Prostate cancer cells cell cell. Medical search. Frequent questions

These four pomegranate compounds inhibited DHT-stimulated androgen receptor nuclear accumulation and the expression of the androgen receptor-dependent genes prostate specific antigen and steroid 5α-reductase type 1 at concentrations ≥10 μM. (nih.gov)
CNPY2 up-regulated gene expression of AR target genes such as KLK3 gene which encodes the prostate specific antigen (PSA) and promoted cell growth of PC cells. (oncotarget.com)
Background: The detection and diagnosis of prostate cancer was greatly improved with the introduction of the prostate specific antigen (PSA) test and the transrectal ultrasound prostate (TRUS) biopsy. (ntu.ac.uk)
With the advancements in prostate-specific antigen (PSA) screening, most prostate cancers are detected at the regional stages (clinically localised disease). (biomedcentral.com)
The only test currently available for prostate cancer - the 'prostate specific antigen' or PSA test - is unreliable so is offered only to men over 50 if they request it. (dailymail.co.uk)
The EPI test assists physicians in determining the need for a prostate biopsy in patients with an ambiguous prostate specific antigen (PSA) test result. (genomeweb.com)
For prostate cancer, grade group information and prostate-specific antigen levels are used in conjunction with TNM status to group cases into four overall stages. (wikipedia.org)
citation needed] Grade Group 1 = Gleason 6 (or less) Grade Group 2 = Gleason 3+4=7 Grade Group 3 = Gleason 4+3=7 Grade Group 4 = Gleason 8 Grade Group 5 = Gleason 9-10 In the AJCC (2018) staging system, the tumor, lymph node, metastasis, gleason grade grouping and Prostate-specific antigen status can be combined into four stages of worsening severity. (wikipedia.org)
The CPG score is decided by looking at the Grade Group or Gleason score, the prostate specific antigen (PSA) level, and the clinical tumor stage. (wikipedia.org)
A more refined prognosis can be established by consideration of prostate-specific antigen, and grade (i.e. (wikipedia.org)
Another striking effect of clorgyline was the induction of androgen receptor (AR) and classic AR target genes such as prostate-specific antigen together with other secretory epithelial cell-specific genes, suggesting that clorgyline promotes differentiation of cancer cells. (biomedcentral.com)
In contrast, each increase of 10% in the percent of the tumor classified as grade 4/5 at the time of surgery leads to a 10% increase in the failure rate as measured by detectable and rising serum prostate specific antigen (PSA), a biomarker of prostate cancer (PCa). (biomedcentral.com)
DURHAM, N.C. - Researchers at the Duke Cancer Institute who have been studying prostate cancer cells for decades now think they know why PSA (prostate-specific antigen) levels reflect cancer progression. (scienceblog.com)
The Cedars-Sinai/UCLA researchers found capsaicin also reduced cancer cell production of prostate specific antigen (PSA). (cancerdefeated.com)
The prostate-specific antigen (PSA) blood test and digital rectal exam are two important screening tests that can help detect prostate cancer before it spreads. (healthgrades.com)
2010 who were aged at least 18 years, had a prostate-specific antigen (PSA) screening test done within 12 months prior to enrollment, and had no prior history of prostate cancer. (cdc.gov)
Screening for prostate-specific antigen (PSA) has led to earlier detection of prostate cancer 3 , but elevated serum PSA levels may be present in non-malignant conditions such as benign prostatic hyperlasia (BPH). (nature.com)
Barry, M. J. Prostate-specific-antigen testing for early diagnosis of prostate cancer. (nature.com)
Over the past 15 years, public health authorities have downgraded recommendations for the prostate-specific antigen test as a screening tool to reduce the overdiagnosis and overtreatment of men … Researchers have made an important discovery about how prostate cancer may start to develop. (barrocotech.com)
To achieve targeted inhibition, we took advantage of the unique expression of the carboxypeptidase prostate-specific membrane antigen (PSMA) by tumor endothelial cells within the microenvironment of solid tumors. (johnshopkins.edu)
Diagnosis is suggested by digital rectal examination (DRE) or prostate-specific antigen (PSA) measurement and confirmed by transrectal ultrasound-guided biopsy. (msdmanuals.com)
Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate-specific antigen (PSA) level: A meta-analysis. (msdmanuals.com)

The findings also show a potential new source for prostate tumors - so-called luminal cells, which secrete various compounds used in the prostate. (nbcnews.com)
But the cells can also form tumors if certain genes meant to stop out-of-control growth get turned off. (nbcnews.com)
Shen said researchers had believed that tumors arise from a different layer of cells in the prostate, called basal cells. (nbcnews.com)
Interestingly, Chang said, his laboratory also discovered that although androgen deprivation therapy shrinks tumors, it also might inadvertently promote cell metastasis due to altered cell signaling in the region of the tumor. (rochester.edu)
Here we show that a 'blocking' antibody to SPINK1 could slow the growth of prostate tumors in mice that were positive for the SPINK protein," says study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and a Howard Hughes Medical Institute Investigator. (sciencedaily.com)
We generated patient-derived cell lines from primary prostate cancers using conditional reprogramming methods and applied targeted sequencing to evaluate the fidelity of these cell lines to the original patient tumors. (broadinstitute.org)
The panel detected driver mutations in a diverse set of clinical samples of prostate cancer, including fresh-frozen tumors, cell-free DNA, CTCs, and cell lines. (broadinstitute.org)
High intratumoral plasma cells content in primary prostate cancer defines a subset of tumors with potential susceptibility to immune-based treatments. (physiciansweekly.com)
The volume and weight of tumors was measured and analyzing the ability of purified DU145 cells isolated from the tumors to migrate and proliferate. (jcancer.org)
The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
Prostate cancer threatens the health of men over sixty years old, and its incidence ranks first among all urinary tumors among men. (biomedcentral.com)
Enzalutamide remains the first-line drug for castration-resistant prostate cancer, however, tumors inevitably become resistant to enzalutamide. (biomedcentral.com)
In a statement 2 from the American Association for Cancer Research, S ren Lehmann, M.D., Ph.D., a visiting scientist at the Cedars-Sinai Medical Center and the UCLA School of Medicine said, 'It [capsaicin] also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models. (cancerdefeated.com)
This protein is often abundant in prostate tumors. (cancerdefeated.com)
A study from Washington University School of Medicine in St. Louis has identified an RNA molecule that suppresses prostate tumors. (genengnews.com)
In this study, we identified a long noncoding RNA (lncRNA), NXTAR (LOC105373241), that is located convergent with the AR gene and is repressed in human prostate tumors and cell lines. (genengnews.com)
This means that in all the prostate cancer samples that we study, we rarely find NXTAR, because it is suppressed by the heavy presence of the androgen receptor in these types of tumors. (genengnews.com)
The researchers demonstrated restoring NXTAR expression caused the tumors to shrink using human prostate tumor samples implanted in mice. (genengnews.com)
Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression. (bvsalud.org)
We aimed to evaluate which immune-related genes and cell types are differentially expressed in AA tumors and how immunobiology impacts prostate cancer progression. (bvsalud.org)
Although estimated immune cell abundances were not different by race , we identified genes involved in metabolism and natural killer cell functions that were differentially expressed between AA and CA tumors . (bvsalud.org)
Among the entire cohort, depletion of mast cells within prostatectomy tumors was characteristic of advanced disease and susceptibility to disease progression . (bvsalud.org)

