepress.com)
General view of vaccine for prostate cancer (DC, dendritic cell). (asmepress.com)
It is a type of autocellular immunotherapeutic vaccine, composed of peripheral mononuclear cells. (asmepress.com)
Protein content, gene expression and non-synonymous - single nucleotide variants (ns-SNVs) present in UbiLT3 DRibbles were compared with prostate adenocarcinomas and the prostate GVAX vaccine cell lines (PC3/LNCaP). (providence.org)
Two companies - Biontech, RNA vaccine and Neon Therapeutics, peptide vaccine - reported very positive results of neo-antigen vaccines in patients with refractory metastatic melanoma. (shu.edu)
Administration of personalized dendritic cell-based vaccine APCEDENR in combination with anthracenedione antineoplastic drug Mitoxantrone. (immucura.com)
DC vaccine optimization through effective antigen presentation strategies and operational combination therapy strategies are the foci of ongoing and upcoming studies. (immucura.com)
In April 2010, the cancer vaccine market experienced one of the biggest achievements in the therapeutic vaccine treatment of cancer-the approval of the prostate cancer vaccine PROVENGE (TM). (kaloramainformation.com)

Currently, most men with advanced prostate cancer develop castration-resistant prostate cancer(CRPC) [6]. (asmepress.com)
Zilovertamab is also being evaluated in two investigator-initiated studies: a Phase 2 clinical trial of zilovertamab in combination with venetoclax, a Bcl-2 inhibitor, in patients with R/R CLL ( NCT04501939 ), and a Phase 1b study of zilovertamab in combination with docetaxel in patients with metastatic castration-resistant prostate cancer ( NCT05156905 ). (oncternal.com)
Castration-resistant prostate cancer (CRPC). (immucura.com)

Such strategies could produce organisms that perform multistep immune functions such as presenting antigen to and co-stimulating helper T cells in a specific manner, or providing integrated signals to B cells to induce affinity maturation and isotype switching during antibody production. (wikipedia.org)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
Celgene acquired EngMab for $600MM to enrich its programs targeting B-cell maturation antigen (BCMA) for the treatment of multiple myeloma. (shu.edu)
Elranatamab is an antibody that binds to both CD3 on T-cells and B-cell maturation antigen (BCMA), which are expressed on the surface of multiple myeloma cells. (medscape.com)

