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  • urinary
  • A urinalysis may be done, for example, to check for urinary tract infection and imaging tests, such as an ultrasound, may be done to examine the prostate. (labtestsonline.org)
  • Prostate cancer in the spine can also compress the spinal cord, causing tingling, leg weakness and urinary and fecal incontinence. (wikipedia.org)
  • Lower urinary tract symptoms (LUTS) refer to a group of clinical symptoms involving the bladder, urinary sphincter, urethra, and, in men, the prostate. (wikipedia.org)
  • Symptoms can be categorised into: Increased frequency of urination Increased urgency of urination Painful urination Excessive passage of urine at night Poor stream (unimproved by straining) Hesitancy (worsened if bladder is very full) Terminal dribbling Incomplete voiding Urinary retention Overflow incontinence (occurs in chronic retention) Episodes of near retention As the symptoms are common and non-specific, LUTS is not necessarily a reason to suspect prostate cancer. (wikipedia.org)
  • Large studies of patients have also failed to show any correlation between lower urinary tract symptoms and a specific diagnosis. (wikipedia.org)
  • molecular
  • Yes, we certainly need the research focus to turn towards the molecular biology of prostate "cancer" wherein a solution to this problem may lie, but until then it is doing a serious disservice to men to state the kind of timid and insipid conclusion of this editorial, rather than a clear cease and desist recommendation on PSA screening. (bmj.com)
  • Slawin is a co-discoverer of -2proPSA (P2PSA), a molecular form of prostate specific antigen, which has been shown to improve the accuracy of prostate cancer screening. (wikipedia.org)
  • The -2proPSA, along with free and total PSA, are measured in a new molecular test called the prostate health index (phi) (Beckman Coulter, Inc.) that was FDA-approved in 2012 is now widely available. (wikipedia.org)
  • Prostatic
  • The complexed form is probably more specific for prostatic cancer but the diagnostic role of complexed PSA assays is not yet established. (edu.au)
  • Sometimes prostate cancer does cause symptoms, often similar to those of diseases such as benign prostatic hyperplasia. (wikipedia.org)
  • Slawin joined the Baylor College of Medicine as Director of The Baylor Prostate Center in 1994, and was appointed the Dan Duncan Family Professor in Prostate Cancer and Prostatic Diseases in 2003, after the well known Houston philanthropist. (wikipedia.org)
  • DU145 (DU-145) and PC3 human prostate cancer cell lines are the "classical" cell lines of prostatic cancer. (wikipedia.org)
  • nanograms per milliliter
  • In a study published in the April 2009 issue of The Journal of Urology , researchers found that in a subgroup of elderly men, among those who were 75 years old or older and had a PSA below 3 ng/ml (nanograms per milliliter), none subsequently died of prostate cancer. (scienceblog.com)
  • bind
  • Aptamers (from the Latin aptus - fit, and Greek meros - part) are oligonucleotide or peptide molecules that bind to a specific target molecule. (wikipedia.org)
  • In contrast to common antibodies, two out of six single-domain antibodies survived a temperature of 90 °C (194 °F) without losing their ability to bind antigens in a 1999 study. (wikipedia.org)
  • Camelid and fish derived sdAbs are able to bind to hidden antigens that are not accessible to whole antibodies, for example to the active sites of enzymes. (wikipedia.org)
  • A type of white blood cell, the B cell that produces antibodies that bind to the antigen are then harvested from the mouse. (wikipedia.org)
  • diagnosis
  • Some organizations, such as the U.S. Preventive Services Task Force, feel that the harms associated with over-diagnosis and over-treatment outweigh the potential benefits and advise against using PSA to screen for prostate cancer in healthy men of any age. (labtestsonline.org)
  • A practical guide to prostate cancer diagnosis and management. (clevelandclinic.org)
  • He is also the co-inventor on several patents related to the advancement of prostate cancer diagnosis, staging and treatment and to the cellular immunotherapy of cancer. (wikipedia.org)
  • biomarkers
  • The most extreme case would be to detect mutant proteins as cancer specific biomarkers through Selected Reaction Monitoring (SRM), since mutant proteins can only come from an existing tumor, thus providing ultimately the best specificity for medical purposes. (wikipedia.org)
  • Prognostic biomarkers indicate the likelihood of patient outcome regardless of a specific treatment. (wikipedia.org)
  • Predictive biomarkers are used to help optimize ideal treatments, and indicates the likelihood of benefiting from a specific therapy. (wikipedia.org)
  • molecule
  • CAMBRIDGE, Mass., July 21, 2011 /PRNewswire/ -- Quanterix Corporation, an in-vitro diagnostics (IVD) company providing life science researchers and IVD labs single molecule technology with unprecedented sensitivity and precision, announced that the analytical performance of AccuPSA™, a fifth-generation digital immunoassay for Prostate Specific Antigen (PSA), demonstrated a robust 2-log improvement in sensitivity over today's ultrasensitive third-generation assays for measuring PSA in patients following radical prostatectomy. (mdtmag.com)
  • Urology
  • In 1962, Dr. George Mellinger, the hospital's chief of urology, who was administering a cooperative research project involving fourteen hospitals, asked Gleason to develop a standardized pathological testing system to measure the development of prostate cancer. (wikipedia.org)
  • receptor
  • Slawin is a co-inventor with David Spencer, PhD, of inducible CD40 (iCD40), a re-engineered dendritic cell receptor protein which allows for the in-vivo activation of the immune system in a specific, controlled manner. (wikipedia.org)
  • Cartilaginous fishes also have heavy-chain antibodies (IgNAR, 'immunoglobulin new antigen receptor'), from which single-domain antibodies called VNAR fragments can be obtained. (wikipedia.org)
  • human
  • E1A was expressed at high levels in CN706-infected human PSA-producing LNCaP cells but not in CN706-infected DU145 cells, which are human prostate cells that do not express PSA. (aacrjournals.org)
  • LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. (wikipedia.org)
  • antibodies
  • Such naïve libraries usually contain only antibodies with low affinity to the desired antigen, making it necessary to apply affinity maturation by random mutagenesis as an additional step. (wikipedia.org)