Primary and metastatic prostate cancers have low mutation rates and recurrent alterations in a small set of genes, enabling targeted sequencing of prostate cancer-associated genes as an efficient approach to characterizing patient samples (compared to whole-exome and whole-genome sequencing). (broadinstitute.org)
We developed a prostate cancer-specific targeted next-generation sequencing (NGS) panel to detect alterations in 62 prostate cancer-associated genes as well as recurring gene fusions with ETS family members, representing the majority of common alterations in prostate cancer. (broadinstitute.org)
The prostate cancer-specific panel identified biologically and clinically relevant alterations, including point mutations in driver oncogenes and ETS family fusion genes, in tumor tissues from 29 radical prostatectomy samples. (broadinstitute.org)
The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
Furthermore, positive correlation of expression levels between CNPY2 and AR/AR target genes was observed in tissue samples from human prostate cancer patients. (oncotarget.com)
Therefore, the aim of this study was to evaluate the effects of common genetic variants among eight immunodeficiency pathway-related genes on disease recurrence in prostate cancer patients treated with radical prostatectomy. (biomedcentral.com)
Genetic and bioinformatic analyses on 19 haplotype-tagging single-nucleotide polymorphisms in eight immunodeficiency pathway-related genes were conducted in 458 patients with prostate cancer after receiving radical prostatectomy. (biomedcentral.com)
The present study suggests the potential role of immunodeficiency pathway-related genes, primarily TNFRSF13B , in prostate cancer progression. (biomedcentral.com)
In the present study, we first conducted a genetic analysis to evaluate the effects of common variants among eight immunodeficiency pathway-related genes on disease recurrence in 458 patients with prostate cancer after receiving radical prostatectomy. (biomedcentral.com)
Until now academics knew of only six genes linked to prostate cancer, but the research gives a total of 23 that can be assessed in a simple spit or blood test. (dailymail.co.uk)
The researchers found that men with four of the newly discovered genes were on average 11 times more likely to have aggressive tumours than prostate cancer patients without the genes. (dailymail.co.uk)
Bioinformatic analyzing approaches were used to identified the over-expressed genes in prostate cancer tumor tissues from three GEO datasets. (biomedcentral.com)
Genes differentially expressed in treated and control cells were identified by Significance Analysis of Microarrays. (biomedcentral.com)
We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
As a consequence, 4HPR led to the regulation of genes controlling cell proliferation, angiogenesis and metastasis. (biomedcentral.com)
Here we establish many associations between genes and prostate cancer. (nature.com)
We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically stratified prostate-cancer specimens. (nature.com)

Previous studies that looked at cetuximab for metastatic prostate cancer have been disappointing, with only 8 percent of patients showing some benefit. (sciencedaily.com)
We tested this panel on primary prostate cancer tissues and blood biopsies from patients with metastatic prostate cancer. (broadinstitute.org)
The targeted panel also identified genomic alterations in cell-free DNA and circulating tumor cells (CTCs) from patients with metastatic prostate cancer, and in standard prostate cancer cell lines. (broadinstitute.org)
Recent advances in the treatment of metastatic prostate cancer (PC) led to the FDA-approval of many effective therapies (abiraterone acetate, enzalutamide, radium-223), which demonstrated a significant survival benefit for patients with castrate resistant PC [ 1 , 2 ] . (oaepublish.com)
The use of circulating tumor cells (CTCs) as a "liquid biopsy" to interrogate the molecular profile of single patients is extremely encouraging, as these cells originate from primary tumor and metastatic sites, providing a comprehensive fingerprint of a given tumor at any time during the course of the disease with a simple blood draw [ 7 ] . (oaepublish.com)
Prostate cancer shows an extremely slow progression, appearing in its metastatic, hormone refractory phenotype mostly in elderly men. (biomedcentral.com)
Processes involved in later stage disease, like development of androgen independence as a consequence of androgen depletion therapy, neoangiogenesis and homing of metastatic cells in lymphatic or bone tissues are generally undetectable at early stages. (biomedcentral.com)
Since angiogenesis and metastatic spread are strictly related, in this study we analyzed the regulation of multiple signaling pathways responsible for cancer cell invasion. (biomedcentral.com)
For the slow evolving prostate tumor to become metastatic multiple mechanisms must be activated and our results identify novel points of regulation by 4HPR, independent of ROS generation, that further support its use as a chemopreventive or therapeutic agent. (biomedcentral.com)
Signature expression profiles of normal adjacent prostate (NAP), BPH, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. (nature.com)