Alicia Morgans interviews Nick Zorko, who shares his excitement about his team's work on natural killer (NK) cell therapies, specifically focusing on engineered NK cells to target the tumor marker B7-H3. (urotoday.review)
Dr. Zorko believes that NK cell therapies will be safer, more accessible, and possibly suitable for outpatient settings, which is particularly beneficial for prostate cancer patients who are often older and may have multiple comorbidities. (urotoday.review)
So the University of Minnesota is very focused on natural killer cell therapies. (urotoday.review)
So we think this is going to be a great target for treating prostate cancer with these cellular therapies. (urotoday.review)
Because of these uncertainties, the shiny new penny of allogeneic CAR-T cell therapies has likely lost some of its luster. (cellandgene.com)
Following the publication of the first preclinical studies of allogeneic CAR-T cell cancer therapies about five years ago, an appealing narrative began to take hold - this "off-the-shelf" CAR-T would inevitably replace the pioneering autologous CAR-Ts. (cellandgene.com)
In one survey, nearly half of respondents pointed to allogeneic immunotherapies as the next big thing in cell therapies. (cellandgene.com)
Given recent developments, the assumptions and perceptions about both autologous and allogeneic CAR -T therapies warrant a closer look. (cellandgene.com)
Though autologous CAR-T therapies are now part of the standard of care for multiple blood diseases, less than 10 years ago they were being hailed as a miracle of modern science. (cellandgene.com)
To date, autologous CAR-T therapies have received six approvals across five products. (cellandgene.com)
This immunity may diminish the efficacy of allogeneic CAR-T cell therapies and could explain why they often require repeat dosing. (cellandgene.com)
Even though the idea of an immune system actively searching for and disposing of potential mutated tumor cells is over a century old, only recent developments in various fields such as mass spectrometry, immuno-checkpoint blockade strategies and in silico modelling have enabled the realization of the full potential of recruiting immune system to fight cancer and the possibilities of personalized therapies. (helsinki.fi)
Throughout the quarter we have advanced our wholly-owned and partnered portfolios of cell and gene therapies for patients with cancer and rare diseases. (poseida.com)
While we remain encouraged by the results in our autologous P-PSMA-101 program, we have stopped enrollment in the Phase 1 trial and deprioritized this program as we believe that our allogeneic platform is the key to unlocking the promise of cell therapies. (poseida.com)
South San Francisco, Calif. - January 5, 2023 - Arsenal Biosciences, Inc. (ArsenalBio), a privately held, clinical stage, programmable cell therapy company engineering advanced CAR T cell therapies for solid tumors, today announced that the first patient has been dosed with AB-1015 in a Phase 1, first-in-human clinical trial for patients with ovarian cancer that is resistant to platinum-based regimens. (arsenalbio.com)
Arsenal Biosciences, Inc. (ArsenalBio), headquartered in South San Francisco, Calif., is a privately held programmable cell therapy company discovering and developing a pipeline of next-generation autologous T cell therapies to defeat cancer. (arsenalbio.com)
While effective, broad use of CAR T-cell therapies is limited by potential for life-threatening toxicities, challenges related to manufacturing a patient-specific product, high costs and inadequate reimbursement, and incomplete or unsustained disease response. (ajmc.com)
Managed care professionals should have an understanding of the clinical trial data and place in therapy in lymphoma, myeloma, and acute lymphoblastic leukemia as well as guideline recommendations for adverse effect management associated with CAR T-cell therapies. (ajmc.com)
CAR T-cell therapies are limited by the potential to cause life-threatening toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). (ajmc.com)
Another way to look at Provenge versus other prostate cancer treatments is that while other therapies work against the body-chemotherapy and radiation therapy are toxic and focus on killing cancer cells, while hormone therapy stops production of hormones-Provenge is a positive approach that makes use of the body's own immune cells (T-cells) which have been activated in a laboratory so they can recognize and battle prostate cancer cells. (prostate.net)

Technologies that can control cell fate include strategies to induce pluripotent stem cell formation and using small molecules to induce stem cells to differentiate into specific cell types. (wikipedia.org)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)
Cancer vaccines use tumor cell-associated antigens to induce a specific anti-tumor immune response that is durable and robust. (asmepress.com)
The general lack of understanding of the mechanisms of immunization, the role of dendritic cells, the ability of cancer to induce tolerance, and the identification of the most suitable antigens to use are just some examples of how the development of effective strategies is still problematic [7-10]. (biomedcentral.com)

We have a couple of other modifications that we've been able to make with our therapeutic partners as well, Fate Therapeutics, and that includes high affinity CD-16 that allows us to add a second monoclonal antibody to redirect the cells as well to give it a second kill signal. (urotoday.review)
The findings indicate that within the pool of 409 patients studied, prostate cancer accounts for 7.7% of cases, with a substantial 66.7% classified as grade 4, signifying advanced-stage diagnoses, and roughly 66.7% presenting with metastatic prostate cancer, underscoring the pressing need for effective therapeutic interventions. (immucura.com)
In contrast, the CAR-T cells of Juno utilize T-cells and monoclonal antibodies, (the current leading immune-oncology therapeutic class) mimic the antibody creation of B-cells to fight cancer. (smithonstocks.com)
ArsenalBio is building the industry's largest DNA library of therapeutic enhancing integrated circuits, incorporating logic gating for improved tumor targeting and synthetic features enabling multiple pharmaceutical functions. (arsenalbio.com)
Vaccines are the most effective and cost-efficient weapons that can be used to prevent (preventive vaccines) or cure (therapeutic vaccines) diseases caused by infectious agents or cancer cells. (biomedcentral.com)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)