A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
The aim of the study is to assess whether alterations in the phenotype and function of NK cells induced by the presence of prostate cancer can be detected in the periphery and be used as parameters for aiding diagnosis and assessing disease progression. (ntu.ac.uk)
However, the link between immunodeficiency and prostate cancer progression remains unclear. (biomedcentral.com)
Radical prostatectomy is a common treatment for localised prostate cancer with intermediate or high risk of disease progression. (biomedcentral.com)
However, no study has yet systematically investigated the effect of gene variants related to immunodeficiency on prostate cancer progression. (biomedcentral.com)
Our study uncovered a novel molecular mechanism of lncRNA SNHG4 in driving prostate cancer progression and enzalutamide resistance, revealing the critical roles and therapeutic potential of RREB1, SNHG4, RRM2 and let-7 miRNAs in anticancer therapy. (biomedcentral.com)
Environmental factors such as diet are thought to influence prostate cancer development and progression. (cdc.gov)
A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
Cadherin switching in human prostate cancer progression. (nature.com)
Shurbaji, M. S., Kalbfleisch, J. H. & Thurmond, T. S. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. (nature.com)
Impaired intratumoral cellular immune composition, especially for TIL-normalized mast cells , may be vital in predicting and contributing to prostate cancer disease progression . (bvsalud.org)

Investigators are starting to realize that tumor proliferation and tumor migration are two different things and should be treated as such," said Chang, the George Hoyt Whipple Distinguished Professor of Pathology, Urology, and Radiation Oncology at the University of Rochester and Wilmot Cancer Institute. (rochester.edu)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
Furthermore, the TNFRSF13B was knocked down in 22Rv1 and PC-3 human prostate cancer cell lines via transfecting short hairpin RNAs and cell proliferation and colony formation assays were performed. (biomedcentral.com)
CCK-8, plate colony formation and EdU assays were performed to assess the cell proliferation. (biomedcentral.com)
In addition, SNHG4 or RRM2 knockdown significantly induced cell cycle arrest and cell senescence, and inhibited DNA damage repair and cell proliferation, and the effects can be partially reversed by let-7a knockdown or RRM2 reoverexpression. (biomedcentral.com)
In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
it has been hypothesized that dietary calcium may increase prostate cancer risk by reducing circulating levels of 1,25-dihydroxyvitamin D (1,25[OH] 2 D) (10), which promotes the differentiation and inhibits the proliferation of prostate cells (11). (cdc.gov)

It has several subtypes, and one type called castrate-resistant prostate cancer (CRPC) eludes the most aggressive treatments including androgen deprivation therapy. (rochester.edu)
However, most PCa patients inevitably develop castration-resistant prostate cancer (CRPC), which is a fatal form of PCa that is difficult to confront [ 6 ]. (biomedcentral.com)
Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate cancer (PC), including castration-resistant prostate cancers (CRPC) that have developed resistance to second-generation AR antagonists such as enzalutamide," the researchers wrote. (genengnews.com)

Yan notes that clinical trials indicated bortezomib is not particularly effective at treating prostate cancer, but in combination with JKE-1674, they have laboratory evidence it becomes a powerful foe against the common cancer. (genengnews.com)
Again, these clinical events underscore the concern that prostate cancer cells spread inadvertently by surgical "treatment", may exist dormant before reactivation and recurrence of disease years later. (urologyweb.com)
NEW YORK (GenomeWeb) - Bio-Techne today announced that it has received a clinical laboratory permit from the New York State Department of Health to provide its liquid biopsy-based ExoDx Prostate IntelliScore (EPI) test in the state. (genomeweb.com)
Prostate cancer stage can be assessed by either clinical or pathological staging methods. (wikipedia.org)
Clinical staging usually occurs before the first treatment and tumour presence is determined through imaging and rectal examination, while pathological staging is done after treatment once a biopsy is performed or the prostate is removed by looking at the cell types within the sample. (wikipedia.org)
In the context of prostate cancer, CTC molecular interrogation can enable longitudinal monitoring of key biological features during treatment with substantial clinical impact, as several biomarkers could predict tumor response to AR signaling inhibitors (abiraterone, enzalutamide) or standard chemotherapy (taxanes). (oaepublish.com)
Clinical adenoviral gene therapy for prostate cancer. (ox.ac.uk)
Therefore, there is a clear clinical need for new treatment modalities that can, on the one hand, enhance the cure rate of primary therapy for localized prostate cancer and, on the other hand, improve the treatment of metastasized disease. (ox.ac.uk)
As the first of a trilogy of reviews on the state of the art and future prospects of gene therapy in prostate cancer, this review focuses on the clinical experiences and progress of adenovirus-mediated gene therapy for this disease. (ox.ac.uk)
New clinical and molecular data emerging from prostate cancers treated by contemporary androgen deprivation therapies, as well as primary lesions, have highlighted the need for refinement of diagnostic terminology to encompass the full spectrum of NE differentiation. (nih.gov)
Therefore, understanding the molecular basis of the aggressive behavior of grade 4/5 cancer is of considerable clinical relevance. (biomedcentral.com)
PC cells usually remain confined in the organ, while a small proportion of carcinomas acquire the ability to metastasize and approximately 80% of patients who have died of advanced hormone refractory PC have clinical evidence of bone metastasis. (biomedcentral.com)
Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer. (nature.com)
On the basis of these data, a phase 1 dose-escalation clinical trial has been initiated with G202 in patients with advanced cancer. (johnshopkins.edu)

These data provide a rationale for the use of metformin in the treatment of hormone naïve and castration-resistant prostate cancer and suggest AR is an important indirect target of metformin. (biomedcentral.com)