Advances in chemical biology include synthetic molecules that modulate B cell activation, structurally complex carbohydrate tumor antigen and adjuvants synthesis, immunogenic chemotherapeutic agents and chemically homogeneous, synthetic vaccines. (wikipedia.org)
Tumor-derived autophagosome vaccines (DRibbles) have the potential to broaden immune response to poorly immunogenic tumors. (biomedcentral.com)
In silico methods were successfully used to characterize previously identified HLA-restricted peptides and one previously identified immunogenic T-cell epitope. (helsinki.fi)
This favors the development of less immunogenic and more apoptosis-resistant neoplastic cells, through a mechanism well known as immune editing [2]. (biomedcentral.com)

P-PSMA-101 is a solid tumor autologous CAR-T product candidate targeting prostate-specific membrane antigen, or PSMA, being developed to treat patients with metastatic castrate-resistant prostate cancer and salivary gland carcinoma. (poseida.com)
The clinical data from the Phase 1 trial is still being collected and analyzed and will be utilized to inform other solid tumor allogeneic programs, including the Company's preclinical allogeneic program, P-PSMA-ALLO1. (poseida.com)
Indeed, CAR-T cells were found to be potent killers of 3D solid tumor cell culture models. (cartherics.com)

Other challenges to this therapy include knowing the affinity of the CAR T cell for the antigen in question.Clearly, prostate-specific membrane antigen, or PSMA, has been a focal target for a variety of different approaches, including immunological approaches with vaccines and antibody-drug conjugates in addition to CAR T cells, and more recently, a theranostic approach with 177-lutetium PSMA-617. (urologytimes.com)
SARS-COV-2 infects hosts via its spike (S) protein, which has two portions, S1 that binds the cell and S2 that is involved in viral entry via fusion with the cell membrane. (nih.gov)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

While advanced prostate cancer was historically defined as distant metastatic disease, the current definition includes disease stages that range from recurrence of prostate-specific antigen (PSA) elevation after failure of local treatment to widespread metastasis. (medscape.com)
[ 6 ] Since the advent of prostate-specific antigen (PSA) screening, prostate cancer is being detected and treated earlier. (medscape.com)
The most common manifestation of advanced prostate cancer is a rising prostate-specific antigen (PSA) level after failure of initial local therapy. (medscape.com)
8. Coccia MA, Brams P. High titer, prostate specific antigen-specific human IgG production by hu-PBL-SCID mice immunized with antigen-mouse IgG2a complex-pulsed autologous dendritic cells. (southernbiotech.com)

Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Most of the other cellular products that are currently being investigated are T-cell based. (urotoday.review)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)
The American Society for Transplantation and Cellular Therapy (ASTCT) guidelines recommend a collection target of 3-5 × 10 6 CD34+ cells/kg. (medscape.com)
The process for administering CAR T-cell therapy is complex, with multiple steps including CAR T-cell manufacturing, lymphodepleting chemotherapy, cellular therapy infusion, and management of short-term and long-term toxicities. (ajmc.com)
2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)

Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
High risk of acute pulmonary toxicity with both myeloablative and non-myeloablative total body irradiation-based conditioning for allogeneic stem cell transplantation. (dukecancerinstitute.org)
UbiLT3 DRibbles were used to monitor anti-tumor responses in patients vaccinated with allogeneic prostate GVAX. (providence.org)
2 This narrative endures, even though allogeneic CAR-Ts have not demonstrated superior efficacy or safety vis-à-vis their autologous counterparts and their promise of lower cost of goods does not appear to have been realized. (cellandgene.com)
Let's explore CAR-T autologous vs allogeneic in detail. (cellandgene.com)
Durability - the immunologic mismatch between a donor and recipient can create problems such as host-versus-graft response, since patients still have some immunity and their cells can attack the allogeneic CAR-T cells. (cellandgene.com)
T-cell exhaustion - the goal of an allogeneic approach is to make as many doses as possible. (cellandgene.com)
Results showed that adding quizartinib to standard chemotherapy with or without allogeneic hematopoietic stem cell transplantation, followed by continuation monotherapy for up to 3 years, resulted in improved overall survival. (medscape.com)
In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)

Loading DCs ex vivo with tumor antigens can stimulate potent antitumor immunity in tumor-bearing mice. (nova.edu)
Similar to the experience of others, we've always been faced with the fact that we used to use retroviral vectors to generate the final CAR product and that there are challenges to in how to maximize the in vivo efficacy of the CAR T cell. (urologytimes.com)
CD26 is expressed on a restricted subpopulation of dendritic cells in vivo. (southernbiotech.com)
Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)
CD3ε FP T cells were predominantly CD8+ effector memory T cells, and exhibited anti-tumor activity in vitro and in vivo. (cartherics.com)