We evaluated a prostate cancer-specific targeted NGS panel to detect common and clinically relevant alterations (including ETS family gene fusions) in prostate cancer. (broadinstitute.org)
Our study supports that a prostate cancer-specific targeted sequencing panel provides an efficient, clinically feasible approach to identify genetic alterations across a spectrum of prostate cancer samples and cell lines. (broadinstitute.org)
Therapeutic strategies designed to reduce Skp2 may clinically play an important role in the treatment of both androgen-sensitive and hormone-refractory prostate cancer. (iiarjournals.org)
The transitional zone and central zone are not common locations for clinically important prostate cancers. (medscape.com)
The field of circulating tumor cell (CTC) enrichment has seen many emerging technologies in recent years, which have resulted in the identification and monitoring of clinically relevant, CTC-based biomarkers that can be analyzed routinely without invasive procedures. (oaepublish.com)

The underlying hypothesis of this study was that the presence of prostate cancer would induce detectable changes in the phenotype and function of NK cells in the periphery and that the detection of these would improve the diagnosis and prognosis of prostate cancer. (ntu.ac.uk)
Increased TNFRSF13B expression suggested poor prognosis in four independent prostate cancer datasets. (biomedcentral.com)
While TNM staging is important, systems based just on anatomic features are not well suited for deciding what treatment is best for a patient with prostate cancer, as there is still considerable heterogeneity of prognosis within the stage categories. (wikipedia.org)

Additionally, evaluation of the EV cargo revealed proteins associated with an AG prostate cancer phenotype elevated in FUT8-transformed EVs, while capturing aberrant activity of the cells endocytic-related machinery. (cancer.gov)
Aim and hypothesis: Evading immune destruction is one of the emerging hallmarks of cancer, as part of which tumours create an immunosuppressive microenvironment which has the potential to modify the phenotype and function of immune cells such as natural killer (NK) cells. (ntu.ac.uk)
Although further investigation is needed, no evidence of an immunosuppressive effect by prostate cancer on the phenotype and function of peripheral NK cells was observed in this study. (ntu.ac.uk)
potential of serial dilutions of rapidly-adherent α2β1hi/CD44hi cells compared to non-adherent cells with α2β1low/CD44low phenotype. (ecologicalsgardens.com)
This non-migratory phenotype was similarly produced in both cell lines by stable silencing of β-catenin. (biomedcentral.com)
These data point to 4HPR as a negative regulator of AKT phosphorylation, effectively targeting the β-catenin pathway and inducing a relatively benign phenotype in prostate cancer cells, limiting neoangiogenesis and cell invasion. (biomedcentral.com)

These glands and ducts are distributed in the prostate and surrounded by stromal tissues. (jcancer.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Such cells can clump to form tumours, which often invade and destroy surrounding tissues. (lu.se)

During the robotic radical prostatectomy treatment, showers of cancer cells are released from the affected prostate gland into the bloodstream. (urologyweb.com)
The prostate is a small gland found in men just below the bladder, surrounding the urethra, the tube urine passes through. (lu.se)
Stage I disease is cancer that is found incidentally in a small part of the sample when prostate tissue was removed for other reasons, such as benign prostatic hypertrophy, and the cells closely resemble normal cells and the gland feels normal to the examining finger. (wikipedia.org)
In Stage II more of the prostate is involved and a lump can be felt within the gland. (wikipedia.org)
have prostate cancer that may have broken through the capsule (covering) of the prostate gland but it hasn't spread any further. (cancerresearchuk.org)

It tests for three exosomal RNA biomarkers to enable physicians to assess whether a patient presenting for an initial biopsy is at greater risk for high-grade prostate cancer. (genomeweb.com)
7) and high-grade prostate cancer (Gleason score ≥7). (cdc.gov)
Calcium from food is associated with lower risk for prostate cancer, particularly among black men, and lower risk for high-grade prostate cancer among all men. (cdc.gov)

In contrast to the systemic spread of cancer cells via surgical manipulation or morcellation, the spillage of cancer cells locally through conventional surgery, needle biopsies or laparoscopic manipulation has also been recorded. (urologyweb.com)
I hate to think of men undergoing prostate biopsies because of faulty PSA tests. (cancerdefeated.com)

This may give a clue as to why prostate cancer often becomes resistant to treatments designed to regulate these androgens in the later stages of the disease," added Rippon, who was not involved in the research. (nbcnews.com)
Michael Shen of Columbia University Medical Center and colleagues named the new stem cells CARNs, for castration-resistant Nkx3.1-expressing cells. (nbcnews.com)
A research team believes that one way to kill resistant prostate cancer cells will be with use of a lot of iron. (genengnews.com)
Yan is putting together a strategy to change that and enable death by iron for treatment-resistant prostate cancer through a cell-death process called ferroptosis. (genengnews.com)
SV40 immortalized mouse embryonic fibroblasts derived from Bax-Bak double-knockout mice were significantly more resistant to GL-induced cell killing compared with wild-type cells. (aspetjournals.org)
It is interesting to note that a representative normal prostate epithelial cell line (PrEC) was relatively more resistant to GL-mediated cellular responses compared with prostate cancer cells. (aspetjournals.org)
this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)

Molecular genetics and epidemiology of prostate carcinoma. (nature.com)
Phytoestrogens: Epidemiology and a possible role in cancer protection. (cdc.gov)

But the MCG research team has found that the gene, ATF3, a regulator of cell stress which they have shown also can suppress prostate cancer, can make prostate cancer cells more vulnerable to a newer compound, JKE-1674, that can help induce ferroptosis. (genengnews.com)
The target, a gene called SPINK1, could be to prostate cancer what HER2 has become for breast cancer. (sciencedaily.com)
But the gene is an ideal target for a monoclonal antibody, the same type of drug as Herceptin, which is aimed at HER2 and has dramatically improved treatment for this aggressive type of breast cancer. (sciencedaily.com)
The androgen receptor (AR) is a ligand-dependent transcription factor that promotes prostate cancer (PC) cell growth through control of target gene expression. (oncotarget.com)
[ 5 ] The length of a polymorphic CAG repeat region in the first exon of the AR gene appears to explain the racial differences in the incidence of prostate cancer. (medscape.com)
Several molecular platforms have been used to investigate the molecular profile of the disease, from high throughput gene expression analyses down to single cell biological dissection. (oaepublish.com)
Gene therapy is now being explored in the clinic as a treatment option for the various stages of prostate cancer. (ox.ac.uk)
We systematically assessed gene expression changes induced by clorgyline in E-CA cells using high-density oligonucleotide microarrays. (biomedcentral.com)
Using microarrays of complementary DNA, we examined gene-expression profiles of more than 50 normal and neoplastic prostate specimens and three common prostate-cancer cell lines. (nature.com)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. (nature.com)
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. (nature.com)
Gene expression was measured using the NanoString platform from which we estimated immune cell abundances and assessed differences between groups based on clinicopathologic data. (bvsalud.org)

These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models. (researchgate.net)
control of prostate ca ncer using in vivo m odels. (researchgate.net)
Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
In vitro and in vivo experiments showed that SNHG4 overexpression markedly enhanced cell resistance to enzalutamide. (biomedcentral.com)
The cancer chemopreventive retinoid N -(4 hydroxyphenyl)retinamide (4HPR) has already been shown to restrain prostate cancer growth in vitro and in vivo, though its mechanisms of action are only partially explained. (biomedcentral.com)
G202 produced substantial tumor regression against a panel of human cancer xenografts in vivo at doses that were minimally toxic to the host. (johnshopkins.edu)

In a cell culture, Yan's team has watched increased ATF3 expression sensitize human prostate cancer cells to death by iron, and the new DOD funded studies are enabling the next steps: studying the induction in a mouse with human prostate cancer, called a humanized mouse model, to see whether ATF3-induced bortezomib paired with JKE-1674 again induces ferroptosis in advanced, typically lethal prostate cancer. (genengnews.com)
In this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent LNCaP human prostate cancer cells. (nih.gov)
We report an anticancer effect and mechanism of GL against human prostate cancer cells. (aspetjournals.org)
Treatment with GL significantly inhibited the viability of human prostate cancer cell line LNCaP (androgen-dependent) and its androgen-independent variant (C81) with an IC 50 of ∼1 μM (24-h treatment), at pharmacologically relevant concentrations standardized to its major active constituent z-guggulsterone. (aspetjournals.org)
Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into athymic nude mice. (jcancer.org)
Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
We have demonstrated that phenylacetate(PA)-induced cell cycle arrest in human prostate cancer is mediated by increase of p27. (iiarjournals.org)
Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). (biomedcentral.com)
Boston) - Researchers from the Boston University School of Medicine (BUSM) have demonstrated that commensal species of the genus Neisseriae are low inducers of human airway epithelial cell responses as compared to the pathogenic species. (scienceblog.com)
In fact, capsaicin caused a whopping 80 percent of human prostate cancer cells injected into living mice to undergo apoptosis-a type of cell suicide. (cancerdefeated.com)
According to the research - conducted in mice implanted with human prostate tumor samples - restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies. (genengnews.com)
Liotta, L. & Petricoin, E. Molecular profiling of human cancer. (nature.com)
A study published in BMC Complementary Medicine and Therapies looked at the effects of two mushroom extracts on human prostate cancer cells in culture. (barrocotech.com)

Cancer Res Commun;3(8): 1423-1434, 2023 08. (bvsalud.org)

Some of the ethnic differences in the incidence of prostate cancer are attributed to diets. (medscape.com)
[ 4 ] For example, Asians have the lowest incidence of prostate cancer, while Asian immigrants who have adopted Western-style diets have an increased incidence of the disease, although still less than that of the white population. (medscape.com)

Results and conclusions: Compared to Gleason 6 patients, a reduced expression of NK cell activating receptors (NKp30, NKp46, 2B4) was observed as the Gleason grade of the patients increased. (ntu.ac.uk)
For prostate cancer, cell morphology is graded based on the Gleason grading system. (wikipedia.org)
Adenocarcinomas of the prostate are categorized according to the Gleason grading system, which consists of five histological patterns based on microscopic tumor architecture [ 1 ]. (biomedcentral.com)

This review of major publications relating to prostate cancer and sleep sought to gain an understanding of the methods used for sleep assessment and the magnitude of effect that ADT has on sleep. (mdpi.com)

The median interval between initial diagnosis of prostatic adenocarcinoma and recurrence of small cell carcinoma is 25 months. (medscape.com)
A genetic breakthrough promises to improve prostate cancer diagnosis. (dailymail.co.uk)
The Daily Mail is campaigning for an urgent improvement in prostate cancer diagnosis, which is lagging years behind other diseases such as breast cancer. (dailymail.co.uk)
Study leader Professor Ros Eeles said: 'Men can receive a diagnosis of prostate cancer without really knowing how the disease is likely to affect them, but in future a test could pick out those who are likely to develop an aggressive disease and need intensive treatment. (dailymail.co.uk)
At the time of diagnosis most men with prostate cancer report no symptoms. (healthgrades.com)
Cancer incidence data are available for the United States, state and metropolitan areas (MSA) by age group, race, sex, ethnicity, year of diagnosis, childhood cancer classifications and cancer site for the years 1999 - 2020. (cdc.gov)
Cancer incidence data are available for Puerto Rico by age group, sex, year of diagnosis, childhood cancer classifications and cancer site for the years 2005 - 2020. (cdc.gov)
Cases were stratified by race, sex, and age for diagnosis (for screening-detected cancers). (cdc.gov)
For example, although breast cancer was the most were further categorized by stage at diagnosis as early-stage, common in 18 subgroups, lung cancer was the most common late-stage, or unknown. (cdc.gov)