To increase the immune response to PAP, it is activated by adding PAP and the recombinant fusion protein of immune activator GM-CSF (PAP-GM-CSF) at a specific stage of cell culture. (asmepress.com)
13. Bian H, Fournier P, Moormann R, Peeters B, Schirrmacher V. Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus. (southernbiotech.com)
To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
Once packaged into a E1-complementing cell line, which provides the E1 products in trans, such as QBI 293A Cells, recombinant viral will be easily propagated. (genemedi.com)
The collected immune cells are sent to a facility where they are activated with a recombinant antigen, which is designed to prompt the immune cells (T-cells) to look for and attack prostate cancer cells. (prostate.net)

The company's clinical product candidates include BPX-601, an autologous GoCAR-T product candidate, which is in Phase 1/2 clinical trials for the treatment of solid tumors expressing the prostate stem cell antigen. (marketbeat.com)
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
An independent data monitoring committee (IDMC) has recommended the continuation of Argos' pivotal phase 3 ADAPT clinical trial of AGS-003 for the treatment of metastatic renal cell carcinoma (mRCC) based on results of the committee's second planned interim data analysis . (shu.edu)
SAN DIEGO , Nov. 10, 2022 /PRNewswire/ -- Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage cell and gene therapy company advancing a new class of treatments for patients with cancer and rare diseases, today announced business updates and financial results for the third quarter ended September 30, 2022 . (poseida.com)
The clinical trial is the first to use products consisting of autologous cytotoxic T lymphocytes that target tumor antigens using Immatics' target warehouse, according to a press release. (pharmacytimes.com)
Thus differential affinities of IgG subclasses to functionally different Fcg receptors are thought to mediate the variation in clinical effectiveness of different antibodies targeting the same antigen. (sanguinebio.com)
AB-1015 is ArsenalBio's first internally discovered T cell medicine to enter clinical development and uses synthetic DNA programming to overcome tumor defenses, increase potency, and target ovarian cancer cells without harming normal tissues. (arsenalbio.com)

A preparation of autologous CD8+ (cytotoxic) T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities. (medicalterminologydb.com)

Thus, even for functionally different (antagonistic versus agonistic) immunotherapeutic antibodies targeting these same T cell populations, FcgR-mediated ADCC of T REG s appears to be a critical mechanism for anti-tumor effects. (sanguinebio.com)

A lot of what we've done has been predicated on various immunologic approaches that included carbohydrate, DNA, and naked DNA vaccines, as well as antibody drug conjugates directed against a variety of cell surface targets. (urologytimes.com)
One blogger wrote that dendritic cell cancer vaccines are no more effective than grapefruit juice. (smithonstocks.com)
The dendritic cell cancer vaccines have the promise of activating both T-cells and B-cells. (smithonstocks.com)

All 4 patients had evidence of specific antibody responses against potential tumor antigens. (biomedcentral.com)
Activating receptors contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAM) and activate the FcgR-expressing cell to mediate functions including antibody-dependant cell mediated cytotoxicity (ADCC) and phagocytosis of the antibody-labeled target cell. (sanguinebio.com)
Even though GITR-activation in effector T cells promotes activities including cytokine production and proliferation, the agonistic properties of this antibody alone were not effective in the absence of activating FcgR engagement. (sanguinebio.com)

As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)

This results in cross-linking of T-cells and myeloma cells and induces a potent cytotoxic T-lymphocyte response against BCMA-expressing cells. (medscape.com)

How Does Provenge Differ From Other Prostate Cancer Treatments? (prostate.net)
Provenge® (sipuleucel-T) is a unique treatment option for men who have asymptomatic or minimally symptomatic prostate cancer that has spread (metastasized) and also resisted hormone therapy (also referred to as metastatic castrate resistant or hormone refractory prostate cancer). (prostate.net)
Before the introduction of Provenge, men with this type of prostate cancer had no promising treatment opportunities. (prostate.net)
Therefore, a series of steps are necessary to create each personalized dose of Provenge using your own blood cells. (prostate.net)
The activated immune cells-your personalized Provenge dose-is given by infusion within about three days of the leukapheresis procedure. (prostate.net)