AZD2461 suppresses the growth of prostate tumor cells since AZD2461 monotherapy could prove to be efficacious, especially against cells not expressing PTEN besides activating the possible apoptosis-independent cell death pathways. (ac.ir)
Signaling by the androgen-induced androgen receptor (AR) promotes cell growth of prostate cancer (PC) cells. (oncotarget.com)

These studies should stimulate the development of antibody-based therapies against SPINK1 or targeting of EGFR in SPINK1-positive cancer patients," says study author Bushra Ateeq, a research fellow at the U-M Medical School. (sciencedaily.com)
This non-invasive form of screening could be helpful in the molecular categorization of prostate cancer patients and administering therapies in a molecularly guided fashion," says Chinnaiyan, S.P. Hicks Endowed Professor of Pathology at the U-M Medical School and an American Cancer Society Research Professor. (sciencedaily.com)
The results of this project are a crucial step in identifying novel metabolic-based therapies that address the overarching goal of improving patient outcomes for men with prostate cancer. (australianrotaryhealth.org.au)
Prostate cancer staging is the process by which physicians categorize the risk of cancer having spread beyond the prostate, or equivalently, the probability of being cured with local therapies such as surgery or radiation. (wikipedia.org)
History Prostate tumor-initiating cells (TICs) have intrinsic resistance to current therapies. (ecologicalsgardens.com)
Although many patients with prostate cancer are treated with therapies that block hormones that fuel tumor growth, most patients develop resistance to these therapies. (genengnews.com)
We are hoping to develop both this (R)-9b drug and NXTAR into new therapies for prostate cancer patients who have developed resistance to the front-line treatments," Mahajan said. (genengnews.com)

The metal that is key to red blood cells carrying oxygen and other body fundamentals also is known to be lethal to cells in big doses, but prostate cancer cells are essentially impervious to it, says Chunhong Yan, PhD, molecular biologist at the Georgia Cancer Center and the department of biochemistry and molecular biology at the Medical College of Georgia (MCG). (genengnews.com)
Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. (ac.ir)
On July 31, 2013, the Prostate Cancer Foundation assembled a working committee on the molecular biology and pathologic classification of neuroendocrine (NE) differentiation in prostate cancer. (nih.gov)
Despite the accumulating knowledge about the biology of PCa, the molecular machineries that differ between grade 3 and 4/5 cancers and mark a critical change from curable to lethal are largely unknown. (biomedcentral.com)
Figure 1: The molecular signature of prostate cancer. (nature.com)
Abate-Shen, C. & Shen, M. M. Molecular genetics of prostate cancer. (nature.com)

Like HER2, SPINK1 occurs in only a small subset of prostate cancers -- about 10 percent. (sciencedaily.com)
About 10 percent of prostate cancer patients are SPINK1-positive and strategies to block SPINK1 signaling may have utility in this subset of patients. (sciencedaily.com)
The researchers will also look to further understand why SPINK1 is elevated in a subset of prostate cancers. (sciencedaily.com)

Researchers have found a stem cell, a kind of master cell, that may cause at least some types of prostate cancer. (nbcnews.com)
Researchers have identified a potential target to treat an aggressive type of prostate cancer. (sciencedaily.com)
Using stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics paired with nanoparticle tracking analysis (NTA), researchers were able to show that cellular increases in FUT8 expression in cancerous cells could reduce the overall number of secreted EVs, while increasing the abundance of cell motility and metastasis-associated proteins within them. (cancer.gov)
We owe this exciting discovery to researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center and colleagues from UCLA Medical School. (cancerdefeated.com)

Cells deprived of steroid hormones were exposed to increasing concentrations (1-100 μM) of pomegranate compounds in the presence of 0.1 nM dihydrotestosterone (DHT), and the inhibition of cell growth was measured by WST-1 colorimetric assay after a 4 day exposure. (nih.gov)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
The cell growth inhibition by CNPY2 knockdown was rescued by AR overexpression. (oncotarget.com)
Together, these results suggested that CNPY2 promoted cell growth of PC cells by inhibition of AR protein degradation through MYLIP-mediated AR ubiquitination. (oncotarget.com)
Inhibition of AR positive and negative prostate cancer cells by metformin suggests involvement of additional targets. (biomedcentral.com)
We found that 4HPR-induced inhibition of PC cell migration and invasion correlates with decreased FAK and AKT phosphorylation, activation of the glycogen synthase kinase 3β(GSK3β) and β-catenin destabilization. (biomedcentral.com)

Colored scanning electron micrograph of the surface of prostate cancer cells. (genengnews.com)
Prostate cancer cell, coloured scanning electron micrograph (SEM). (lu.se)

Although recorded, these localised tumor recurrences because of local cancer cell spillage are unusual and probably more likely to be associated with evaluations or treatments involving individuals with high-grade or aggressive cancers because their cells spread more readily. (urologyweb.com)
Treatments range from watchful waiting with careful follow-up for less aggressive cancers to combinations of surgery, radiation therapy, chemotherapy , and hormonal therapy for more aggressive or widespread cancers. (healthgrades.com)

A recent study by cancer researcher Chawnshang Chang, Ph.D. , provides additional proof of a concept he's been investigating for years: that the environment surrounding a prostate tumor plays a major role in metastasis, and new treatments should be designed to target that environment as well as the tumor itself. (rochester.edu)
Published by the International Journal of Oncology , Chang's laboratory found that bone marrow derived stem cells, which are recruited to the site of a growing tumor, are able to convert nearby normal fibroblast cells into cancer cells, resulting in tumor metastasis. (rochester.edu)
The latest paper suggests the microenvironment-the neighborhood of cells surrounding the tumor-is where stem cells can be recruited through altered cytokine-AR signals to boost prostate cancer metastasis. (rochester.edu)
The most common is promulgated by the American Joint Committee on Cancer (AJCC), and is known as the TNM system, which evaluates the size of the tumor, the extent of involved lymph nodes, and any metastasis (distant spread) and also takes into account cancer grade. (wikipedia.org)
Low ratios of mast cells versus TILs were associated with worse BCR-free survival and metastasis -free survival . (bvsalud.org)

Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers . (medscape.com)
Approximately 50% of patients have pure small cell carcinoma at initial presentation. (medscape.com)
[ 2 ] Another 25-40% of cases are initially diagnosed as prostatic adenocarcinoma and recur as small cell carcinoma after hormonal therapy. (medscape.com)
Unlike prostatic adenocarcinoma, small cell carcinoma of the prostate may present with metastases in up to 25% of patients. (medscape.com)
The distribution of prostatic small cell carcinoma is similar to that of prostatic adenocarcinoma. (medscape.com)
The risk factors for prostatic small cell carcinoma are related to those for prostatic adenocarcinoma and include age, race, and family history. (medscape.com)
[ 3 ] The overall risk of developing prostatic small cell carcinoma increases with age, with disease occurrence typically being in men older than 60 years. (medscape.com)
this finding is not surprising, since many patients actually have prostatic adenocarcinoma with a component of small cell carcinoma. (medscape.com)
The genetic changes specific to prostatic small cell carcinoma have not been studied in great detail. (medscape.com)
Undifferentiated prostate cancer, squamous cell carcinoma, and ductal transitional carcinoma also occur infrequently. (msdmanuals.com)

Prostate cancer shares many symptoms with benign prostatic hypertrophy (BPH), which is a noncancerous enlargement of the prostate, although BPH does not cause prostate cancer. (healthgrades.com)

In vitro ubiquitination assay showed a decreased p27 ubquitination in PA-treated prostate cancer cells. (iiarjournals.org)

however, no prostate cancer-specific mutations were identified in the tumor-derived cell lines, suggesting preferential outgrowth of normal prostate epithelial cells. (broadinstitute.org)
Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. (biomedcentral.com)

Furthermore, these released malignant cells can be in circulation for several years undetectable by conventional imaging means such as bone scans, MRIs and PET scans. (urologyweb.com)
Despite the finding of malignant cells in the bloodstream and bone marrow from a cancerous organ before any surgical manipulation and, the increased number of these cancer cells in the circulation after surgical manipulation, the natural history of these dispersed cancer cells is uncertain, but worrisome. (urologyweb.com)
However, the dispersed malignant cells can survive and exist dormant in various areas of the body for at least several years. (urologyweb.com)
Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. (biomedcentral.com)

ATF3 in turn induces expression of HMOX1, an enzyme and known antioxidant which basically cuts iron loose from places like hemoglobin so more can accumulate inside cells, which is lethal. (genengnews.com)

Interestingly, reduction of phospho-Akt and up-regulation of p27 mRNA levels were observed only in PC-3 cells. (iiarjournals.org)

The role of stem cells in the development of prostate cancer has been a focus of speculation for many years," Dr. Helen Rippon of Britain's Prostate Cancer Charity said in a statement. (nbcnews.com)
Other lifestyle factors, such as sexual practices and occupation, are currently not considered important with regard to the development of prostate cancer. (medscape.com)

It can be detected in the urine of prostate cancer patients, making it an easy test for urologists to perform routinely. (sciencedaily.com)
Unfortunately, its effectiveness in stratifying low risk patients from those with aggressive (AG) prostate cancer is poor. (cancer.gov)
Results from a study funded by Australian Rotary Health (ARH) was aimed to identify novel treatment strategies for prostate cancer patients, which remains a leading cause of death for men in Australia. (australianrotaryhealth.org.au)
Hormone therapy for most patients with prostate cancer aims to remove or block the function of the male hormone androgen. (jcancer.org)
Limited investigations into the ability of NK cells from patients to be primed only found phenotypic differences between healthy volunteers and patients in general (regardless of the presence of disease). (ntu.ac.uk)
Priming of NK cells from patients induced a lower induction of CD137 and CRTAM expression, and a greater down-regulation of NKp46 and CD96 expression compared to that which was observed following the priming of NK cells from healthy volunteers. (ntu.ac.uk)
Recent reports have also described a relatively early onset of breast and prostate cancers in patients with immunodeficiency [ 12 , 13 ]. (biomedcentral.com)
In men already diagnosed with prostate cancer, the test could pick out patients with the most aggressive disease, saving thousands from unnecessary treatment, while ensuring rapid attention for those whose lives are at risk. (dailymail.co.uk)
However, a substantial number of patients experience a recurrence, resulting in spreading of tumor cells to other parts of the body. (ox.ac.uk)
The drugs that we have to treat prostate cancer are effective initially, but most patients start developing resistance, and the drugs usually stop working after a year or two," explained senior author Nupam P. Mahajan, PhD, a professor of surgery in the division of urologic surgery. (genengnews.com)