Oncternal has initiated Study ONCT-808-101 ( NCT05588440 ) for the treatment of patients with relapsed or refractory aggressive B-cell lymphoma, including patients who have failed previous CD19 CAR T treatment. (oncternal.com)
In the present study, the case of a patient diagnosed with diffuse large B‑cell lymphoma, who received chemotherapy and autologous hematopoietic stem cell transplantation is presented. (spandidos-publications.com)
In the present study, the case of a patient with diffuse large B-cell lymphoma evolving from grade 3a follicular lymphoma, who maintained a complete response for 4-years, and then presented with severe isolated thrombocytopenia, is reported. (spandidos-publications.com)
The patient had been diagnosed 5 years prior to this presentation with diffuse large B-cell lymphoma evolving from grade 3a follicular lymphoma. (spandidos-publications.com)
Published in Frontiers in Immunology ( https://doi.org/10.3389/fimmu.2022.968395 ), Van To and colleagues review the current potential CAR-T cell targets for Cutaneous T cell lymphoma (CTCL), and the strategies required for more effective treatment of the disease. (cartherics.com)

5. Chang J, Cha H, Chang S, Ko H, Seo S, Kweon M. IFN-γ secreted by CD103 + dendritic cells leads to IgG generation in the mesenteric lymph node in the absence of vitamin A. J Immunol. (southernbiotech.com)
One cycle of vaccinations consisted of three biweekly vaccinations administered intranodally in a clinically tumour-free lymph node. (immucura.com)
Tumor-associated T REGS expressedhigher levels of CTLA-4 than their effector T cell counterparts, or than T REGS present in the lymph node, indicating that higher CTLA-4 expression levels mediate ADCC via macrophages in the tumor. (sanguinebio.com)

and loaded with whole-tumour lysate. (immucura.com)

Research on a heart medication for childhood cancer survivors and new immunotherapies for blood and solid tumors will be presented. (wkrn.com)

Immucura's exhaustive examination of cancer data and survival rates, spanning from December 2020 to April 2023, centers its focus on prostate cancer. (immucura.com)

Genes are inserted encoding a PSMA-targeted Centyrin CAR with an iCasp9-based safely switch and DHFR to purify CAR T Cells.These T stem cell memory cells have bone marrow homing capability that may be particularly relevant to bone tropic tumors, such as prostate cancer. (urologytimes.com)
This PSMA 101 platform has resulted in an ongoing phase 1, dose-escalating multicenter trial that seeks to determine safety and tolerability of the CAR T cell. (urologytimes.com)

The blood flows through a tube to a machine where immune cells, platelets, and some red blood cells are collected from the blood sample. (prostate.net)

Importantly, the benefit of this platform is that it will provide immunologic memory such that the CAR T cells will persist at the site of tumor, leading to more time for the cell to elicit an antitumor response. (urologytimes.com)

High-grade prostate cancer, particularly the percentage presence of Gleason grades 4 and 5, is associated with adverse pathologic findings and disease progression. (medscape.com)
Oncternal pursues drug development targeting promising, yet untapped biological pathways implicated in cancer generation or progression, focusing on hematological malignancies and prostate cancer. (oncternal.com)
IFN-γ+ antigen-specific T cells median radiological progression free survival (rPFS) was 18.8 months (n= 5) vs. 5.1 months (n= 16) in patients without IFN-γ-producing antigen-specific T cells (p= 0.02). (immucura.com)
OBJECTIVE: Active surveillance (AS) is an increasingly utilized strategy for monitoring men with low-risk prostate cancer (PCa) that allows them to defer active treatment (AT) in the absence of cancer progression. (cdc.gov)

The ability to amplify RNA from microscopic amounts of tumor tissue extends the use of DC vaccination to virtually every cancer patient. (nova.edu)
Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10 + IgA plasma cells following mucosal vaccination via estrogen control. (southernbiotech.com)

With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)

Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)