recently released a study examining the impact of altered FUT8 expression on EV biogenesis and subsequent EV protein profiles, comparing aggressive prostate cancer cells to less aggressive ones. (cancer.gov)
This study establishes evidence of how altered cellular glycosylation enzyme expression impacts EV vesicle abundance and the protein content of EVs secreted from prostate cancer cells via dysregulation of the cell's endocytic pathway. (cancer.gov)
It also shows how differences in EV protein cargo, including glycosite occupancy and glycosylation patterns, may contribute to prostate carcinogenesis - making a case for EV-based diagnostics that incorporate glycosylation information for prostate cancer screening. (cancer.gov)
The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells. (aspetjournals.org)
A striking decrease in Skp2 mRNA and protein expression and reciprocal increase in p27 protein level were observed in three PA-treated prostate cancer cells. (iiarjournals.org)
This report suggests that Canopy FGF signaling regulator 2 (CNPY2) controls AR protein levels in PC cells. (oncotarget.com)
Western blot was used for analysis of protein levels, Boyden chamber assays for analyses of cell migration and co-immunoprecipitation (CoIP) followed by western blot, PCR or qPCR for analysis of protein-protein and protein-mRNA interactions. (biomedcentral.com)
It disrupted the AR translational MID1 regulator complex leading to release of the associated AR mRNA and subsequently to downregulation of AR protein in AR positive cell lines. (biomedcentral.com)
analyses using insulinoma cell lines showed that MENIN regulated MAFA protein and mRNA AP24534 (Ponatinib) levels and bound to promoter sequences. (ecologicalsgardens.com)
Stanford, CA - Plant biologists have discovered the last major element of the series of chemical signals that one class of plant hormones, called brassinosteroids, send from a protein on the surface of a plant cell to the cell's nucleus. (scienceblog.com)
We describe a strategy to selectively inhibit, within tumor sites, the function of a critical intracellular protein, the sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump, whose proper function is required by all cell types for viability. (johnshopkins.edu)

In conclusion, punicic acid, the main constituent of pomegranate seed (70-80%), exhibited potent growth inhibitory activities in androgen-dependent LNCaP cells, which appear to be mediated by both antiandrogenic and pro-apoptotic mechanisms. (nih.gov)
In this study, we further investigated the mechanism of PA-induced p27 expression in prostate cancer cells (LNCaP, androgen-independent LNCaP [AIDL] and PC-3). (iiarjournals.org)

For example, targeted sequencing provides a flexible, rapid, and cost-effective method for genomic assessment of patient-derived cell lines to evaluate fidelity to initial patient tumor samples. (broadinstitute.org)

For this reason, many doctors use PSA tests along with a digital rectal exam to help detect prostate cancer in men aged 50 and older. (cancerdefeated.com)

In contrast, the data was significantly lower with DU145 and stromal cells from TZ than DU145 alone. (jcancer.org)
These effects of the stromal cells in the PZ on DU145 cells could be blocked using imatinib mesylate. (jcancer.org)
MTT viability test, Annexin V‐FITC/propidium iodide double staining, and caspase3 activity assay were used to evaluate the apoptosis and relative expression of PTEN and VEGF in PC-3 and DU145 cell lines using real-time PCR. (ac.ir)
MTT results showed that the inhibitory effects of AZD2461 were higher in PC-3 than DU145 cells (with IC 50 of 36.48 and 59.03 µM at 48 hours of treatment, respectively). (ac.ir)

The C-Kit inhibitor, imatinib mesylate, was administrated to confirm the effect of stromal cells on the tumorigenesis. (jcancer.org)
Therefore, this preliminary study was designed to evaluate whether PTEN expression status could have an impact on the sensitivity of invasive Pca cells to the PARP inhibitor, AZD2461. (ac.ir)

Since SPINK1 can be made on the surface of cells, it attracted our attention as a therapeutic target. (sciencedaily.com)
These results revealed that cancers such as prostate cancer can be targeted based on these features and could lead to new therapeutic opportunities. (australianrotaryhealth.org.au)

Whether caused by cancer or BPH, prostate enlargement can interfere with the normal flow of urine and can lead to urinary hesitancy, dribbling, and incomplete bladder emptying. (healthgrades.com)
More advanced prostate cancers may cause blood in the urine and lower back or pelvic pain . (healthgrades.com)
When they occur, many of the symptoms of prostate cancer are related to constriction of the urethra and involve changes in urine flow. (healthgrades.com)
Prostate cancer can also cause pain in the pelvis or lower back and blood in the urine. (healthgrades.com)

Their findings are only experimental - the stem cells were found in mice - but could explain at least some types of prostate cancer and eventually offer new ways to treat it, they reported on Wednesday in the journal Nature. (nbcnews.com)
Previous research suggested that prostate cancer originates from basal stem cells, and that during cancer formation these cells differentiate into luminal cells," Shen said in a statement. (nbcnews.com)
Chang data's suggests several targeted treatment possibilities, by either interrupting the conversion process, or preventing the recruitment of stem cells from taking place. (rochester.edu)
The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)

But despite these efforts-about 90 percent of prostate cancer cells still may go unnoticed. (cancerdefeated.com)

And, in one study, the detection of prostate cancer cells in the blood of some men after their radical prostatectomy correlated with a rising PSA during follow-up and therefore, failure to cure. (urologyweb.com)

Hormonal influences contribute to the course of adenocarcinoma but almost certainly not to other types of prostate cancer. (msdmanuals.com)

MAO-A is also highly expressed in basal cells of the normal prostatic epithelium. (biomedcentral.com)

Anatomy13

Organisms4

Diseases29

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Phenomena and Processes49

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Health Care22

Geographicals1

Antigen22

Tumors23

Genes17

Metastatic10

Progression11

Proliferation9

CRPC3

Clinical14

Castration-resistant prostate cancer1

Clinically5

Prognosis3

Phenotype6

Tissues3

Gland5

High-grade prostate cancer3

Biopsies2

Resistant7

Epidemiology2

Gene12

Vivo6

Human13

20231

Incidence of prostate cancer2

Gleason3

Methods1

Diagnosis9

Growth of prostate2

Therapies7

Molecular6

Subset3

Researchers4

Inhibition6

Scanning electron m2

Aggressive cancers2

Metastasis5

Carcinoma11

Benign1

Vitro1

Normal prostate2

Malignant4

Induces1

Interestingly1

Development of prostate cancer2

Patients10

Protein11

LNCaP2

Tumor samples1

Help detect prostate cancer1

DU1454

Inhibitor2

Therapeutic2

Urine4

Stem cells5

Percent of prostate cancer1

Detection of prostate cancer1

Types of prostate cancer1

Basal cells1