In 2016 researchers transdifferentiated fibroblasts into induced neural stem cells. (wikipedia.org)
it is a non-viral transposon system (piggyBac®) that results in a CAR T product comprised of a high percentage of T stem cell memory cells. (urologytimes.com)
He was treated with chemotherapy (8 R-CHOP protocols) with partial response, followed by high-dose chemotherapy and autologous hematopoietic stem cell transplantation, with a complete response, and was stable for the previous 4 years. (spandidos-publications.com)
Motixafortide is indicated in combination with filgrastim to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma. (medscape.com)
SDF-1α and CXCR4 play a role in trafficking and homing of human hematopoietic stem cells to the marrow compartment. (medscape.com)

Sipuleucel-T consists of autologous peripheral blood mononuclear cells including antigen presenting cells (APCs). (asmepress.com)
Peripheral blood mononuclear cells from patients were obtained by a standard procedure of leukocyte separation approximately 3 days prior to infusion. (asmepress.com)

Dedifferentiation could be used to turn autoimmune cells into inactive progenitors or to suppress rejection of transplanted organs. (wikipedia.org)
In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may serve as cancer rejection antigens. (providence.org)

Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
Although cure of metastatic prostate cancer remains elusive, continuous advances in management have improved the outlook in these patients. (medscape.com)
Three of four patients had tumor cells available for testing. (biomedcentral.com)
Patients receive lympho-depleting chemotherapy of standard regimen fludarabine and cyclophosphamide, followed 72 hours later by the infusion of the autologous CAR T cells. (urologytimes.com)
The incidence of prostate cancer is high in the elderly male patients, which seriously threatens the life and health. (asmepress.com)
During his time at Johns Hopkins, Dr. Lim built one of the largest brain tumor and trigeminal neuralgia practices and utilized the most advanced surgical technologies and techniques for his patients. (stanfordhealthcare.org)
Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer. (providence.org)
Since the process is far from perfect, theoretically as many as several million unedited naïve T-cells from a third party could be present in a dose given to patients. (cellandgene.com)
21 chemo naive CRPC patients received maximally 9 vaccinations with mature myeloid dendritic cells (mDCs), plasmacytoid (pDCs) or a combination of mDCs plus pDCs. (immucura.com)
The primary objective of the new study is to assess the safety and tolerability of the ACTolog therapy in patients with target-positive solid tumors, according to the release. (pharmacytimes.com)
The ORR was 64% in patients with prior T-cell redirecting therapy. (medscape.com)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). (medscape.com)

Broadly, most chemotherapeutic drugs work by impairing mitosis ( cell division ), effectively targeting fast-dividing cells . (wikidoc.org)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)

One common feature to these antigens is their presence in central immunological tolerance. (nih.gov)

AB-1015 is an ICT cell therapy engineered to treat ovarian cancer. (arsenalbio.com)

Thus, development of methods to screen for therapy-induced anti-tumor responses is a high priority that could help tailor therapy. (providence.org)
Quality control - after a product is made, what methods can be used to ensure the gene editing process has done the work and 100% of the cells in the infused product have undergone successful gene editing? (cellandgene.com)
This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)

Anatomy25

Organisms8

Diseases54

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes43

Disciplines and Occupations1

Information Science4

Health Care8

Immunotherapy39

Chimeric antigen receptor11

Receptor10

Cancers18

Microenvironment4

Malignant10

Patient's5

Prostatectomized prostate cancer1

Vaccine12

Castration-resistant prostate cancer3

Maturation4

Therapies20

Induce5

Therapeutic6

Immunogenic4

Solid tumor3

Membrane3

Specific antigen4

Cellular6

Allogeneic9

Vivo5

Recombinant5

Clinical8

Cancer-testis1

Anti-tumor effects1

Vaccines3

Antibody3

Chemotherapy affects cell division2

BCMA1

Provenge5

Lymphoma5

Lymph node3

Lysate1

Immunotherapies1

20231

PSMA2

Immune cells1

Antitumor1

Progression4

Vaccination2

Differentiation1

Vitro1

Stem5

Peripheral blood2

Rejection2

Patients14

Chemotherapeutic4

Immunological1

Ovarian cancer1

Methods5